Active immunization against nicotine suppresses nicotine-induced dopamine release in the rat nucleus accumbens shell

Respiration

Volumn 69, Issue 3, 2002, Pages 247-253

  De Villiers, S H L ^a   Lindblom, N ^a   Kalayanov, G ^b   Gordon, S ^b   Malmerfelt, A ^a   Johansson, A M ^b   Svensson, T H ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b UPPSALA UNIVERSITY   (Sweden)

Author keywords

Antibody selectivity; Dopamine; Immunization; Nicotine; Nicotine immunoconjugates; Nucleus accumbens

Indexed keywords

ANTIBODY; ANTIGEN; DOPAMINE; FREUND ADJUVANT; NICOTINE;

ACTIVE IMMUNIZATION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY PRODUCTION; ANTIBODY RESPONSE; ANTIBODY SPECIFICITY; ANTIBODY TITER; ARTICLE; CONTROLLED STUDY; DOPAMINE RELEASE; DOPAMINERGIC SYSTEM; DRUG EFFECT; ENZYME LINKED IMMUNOSORBENT ASSAY; LIMBIC SYSTEM; MALE; NONHUMAN; NUCLEUS ACCUMBENS; POTENTIOMETRY; PRIORITY JOURNAL; RAT; TOBACCO DEPENDENCE;

ANIMALS; DOPAMINE; ENZYME-LINKED IMMUNOSORBENT ASSAY; HEMOCYANIN; IMMUNOCONJUGATES; MALE; NICOTINE; NICOTINIC AGONISTS; NUCLEUS ACCUMBENS; RATS; TOBACCO USE DISORDER; VACCINATION; VACCINES, CONJUGATE;

EID: 0036315770     PISSN: 00257931     EISSN: None     Source Type: Journal    
DOI: 10.1159/000063628     Document Type: Article

References (43)

1. Smoking and death: The past 40 years and the next 40
2. Pharmacologic basis and treatment of cigarette smoking
3. Efficacy of nicotine chewing gum: A review
4. Influencing cigarette smoking with nicotine antagonists
5. Nicotine maintains robust self-administration in rats on a limited-access schedule
6. Rodent model of nicotine abstinence syndrome
7. Behavioral manifestations of the nicotine abstinence syndrome in the rat: Peripheral versus central mechanisms
8. Dramatic decreases in brain reward function during nicotine withdrawal
9. Reward, motivation and cognition: Psychobiology of the mesotelencephalic dopamine systems
10. Nicotinic effects on the firing pattern of midbrain dopamine neurons
11. Selective stimulation of limbic dopamine activity by nicotine
12. Nicotine preferentially stimulates dopamine release in the limbic system of freely moving rats
13. Infusion of nicotine in the ventral tegmental area or the nucleus accumbens of the rat differentially affects accumbal dopamine release
14. Differential effects of acute and chronic nicotine on dopamine output in the core and shell of the rat nucleus accumbens
15. Pharmacological characterization of dopamine systems in the nucleus accumbens core and shell
16. Prefrontal cortical dopamine systems and the elaboration of functional corticostriatal circuits: Implications for schizophrenia and Parkinson's disease
17. The mesolimbic dopaminergic system is implicated in the reinforcing effects of nicotine
18. A controlled trial of sustained-release bupropion, a nicotine patch, or both for smoking cessation
19. Changes in heroin self-administration by a rhesus monkey after morphine immunisation
20. Suppression of psychoactive effects of cocaine by active immunization
21. Efficacy of a therapeutic cocaine vaccine in rodent models
22. Conjugate of bovine serum albumin with nicotine
23. Radioimmunoassay of nicotine
24. Nicotine antibody production: Comparison of two nicotine conjugates in different animal species
25. Treated carbon fiber electrodes for measuring catechols and ascorbic acid
26. Nonlinear relationship between impulse flow and dopamine released by rat midbrain dopaminergic neurons as studied by in vivo electrochemistry
27. Nornicotine is self-administered intravenously by rats
28. Nicotine metabolic profile in man: Comparison of cigarette smoking and transdermal nicotine
29. Cotinine disposition and effects
30. Plasma histamine and catecholamines in stable asthmatic subjects
31. Catecholamines and their metabolites
32. Peripheral markers of serotonergic and noradrenergic function in post-pubertal, Caucasian males with autistic disorder
33. A nicotine conjugate vaccine reduces nicotine distribution to brain and attenuates its behavioral and cardiovascular effects in rats
34. Daily intake of nicotine during cigarette smoking
35. Altered disposition of repeated nicotine doses in rats immunized against nicotine
36. Nicotine delivery kinetics and abuse liability
37. A comparison of the abuse liability and dependence potential of nicotine patch, gum, spray and inhaler
38. Smoking withdrawal symptoms in two weeks of abstinence