메뉴 건너뛰기




Volumn 87, Issue 1, 2010, Pages 14-24

Analysis of three functional polymorphisms in relation to osteoporosis phenotypes: Replication in a Spanish cohort

Author keywords

Association study; BMD; Fracture; LCT; LRP6; MTHFR

Indexed keywords

5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2); ALANINE; ISOLEUCINE; LACTASE; LOW DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN 6; VALINE; GLYCOSYLCERAMIDASE; METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH2);

EID: 77953873197     PISSN: 0171967X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00223-010-9361-4     Document Type: Article
Times cited : (23)

References (89)
  • 1
    • 0035857351 scopus 로고    scopus 로고
    • Osteoporosis prevention, diagnosis, and therapy
    • NIH Consensus Development Panel on Osteoporosis Prevention, Detection, and Therapy. 10.1001/jama.285.6.785
    • NIH Consensus Development Panel on Osteoporosis Prevention, Detection, and Therapy 2001 Osteoporosis prevention, diagnosis, and therapy JAMA 285 785 795 10.1001/jama.285.6.785
    • (2001) JAMA , vol.285 , pp. 785-795
  • 2
    • 0036078514 scopus 로고    scopus 로고
    • Genetic control of susceptibility to osteoporosis
    • DOI 10.1210/jc.87.6.2460
    • SH Ralston 2002 Genetic control of susceptibility to osteoporosis J Clin Endocrinol Metab 87 2460 2466 10.1210/jc.87.6.2460 1:CAS:528: DC%2BD38XkvFakt7c%3D 12050200 (Pubitemid 34655301)
    • (2002) Journal of Clinical Endocrinology and Metabolism , vol.87 , Issue.6 , pp. 2460-2466
    • Ralston, S.H.1
  • 3
    • 0023508467 scopus 로고
    • Genetic determinants of bone mass in adults. A twin study
    • 10.1172/JCI113125 1:STN:280:DyaL2szgvVyjtQ%3D%3D 3624485
    • NA Pocock JA Eisman JL Hopper MG Yeates PN Sambrook S Eberl 1987 Genetic determinants of bone mass in adults. A twin study J Clin Invest 80 706 710 10.1172/JCI113125 1:STN:280:DyaL2szgvVyjtQ%3D%3D 3624485
    • (1987) J Clin Invest , vol.80 , pp. 706-710
    • Pocock, N.A.1    Eisman, J.A.2    Hopper, J.L.3    Yeates, M.G.4    Sambrook, P.N.5    Eberl, S.6
  • 4
    • 57049168654 scopus 로고    scopus 로고
    • Human genetics of osteoporosis
    • 10.1016/j.beem.2008.08.007 1:CAS:528:DC%2BD1cXhsVWmsbnP 19028354
    • S Ferrari 2008 Human genetics of osteoporosis Best Pract Res Clin Endocrinol Metab 22 723 735 10.1016/j.beem.2008.08.007 1:CAS:528: DC%2BD1cXhsVWmsbnP 19028354
    • (2008) Best Pract Res Clin Endocrinol Metab , vol.22 , pp. 723-735
    • Ferrari, S.1
  • 5
    • 0026034240 scopus 로고
    • Thermolabile methylenetetrahydrofolate reductase: An inherited risk factor for coronary artery disease
    • 1:STN:280:DyaK3M7ltVOltg%3D%3D 1998339
    • SS Kang PW Wong A Susmano J Sora M Norusis N Ruggie 1991 Thermolabile methylenetetrahydrofolate reductase: an inherited risk factor for coronary artery disease Am J Hum Genet 48 536 545 1:STN:280:DyaK3M7ltVOltg%3D%3D 1998339
    • (1991) Am J Hum Genet , vol.48 , pp. 536-545
    • Kang, S.S.1    Wong, P.W.2    Susmano, A.3    Sora, J.4    Norusis, M.5    Ruggie, N.6
  • 8
    • 0034966495 scopus 로고    scopus 로고
    • Plasma homocysteine, methylenetetrahydrofolate reductase mutation and carotid damage in elderly healthy women
    • DOI 10.1016/S0021-9150(00)00696-1, PII S0021915000006961
    • A Passaro A Vanini F Calzoni L Alberti PF Zamboni R Fellin A Solini 2001 Plasma homocysteine, methylenetetrahydrofolate reductase mutation and carotid damage in elderly healthy women Atherosclerosis 157 175 180 10.1016/S0021- 9150(00)00696-1 1:CAS:528:DC%2BD3MXksVGku7s%3D 11427218 (Pubitemid 32539368)
    • (2001) Atherosclerosis , vol.157 , Issue.1 , pp. 175-180
    • Passaro, A.1    Vanini, A.2    Calzoni, F.3    Alberti, L.4    Zamboni, P.F.5    Fellin, R.6    Solini, A.7
  • 9
    • 0035864690 scopus 로고    scopus 로고
    • The effect of the C677T and A1298C polymorphisms in the methylenetetrahydrofolate reductase gene on homocysteine levels in elderly men and women from the British regional heart study
    • DOI 10.1016/S0021-9150(00)00522-0, PII S0021915000005220
    • V Dekou P Whincup O Papacosta S Ebrahim L Lennon PM Ueland H Refsum SE Humphries V Gudnason 2001 The effect of the C677T and A1298C polymorphisms in the methylenetetrahydrofolate reductase gene on homocysteine levels in elderly men and women from the British regional heart study Atherosclerosis 154 659 666 10.1016/S0021-9150(00)00522-0 1:CAS:528:DC%2BD3MXitVOmsr8%3D 11257267 (Pubitemid 32232163)
    • (2001) Atherosclerosis , vol.154 , Issue.3 , pp. 659-666
    • Dekou, V.1    Whincup, P.2    Papacosta, O.3    Ebrahim, S.4    Lennon, L.5    Ueland, P.M.6    Refsum, H.7    Humphries, S.E.8    Gudnason, V.9
  • 10
    • 0029887713 scopus 로고    scopus 로고
    • Evidence for McKusick's hypothesis of deficient collagen cross-linking in patients with homocystinuria
    • 8611653
    • B Lubec S Fang-Kircher T Lubec HJ Blom GH Boers 1996 Evidence for McKusick's hypothesis of deficient collagen cross-linking in patients with homocystinuria Biochim Biophys Acta 1315 159 162 8611653
    • (1996) Biochim Biophys Acta , vol.1315 , pp. 159-162
    • Lubec, B.1    Fang-Kircher, S.2    Lubec, T.3    Blom, H.J.4    Boers, G.H.5
  • 11
    • 0033953774 scopus 로고    scopus 로고
    • Association of methylenetetrahydrofolate reductase (MTHFR) polymorphism with bone mineral density in postmenopausal Japanese women
    • DOI 10.1007/s002230010038
    • M Miyao H Morita T Hosoi H Kurihara S Inoue S Hoshino M Shiraki Y Yazaki Y Ouchi 2000 Association of methylenetetrahydrofolate reductase (MTHFR) polymorphism with bone mineral density in postmenopausal Japanese women Calcif Tissue Int 66 190 194 10.1007/s002230010038 1:CAS:528:DC%2BD3cXhslSiurw%3D 10666493 (Pubitemid 30091759)
    • (2000) Calcified Tissue International , vol.66 , Issue.3 , pp. 190-194
    • Miyao, M.1    Morita, H.2    Hosoi, T.3    Kurihara, H.4    Inoue, S.5    Hoshino, S.6    Shiraki, M.7    Yazaki, Y.8    Ouchi, Y.9
  • 13
    • 0035505057 scopus 로고    scopus 로고
    • Variance component linkage analysis indicates a QTL for femoral neck bone mineral density on chromosome 1p36
    • 10.1093/hmg/10.21.2447 1:CAS:528:DC%2BD3MXos1aqsbo%3D 11689491
    • M Devoto C Specchia HH Li J Caminis A Tenenhouse H Rodriguez LD Spotila 2001 Variance component linkage analysis indicates a QTL for femoral neck bone mineral density on chromosome 1p36 Hum Mol Genet 10 2447 2452 10.1093/hmg/10.21.2447 1:CAS:528:DC%2BD3MXos1aqsbo%3D 11689491
    • (2001) Hum Mol Genet , vol.10 , pp. 2447-2452
    • Devoto, M.1    Specchia, C.2    Li, H.H.3    Caminis, J.4    Tenenhouse, A.5    Rodriguez, H.6    Spotila, L.D.7
  • 14
    • 0036821122 scopus 로고    scopus 로고
    • Mapping of quantitative ultrasound of the calcaneus bone to chromosome 1 by genome-wide linkage analysis
    • DOI 10.1007/s001980200110
    • D Karasik RH Myers MT Hannan D Gagnon RR McLean LA Cupples DP Kiel 2002 Mapping of quantitative ultrasound of the calcaneus bone to chromosome 1 by genome-wide linkage analysis Osteoporos Int 13 796 802 10.1007/s001980200110 1:STN:280:DC%2BD38nitFSmtw%3D%3D 12378368 (Pubitemid 36336724)
    • (2002) Osteoporosis International , vol.13 , Issue.10 , pp. 796-802
    • Karasik, D.1    Myers, R.H.2    Hannan, M.T.3    Gagnon, D.4    McLean, R.R.5    Cupples, L.A.6    Kiel, D.P.7
  • 15
    • 33744990856 scopus 로고    scopus 로고
    • Meta-analysis of genome-wide linkage studies for bone mineral density
    • DOI 10.1007/s10038-006-0390-9
    • YH Lee YH Rho SJ Choi JD Ji GG Song 2006 Meta-analysis of genome-wide linkage studies for bone mineral density J Hum Genet 51 480 486 10.1007/s10038-006-0390-9 16534542 (Pubitemid 43863786)
    • (2006) Journal of Human Genetics , vol.51 , Issue.5 , pp. 480-486
    • Lee, Y.H.1    Rho, Y.H.2    Choi, S.J.3    Ji, J.D.4    Song, G.G.5
  • 16
    • 63649101425 scopus 로고    scopus 로고
    • Multiple osteoporosis susceptibility genes on chromosome 1p36 in Chinese
    • 10.1016/j.bone.2009.01.368 1:CAS:528:DC%2BD1MXktFagtrw%3D 19442614
    • QY Huang GH Li AW Kung 2009 Multiple osteoporosis susceptibility genes on chromosome 1p36 in Chinese Bone 44 984 988 10.1016/j.bone.2009.01.368 1:CAS:528:DC%2BD1MXktFagtrw%3D 19442614
    • (2009) Bone , vol.44 , pp. 984-988
    • Huang, Q.Y.1    Li, G.H.2    Kung, A.W.3
  • 17
    • 35748963239 scopus 로고    scopus 로고
    • Genome-wide association with bone mass and geometry in the framingham heart study
    • DOI 10.1186/1471-2350-8-S1-S14
    • DP Kiel S Demissie J Dupuis KL Lunetta JM Murabito D Karasik 2007 Genome-wide association with bone mass and geometry in the Framingham Heart Study BMC Med Genet 8 Suppl 1 S14 10.1186/1471-2350-8-S1-S14 17903296 (Pubitemid 351958747)
    • (2007) BMC Medical Genetics , vol.8 , Issue.SUPPL. 1
    • Kiel, D.P.1    Demissie, S.2    Dupuis, J.3    Lunetta, K.L.4    Murabito, J.M.5    Karasik, D.6
  • 20
    • 0036479030 scopus 로고    scopus 로고
    • Identification of a variant associated with adult-type hypolactasia
    • 10.1038/ng826 1:CAS:528:DC%2BD38XhtFWltbw%3D 11788828
    • NS Enattah T Sahi E Savilahti JD Terwilliger L Peltonen I Jarvela 2002 Identification of a variant associated with adult-type hypolactasia Nat Genet 30 233 237 10.1038/ng826 1:CAS:528:DC%2BD38XhtFWltbw%3D 11788828
    • (2002) Nat Genet , vol.30 , pp. 233-237
    • Enattah, N.S.1    Sahi, T.2    Savilahti, E.3    Terwilliger, J.D.4    Peltonen, L.5    Jarvela, I.6
  • 21
    • 0028969249 scopus 로고
    • The lactase persistence/non-persistence polymorphism is controlled by a cis-acting element
    • 10.1093/hmg/4.4.657 1:CAS:528:DyaK2MXltlSju7o%3D 7543318
    • Y Wang CB Harvey WS Pratt VR Sams M Sarner M Rossi S Auricchio DM Swallow 1995 The lactase persistence/non-persistence polymorphism is controlled by a cis-acting element Hum Mol Genet 4 657 662 10.1093/hmg/4.4.657 1:CAS:528:DyaK2MXltlSju7o%3D 7543318
    • (1995) Hum Mol Genet , vol.4 , pp. 657-662
    • Wang, Y.1    Harvey, C.B.2    Pratt, W.S.3    Sams, V.R.4    Sarner, M.5    Rossi, M.6    Auricchio, S.7    Swallow, D.M.8
  • 23
    • 0038476614 scopus 로고    scopus 로고
    • Transcriptional regulation of the lactase-phlorizin hydrolase gene by polymorphisms associated with adult-type hypolactasia
    • DOI 10.1136/gut.52.5.647
    • M Kuokkanen NS Enattah A Oksanen E Savilahti A Orpana I Jarvela 2003 Transcriptional regulation of the lactase-phlorizin hydrolase gene by polymorphisms associated with adult-type hypolactasia Gut 52 647 652 10.1136/gut.52.5.647 1:CAS:528:DC%2BD3sXjvVeiu74%3D 12692047 (Pubitemid 36528864)
    • (2003) Gut , vol.52 , Issue.5 , pp. 647-652
    • Kuokkanen, M.1    Enattah, N.S.2    Oksanen, A.3    Savilahti, E.4    Orpana, A.5    Jarvela, I.6
  • 24
    • 29644439954 scopus 로고    scopus 로고
    • -13910 DNA variant associated with lactase persistence interacts with Oct-1 and stimulates lactase promoter activity in vitro
    • DOI 10.1093/hmg/ddi418
    • RH Lewinsky TG Jensen J Moller A Stensballe J Olsen JT Troelsen 2005 T-13910 DNA variant associated with lactase persistence interacts with Oct-1 and stimulates lactase promoter activity in vitro Hum Mol Genet 14 3945 3953 10.1093/hmg/ddi418 1:CAS:528:DC%2BD2MXhtlChsrrN 16301215 (Pubitemid 43020095)
    • (2005) Human Molecular Genetics , vol.14 , Issue.24 , pp. 3945-3953
    • Lewinsky, R.H.1    Jensen, T.G.K.2    Moller, J.3    Stensballe, A.4    Olsen, J.5    Troelsen, J.T.6
  • 25
    • 0014214497 scopus 로고
    • Osteoporosis, intestinal lactase deficiency and low dietary calcium intake
    • 1:CAS:528:DyaF2sXktF2lurc%3D 6071242
    • SJ Birge Jr HT Keutmann P Cuatrecasas GD Whedon 1967 Osteoporosis, intestinal lactase deficiency and low dietary calcium intake N Engl J Med 276 445 448 1:CAS:528:DyaF2sXktF2lurc%3D 6071242
    • (1967) N Engl J Med , vol.276 , pp. 445-448
    • Birge Jr., S.J.1    Keutmann, H.T.2    Cuatrecasas, P.3    Whedon, G.D.4
  • 26
    • 0022610714 scopus 로고
    • Lactose absorption, milk consumption, and fasting blood glucose concentrations in women with idiopathic osteoporosis
    • 10.1136/bmj.292.6514.161 1:STN:280:DyaL287gsFShtw%3D%3D 3080115
    • G Finkenstedt F Skrabal RW Gasser H Braunsteiner 1986 Lactose absorption, milk consumption, and fasting blood glucose concentrations in women with idiopathic osteoporosis BMJ 292 161 162 10.1136/bmj.292.6514.161 1:STN:280:DyaL287gsFShtw%3D%3D 3080115
    • (1986) BMJ , vol.292 , pp. 161-162
    • Finkenstedt, G.1    Skrabal, F.2    Gasser, R.W.3    Braunsteiner, H.4
  • 27
    • 0023134964 scopus 로고
    • Lactose and calcium absorption in postmenopausal osteoporosis
    • DOI 10.1001/archinte.147.3.534
    • M Horowitz J Wishart L Mundy BE Nordin 1987 Lactose and calcium absorption in postmenopausal osteoporosis Arch Intern Med 147 534 536 10.1001/archinte.147.3.534 1:STN:280:DyaL2s7lsFKmtA%3D%3D 3827431 (Pubitemid 17036597)
    • (1987) Archives of Internal Medicine , vol.147 , Issue.3 , pp. 534-536
    • Horowitz, M.1    Wishart, J.2    Mundy, L.3    Nordin, B.E.C.4
  • 28
    • 0023126639 scopus 로고
    • Differences between lactase deficient and non-lactase deficient women with spinal osteoporosis
    • 3100122
    • VJ Vigorita M Lane MK Suda M Nelkin 1987 Differences between lactase deficient and non-lactase deficient women with spinal osteoporosis Clin Orthop Relat Res 215 248 253 3100122
    • (1987) Clin Orthop Relat Res , vol.215 , pp. 248-253
    • Vigorita, V.J.1    Lane, M.2    Suda, M.K.3    Nelkin, M.4
  • 29
    • 0025989157 scopus 로고
    • Lactose intolerance, calcium intake, and osteopenia
    • 10.1016/0140-6736(91)92024-V 1:STN:280:DyaK38%2Fkslyluw%3D%3D 1682584
    • P Mainguet I Faille L Destrebecq JP Devogelaer C Nagant de Deuxchaisnes 1991 Lactose intolerance, calcium intake, and osteopenia Lancet 338 1156 1157 10.1016/0140-6736(91)92024-V 1:STN:280:DyaK38%2Fkslyluw%3D%3D 1682584
    • (1991) Lancet , vol.338 , pp. 1156-1157
    • Mainguet, P.1    Faille, I.2    Destrebecq, L.3    Devogelaer, J.P.4    Nagant De Deuxchaisnes, C.5
  • 30
    • 0026326318 scopus 로고
    • No evidence for an effect of lactase deficiency on bone mass in pre-or postmenopausal women
    • 10.1002/jbmr.5650061214 1:STN:280:DyaK387ntVCjsQ%3D%3D 1792946
    • CW Slemenda JC Christian S Hui J Fitzgerald CC Johnston Jr 1991 No evidence for an effect of lactase deficiency on bone mass in pre-or postmenopausal women J Bone Miner Res 6 1367 1371 10.1002/jbmr.5650061214 1:STN:280:DyaK387ntVCjsQ%3D%3D 1792946
    • (1991) J Bone Miner Res , vol.6 , pp. 1367-1371
    • Slemenda, C.W.1    Christian, J.C.2    Hui, S.3    Fitzgerald, J.4    Johnston Jr., C.C.5
  • 31
    • 0028913115 scopus 로고
    • Lactose intolerance and bone mass in postmenopausal Italian women
    • 10.1079/BJN19950050 1:CAS:528:DyaK2MXkvFWlsLg%3D 7766570
    • GR Corazza G Benati A Di Sario C Tarozzi A Strocchi M Passeri G Gasbarrini 1995 Lactose intolerance and bone mass in postmenopausal Italian women Br J Nutr 73 479 487 10.1079/BJN19950050 1:CAS:528:DyaK2MXkvFWlsLg%3D 7766570
    • (1995) Br J Nutr , vol.73 , pp. 479-487
    • Corazza, G.R.1    Benati, G.2    Di Sario, A.3    Tarozzi, C.4    Strocchi, A.5    Passeri, M.6    Gasbarrini, G.7
  • 32
    • 0029582794 scopus 로고
    • Lactose intolerance and osteoporosis in men
    • 1:STN:280:DyaK2s%2Fit1ymug%3D%3D 8869218
    • M Laroche E Bon L Moulinier A Cantagrel B Mazieres 1995 Lactose intolerance and osteoporosis in men Rev Rhum Engl Ed 62 766 769 1:STN:280:DyaK2s%2Fit1ymug%3D%3D 8869218
    • (1995) Rev Rhum Engl Ed , vol.62 , pp. 766-769
    • Laroche, M.1    Bon, E.2    Moulinier, L.3    Cantagrel, A.4    Mazieres, B.5
  • 33
    • 0344333452 scopus 로고    scopus 로고
    • Lactose intolerance associated with fractures of weight-bearing bones in Finnish women aged 38-57 years
    • DOI 10.1016/S8756-3282(97)00172-5, PII S8756328297001725
    • R Honkanen H Kroger E Alhava P Turpeinen M Tuppurainen S Saarikoski 1997 Lactose intolerance associated with fractures of weight-bearing bones in Finnish women aged 38-57 years Bone 21 473 477 10.1016/S8756-3282(97)00172-5 1:STN:280:DyaK1c%2FptVWjsg%3D%3D 9430235 (Pubitemid 28029688)
    • (1997) Bone , vol.21 , Issue.6 , pp. 473-477
    • Honkanen, R.1    Kroger, H.2    Alhava, E.3    Turpeinen, P.4    Tuppurainen, M.5    Saarikoski, S.6
  • 35
    • 12944278743 scopus 로고    scopus 로고
    • Molecularly defined lactose malabsorption, peak bone mass and bone turnover rate in young Finnish men
    • DOI 10.1007/s00223-004-0029-9
    • N Enattah VV Valimaki MJ Valimaki E Loyttyniemi T Sahi I Jarvela 2004 Molecularly defined lactose malabsorption, peak bone mass and bone turnover rate in young Finnish men Calcif Tissue Int 75 488 493 10.1007/s00223-004-0029-9 1:CAS:528:DC%2BD2MXksVGqtg%3D%3D 15365657 (Pubitemid 40174507)
    • (2004) Calcified Tissue International , vol.75 , Issue.6 , pp. 488-493
    • Enattah, N.1    Valimaki, V.-V.2    Valimaki, M.J.3    Loyttyniemi, E.4    Sahi, T.5    Jarvela, I.6
  • 36
    • 27144441479 scopus 로고    scopus 로고
    • Genetically defined adult-type hypolactasia and self-reported lactose intolerance as risk factors of osteoporosis in Finnish postmenopausal women
    • DOI 10.1038/sj.ejcn.1602219, PII 1602219
    • N Enattah T Pekkarinen MJ Valimaki E Loyttyniemi I Jarvela 2005 Genetically defined adult-type hypolactasia and self-reported lactose intolerance as risk factors of osteoporosis in Finnish postmenopausal women Eur J Clin Nutr 59 1105 1111 10.1038/sj.ejcn.1602219 1:CAS:528:DC%2BD2MXhtVGrurvM 16015262 (Pubitemid 41508656)
    • (2005) European Journal of Clinical Nutrition , vol.59 , Issue.10 , pp. 1105-1111
    • Enattah, N.1    Pekkarinen, T.2    Valimaki, M.J.3    Loyttyniemi, E.4    Jarvela, I.5
  • 39
    • 62149130092 scopus 로고    scopus 로고
    • Milk, rather than other foods, is associated with vertebral bone mass and circulating IGF-1 in female adolescents
    • 10.1007/s00198-008-0708-x 1:CAS:528:DC%2BD1MXis1Glurk%3D 18704544
    • L Esterle JP Sabatier F Guillon-Metz O Walrant-Debray G Guaydier-Souquieres F Jehan M Garabedian 2009 Milk, rather than other foods, is associated with vertebral bone mass and circulating IGF-1 in female adolescents Osteoporos Int 20 567 575 10.1007/s00198-008-0708-x 1:CAS:528: DC%2BD1MXis1Glurk%3D 18704544
    • (2009) Osteoporos Int , vol.20 , pp. 567-575
    • Esterle, L.1    Sabatier, J.P.2    Guillon-Metz, F.3    Walrant-Debray, O.4    Guaydier-Souquieres, G.5    Jehan, F.6    Garabedian, M.7
  • 40
    • 62149150989 scopus 로고    scopus 로고
    • LCT 13910 C/T polymorphism, serum calcium, and bone mineral density in postmenopausal women
    • 10.1007/s00198-008-0709-9 1:CAS:528:DC%2BD1MXis1Gluro%3D 18704543
    • K Bacsi JP Kosa A Lazary B Balla H Horvath A Kis Z Nagy I Takacs P Lakatos G Speer 2009 LCT 13910 C/T polymorphism, serum calcium, and bone mineral density in postmenopausal women Osteoporos Int 20 639 645 10.1007/s00198-008- 0709-9 1:CAS:528:DC%2BD1MXis1Gluro%3D 18704543
    • (2009) Osteoporos Int , vol.20 , pp. 639-645
    • Bacsi, K.1    Kosa, J.P.2    Lazary, A.3    Balla, B.4    Horvath, H.5    Kis, A.6    Nagy, Z.7    Takacs, I.8    Lakatos, P.9    Speer, G.10
  • 41
    • 33646433058 scopus 로고    scopus 로고
    • Regulation of bone mass by Wnt signaling
    • 10.1172/JCI28551 1:CAS:528:DC%2BD28XksVWgu7s%3D 16670761
    • V Krishnan HU Bryant OA Macdougald 2006 Regulation of bone mass by Wnt signaling J Clin Invest 116 1202 1209 10.1172/JCI28551 1:CAS:528: DC%2BD28XksVWgu7s%3D 16670761
    • (2006) J Clin Invest , vol.116 , pp. 1202-1209
    • Krishnan, V.1    Bryant, H.U.2    MacDougald, O.A.3
  • 42
    • 0034727078 scopus 로고    scopus 로고
    • An LDL-receptor-related protein mediates Wnt signalling in mice
    • 10.1038/35035124 1:CAS:528:DC%2BD3cXntlSrtro%3D 11029008
    • KI Pinson J Brennan S Monkley BJ Avery WC Skarnes 2000 An LDL-receptor-related protein mediates Wnt signalling in mice Nature 407 535 538 10.1038/35035124 1:CAS:528:DC%2BD3cXntlSrtro%3D 11029008
    • (2000) Nature , vol.407 , pp. 535-538
    • Pinson, K.I.1    Brennan, J.2    Monkley, S.3    Avery, B.J.4    Skarnes, W.C.5
  • 43
    • 9444235153 scopus 로고    scopus 로고
    • Skeletal defects in ringelschwanz mutant mice reveal that Lrp6 is required for proper somitogenesis and osteogenesis
    • DOI 10.1242/dev.01405
    • C Kokubu U Heinzmann T Kokubu N Sakai T Kubota M Kawai MB Wahl J Galceran R Grosschedl K Ozono K Imai 2004 Skeletal defects in ringelschwanz mutant mice reveal that Lrp6 is required for proper somitogenesis and osteogenesis Development 131 5469 5480 10.1242/dev.01405 1:CAS:528:DC%2BD2cXhtVCjs7fL 15469977 (Pubitemid 39562189)
    • (2004) Development , vol.131 , Issue.21 , pp. 5469-5480
    • Kokubu, C.1    Heinzmann, U.2    Kokubu, T.3    Sakai, N.4    Kubota, T.5    Kawai, M.6    Wahl, M.B.7    Galceran, J.8    Grosschedl, R.9    Ozono, K.10    Imai, K.11
  • 50
    • 0024284028 scopus 로고
    • A simple salting out procedure for extracting DNA from human nucleated cells
    • 10.1093/nar/16.3.1215 1:CAS:528:DyaL1cXhsVKlsrs%3D 3344216
    • SA Miller DD Dykes HF Polesky 1988 A simple salting out procedure for extracting DNA from human nucleated cells Nucleic Acids Res 16 1215 10.1093/nar/16.3.1215 1:CAS:528:DyaL1cXhsVKlsrs%3D 3344216
    • (1988) Nucleic Acids Res , vol.16 , pp. 1215
    • Miller, S.A.1    Dykes, D.D.2    Polesky, H.F.3
  • 51
    • 33747827929 scopus 로고    scopus 로고
    • SNPStats: A web tool for the analysis of association studies
    • DOI 10.1093/bioinformatics/btl268
    • X Sole E Guino J Valls R Iniesta V Moreno 2006 SNPStats: a web tool for the analysis of association studies Bioinformatics 22 1928 1929 10.1093/bioinformatics/btl268 1:CAS:528:DC%2BD28Xotl2qsLo%3D 16720584 (Pubitemid 44283043)
    • (2006) Bioinformatics , vol.22 , Issue.15 , pp. 1928-1929
    • Sole, X.1    Guino, E.2    Valls, J.3    Iniesta, R.4    Moreno, V.5
  • 52
    • 0036499241 scopus 로고    scopus 로고
    • Sample size requirements for association studies of gene-gene interaction
    • DOI 10.1093/aje/155.5.478
    • WJ Gauderman 2002 Sample size requirements for association studies of gene-gene interaction Am J Epidemiol 155 478 484 10.1093/aje/155.5.478 11867360 (Pubitemid 34174160)
    • (2002) American Journal of Epidemiology , vol.155 , Issue.5 , pp. 478-484
    • Gauderman, W.J.1
  • 57
    • 33646000274 scopus 로고    scopus 로고
    • Genetics of osteoporosis
    • 10.1007/s10354-005-0249-2 16823531
    • B Obermayer-Pietsch 2006 Genetics of osteoporosis Wien Med Wochenschr 156 162 167 10.1007/s10354-005-0249-2 16823531
    • (2006) Wien Med Wochenschr , vol.156 , pp. 162-167
    • Obermayer-Pietsch, B.1
  • 60
    • 5344224747 scopus 로고    scopus 로고
    • Methylenetetrahydrofolate reductase polymorphism interacts with riboflavin intake to influence bone mineral density
    • DOI 10.1016/j.bone.2004.05.018, PII S8756328204002443
    • HM Macdonald FE McGuigan WD Fraser SA New SH Ralston DM Reid 2004 Methylenetetrahydrofolate reductase polymorphism interacts with riboflavin intake to influence bone mineral density Bone 35 957 964 10.1016/j.bone.2004.05. 018 1:CAS:528:DC%2BD2cXnvV2rtb8%3D 15454103 (Pubitemid 39349227)
    • (2004) Bone , vol.35 , Issue.4 , pp. 957-964
    • Macdonald, H.M.1    McGuigan, F.E.2    Fraser, W.D.3    New, S.A.4    Ralston, S.H.5    Reid, D.M.6
  • 61
    • 2342598882 scopus 로고    scopus 로고
    • Association of a common polymorphism in the Methylenetetrahydrofolate reductase (MTHFR) gene with bone phenotypes depends on plasma folate status
    • DOI 10.1359/JBMR.0301261
    • RR McLean D Karasik J Selhub KL Tucker JM Ordovas GT Russo LA Cupples PF Jacques DP Kiel 2004 Association of a common polymorphism in the methylenetetrahydrofolate reductase (MTHFR) gene with bone phenotypes depends on plasma folate status J Bone Miner Res 19 410 418 10.1359/JBMR.0301261 1:CAS:528:DC%2BD2cXisFCrsLc%3D 15040829 (Pubitemid 38787396)
    • (2004) Journal of Bone and Mineral Research , vol.19 , Issue.3 , pp. 410-418
    • McLean, R.R.1    Karasik, D.2    Selhub, J.3    Tucker, K.L.4    Ordovas, J.M.5    Russo, G.T.6    Cupples, L.A.7    Jacques, P.F.8    Kiel, D.P.9
  • 62
    • 15544384276 scopus 로고    scopus 로고
    • Are effects of MTHFR (C677T) genotype on BMD confined to women with low folate and riboflavin intake? Analysis of food records from the Danish osteoporosis prevention study
    • DOI 10.1016/j.bone.2004.12.014
    • B Abrahamsen JS Madsen CL Tofteng L Stilgren EM Bladbjerg SR Kristensen K Brixen L Mosekilde 2005 Are effects of MTHFR (C677T) genotype on BMD confined to women with low folate and riboflavin intake? Analysis of food records from the Danish Osteoporosis Prevention Study Bone 36 577 583 10.1016/j.bone.2004.12. 014 1:CAS:528:DC%2BD2MXisFGrtLY%3D 15777680 (Pubitemid 40403857)
    • (2005) Bone , vol.36 , Issue.3 , pp. 577-583
    • Abrahamsen, B.1    Madsen, J.S.2    Tofteng, C.L.3    Stilgren, L.4    Bladbjerg, E.M.5    Kristensen, S.R.6    Brixen, K.7    Mosekilde, L.8
  • 64
    • 0029069203 scopus 로고
    • 6 supplements in elderly people with normal serum vitamin concentrations
    • 10.1016/S0140-6736(95)92113-3 1:CAS:528:DyaK2MXnt1ymtLY%3D 7603218
    • 6 supplements in elderly people with normal serum vitamin concentrations Lancet 346 85 89 10.1016/S0140-6736(95)92113-3 1:CAS:528:DyaK2MXnt1ymtLY%3D 7603218
    • (1995) Lancet , vol.346 , pp. 85-89
    • Naurath, H.J.1    Joosten, E.2    Riezler, R.3    Stabler, S.P.4    Allen, R.H.5    Lindenbaum, J.6
  • 65
    • 0031748093 scopus 로고    scopus 로고
    • The metabolism of homocysteine: Pathways and regulation
    • 10.1007/PL00014300 1:CAS:528:DyaK1cXivVeksbg%3D 9587024
    • JD Finkelstein 1998 The metabolism of homocysteine: pathways and regulation Eur J Pediatr 157 Suppl 2 S40 S44 10.1007/PL00014300 1:CAS:528:DyaK1cXivVeksbg%3D 9587024
    • (1998) Eur J Pediatr , vol.157 , Issue.SUPPL. 2
    • Finkelstein, J.D.1
  • 66
    • 0036076711 scopus 로고    scopus 로고
    • Impaired functioning of thermolabile methylenetetrahydrofolate reductase is dependent on riboflavin status: Implications for riboflavin requirements
    • 1:CAS:528:DC%2BD38XlslOlt7k%3D 12145019
    • H McNulty MC McKinley B Wilson J McPartlin JJ Strain DG Weir JM Scott 2002 Impaired functioning of thermolabile methylenetetrahydrofolate reductase is dependent on riboflavin status: implications for riboflavin requirements Am J Clin Nutr 76 436 441 1:CAS:528:DC%2BD38XlslOlt7k%3D 12145019
    • (2002) Am J Clin Nutr , vol.76 , pp. 436-441
    • McNulty, H.1    McKinley, M.C.2    Wilson, B.3    McPartlin, J.4    Strain, J.J.5    Weir, D.G.6    Scott, J.M.7
  • 68
    • 34047104431 scopus 로고    scopus 로고
    • Prediction of absolute risk of non-spinal fractures using clinical risk factors and heel quantitative ultrasound
    • DOI 10.1007/s00198-006-0297-5
    • A Diez-Perez J Gonzalez-Macias F Marin M Abizanda R Alvarez A Gimeno E Pegenaute J Vila 2007 Prediction of absolute risk of non-spinal fractures using clinical risk factors and heel quantitative ultrasound Osteoporos Int 18 629 639 10.1007/s00198-006-0297-5 1:STN:280:DC%2BD2s7ptFOlsA%3D%3D 17235664 (Pubitemid 46525547)
    • (2007) Osteoporosis International , vol.18 , Issue.5 , pp. 629-639
    • Diez-Perez, A.1    Gonzalez-Macias, J.2    Marin, F.3    Abizanda, M.4    Alvarez, R.5    Gimeno, A.6    Pegenaute, E.7    Vila, J.8
  • 69
    • 49549091386 scopus 로고    scopus 로고
    • Contribution of gender-specific genetic factors to osteoporosis risk
    • 10.1111/j.1469-1809.2008.00447.x 1:STN:280:DC%2BD1cnks1egtw%3D%3D 18485052
    • D Karasik SL Ferrari 2008 Contribution of gender-specific genetic factors to osteoporosis risk Ann Hum Genet 72 696 714 10.1111/j.1469-1809.2008.00447.x 1:STN:280:DC%2BD1cnks1egtw%3D%3D 18485052
    • (2008) Ann Hum Genet , vol.72 , pp. 696-714
    • Karasik, D.1    Ferrari, S.L.2
  • 72
    • 0042807404 scopus 로고    scopus 로고
    • A common methylenetetrahydrofolate reductase (C677T) polymorphism is associated with low bone mineral density and increased fracture incidence after menopause: Longitudinal data from the Danish Osteoporosis Prevention Study
    • 10.1359/jbmr.2003.18.4.723 1:CAS:528:DC%2BD3sXivFKks7g%3D 12674333
    • B Abrahamsen JS Madsen CL Tofteng L Stilgren EM Bladbjerg SR Kristensen K Brixen L Mosekilde 2003 A common methylenetetrahydrofolate reductase (C677T) polymorphism is associated with low bone mineral density and increased fracture incidence after menopause: longitudinal data from the Danish Osteoporosis Prevention Study J Bone Miner Res 18 723 729 10.1359/jbmr.2003.18.4.723 1:CAS:528:DC%2BD3sXivFKks7g%3D 12674333
    • (2003) J Bone Miner Res , vol.18 , pp. 723-729
    • Abrahamsen, B.1    Madsen, J.S.2    Tofteng, C.L.3    Stilgren, L.4    Bladbjerg, E.M.5    Kristensen, S.R.6    Brixen, K.7    Mosekilde, L.8
  • 73
    • 4344608282 scopus 로고    scopus 로고
    • Association of plasma folate, plasma total homocysteine, but not methylenetetrahydrofolate reductase C667T polymorphism, with bone mineral density in postmenopausal Iranian women: A cross-sectional study
    • DOI 10.1016/j.bone.2004.04.018, PII S8756328204001772
    • J Golbahar A Hamidi MA Aminzadeh GR Omrani 2004 Association of plasma folate, plasma total homocysteine, but not methylenetetrahydrofolate reductase C667T polymorphism, with bone mineral density in postmenopausal Iranian women: a cross-sectional study Bone 35 760 765 10.1016/j.bone.2004.04.018 1:CAS:528:DC%2BD2cXntFChu7Y%3D 15336613 (Pubitemid 39141877)
    • (2004) Bone , vol.35 , Issue.3 , pp. 760-765
    • Golbahar, J.1    Hamidi, A.2    Aminzadeh, M.A.3    Omrani, G.R.4
  • 74
    • 13944266746 scopus 로고    scopus 로고
    • Methylenetetrahydrofolate reductase polymorphism (MTHFR C677T) and bone mineral density in Chinese men and women
    • DOI 10.1016/j.bone.2004.09.008
    • M Li EM Lau J Woo 2004 Methylenetetrahydrofolate reductase polymorphism (MTHFR C677T) and bone mineral density in Chinese men and women Bone 35 1369 1374 10.1016/j.bone.2004.09.008 1:CAS:528:DC%2BD2cXhtVOntb%2FM 15589218 (Pubitemid 40267636)
    • (2004) Bone , vol.35 , Issue.6 , pp. 1369-1374
    • Li, M.1    Lau, E.M.C.2    Woo, J.3
  • 75
    • 16844371643 scopus 로고    scopus 로고
    • Methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism is associated with osteoporotic vertebral fractures, but is a weak predictor of BMD
    • DOI 10.1007/s00198-004-1704-4
    • MM Villadsen MH Bunger M Carstens L Stenkjaer BL Langdahl 2005 Methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism is associated with osteoporotic vertebral fractures, but is a weak predictor of BMD Osteoporos Int 16 411 416 10.1007/s00198-004-1704-4 1:CAS:528:DC%2BD2MXisVCitrs%3D 15300362 (Pubitemid 40487399)
    • (2005) Osteoporosis International , vol.16 , Issue.4 , pp. 411-416
    • Villadsen, M.M.1    Bunger, M.H.2    Carstens, M.3    Stenkjaer, L.4    Langdahl, B.L.5
  • 76
    • 33846577275 scopus 로고    scopus 로고
    • Association of the methylenetetrahydrofolate reductase C677T polymorphism and fracture risk in Chinese postmenopausal women
    • DOI 10.1016/j.bone.2006.09.031, PII S8756328206007381
    • X Hong YH Hsu H Terwedow G Tang X Liu S Jiang X Xu X Xu 2007 Association of the methylenetetrahydrofolate reductase C677T polymorphism and fracture risk in Chinese postmenopausal women Bone 40 737 742 10.1016/j.bone.2006.09.031 1:CAS:528:DC%2BD2sXhtlSksbY%3D 17174622 (Pubitemid 46187215)
    • (2007) Bone , vol.40 , Issue.3 , pp. 737-742
    • Hong, X.1    Hsu, Y.-H.2    Terwedow, H.3    Tang, G.4    Liu, X.5    Jiang, S.6    Xu, X.7    Xu, X.8
  • 77
    • 63949086104 scopus 로고    scopus 로고
    • No association between hip geometry and four common polymorphisms associated with fracture: The Danish Osteoporosis Prevention Study
    • 10.1007/s00223-009-9219-9 1:CAS:528:DC%2BD1MXjvVWrt7s%3D 19225709
    • N Nissen JS Madsen EM Bladbjerg JE Beck Jensen NR Jorgensen B Langdahl B Abrahamsen K Brixen 2009 No association between hip geometry and four common polymorphisms associated with fracture: the Danish Osteoporosis Prevention Study Calcif Tissue Int 84 276 285 10.1007/s00223-009-9219-9 1:CAS:528: DC%2BD1MXjvVWrt7s%3D 19225709
    • (2009) Calcif Tissue Int , vol.84 , pp. 276-285
    • Nissen, N.1    Madsen, J.S.2    Bladbjerg, E.M.3    Beck Jensen, J.E.4    Jorgensen, N.R.5    Langdahl, B.6    Abrahamsen, B.7    Brixen, K.8
  • 78
    • 0038099459 scopus 로고    scopus 로고
    • Association of a common allelic polymorphism (C677T) in the methylene tetrahydrofolate reductase gene with a reduced risk of osteoporotic fractures. A case control study in Danish postmenopausal women
    • DOI 10.1007/s00223-001-2126-3
    • HL Jorgensen JS Madsen B Madsen MM Saleh B Abrahamsen M Fenger JB Lauritzen 2002 Association of a common allelic polymorphism (C677T) in the methylene tetrahydrofolate reductase gene with a reduced risk of osteoporotic fractures. A case control study in Danish postmenopausal women Calcif Tissue Int 71 386 392 10.1007/s00223-001-2126-3 1:CAS:528:DC%2BD38XovF2js7Y%3D 12232679 (Pubitemid 36929600)
    • (2002) Calcified Tissue International , vol.71 , Issue.5 , pp. 386-392
    • Jorgensen, H.L.1    Madsen, J.S.2    Madsen, B.3    Saleh, M.M.A.4    Abrahamsen, B.5    Fenger, M.6    Lauritzen, J.B.7
  • 79
    • 4344700011 scopus 로고    scopus 로고
    • Evidence for an association of methylene tetrahydrofolate reductase polymorphism C677T and an increased risk of fractures: Results from a population-based Danish twin study
    • 10.1007/s00198-003-1584-z 1:CAS:528:DC%2BD2cXmt1KltLc%3D 14727014
    • L Bathum J von Bornemann Hjelmborg L Christiansen JS Madsen A Skytthe K Christensen 2004 Evidence for an association of methylene tetrahydrofolate reductase polymorphism C677T and an increased risk of fractures: results from a population-based Danish twin study Osteoporos Int 15 659 664 10.1007/s00198-003-1584-z 1:CAS:528:DC%2BD2cXmt1KltLc%3D 14727014
    • (2004) Osteoporos Int , vol.15 , pp. 659-664
    • Bathum, L.1    Von Bornemann Hjelmborg, J.2    Christiansen, L.3    Madsen, J.S.4    Skytthe, A.5    Christensen, K.6
  • 80
    • 58149229958 scopus 로고    scopus 로고
    • The synergistic effect of bone mineral density and methylenetetrahydrofolate reductase (MTHFR) polymorphism (C677T) on fractures
    • 10.1007/s00774-008-0878-9 1:CAS:528:DC%2BD1cXhtlWhtbzP 18979159
    • M Shiraki T Urano T Kuroda M Saito S Tanaka M Miyao-Koshizuka S Inoue 2008 The synergistic effect of bone mineral density and methylenetetrahydrofolate reductase (MTHFR) polymorphism (C677T) on fractures J Bone Miner Metab 26 595 602 10.1007/s00774-008-0878-9 1:CAS:528: DC%2BD1cXhtlWhtbzP 18979159
    • (2008) J Bone Miner Metab , vol.26 , pp. 595-602
    • Shiraki, M.1    Urano, T.2    Kuroda, T.3    Saito, M.4    Tanaka, S.5    Miyao-Koshizuka, M.6    Inoue, S.7
  • 83
    • 0141702274 scopus 로고    scopus 로고
    • Lactase persistence DNA variant enhances lactase promoter activity in vitro: Functional role as a cis regulatory element
    • DOI 10.1093/hmg/ddg244
    • LC Olds E Sibley 2003 Lactase persistence DNA variant enhances lactase promoter activity in vitro: functional role as a cis regulatory element Hum Mol Genet 12 2333 2340 10.1093/hmg/ddg244 1:CAS:528:DC%2BD3sXntVCru7s%3D 12915462 (Pubitemid 37160877)
    • (2003) Human Molecular Genetics , vol.12 , Issue.18 , pp. 2333-2340
    • Olds, L.C.1    Sibley, E.2
  • 85
    • 0347416709 scopus 로고    scopus 로고
    • Genetics of lactase persistence and lactose intolerance
    • DOI 10.1146/annurev.genet.37.110801.143820
    • DM Swallow 2003 Genetics of lactase persistence and lactose intolerance Annu Rev Genet 37 197 219 10.1146/annurev.genet.37.110801.143820 1:CAS:528:DC%2BD2cXhsFGluw%3D%3D 14616060 (Pubitemid 38041425)
    • (2003) Annual Review of Genetics , vol.37 , pp. 197-219
    • Swallow, D.M.1
  • 87
    • 33847005874 scopus 로고    scopus 로고
    • Prevalence and trends in adult-type hypolactasia in different age cohorts in central Sweden diagnosed by genotyping for the adult-type hypolactasia-linked LCT-13910C>T mutation
    • 10.1080/00365520600825257 1:CAS:528:DC%2BD2sXjtF2jsb0%3D 17327935
    • R Almon P Engfeldt C Tysk M Sjostrom TK Nilsson 2007 Prevalence and trends in adult-type hypolactasia in different age cohorts in central Sweden diagnosed by genotyping for the adult-type hypolactasia-linked LCT-13910C>T mutation Scand J Gastroenterol 42 165 170 10.1080/00365520600825257 1:CAS:528:DC%2BD2sXjtF2jsb0%3D 17327935
    • (2007) Scand J Gastroenterol , vol.42 , pp. 165-170
    • Almon, R.1    Engfeldt, P.2    Tysk, C.3    Sjostrom, M.4    Nilsson, T.K.5
  • 88
    • 60549094439 scopus 로고    scopus 로고
    • Effects of the lactase 13910 C/T and calcium-sensor receptor A986S G/T gene polymorphisms on the incidence and recurrence of colorectal cancer in Hungarian population
    • 10.1186/1471-2407-8-317 18980667
    • K Bacsi E Hitre JP Kosa H Horvath A Lazary PL Lakatos B Balla B Budai P Lakatos G Speer 2008 Effects of the lactase 13910 C/T and calcium-sensor receptor A986S G/T gene polymorphisms on the incidence and recurrence of colorectal cancer in Hungarian population BMC Cancer 8 317 10.1186/1471-2407-8- 317 18980667
    • (2008) BMC Cancer , vol.8 , pp. 317
    • Bacsi, K.1    Hitre, E.2    Kosa, J.P.3    Horvath, H.4    Lazary, A.5    Lakatos, P.L.6    Balla, B.7    Budai, B.8    Lakatos, P.9    Speer, G.10


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.