Nicotine exposure and bronchial epithelial cell nicotinic acetylcholine receptor expression in the pathogenesis of lung cancer

Journal of Clinical Investigation

Volumn 111, Issue 1, 2003, Pages 31-33

  Minna, John D ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

NICOTINE; NICOTINIC RECEPTOR;

ANGIOGENESIS; APOPTOSIS; BRONCHUS MUCOSA; CELL MIGRATION; CIGARETTE SMOKING; ENZYME ACTIVATION; EPITHELIUM CELL; HUMAN; INHIBITION KINETICS; LUNG CARCINOGENESIS; MOLECULAR DYNAMICS; MOLECULAR INTERACTION; MOLECULAR MECHANICS; NOTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; WOUND HEALING;

ANIMALS; APOPTOSIS; BRONCHI; CARCINOGENS; ENZYME ACTIVATION; EPITHELIAL CELLS; HUMANS; LUNG NEOPLASMS; NICOTINE; NITROSAMINES; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; RECEPTORS, NICOTINIC;

EID: 0037251896     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI200317492     Document Type: Note

References (24)

1. Karnath, B. 2002. Smoking cessation. Am. J. Med. 112:399-405.
2. Itier, V., and Bertrand, D. 2001. Neuronal nicotinic receptors: from protein structure to function. FEBS Lett. 504:118-125.
3. Maneckjee, R., and Minna, J.D. 1994. Opioids induce while nicotine suppresses apoptosis in human lung cancer cells. Cell Growth Differ. 5:1033-1040.
4. Maus, A.D., et al. 1998. Human and rodent bronchial epithelial cells express functional nicotinic acetylcholine receptors. Mol. Pharmacol. 54:779-788.
5. Wang, Y., et al. 2001. Human bronchial epithelial and endothelial cells express alpha7 nicotinic acetylcholine receptors. Mol. Pharmacol. 60:1201-1209.
6. Grando, S.A., et al. 1996. Activation of keratinocyte nicotinic cholinergic receptors stimulates calcium influx and enhances cell differentiation. J. Invest. Dermatol. 107:412-418.
7. Arredondo, J., et al. 2002. Central role of alpha7 nicotinic receptor in differentiation of the stratified squamous epithelium. J. Cell. Biol. 159:325-336.
8. Schuller, H.M., and Orloff, M. 1998. Tobacco-specific carcinogenic nitrosamines. Ligands for nicotinic acetylcholine receptors in human lung cancer cells. Biochem. Pharmacol. 55:1377-1384.
9. Plummer, H.K., 3rd, Sheppard, B.J., and Schuller, H.M. 2000. Interaction of tobacco-specific toxicants with nicotinic cholinergic regulation of fetal pulmonary neuroendocrine cells: implications for pediatric lung disease. Exp. Lung. Res. 26:121-135.
10. Schuller, H.M., Jull, B.A., Sheppard, B.J., and Plummer, H.K. 2000. Interaction of tobacco-specific toxicants with the neuronal alpha (7) nicotinic acetylcholine receptor and its associated mitogenic signal transduction pathway: potential role in lung carcinogenesis and pediatric lung disorders. Eur. J. Pharmacol. 393:265-277.
11. West, K.A., et al. 2003. Rapid Akt activation by nicotine and a tobacco carcinogen modulates the phenotype of normal human airway epithelial cells. J. Clin. Invest. 111:81-90. doi: 10.1172/JCI200316147.
12. Vanhaesebroeck, B., and Alessi, D.R. 2000. The PI3K-PDK1 connection: more than just a road to PKB. Biochem. J. 346:561-576.
13. Mai, H., May, W.S., Gao, F., Jin, Z., and Deng, X. 2002. A functional role for nicotine in Bcl2 phosphorylation and suppression of apoptosis. J. Biol. Chem. doi:10.1074/jbc.M209044200.
14. Chen, G.Q., Lin, B., Dawson, M.I., and Zhang, X.K. 2002. Nicotine modulates the effects of retinoids on growth inhibition and RAR beta expression in lung cancer cells. Int. J. Cancer. 99:171-178.
15. Brognard, J., Clark, A.S., Ni, Y., and Dennis, P.A. 2001. Akt/protein kinase B is constitutively active in non-small cell lung cancer cells and promotes cellular survival and resistance to chemotherapy and radiation. Cancer Res. 61:3986-3997.
16. Benowitz, N.L., Perez-Stable, E.J., Herrera, B., and Jacob, P., 3rd. 2002. Slower metabolism and reduced intake of nicotine from cigarette smoking in Chinese-Americans. J. Natl. Cancer Inst. 94:108-115.
17. Conti-Fine, B.M., Navaneetham, D., Lei, S., and Maus, A.D. 2000. Neutonal nicotinic receptors in non-neuronal cells: new mediators of tobacco toxicity? Eur. J. Pharmacol. 393:279-294.
18. Shaw, S., Bencherif, M., and Marrero, M.B. 2002. Janus kinase 2: an early target of Alpha7-mediated nicotinic acetylcholine receptor neuroprotection against Abeta (1-42) Amyloid. J. Biol. Chem. 277:44920-44924.
19. Dajas-Bailador, F.A., Soliakov, L., and Wonnacott, S. 2002. Nicotine activates the extracellular signal-regulated kinase 1/2 via the alpha7 nicotinic acetylcholine receptor and protein kinase A, in SH-SYSY cells and hippocampal neurones. J. Neurochem. 80:520-530.
20. Heeschen, C., et al. 2001. Nicotine stimulates angiogenesis and promotes tumor growth and atherosclerosis. Nat. Med. 7:833-839.
21. Heeschen, C., Weis, M., Aicher, A., Dimmeler, S., and Cooke, J.P. 2002. A novel angiogenic pathway mediated by non-neuronal nicotinic acetylcholine receptors. J. Clin. Invest. 110:527-536. doi:10.1172/JCI200214676.
22. Conklin, B.S., Zhao, W., Zhong, D.S., and Chen, C. 2002. Nicotine and cotinine up-regulate vascular endothelial growth factor expression in endothelial cells. Am. J. Pathol. 160:413-418.
23. Jacobi, J., et al. 2002. Nicotine accelerates angiogenesis and wound healing in genetically diabetic mice. Am. J. Pathol. 161:97-104.
24. Zia, S., Ndoye, A., Lee, T.X., Webber, R.J., and Grando, S.A. 2000. Receptor-mediated inhibition of keratinocyte migration by nicotine involves modulations of calcium influx and intracellular concentration. J. Pharmacol. Exp. Ther. 293:973-981.