-
1
-
-
33847381116
-
The fundamental basis of inflammatory bowel disease
-
Strober, W., Fuss, I. and Mannon, P. (2007) The fundamental basis of inflammatory bowel disease. J. Clin. Invest. 117, 514-521
-
(2007)
J. Clin. Invest.
, vol.117
, pp. 514-521
-
-
Strober, W.1
Fuss, I.2
Mannon, P.3
-
2
-
-
70049105092
-
Intestinal effector T cells in health and disease
-
Maynard, C. L. and Weaver, C. T. (2009) Intestinal effector T cells in health and disease. Immunity 31, 389-400
-
(2009)
Immunity
, vol.31
, pp. 389-400
-
-
Maynard, C.L.1
Weaver, C.T.2
-
3
-
-
12344278984
-
Physiological basis for novel drug therapies used to treat the inflammatory bowel diseases. I. Immunology and therapeutic potential of antiadhesion molecule therapy in inflammatory bowel disease
-
Van Assche, G. and Rutgeerts, P. (2005) Physiological basis for novel drug therapies used to treat the inflammatory bowel diseases. I. Immunology and therapeutic potential of antiadhesion molecule therapy in inflammatory bowel disease. Am. J. Physiol. Gastrointest. Liver Physiol. 288, G169-G174
-
(2005)
Am. J. Physiol. Gastrointest. Liver Physiol.
, vol.288
-
-
Van Assche, G.1
Rutgeerts, P.2
-
4
-
-
33847000579
-
Apoptosis of T cells and the control of inflammatory bowel disease: Therapeutic implications
-
Mudter, J. and Neurath, M. F. (2007) Apoptosis of T cells and the control of inflammatory bowel disease: therapeutic implications. Gut 56, 293-303
-
(2007)
Gut
, vol.56
, pp. 293-303
-
-
Mudter, J.1
Neurath, M.F.2
-
5
-
-
44949175035
-
Mucosal T cell proliferation and apoptosis in inflammatory bowel disease
-
Sturm, A., de Souza, H. S. and Fiocchi, C. (2008) Mucosal T cell proliferation and apoptosis in inflammatory bowel disease. Curr. Drug Targets 9, 381-387
-
(2008)
Curr. Drug Targets
, vol.9
, pp. 381-387
-
-
Sturm, A.1
De Souza, H.S.2
Fiocchi, C.3
-
6
-
-
70049098536
-
Regulatory T cells reinforce intestinal homeostasis
-
Barnes, M. J. and Powrie, F. (2009) Regulatory T cells reinforce intestinal homeostasis. Immunity 31, 401-411
-
(2009)
Immunity
, vol.31
, pp. 401-411
-
-
Barnes, M.J.1
Powrie, F.2
-
7
-
-
2342646956
-
Bacterial flagellin is a dominant antigen in Crohn disease
-
Lodes, M. J., Cong, Y., Elson, C. O., Mohamath, R., Landers, C. J., Targan, S. R., Fort, M. and Hershberg, R. M. (2004) Bacterial flagellin is a dominant antigen in Crohn disease. J. Clin. Invest. 113, 1296-1306
-
(2004)
J. Clin. Invest.
, vol.113
, pp. 1296-1306
-
-
Lodes, M.J.1
Cong, Y.2
Elson, C.O.3
Mohamath, R.4
Landers, C.J.5
Targan, S.R.6
Fort, M.7
Hershberg, R.M.8
-
8
-
-
54349092860
-
Identification of the predominant antigenic epitopes in intestinal flora in IBD
-
Ergin, A., Adam, T., Bussow, K., Thiel, A., Sieper, J. and Duchmann, R. (2008) Identification of the predominant antigenic epitopes in intestinal flora in IBD. Mucosal Immunol. 1, (Suppl. 1), S19-S23
-
(2008)
Mucosal Immunol.
, vol.1
, Issue.SUPPL. 1
-
-
Ergin, A.1
Adam, T.2
Bussow, K.3
Thiel, A.4
Sieper, J.5
Duchmann, R.6
-
9
-
-
15744405106
-
Autologous hematopoietic stem cell transplantation in patients with refractory Crohn's disease
-
Oyama, Y., Craig, R. M., Traynor, A. E., Quigley, K., Statkute, L., Halverson, A., Brush, M., Verda, L., Kowalska, B., Krosnjar, N. et al. (2005) Autologous hematopoietic stem cell transplantation in patients with refractory Crohn's disease. Gastroenterology 128, 552-563
-
(2005)
Gastroenterology
, vol.128
, pp. 552-563
-
-
Oyama, Y.1
Craig, R.M.2
Traynor, A.E.3
Quigley, K.4
Statkute, L.5
Halverson, A.6
Brush, M.7
Verda, L.8
Kowalska, B.9
Krosnjar, N.10
-
10
-
-
14444267546
-
Crohn's disease stable remission after human immunodeficiency virus infection
-
Pospai, D., Rene, E., Fiasse, R., Farahat, K., Beaugery, L., Lammens, P., Reimund, C., Duclos, B., Le Quintrec, Y., Vandercam, B. and Mignon, M. (1998) Crohn's disease stable remission after human immunodeficiency virus infection. Dig. Dis. Sci. 43, 412-419
-
(1998)
Dig. Dis. Sci.
, vol.43
, pp. 412-419
-
-
Pospai, D.1
Rene, E.2
Fiasse, R.3
Farahat, K.4
Beaugery, L.5
Lammens, P.6
Reimund, C.7
Duclos, B.8
Le Quintrec, Y.9
Vandercam, B.10
Mignon, M.11
-
11
-
-
48849110462
-
Immune-mediated inflammatory diseases and psoriasis
-
Delaporte, E. (2008) Immune-mediated inflammatory diseases and psoriasis. Ann. Dermatol. Venereol. 135, (Suppl. 4), S269-S274
-
(2008)
Ann. Dermatol. Venereol.
, vol.135
, Issue.SUPPL. 4
-
-
Delaporte, E.1
-
12
-
-
0026446475
-
Association of gluten-sensitive enteropathy and Crohn's colitis
-
Curtis, W. D., Schuman, B. M. and Griffin, Jr, J.W. (1992) Association of gluten-sensitive enteropathy and Crohn's colitis. Am. J. Gastroenterol. 87, 1634-1637
-
(1992)
Am. J. Gastroenterol.
, vol.87
, pp. 1634-1637
-
-
Curtis, W.D.1
Schuman, B.M.2
Griffin Jr., J.W.3
-
13
-
-
8344258233
-
Cytokine-based therapies for Crohn's disease-new paradigms
-
Cominelli, F. (2004) Cytokine-based therapies for Crohn's disease-new paradigms. N. Engl. J. Med. 351, 2045-2048
-
(2004)
N. Engl. J. Med.
, vol.351
, pp. 2045-2048
-
-
Cominelli, F.1
-
14
-
-
0026770377
-
Integrins: Versatility, modulation, and signaling in cell adhesion
-
Hynes, R. O. (1992) Integrins: versatility, modulation, and signaling in cell adhesion. Cell 69, 11-25
-
(1992)
Cell
, vol.69
, pp. 11-25
-
-
Hynes, R.O.1
-
15
-
-
0033546663
-
The effect of anti-α4 integrin antibody on brain lesion activity in MS
-
Tubridy, N., Behan, P. O., Capildeo, R., Chaudhuri, A., Forbes, R., Hawkins, C. P., Hughes, R. A., Palace, J., Sharrack, B., Swingler, R. et al. (1999) The effect of anti-α4 integrin antibody on brain lesion activity in MS. Neurology 53, 466-472
-
(1999)
Neurology
, vol.53
, pp. 466-472
-
-
Tubridy, N.1
Behan, P.O.2
Capildeo, R.3
Chaudhuri, A.4
Forbes, R.5
Hawkins, C.P.6
Hughes, R.A.7
Palace, J.8
Sharrack, B.9
Swingler, R.10
-
16
-
-
27644441529
-
Natalizumab induction and maintenance therapy for Crohn's disease
-
Sandborn, W. J., Colombel, J. F., Enns, R., Feagan, B. G., Hanauer, S. B., Lawrance, I. C., Panaccione, R., Sanders, M., Schreiber, S., Targan, S. et al. (2005) Natalizumab induction and maintenance therapy for Crohn's disease. N. Engl. J. Med. 353, 1912-1925
-
(2005)
N. Engl. J. Med.
, vol.353
, pp. 1912-1925
-
-
Sandborn, W.J.1
Colombel, J.F.2
Enns, R.3
Feagan, B.G.4
Hanauer, S.B.5
Lawrance, I.C.6
Panaccione, R.7
Sanders, M.8
Schreiber, S.9
Targan, S.10
-
17
-
-
34247884424
-
Natalizumab for the Treatment of Active Crohn's Disease: Results of the ENCORE Trial
-
DOI 10.1053/j.gastro.2007.03.024, PII S0016508507005380
-
Targan, S. R., Feagan, B. G., Fedorak, R. N., Lashner, B. A., Panaccione, R., Present, D. H., Spehlmann, M. E., Rutgeerts, P. J., Tulassay, Z., Volfova, M. et al. (2007) Natalizumab for the treatment of active Crohn's disease: results of the ENCORE Trial. Gastroenterology 132, 1672-1683 (Pubitemid 46695722)
-
(2007)
Gastroenterology
, vol.132
, Issue.5
, pp. 1672-1683
-
-
Targan, S.R.1
Feagan, B.G.2
Fedorak, R.N.3
Lashner, B.A.4
Panaccione, R.5
Present, D.H.6
Spehlmann, M.E.7
Rutgeerts, P.J.8
Tulassay, Z.9
Volfova, M.10
Wolf, D.C.11
Hernandez, C.12
Bornstein, J.13
Sandborn, W.J.14
-
18
-
-
22844445587
-
Progressive multifocal leukoencephalopathy after natalizumab therapy for Crohn's disease
-
Van Assche, G., Van Ranst, M., Sciot, R., Dubois, B., Vermeire, S., Noman, M., Verbeeck, J., Geboes, K., Robberecht, W. and Rutgeerts, P. (2005) Progressive multifocal leukoencephalopathy after natalizumab therapy for Crohn's disease. N. Engl. J. Med. 353, 362-368
-
(2005)
N. Engl. J. Med.
, vol.353
, pp. 362-368
-
-
Van Assche, G.1
Van Ranst, M.2
Sciot, R.3
Dubois, B.4
Vermeire, S.5
Noman, M.6
Verbeeck, J.7
Geboes, K.8
Robberecht, W.9
Rutgeerts, P.10
-
19
-
-
20444469332
-
Treatment of ulcerative colitis with a humanized antibody to the α4β7 integrin
-
Feagan, B. G., Greenberg, G. R., Wild, G., Fedorak, R. N., Pare, P., McDonald, J. W., Dube, R., Cohen, A., Steinhart, A. H., Landau, S. et al. (2005) Treatment of ulcerative colitis with a humanized antibody to the α4β7 integrin. N. Engl. J. Med. 352, 2499-2507
-
(2005)
N. Engl. J. Med.
, vol.352
, pp. 2499-2507
-
-
Feagan, B.G.1
Greenberg, G.R.2
Wild, G.3
Fedorak, R.N.4
Pare, P.5
McDonald, J.W.6
Dube, R.7
Cohen, A.8
Steinhart, A.H.9
Landau, S.10
-
20
-
-
0142157983
-
Efficacy and safety of a humanized α4β7 antibody in active Crohn's disease (CD)
-
Feagan, B. G., Greenberg, G., Wild, G., McDonald, J. W., Fedorak, R., Pare, P., Kishimoto, K., Gutierrez-Ramos, J. C. and Krop, J. (2003) Efficacy and safety of a humanized α4β7 antibody in active Crohn's disease (CD). Gastroenterology 124, A25-A26
-
(2003)
Gastroenterology
, vol.124
-
-
Feagan, B.G.1
Greenberg, G.2
Wild, G.3
McDonald, J.W.4
Fedorak, R.5
Pare, P.6
Kishimoto, K.7
Gutierrez-Ramos, J.C.8
Krop, J.9
-
21
-
-
0031782392
-
A placebo-controlled trial of ICAM-1 antisense oligonucleotide in the treatment of Crohn's disease
-
Yacyshyn, B. R., Bowen-Yacyshyn, M. B., Jewell, L., Tami, J. A., Bennett, C. F., Kisner, D. L. and Shanahan, Jr, W. R. (1998) A placebo-controlled trial of ICAM-1 antisense oligonucleotide in the treatment of Crohn's disease. Gastroenterology 114, 1133-1142
-
(1998)
Gastroenterology
, vol.114
, pp. 1133-1142
-
-
Yacyshyn, B.R.1
Bowen-Yacyshyn, M.B.2
Jewell, L.3
Tami, J.A.4
Bennett, C.F.5
Kisner, D.L.6
Shanahan Jr., W.R.7
-
22
-
-
33846804162
-
A randomized, double-masked, placebo-controlled study of alicaforsen, an antisense inhibitor of intercellular adhesion molecule 1, for the treatment of subjects with active Crohn's disease
-
Yacyshyn, B., Chey, W. Y., Wedel, M. K., Yu, R. Z., Paul, D. and Chuang, E. (2007) A randomized, double-masked, placebo-controlled study of alicaforsen, an antisense inhibitor of intercellular adhesion molecule 1, for the treatment of subjects with active Crohn's disease. Clin. Gastroenterol. Hepatol. 5, 215-220
-
(2007)
Clin. Gastroenterol. Hepatol.
, vol.5
, pp. 215-220
-
-
Yacyshyn, B.1
Chey, W.Y.2
Wedel, M.K.3
Yu, R.Z.4
Paul, D.5
Chuang, E.6
-
23
-
-
34848886760
-
Ccx282-B, an orally active inhibitor of chemokine receptor Ccr9, shows anti-inflammatory and clinical activity in the treatment of Crohn's disease
-
Keshav, S., Ungashe, S., Zheng, W., Bekker, P., Wright, K. and Schall, T. (2007) Ccx282-B, an orally active inhibitor of chemokine receptor Ccr9, shows anti-inflammatory and clinical activity in the treatment of Crohn's disease. Gastroenterology 137, A157
-
(2007)
Gastroenterology
, vol.137
-
-
Keshav, S.1
Ungashe, S.2
Zheng, W.3
Bekker, P.4
Wright, K.5
Schall, T.6
-
24
-
-
61849085112
-
Calmodulin-dependent phosphatase, kinases, and transcriptional corepressors involved in T-cell activation
-
Liu, J. O. (2009) Calmodulin-dependent phosphatase, kinases, and transcriptional corepressors involved in T-cell activation. Immunol. Rev. 228, 184-198
-
(2009)
Immunol. Rev.
, vol.228
, pp. 184-198
-
-
Liu, J.O.1
-
25
-
-
0033634846
-
Concerted dephosphorylation of the transcription factor NFAT1 induces a conformational switch that regulates transcriptional activity
-
Okamura, H., Aramburu, J., Garcia-Rodriguez, C., Viola, J. P., Raghavan, A., Tahiliani, M., Zhang, X., Qin, J., Hogan, P. G. and Rao, A. (2000) Concerted dephosphorylation of the transcription factor NFAT1 induces a conformational switch that regulates transcriptional activity. Mol. Cell 6, 539-550
-
(2000)
Mol. Cell
, vol.6
, pp. 539-550
-
-
Okamura, H.1
Aramburu, J.2
Garcia-Rodriguez, C.3
Viola, J.P.4
Raghavan, A.5
Tahiliani, M.6
Zhang, X.7
Qin, J.8
Hogan, P.G.9
Rao, A.10
-
26
-
-
0023821516
-
Identification of a putative regulator of early T cell activation genes
-
Shaw, J. P., Utz, P. J., Durand, D. B., Toole, J. J., Emmel, E. A. and Crabtree, G. R. (1988) Identification of a putative regulator of early T cell activation genes. Science 241, 202-205
-
(1988)
Science
, vol.241
, pp. 202-205
-
-
Shaw, J.P.1
Utz, P.J.2
Durand, D.B.3
Toole, J.J.4
Emmel, E.A.5
Crabtree, G.R.6
-
27
-
-
0028197044
-
Efficacy of cyclosporine in treatment of fistula of Crohn's disease
-
Present, D. H. and Lichtiger, S. (1994) Efficacy of cyclosporine in treatment of fistula of Crohn's disease. Dig. Dis. Sci. 39, 374-380
-
(1994)
Dig. Dis. Sci.
, vol.39
, pp. 374-380
-
-
Present, D.H.1
Lichtiger, S.2
-
28
-
-
12344329448
-
Ciclosporin use in acute ulcerative colitis: A long-term experience
-
Campbell, S., Travis, S. and Jewell, D. (2005) Ciclosporin use in acute ulcerative colitis: a long-term experience. Eur. J. Gastroenterol. Hepatol. 17, 79-84
-
(2005)
Eur. J. Gastroenterol. Hepatol.
, vol.17
, pp. 79-84
-
-
Campbell, S.1
Travis, S.2
Jewell, D.3
-
29
-
-
0034933911
-
Cyclosporine in ulcerative colitis: State of the art
-
Sandborn, W. J. (2001) Cyclosporine in ulcerative colitis: state of the art. Acta Gastroenterol. Belg. 64, 201-204
-
(2001)
Acta Gastroenterol. Belg.
, vol.64
, pp. 201-204
-
-
Sandborn, W.J.1
-
30
-
-
0041665068
-
Tacrolimus for the treatment of fistulas in patients with Crohn's disease: A randomized, placebo-controlled trial
-
Sandborn, W. J., Present, D. H., Isaacs, K. L., Wolf, D. C., Greenberg, E., Hanauer, S. B., Feagan, B. G., Mayer, L., Johnson, T., Galanko, J. et al. (2003) Tacrolimus for the treatment of fistulas in patients with Crohn's disease: a randomized, placebo-controlled trial. Gastroenterology 125, 380-388
-
(2003)
Gastroenterology
, vol.125
, pp. 380-388
-
-
Sandborn, W.J.1
Present, D.H.2
Isaacs, K.L.3
Wolf, D.C.4
Greenberg, E.5
Hanauer, S.B.6
Feagan, B.G.7
Mayer, L.8
Johnson, T.9
Galanko, J.10
-
31
-
-
33747790601
-
A randomised dose finding study of oral tacrolimus (FK506) therapy in refractory ulcerative colitis
-
Ogata, H., Matsui, T., Nakamura, M., Iida, M., Takazoe, M., Suzuki, Y. and Hibi, T. (2006) A randomised dose finding study of oral tacrolimus (FK506) therapy in refractory ulcerative colitis. Gut 55, 1255-1262
-
(2006)
Gut
, vol.55
, pp. 1255-1262
-
-
Ogata, H.1
Matsui, T.2
Nakamura, M.3
Iida, M.4
Takazoe, M.5
Suzuki, Y.6
Hibi, T.7
-
32
-
-
33750343050
-
Daclizumab, a humanised monoclonal antibody to the interleukin 2 receptor (CD25), for the treatment of moderately to severely active ulcerative colitis: A randomised, double blind, placebo controlled, dose ranging trial
-
Van Assche, G., Sandborn, W. J., Feagan, B. G., Salzberg, B. A., Silvers, D., Monroe, P. S., Pandak, W. M., Anderson, F. H., Valentine, J. F., Wild, G. E. et al. (2006) Daclizumab, a humanised monoclonal antibody to the interleukin 2 receptor (CD25), for the treatment of moderately to severely active ulcerative colitis: a randomised, double blind, placebo controlled, dose ranging trial. Gut 55, 1568-1574
-
(2006)
Gut
, vol.55
, pp. 1568-1574
-
-
Van Assche, G.1
Sandborn, W.J.2
Feagan, B.G.3
Salzberg, B.A.4
Silvers, D.5
Monroe, P.S.6
Pandak, W.M.7
Anderson, F.H.8
Valentine, J.F.9
Wild, G.E.10
-
33
-
-
10744232542
-
Basiliximab (anti-CD25) in combination with steroids may be an effective new treatment for steroid-resistant ulcerative colitis
-
Creed, T. J., Norman, M. R., Probert, C. S., Harvey, R. F., Shaw, I. S., Smithson, J., Anderson, J., Moorghen, M., Gupta, J., Shepherd, N. A. et al. (2003) Basiliximab (anti-CD25) in combination with steroids may be an effective new treatment for steroid-resistant ulcerative colitis. Aliment. Pharmacol. Ther. 18, 65-75
-
(2003)
Aliment. Pharmacol. Ther.
, vol.18
, pp. 65-75
-
-
Creed, T.J.1
Norman, M.R.2
Probert, C.S.3
Harvey, R.F.4
Shaw, I.S.5
Smithson, J.6
Anderson, J.7
Moorghen, M.8
Gupta, J.9
Shepherd, N.A.10
-
34
-
-
33646232018
-
Basiliximab for the treatment of steroid-resistant ulcerative colitis: Further experience in moderate and severe disease
-
Creed, T. J., Probert, C. S., Norman, M. N., Moorghen, M., Shepherd, N. A., Hearing, S. D. and Dayan, C. M. (2006) Basiliximab for the treatment of steroid-resistant ulcerative colitis: further experience in moderate and severe disease. Aliment. Pharmacol. Ther. 23, 1435-1442
-
(2006)
Aliment. Pharmacol. Ther.
, vol.23
, pp. 1435-1442
-
-
Creed, T.J.1
Probert, C.S.2
Norman, M.N.3
Moorghen, M.4
Shepherd, N.A.5
Hearing, S.D.6
Dayan, C.M.7
-
35
-
-
0033011679
-
Lamina propria T cells in Crohn's disease and other gastrointestinal inflammation show defective CD2 pathway-induced apoptosis
-
Boirivant, M., Marini, M., Di Felice, G., Pronio, A. M., Montesani, C., Tersigni, R. and Strober, W. (1999) Lamina propria T cells in Crohn's disease and other gastrointestinal inflammation show defective CD2 pathway-induced apoptosis. Gastroenterology 116, 557-565 (Pubitemid 29106763)
-
(1999)
Gastroenterology
, vol.116
, Issue.3
, pp. 557-565
-
-
Boirivant, M.1
Marini, M.2
Di Felice, G.3
Pronio, A.M.4
Montesani, C.5
Tersigni, R.6
Strober, W.7
-
36
-
-
32044433980
-
A functional role of flip in conferring resistance of Crohn's disease lamina propria lymphocytes to FAS-mediated apoptosis
-
DOI 10.1053/j.gastro.2005.10.021, PII S0016508505021773
-
Monteleone, I., Monteleone, G., Fina, D., Caruso, R., Petruzziello, C., Calabrese, E., Biancone, L. and Pallone, F. (2006) A functional role of flip in conferring resistance of Crohn's disease lamina propria lymphocytes to FAS-mediated apoptosis. Gastroenterology 130, 389-397 (Pubitemid 43202038)
-
(2006)
Gastroenterology
, vol.130
, Issue.2
, pp. 389-397
-
-
Monteleone, I.1
Monteleone, G.2
Fina, D.3
Caruso, R.4
Petruzziello, C.5
Calabrese, E.6
Biancone, L.7
Pallone, F.8
-
37
-
-
56549101145
-
Transcriptional and post-translational regulation of Flip, an inhibitor of Fas-mediated apoptosis, in human gut inflammation
-
Caprioli, F., Stolfi, C., Caruso, R., Fina, D., Sica, G., Biancone, L., Pallone, F. and Monteleone, G. (2008) Transcriptional and post-translational regulation of Flip, an inhibitor of Fas-mediated apoptosis, in human gut inflammation. Gut 57, 1674-1680
-
(2008)
Gut
, vol.57
, pp. 1674-1680
-
-
Caprioli, F.1
Stolfi, C.2
Caruso, R.3
Fina, D.4
Sica, G.5
Biancone, L.6
Pallone, F.7
Monteleone, G.8
-
38
-
-
18344410191
-
Blockade of interleukin 6 trans signaling suppresses T-cell resistance against apoptosis in chronic intestinal inflammation: Evidence in crohn disease and experimental colitis in vivo
-
Atreya, R., Mudter, J., Finotto, S., Mullberg, J., Jostock, T., Wirtz, S., Schutz, M., Bartsch, B., Holtmann, M., Becker, C. et al. (2000) Blockade of interleukin 6 trans signaling suppresses T-cell resistance against apoptosis in chronic intestinal inflammation: evidence in crohn disease and experimental colitis in vivo. Nat. Med. 6, 583-588
-
(2000)
Nat. Med.
, vol.6
, pp. 583-588
-
-
Atreya, R.1
Mudter, J.2
Finotto, S.3
Mullberg, J.4
Jostock, T.5
Wirtz, S.6
Schutz, M.7
Bartsch, B.8
Holtmann, M.9
Becker, C.10
-
39
-
-
0036784641
-
+ T cells through phosphatidylinositol 3-kinase/Akt signaling pathway
-
+ T cells through phosphatidylinositol 3-kinase/Akt signaling pathway. J Immunol. 169, 3637-3643
-
(2002)
J Immunol.
, vol.169
, pp. 3637-3643
-
-
Yoo, J.K.1
Cho, J.H.2
Lee, S.W.3
Sung, Y.C.4
-
40
-
-
84921430591
-
Azathioprine or 6-mercaptopurine for inducing remission of Crohn's disease
-
CD000545 doi:10.1002/14651858.CD000545.pub2
-
Sandborn, W., Sutherland, L., Pearson, D., May, G., Modigliani, R. and Prantera, C. (2000) Azathioprine or 6-mercaptopurine for inducing remission of Crohn's disease, Cochrane Database Syst. Rev., CD000545 doi:10.1002/14651858. CD000545.pub2
-
(2000)
Cochrane Database Syst. Rev.
-
-
Sandborn, W.1
Sutherland, L.2
Pearson, D.3
May, G.4
Modigliani, R.5
Prantera, C.6
-
41
-
-
39149120115
-
Azathioprine and 6-mercaptopurine for maintenance of remission in ulcerative colitis
-
CD000478 doi:10.1002/14651858.CD000478.pub2
-
Timmer, A., McDonald, J.W. and Macdonald, J. K. (2007) Azathioprine and 6-mercaptopurine for maintenance of remission in ulcerative colitis, Cochrane Database Syst. Rev., CD000478 doi:10.1002/14651858.CD000478.pub2
-
(2007)
Cochrane Database Syst. Rev.
-
-
Timmer, A.1
McDonald, J.W.2
Macdonald, J.K.3
-
42
-
-
0242464926
-
+ T lymphocytes
-
+ T lymphocytes. J. Clin. Invest. 111, 1133-1145
-
(2003)
J. Clin. Invest.
, vol.111
, pp. 1133-1145
-
-
Tiede, I.1
Fritz, G.2
Strand, S.3
Poppe, D.4
Dvorsky, R.5
Strand, D.6
Lehr, H.A.7
Wirtz, S.8
Becker, C.9
Atreya, R.10
-
43
-
-
61649121587
-
Early preservation of effector functions followed by eventual T cell memory depletion: A model for the delayed onset of the effect of thiopurines
-
Ben-Horin, S., Goldstein, I., Fudim, E., Picard, O., Yerushalmi, Z., Barshack, I., Bank, I., Goldschmid, Y., Meir, S. B., Mayer, L. and Chowers, Y. (2009) Early preservation of effector functions followed by eventual T cell memory depletion: a model for the delayed onset of the effect of thiopurines. Gut 58, 396-403
-
(2009)
Gut
, vol.58
, pp. 396-403
-
-
Ben-Horin, S.1
Goldstein, I.2
Fudim, E.3
Picard, O.4
Yerushalmi, Z.5
Barshack, I.6
Bank, I.7
Goldschmid, Y.8
Meir, S.B.9
Mayer, L.10
Chowers, Y.11
-
44
-
-
0030954732
-
A short-term study of chimeric monoclonal antibody cA2 to tumor necrosis factor α for Crohn's disease
-
Targan, S. R., Hanauer, S. B., van Deventer, S. J., Mayer, L., Present, D. H., Braakman, T., DeWoody, K. L., Schaible, T. F. and Rutgeerts, P. J. (1997) A short-term study of chimeric monoclonal antibody cA2 to tumor necrosis factor α for Crohn's disease. N. Engl. J. Med. 337, 1029-1035
-
(1997)
N. Engl. J. Med.
, vol.337
, pp. 1029-1035
-
-
Targan, S.R.1
Hanauer, S.B.2
Van Deventer, S.J.3
Mayer, L.4
Present, D.H.5
Braakman, T.6
DeWoody, K.L.7
Schaible, T.F.8
Rutgeerts, P.J.9
-
45
-
-
0033842357
-
Use of infliximab in the treatment of Crohn's disease in children and adolescents
-
DOI 10.1067/mpd.2000.107161
-
Hyams, J. S., Markowitz, J. and Wyllie, R. (2000) Use of infliximab in the treatment of Crohn's disease in children and adolescents. J. Pediatr. 137, 192-196 (Pubitemid 30659226)
-
(2000)
Journal of Pediatrics
, vol.137
, Issue.2
, pp. 192-196
-
-
Hyams, J.S.1
Markowitz, J.2
Wyllie, R.3
-
46
-
-
28844473957
-
Infliximab for induction and maintenance therapy for ulcerative colitis
-
Rutgeerts, P., Sandborn, W. J., Feagan, B. G., Reinisch, W., Olson, A., Johanns, J., Travers, S., Rachmilewitz, D., Hanauer, S. B., Lichtenstein, G. R. et al. (2005) Infliximab for induction and maintenance therapy for ulcerative colitis. N. Engl. J. Med. 353, 2462-2476
-
(2005)
N. Engl. J. Med.
, vol.353
, pp. 2462-2476
-
-
Rutgeerts, P.1
Sandborn, W.J.2
Feagan, B.G.3
Reinisch, W.4
Olson, A.5
Johanns, J.6
Travers, S.7
Rachmilewitz, D.8
Hanauer, S.B.9
Lichtenstein, G.R.10
-
47
-
-
0033529049
-
Infliximab for the treatment of fistulas in patients with Crohn's disease
-
Present, D. H., Rutgeerts, P., Targan, S., Hanauer, S. B., Mayer, L., van Hogezand, R. A., Podolsky, D. K., Sands, B. E., Braakman, T., DeWoody, K. L. et al. (1999) Infliximab for the treatment of fistulas in patients with Crohn's disease. N. Engl. J. Med. 340, 1398-1405
-
(1999)
N. Engl. J. Med.
, vol.340
, pp. 1398-1405
-
-
Present, D.H.1
Rutgeerts, P.2
Targan, S.3
Hanauer, S.B.4
Mayer, L.5
Van Hogezand, R.A.6
Podolsky, D.K.7
Sands, B.E.8
Braakman, T.9
DeWoody, K.L.10
-
48
-
-
10744221312
-
Infliximab maintenance therapy for fistulizing Crohn's disease
-
Sands, B. E., Anderson, F. H., Bernstein, C. N., Chey, W. Y., Feagan, B. G., Fedorak, R. N., Kamm, M. A., Korzenik, J. R., Lashner, B. A., Onken, J. E. et al. (2004) Infliximab maintenance therapy for fistulizing Crohn's disease. N. Engl. J. Med. 350, 876-885
-
(2004)
N. Engl. J. Med.
, vol.350
, pp. 876-885
-
-
Sands, B.E.1
Anderson, F.H.2
Bernstein, C.N.3
Chey, W.Y.4
Feagan, B.G.5
Fedorak, R.N.6
Kamm, M.A.7
Korzenik, J.R.8
Lashner, B.A.9
Onken, J.E.10
-
49
-
-
33846242958
-
Adalimumab for maintenance of clinical response and remission in patients with Crohn's disease: The CHARM trial
-
Colombel, J. F., Sandborn, W. J., Rutgeerts, P., Enns, R., Hanauer, S. B., Panaccione, R., Schreiber, S., Byczkowski, D., Li, J., Kent, J. D. and Pollack, P. F. (2007) Adalimumab for maintenance of clinical response and remission in patients with Crohn's disease: the CHARM trial. Gastroenterology 132, 52-65
-
(2007)
Gastroenterology
, vol.132
, pp. 52-65
-
-
Colombel, J.F.1
Sandborn, W.J.2
Rutgeerts, P.3
Enns, R.4
Hanauer, S.B.5
Panaccione, R.6
Schreiber, S.7
Byczkowski, D.8
Li, J.9
Kent, J.D.10
Pollack, P.F.11
-
50
-
-
67649662356
-
Adalimumab for the treatment of fistulas in patients with Crohn's disease
-
Colombel, J. F., Schwartz, D. A., Sandborn, W. J., Kamm, M. A., D'Haens, G., Rutgeerts, P., Enns, R., Panaccione, R., Schreiber, S., Li, J. et al. (2009) Adalimumab for the treatment of fistulas in patients with Crohn's disease. Gut 58, 940-948
-
(2009)
Gut
, vol.58
, pp. 940-948
-
-
Colombel, J.F.1
Schwartz, D.A.2
Sandborn, W.J.3
Kamm, M.A.4
D'Haens, G.5
Rutgeerts, P.6
Enns, R.7
Panaccione, R.8
Schreiber, S.9
Li, J.10
-
51
-
-
0036151047
-
Infliximab treatment induces apoptosis of lamina propria T lymphocytes in Crohn's disease
-
ten Hove, T., van Montfrans, C., Peppelenbosch, M. P. and van Deventer, S. J. (2002) Infliximab treatment induces apoptosis of lamina propria T lymphocytes in Crohn's disease. Gut 50, 206-211
-
(2002)
Gut
, vol.50
, pp. 206-211
-
-
Ten Hove, T.1
Van Montfrans, C.2
Peppelenbosch, M.P.3
Van Deventer, S.J.4
-
52
-
-
0029004771
-
Chimeric anti-TNF-α monoclonal antibody cA2 binds recombinant transmembrane TNF-α and activates immune effector functions
-
Scallon, B. J., Moore, M. A., Trinh, H., Knight, D. M. and Ghrayeb, J. (1995) Chimeric anti-TNF-α monoclonal antibody cA2 binds recombinant transmembrane TNF-α and activates immune effector functions. Cytokine 7, 251-259
-
(1995)
Cytokine
, vol.7
, pp. 251-259
-
-
Scallon, B.J.1
Moore, M.A.2
Trinh, H.3
Knight, D.M.4
Ghrayeb, J.5
-
53
-
-
0346461662
-
Defective mucosal T cell death is sustainably reverted by infliximab in a caspase dependent pathway in Crohn's disease
-
DOI 10.1136/gut.53.1.70
-
Di Sabatino, A., Ciccocioppo, R., Cinque, B., Millimaggi, D., Morera, R., Ricevuti, L., Cifone, M. G. and Corazza, G. R. (2004) Defective mucosal T cell death is sustainably reverted by infliximab in a caspase dependent pathway in Crohn's disease. Gut 53, 70-77 (Pubitemid 38083013)
-
(2004)
Gut
, vol.53
, Issue.1
, pp. 70-77
-
-
Di Sabatino, A.1
Ciccocioppo, R.2
Cinque, B.3
Millimaggi, D.4
Morera, R.5
Ricevuti, L.6
Cifone, M.G.7
Corazza, G.R.8
-
54
-
-
0034754480
-
Infliximab induces apoptosis in monocytes from patients with chronic active Crohn's disease by using a caspase-dependent pathway
-
Lugering, A., Schmidt, M., Lugering, N., Pauels, H. G., Domschke, W. and Kucharzik, T. (2001) Infliximab induces apoptosis in monocytes from patients with chronic active Crohn's disease by using a caspase-dependent pathway. Gastroenterology 121, 1145-1157 (Pubitemid 33022095)
-
(2001)
Gastroenterology
, vol.121
, Issue.5
, pp. 1145-1157
-
-
Lugering, A.1
Schmidt, M.2
Lugering, N.3
Pauels, H.-G.4
Domschke, W.5
Kucharzik, T.6
-
55
-
-
14944382276
-
Infliximab induces potent anti-inflammatory responses by outside-to-inside signals through transmembrane TNF-α
-
Mitoma, H., Horiuchi, T., Hatta, N., Tsukamoto, H., Harashima, S., Kikuchi, Y., Otsuka, J., Okamura, S., Fujita, S. and Harada, M. (2005) Infliximab induces potent anti-inflammatory responses by outside-to-inside signals through transmembrane TNF-α. Gastroenterology 128, 376-392
-
(2005)
Gastroenterology
, vol.128
, pp. 376-392
-
-
Mitoma, H.1
Horiuchi, T.2
Hatta, N.3
Tsukamoto, H.4
Harashima, S.5
Kikuchi, Y.6
Otsuka, J.7
Okamura, S.8
Fujita, S.9
Harada, M.10
-
56
-
-
0037089222
-
A humanized non-FcR-binding anti-CD3 antibody, visilizumab, for treatment of steroid-refractory acute graft-versus-host disease
-
Carpenter, P. A., Appelbaum, F. R., Corey, L., Deeg, H. J., Doney, K., Gooley, T., Krueger, J., Martin, P., Pavlovic, S., Sanders, J. et al. (2002) A humanized non-FcR-binding anti-CD3 antibody, visilizumab, for treatment of steroid-refractory acute graft-versus-host disease. Blood 99, 2712-2719
-
(2002)
Blood
, vol.99
, pp. 2712-2719
-
-
Carpenter, P.A.1
Appelbaum, F.R.2
Corey, L.3
Deeg, H.J.4
Doney, K.5
Gooley, T.6
Krueger, J.7
Martin, P.8
Pavlovic, S.9
Sanders, J.10
-
57
-
-
45249104849
-
Visilizumab induces apoptosis of mucosal T lymphocytes in ulcerative colitis through activation of caspase 3 and 8 dependent pathways
-
Yu, Q. T., Saruta, M. and Papadakis, K. A. (2008) Visilizumab induces apoptosis of mucosal T lymphocytes in ulcerative colitis through activation of caspase 3 and 8 dependent pathways. Clin. Immunol. 127, 322-329
-
(2008)
Clin. Immunol.
, vol.127
, pp. 322-329
-
-
Yu, Q.T.1
Saruta, M.2
Papadakis, K.A.3
-
58
-
-
35648941736
-
A phase I study of visilizumab, a humanized anti-CD3 monoclonal antibody, in severe steroid-refractory ulcerative colitis
-
Plevy, S., Salzberg, B., Van Assche, G., Regueiro, M., Hommes, D., Sandborn, W., Hanauer, S., Targan, S., Mayer, L., Mahadevan, U. et al. (2007) A phase I study of visilizumab, a humanized anti-CD3 monoclonal antibody, in severe steroid-refractory ulcerative colitis. Gastroenterology 133, 1414-1422
-
(2007)
Gastroenterology
, vol.133
, pp. 1414-1422
-
-
Plevy, S.1
Salzberg, B.2
Van Assche, G.3
Regueiro, M.4
Hommes, D.5
Sandborn, W.6
Hanauer, S.7
Targan, S.8
Mayer, L.9
Mahadevan, U.10
-
59
-
-
77949507036
-
Prospective randomized open-label multicenter phase I/II dose escalation trial of visilizumab (HuM291) in severe steroid-refractory ulcerative colitis
-
doi: 10.1002/ibd.21084
-
Baumgart, D. C., Targan, S. R., Dignass, A. U., Mayer, L., Assche, G. V., Hommes, D.W., Hanauer, S. B., Mahadevan, U., Reinisch, W., Plevy, S. E. et al. (2009) Prospective randomized open-label multicenter phase I/II dose escalation trial of visilizumab (HuM291) in severe steroid-refractory ulcerative colitis. Inflamm, Bowel Dis., doi: 10.1002/ibd.21084
-
(2009)
Inflamm, Bowel Dis.
-
-
Baumgart, D.C.1
Targan, S.R.2
Dignass, A.U.3
Mayer, L.4
Assche, G.V.5
Hommes, D.W.6
Hanauer, S.B.7
Mahadevan, U.8
Reinisch, W.9
Plevy, S.E.10
-
60
-
-
34548190038
-
Il-6 signaling in inflammatory bowel disease: Pathophysiological role and clinical relevance
-
Mudter, J. and Neurath, M. F. (2007) Il-6 signaling in inflammatory bowel disease: pathophysiological role and clinical relevance. Inflamm. Bowel Dis. 13, 1016-1023
-
(2007)
Inflamm. Bowel Dis.
, vol.13
, pp. 1016-1023
-
-
Mudter, J.1
Neurath, M.F.2
-
61
-
-
11144358366
-
A pilot randomized trial of a human anti-interleukin-6 receptor monoclonal antibody in active Crohn's disease
-
Ito, H., Takazoe, M., Fukuda, Y., Hibi, T., Kusugami, K., Andoh, A., Matsumoto, T., Yamamura, T., Azuma, J., Nishimoto, N. et al. (2004) A pilot randomized trial of a human anti-interleukin-6 receptor monoclonal antibody in active Crohn's disease. Gastroenterology 126, 989-996
-
(2004)
Gastroenterology
, vol.126
, pp. 989-996
-
-
Ito, H.1
Takazoe, M.2
Fukuda, Y.3
Hibi, T.4
Kusugami, K.5
Andoh, A.6
Matsumoto, T.7
Yamamura, T.8
Azuma, J.9
Nishimoto, N.10
-
62
-
-
0027397169
-
Induction of alloantigen-specific hyporesponsiveness in human T lymphocytes by blocking interaction of CD28 with its natural ligand B7/BB1
-
Tan, P., Anasetti, C., Hansen, J. A., Melrose, J., Brunvand, M., Bradshaw, J., Ledbetter, J. A. and Linsley, P. S. (1993) Induction of alloantigen-specific hyporesponsiveness in human T lymphocytes by blocking interaction of CD28 with its natural ligand B7/BB1. J. Exp. Med. 177, 165-173
-
(1993)
J. Exp. Med.
, vol.177
, pp. 165-173
-
-
Tan, P.1
Anasetti, C.2
Hansen, J.A.3
Melrose, J.4
Brunvand, M.5
Bradshaw, J.6
Ledbetter, J.A.7
Linsley, P.S.8
-
63
-
-
0029899783
-
CTLA-4 engagement inhibits IL-2 accumulation and cell cycle progression upon activation of resting T cells
-
Krummel, M. F. and Allison, J. P. (1996) CTLA-4 engagement inhibits IL-2 accumulation and cell cycle progression upon activation of resting T cells. J. Exp. Med. 183, 2533-2540
-
(1996)
J. Exp. Med.
, vol.183
, pp. 2533-2540
-
-
Krummel, M.F.1
Allison, J.P.2
-
64
-
-
0025333699
-
Tumour necrosis factor-α and interferon-gamma production measured at the single cell level in normal and inflamed human intestine
-
MacDonald, T. T., Hutchings, P., Choy, M. Y., Murch, S. and Cooke, A. (1990) Tumour necrosis factor-α and interferon-gamma production measured at the single cell level in normal and inflamed human intestine. Clin. Exp. Immunol. 81, 301-305
-
(1990)
Clin. Exp. Immunol.
, vol.81
, pp. 301-305
-
-
MacDonald, T.T.1
Hutchings, P.2
Choy, M.Y.3
Murch, S.4
Cooke, A.5
-
65
-
-
0030209985
-
+ lamina propria (LP) lymphokine secretion profiles in inflammatory bowel disease. Crohn's disease LP cells manifest increased secretion of IFN-γ, whereas ulcerative colitis LP cells manifest increased secretion of IL-5
-
+ lamina propria (LP) lymphokine secretion profiles in inflammatory bowel disease. Crohn's disease LP cells manifest increased secretion of IFN-γ, whereas ulcerative colitis LP cells manifest increased secretion of IL-5. J. Immunol. 157, 1261-1270
-
(1996)
J. Immunol.
, vol.157
, pp. 1261-1270
-
-
Fuss, I.J.1
Neurath, M.2
Boirivant, M.3
Klein, J.S.4
De La Motte, C.5
Strong, S.A.6
Fiocchi, C.7
Strober, W.8
-
66
-
-
85047690640
-
Nonclassical CD1d-restricted NK T cells that produce IL-13 characterize an atypical Th2 response in ulcerative colitis
-
Fuss, I. J., Heller, F., Boirivant, M., Leon, F., Yoshida, M., Fichtner-Feigl, S., Yang, Z., Exley, M., Kitani, A., Blumberg, R. S. et al. (2004) Nonclassical CD1d-restricted NK T cells that produce IL-13 characterize an atypical Th2 response in ulcerative colitis. J. Clin. Invest. 113, 1490-1497
-
(2004)
J. Clin. Invest.
, vol.113
, pp. 1490-1497
-
-
Fuss, I.J.1
Heller, F.2
Boirivant, M.3
Leon, F.4
Yoshida, M.5
Fichtner-Feigl, S.6
Yang, Z.7
Exley, M.8
Kitani, A.9
Blumberg, R.S.10
-
67
-
-
67650224449
-
Crohn's disease: Th1, Th17 or both? the change of a paradigm: new immunological and genetic insights implicate Th17 cells in the pathogenesis of Crohn's disease
-
Brand, S. (2009) Crohn's disease: Th1, Th17 or both? The change of a paradigm: new immunological and genetic insights implicate Th17 cells in the pathogenesis of Crohn's disease. Gut 58, 1152-1167
-
(2009)
Gut
, vol.58
, pp. 1152-1167
-
-
Brand, S.1
-
68
-
-
0031767833
-
Interleukin 12 and Th1 responses in inflammatory bowel disease
-
Pallone, F. and Monteleone, G. (1998) Interleukin 12 and Th1 responses in inflammatory bowel disease. Gut 43, 735-736 (Pubitemid 28539644)
-
(1998)
Gut
, vol.43
, Issue.6
, pp. 735-736
-
-
Pallone, F.1
Monteleone, G.2
-
69
-
-
56549104968
-
IL23 differentially regulates the Th1/Th17 balance in ulcerative colitis and Crohn's disease
-
Kobayashi, T., Okamoto, S., Hisamatsu, T., Kamada, N., Chinen, H., Saito, R., Kitazume, M. T., Nakazawa, A., Sugita, A., Koganei, K. et al. (2008) IL23 differentially regulates the Th1/Th17 balance in ulcerative colitis and Crohn's disease. Gut 57, 1682-1689
-
(2008)
Gut
, vol.57
, pp. 1682-1689
-
-
Kobayashi, T.1
Okamoto, S.2
Hisamatsu, T.3
Kamada, N.4
Chinen, H.5
Saito, R.6
Kitazume, M.T.7
Nakazawa, A.8
Sugita, A.9
Koganei, K.10
-
70
-
-
0028861975
-
Antibodies to interleukin 12 abrogate established experimental colitis in mice
-
Neurath, M. F., Fuss, I., Kelsall, B. L., Stuber, E. and Strober, W. (1995) Antibodies to interleukin 12 abrogate established experimental colitis in mice. J. Exp. Med. 182, 1281-1290
-
(1995)
J. Exp. Med.
, vol.182
, pp. 1281-1290
-
-
Neurath, M.F.1
Fuss, I.2
Kelsall, B.L.3
Stuber, E.4
Strober, W.5
-
71
-
-
8344284998
-
Anti-interleukin-12 antibody for active Crohn's disease
-
Mannon, P. J., Fuss, I. J., Mayer, L., Elson, C. O., Sandborn, W. J., Present, D., Dolin, B., Goodman, N., Groden, C., Hornung, R. L. et al. (2004) Anti-interleukin-12 antibody for active Crohn's disease. N. Engl. J. Med. 351, 2069-2079
-
(2004)
N. Engl. J. Med.
, vol.351
, pp. 2069-2079
-
-
Mannon, P.J.1
Fuss, I.J.2
Mayer, L.3
Elson, C.O.4
Sandborn, W.J.5
Present, D.6
Dolin, B.7
Goodman, N.8
Groden, C.9
Hornung, R.L.10
-
72
-
-
53049091561
-
A randomized trial of Ustekinumab, a human interleukin-12/23 monoclonal antibody, in patients with moderate-to-severe Crohn's disease
-
Sandborn, W. J., Feagan, B. G., Fedorak, R. N., Scherl, E., Fleisher, M. R., Katz, S., Johanns, J., Blank, M. and Rutgeerts, P. (2008) A randomized trial of Ustekinumab, a human interleukin-12/23 monoclonal antibody, in patients with moderate-to-severe Crohn's disease. Gastroenterology 135, 1130-1141
-
(2008)
Gastroenterology
, vol.135
, pp. 1130-1141
-
-
Sandborn, W.J.1
Feagan, B.G.2
Fedorak, R.N.3
Scherl, E.4
Fleisher, M.R.5
Katz, S.6
Johanns, J.7
Blank, M.8
Rutgeerts, P.9
-
73
-
-
29744450121
-
Both IL-12p70 and IL-23 are synthesized during active Crohn's disease and are down-regulated by treatment with anti-IL-12 p40 monoclonal antibody
-
Fuss, I. J., Becker, C., Yang, Z., Groden, C., Hornung, R. L., Heller, F., Neurath, M. F., Strober, W. and Mannon, P. J. (2006) Both IL-12p70 and IL-23 are synthesized during active Crohn's disease and are down-regulated by treatment with anti-IL-12 p40 monoclonal antibody. Inflamm. Bowel Dis. 12, 9-15
-
(2006)
Inflamm. Bowel Dis.
, vol.12
, pp. 9-15
-
-
Fuss, I.J.1
Becker, C.2
Yang, Z.3
Groden, C.4
Hornung, R.L.5
Heller, F.6
Neurath, M.F.7
Strober, W.8
Mannon, P.J.9
-
74
-
-
34250026960
-
Monoclonal Anti-Interleukin 23 Reverses Active Colitis in a T Cell-Mediated Model in Mice
-
DOI 10.1053/j.gastro.2007.03.104, PII S0016508507006300
-
Elson, C. O., Cong, Y., Weaver, C. T., Schoeb, T. R., McClanahan, T. K., Fick, R. B. and Kastelein, R. A. (2007) Monoclonal anti-interleukin 23 reverses active colitis in a T cell-mediated model in mice. Gastroenterology 132, 2359-2370 (Pubitemid 46890867)
-
(2007)
Gastroenterology
, vol.132
, Issue.7
, pp. 2359-2370
-
-
Elson, C.O.1
Cong, Y.2
Weaver, C.T.3
Schoeb, T.R.4
McClanahan, T.K.5
Fick, R.B.6
Kastelein, R.A.7
-
75
-
-
33846864685
-
Selective abrogation of Th1 response by STA-5326, a potent IL-12/IL-23 inhibitor
-
Wada, Y., Lu, R., Zhou, D., Chu, J., Przewloka, T., Zhang, S., Li, L., Wu, Y., Qin, J., Balasubramanyam, V. et al. (2007) Selective abrogation of Th1 response by STA-5326, a potent IL-12/IL-23 inhibitor. Blood 109, 1156-1164
-
(2007)
Blood
, vol.109
, pp. 1156-1164
-
-
Wada, Y.1
Lu, R.2
Zhou, D.3
Chu, J.4
Przewloka, T.5
Zhang, S.6
Li, L.7
Wu, Y.8
Qin, J.9
Balasubramanyam, V.10
-
76
-
-
77953693548
-
Randomized, double-blind, placebo-controlled trial of the oral interleukin-12/23 inhibitor apilimod mesylate for treatment of active Crohn's disease
-
doi 10.1002/ibd.21159
-
Sands, B. E., Jacobson, E. W., Sylwestrowicz, T., Younes, Z., Dryden, G., Fedorak, R. and Greenbloom, S. (2009) Randomized, double-blind, placebo-controlled trial of the oral interleukin-12/23 inhibitor apilimod mesylate for treatment of active Crohn's disease. Inflamm, Bowel Dis., doi 10.1002/ibd.21159
-
(2009)
Inflamm, Bowel Dis.
-
-
Sands, B.E.1
Jacobson, E.W.2
Sylwestrowicz, T.3
Younes, Z.4
Dryden, G.5
Fedorak, R.6
Greenbloom, S.7
-
77
-
-
69349093225
-
Interleukin-17 and type 17 helper T cells
-
Miossec, P., Korn, T. and Kuchroo, V. K. (2009) Interleukin-17 and type 17 helper T cells. N. Engl. J. Med. 361, 888-898
-
(2009)
N. Engl. J. Med.
, vol.361
, pp. 888-898
-
-
Miossec, P.1
Korn, T.2
Kuchroo, V.K.3
|