Reduced anxiety and improved stress coping ability in mice lacking NPY-Y2 receptors

European Journal of Neuroscience

Volumn 18, Issue 1, 2003, Pages 143-148

  Tschenett, Alexandra ^a   Singewald, Nicolas ^b   Carli, Mirjana ^c   Balducci, Claudia ^c   Salchner, Peter ^b   Vezzani, Annamaria ^c   Herzog, Herbert ^d   Sperk, Günther ^a  

^a INNSBRUCK MEDICAL UNIVERSITY   (Austria)

^b UNIVERSITY OF INNSBRUCK   (Austria)

^c MARIO NEGRI INSTITUTE FOR PHARMACOLOGICAL RESEARCH   (Italy)

^d ST VINCENT S HOSPITAL   (Australia)

Author keywords

Amygdala; Anxiety; Depression; Hippocampus; Neuropeptide Y; Stress coping; Y2 receptor knockout

Indexed keywords

NEUROPEPTIDE Y2 RECEPTOR;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANXIETY; ARTICLE; BRAIN REGION; CONTROLLED STUDY; COPING BEHAVIOR; DEPRESSION; GENE DELETION; KNOCKOUT MOUSE; LOCOMOTION; MAZE TEST; MOOD DISORDER; MOUSE; NEGATIVE FEEDBACK; NEUROTRANSMITTER RELEASE; NONHUMAN; OPEN FIELD BEHAVIOR; PATHOPHYSIOLOGY; PRESYNAPTIC MEMBRANE; PRIORITY JOURNAL; RECEPTOR INTRINSIC ACTIVITY; STRESS; SWIMMING;

ADAPTATION, PSYCHOLOGICAL; ANIMALS; ANXIETY; AUTORADIOGRAPHY; BEHAVIOR, ANIMAL; DARKNESS; HIPPOCAMPUS; LIGHT; MICE; MICE, KNOCKOUT; RECEPTORS, NEUROPEPTIDE Y; STRESS, PSYCHOLOGICAL; SWIMMING;

EID: 0043169380     PISSN: 0953816X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1460-9568.2003.02725.x     Document Type: Article

References (48)

1. Bannon, A.W., Seda, J., Carmouche, M., Francis, J.M., Norman, M.H., Karbon, B. & McCaleb, M.L. (2000) Behavioral characterization of neuropeptide Y knockout mice. Brain Res., 868, 79-87.
2. Bouchard, P., Maurice, T., St-Pierre, S., Privat, A. & Quirion, R. (1997) Neuropeptide Y and the calcitonin gene-related peptide attenuate learning impairments induced by MK-801 via a sigma receptor-related mechanism. Eur. J. Neurosci., 9, 2142-2151.
3. Britton, K.T., Southerland, S., Van Uden, E., Kirby, D., Rivier, J. & Koob, G. (1997) Anxiolytic activity of NPY receptor agonists in the conflict test. Psychopharmacology (Berl), 132, 6-13.
4. Broqua, P., Wettstein, J.G., Rocher, M.N., Gauthier-Martin, B. & Junien, J.L. (1995) Behavioral effects of neuropeptide Y receptor agonists in the elevated plus-maze and fear-potentiated startle procedures. Behav. Pharmacol., 6, 215-222.
5. Caberlotto, L., Fuxe, K. & Hurd, Y.L. (2000) Characterization ofNPY mRNA-expressing cells in the human brain: co-localization with Y2 but not Y1 mRNA in the cerebral cortex, hippocampus, amygdala, and striatum. J. Chem. Neuroanat., 20, 327-337.
6. Chen, G. & van den Pol, A.N. (1996) Multiple NPY receptors coexist in pre- and postsynaptic sites: inhibition of GABA release in isolated self-innervating SCN neurons. J. Neurosci., 16, 7711-7724.
7. Colmers, W.F., Klapstein, G.J., Fournier, A., St-Pierre, S. & Treherne, K.A. (1991) Presynaptic inhibition by neuropeptide Y in rat hippocampal slice in vitro is mediated by a Y2 receptor. Br. J. Pharmacol., 102, 41-44.
8. Contarino, A. & Gold, L.H. (2002) Targeted mutations of the corticotropin-releasing factor system: effects on physiology and behavior. Neuropeptides, 36, 103-116.
9. Crawley, J. & Goodwin, F.K. (1980) Preliminary report of a simple animal behavior model for the anxiolytic effects of benzodiazepines. Pharmacol. Biochem. Behav., 13, 167-170.
10. Cryan, J.F., Markou, A. & Lucki, I. (2002) Assessing antidepressant activity in rodents: recent developments and future needs. Trends Pharmacol. Sci., 23, 238-245.
11. Diez, M., Koistinaho, J., DeArmond, S.J., Camerino, A.P., Groth, D., Caytano, J.C., Prusiner, S.B. & Hokfelt, T. (1996) Aberrant induction of neuropeptide Y mRNA in hippocampal CA3 pyramidal neurones in scrapie-infected mice. Neuroreport, 7, 1887-1892.
12. 125I]PYY3-36 binding sites in the rat brain evaluated with two newly developed Y1 and Y2 receptor radioligands. Synapse, 22, 139-158.
13. File, S.E. (2001) Factors controlling measures of anxiety and responses to novelty in the mouse. Behav. Brain Res., 125, 151-157.
14. Flood, J.F., Baker, M.L., Hernandez, E.N. & Morley, J.E. (1989) Modulation of memory processing by neuropeptide Y varies with brain injection site. Brain Res., 503, 73-82.
15. Furtinger, S., Pirker, S., Czech, T., Baumgartner, C., Ransmayr, G. & Sperk, G. (2001) Plasticity of Y1 and Y2 receptors and neuropeptide Y fibers in patients with temporal lobe epilepsy. J. Neurosci., 21, 5804-5812.
16. Griebel, G., Belzung, C., Perrault, G. & Sanger, D.J. (2000) Differences in anxiety-related behaviours and in sensitivity to diazepam in inbred and outbred strains of mice. Psychopharmacology (Berl), 148, 164-170.
17. Handley, S.L. & McBlane, J.W. (1993) An assessment of the elevated X-maze for studying anxiety and anxiety-modulating drugs. J. Pharmacol. Toxicol. Meth., 29, 129-138.
18. Hascoet, M., Bourin, M. & Dhonnchadha, B.A. (2001) The mouse light-dark paradigm: a review. Prog. Neuropsychopharmacol. Biol. Psychiatry, 25, 141-166.
19. Heilig, M., McLeod, S., Brot, M., Heinrichs, S.C., Menzaghi, F., Koob, G.F. & Britton, K.T. (1993) Anxiolytic-like action of neuropeptide Y: mediation by Y1 receptors in amygdala, and dissociation from food intake effects. Neuropsychopharmacology, 8, 357-363.
20. Heilig, M., Soderpalm, B., Engel, J.A. & Widerlov, E. (1989) Centrally administered neuropeptide Y (NPY) produces anxiolytic-like effects in animal anxiety models. Psychopharmacology (Berl), 98, 524-529.
21. Hokfelt, T., Broberger, C., Zhang, X., Diez, M., Kopp, J., Xu, Z., Landry, M., Bao, L., Schalling, M., Koistinaho, J., DeArmond, S.J., Prusiner, S., Gong, J. & Walsh, J.H. (1998) Neuropeptide Y: some viewpoints on a multifaceted peptide in the normal and diseased nervous system. Brain Res. Brain Res. Rev., 26, 154-166.
22. Kask, A., Harro, J., von Horsten, S., Redrobe, J.P., Dumont, Y. & Quirion, R. (2002) The neurocircuitry and receptor subtypes mediating anxiolytic-like effects of neuropeptide Y. Neurosci. Biobehav. Rev., 26, 259-283.
23. Kask, A., Rago, L. & Harro, J. (1996) Anxiogenic-like effect of the neuropeptide Y Y 1 receptor antagonist BIBP3226: antagonism with diazepam Eur. J. Pharmacol., 317, R3-R4.
24. Kask, A., Rago, L. & Harro, J. (1998) Anxiolytic-like effect of neuropeptide Y (NPY) and NPY13-36 microinjected into vicinity of locus coeruleus in rats. Brain Res., 788, 345-348.
25. LaBuda, C.J. & Fuchs, P.N. (2001) The anxiolytic effect of acute ethanol or diazepam exposure is unaltered in mu-opioid receptor knockout mice. Brain Res. Bull., 55, 755-760.
26. Lamberty, Y. & Gower, A.J. (1996) Arm width and brightness modulation of spontaneous behaviour of two strains of mice tested in the elevated plus-maze. Physiol. Behav, 59, 439-444.
27. Larsen, P.J., Sheikh, S.P., Jakobsen, C.R., Schwartz, T.W. & Mikkelsen, J.D. (1993) Regional distribution of putative NPY Y1 receptors and neurons expressing Y1 mRNA in forebrain areas of the rat central nervous system. Eur. J. Neurosci., 5, 1622-1637.
28. LeDoux, J.E. (2000) Emotion circuits in the brain. Annu. Rev. Neurosci., 23, 155-184.
29. McDonald, A.J. & Pearson, J.C. (1989) Coexistence of GABA and peptide immunoreactivity in non-pyramidal neurons of the basolateral amygdala. Neurosci. Lett., 100, 53-58.
30. Menzaghi, F., Howard, R.L., Heinrichs, S.C., Vale, W., Rivier, J. & Koob, G.F. (1994) Characterization of a novel and potent corticotropin-releasing factor antagonist in rats. J. Pharmacol. Exp. The.r, 269, 564-572.
31. Michel, M.C., Beck-Sickinger, A., Cox, H., Doods, H.N., Herzog, H., Larhammar, D., Quirion, R., Schwartz, T. & Westfall, T. (1998) XVI. International Union of Pharmacology recommendations for the nomenclature of neuropeptide Y, peptide YY, and pancreatic polypeptide receptors. Pharmacol. Rev., 50, 143-150.
32. Muglia, L., Jacobson, L., Dikkes, P. & Majzoub, J.A. (1995) Corticotropin-releasing hormone deficiency reveals major fetal but not adult glucocorticoid need. Nature, 373, 427-432.
33. Nakajima, M., Inui, A., Asakawa, A., Momose, K., Ueno, N., Teranishi, A., Baba, S. & Kasuga, M. (1998) Neuropeptide Y produces anxiety via Y2-type receptors. Peptides, 19, 359-363.
34. Pellow, S. & File, S.E. (1986) Anxiolytic and anxiogenic drug effects on exploratory activity in an elevated plus-maze: a novel test of anxiety in the rat. Pharmacol. Biochem. Behav, 24, 525-529.
35. Porsolt, R.D., Bertin, A. & Jalfre, M. (1977) Behavioral despair in mice: a primary screening test for antidepressants. Arch. Int. Pharmacodyn. Ther., 229, 327-336.
36. Redrobe, J. P., Dumont, Y., Fournier, A & Quirion, R. (2002) The neuropeptide Y (NPY) Y1 receptor subtype mediates NPY-induced antidepressant-like activity in the mouse forced swimming test. Neuropsychopharmacology, 26, 615-624.
37. Sainsbury, A., Schwarzer, C., Couzens, M., Fetissov, S., Furtinger, S., Jenkins, A., Cox, H.M., Sperk, G., Hokfelt, T. & Herzog, H. (2002) Important role of hypothalamic Y2 receptors in body weight regulation revealed in conditional knockout mice. Proc. Natl Acad. Sci. USA, 99, 8938-8943.
38. Sajdyk, T.J., Schober, D.A., Smiley, D.L. & Gehlert, D.R. (2002) Neuropeptide Y-Y2 receptors mediate anxiety in the amygdala. Pharmacol. Biochem. Behav., 71, 419-423.
39. Stanley, B.G. & Leibowitz, S.F. (1985) Neuropeptide Y injected in the paraventricular hypothalamus: a powerful stimulant of feeding behavior. Proc. Natl Acad. Sci. USA, 82, 3940-3943.
40. Stenzel-Poore, M.P., Cameron, V.A., Vaughan, J., Sawchenko, P.E. & Vale, W. (1992) Development of Cushing's syndrome in corticotropin-releasing factor transgenic mice. Endocrinology, 130, 3378-3386.
41. Stogner, K.A. & Holmes, P.V. (2000) Neuropeptide-Yexerts antidepressant-like effects in the forced swim test in rats. Eur. J. Pharmacol., 387, R9-R10.
42. Sun, Q.Q., Akk, G., Huguenard, J.R. & Prince, D.A. (2001) Differential regulation of GABA release and neuronal excitability mediated by neuropeptide Y1 and Y2 receptors in rat thalamic neurons. J. Physiol. (Lond.), 531, 81-94.
43. Tatemoto, K., Carlquist, M. & Mutt, V. (1982) Neuropeptide Y - a novel brain peptide with structural similarities to peptide YY and pancreatic polypeptide. Nature, 296, 659-660.
44. Thorsell, A., Michalkiewicz, M., Dumont, Y., Quirion, R., Caberlotto, L., Rimondini, R., Mathe, A.A. & Heilig, M. (2000) Behavioral insensitivity to restraint stress, absent fear suppression of behavior and impaired spatial learning in transgenic rats with hippocampal neuropeptide Yoverexpression. Proc. Natl Acad. Sci. USA, 97, 12852-12857.
45. Thorsell, A., Svensson, P., Wiklund, L., Sommer, W., Ekman, R. & Heilig, M. (1998) Suppressed neuropeptide Y (NPY) mRNA in rat amygdala following restraint stress. Regul. Pept., 75-76, 247-254.
46. Vezzani, A., Sperk, G. & Colmers, W.F. (1999) Neuropeptide Y: emerging evidence for a functional role in seizure modulation. Trends Neurosci., 22, 25-30.
47. Wahlestedt, C., Pich, E.M., Koob, G.F., Yee, F. & Heilig, M. (1993) Modulation of anxiety and neuropeptide Y-Y 1 receptors by antisense oligodeoxynucleotides. Science, 259, 528-531.
48. Zhang, X., Meister, B., Elde, R., Verge, V.M. & Hokfelt, T. (1993) Large calibre primary afferent neurons projecting to the gracile nucleus express neuropeptide Y after sciatic nerve lesions: an immunohistochemical and in situ hybridization study in rats. Eur. J. Neurosci., 5, 1510-1519.