Associations of genetic lactase non-persistence and sex with bone loss in young adulthood

Bone

Volumn 44, Issue 5, 2009, Pages 1003-1009

  Laaksonen, Marika M L ^a   Impivaara, Olli ^b   Sievänen, Harri ^c   Viikari, Jorma S A ^d   Lehtimäki, Terho J ^e   Lamberg Allardt, Christel J E ^a   Kärkkäinen, Merja U M ^a   Välimäki, Matti ^f   Heikkinen, Jorma ^g   Kröger, Liisa M ^h   Kröger, Heikki P J ^h   Jurvelin, Jukka S ⁱ   Kähönen, Mika A P ^j   Raitakari, Olli T ^d  

^a UNIVERSITY OF HELSINKI   (Finland)

^b NATIONAL PUBLIC HEALTH INSTITUTE   (Finland)

^c UKK INSTITUTE FOR HEALTH PROMOTION RESEARCH   (Finland)

^d TURKU UNIVERSITY HOSPITAL   (Finland)

^e TAMPERE UNIVERSITY HOSPITAL   (Finland)

^f HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

^g OULU DEACONESS INSTITUTE   (Finland)

^h KUOPIO UNIVERSITY HOSPITAL   (Finland)

ⁱ UNIVERSITY OF EASTERN FINLAND   (Finland)

^j TAMPERE UNIVERSITY OF TECHNOLOGY   (Finland)

more..

Author keywords

Bone loss; Calcium intake; Lactase genotype; Osteoporosis; Peak bone mass

Indexed keywords

LACTASE;

ADULT; ADULTHOOD; AGED; ALLELE; ARTICLE; ATHEROSCLEROSIS; BONE DENSITY; BONE MASS; BONE MINERAL; CALCIUM INTAKE; CARDIOVASCULAR RISK; CONTROLLED STUDY; DISEASE PREDISPOSITION; DUAL ENERGY X RAY ABSORPTIOMETRY; FEMALE; FEMUR NECK; FINLAND; FOLLOW UP; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENETIC SUSCEPTIBILITY; GENOTYPE; HEREDITY; HUMAN; LIFESTYLE; LUMBAR SPINE; MAJOR CLINICAL STUDY; MALE; MEASUREMENT; MOLECULAR PROBE; OSTEOLYSIS; PHYSICAL ACTIVITY; POLYMERASE CHAIN REACTION; PREDICTION; QUESTIONNAIRE; SEX DIFFERENCE;

ADULT; BONE DENSITY; CALCIUM; FEMALE; GENOTYPE; HUMANS; LACTASE; LACTOSE INTOLERANCE; MALE; OSTEOPOROSIS; POLYMORPHISM, SINGLE NUCLEOTIDE; SEX FACTORS; YOUNG ADULT;

EID: 63649121079     PISSN: 87563282     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bone.2008.12.019     Document Type: Article

References (59)

1. Melton L.J., Wahner H.W., and Riggs B.L. Lifetime fracture risk: an approach to hip fracture risk assessment based on bone mineral density and age. J. Clin. Epidemiol. 41 (1988) 985-994
2. Rubin L.A., Hawker G.A., Peltekova V.D., Fielding L.J., Ridout R., and Cole D.E. Determinants of peak bone mass: clinical and genetic analyses in young female Canadian cohort. J. Bone Miner. Res. 14 (1999) 633-643
3. Seeman E. Invited review: pathogenesis of osteoporosis. J. Appl. Physiol. 95 (2003) 2142-2151
4. Buchanan J.R., Myers C., Lloyd T., and Greer III R.B. Early vertebral trabecular bone loss in normal premenopausal women. J. Bone Miner. Res. 3 (1988) 583-587
5. Rodin A., Murby B., Smith M.A., Caleffi M., Fentiman I., Chapman M.G., and Fogelman I. Premenopausal bone loss in the lumbar spine and neck of femur: a study of 225 Caucasian women. Bone 11 (1990) 1-5
6. Sowers M., Kshirsagar A., Crutchfield M., and Updike S. Body composition, age and femoral neck bone mass of young adult women. Ann. Epidemiol. 1 (1991) 245-254
7. Ravn P., Hetland M.L., Overgaard K., and Christiansen C. Premenopausal and postmenopausal changes in bone mineral density of the proximal femur measured by dual-energy X-ray absorptiometry. J. Bone Miner. Res. 9 (1994) 1975-1980
8. Arlot M.E., Sornay-Rendu E., Garnero P., Vey-Marty B., and Delmas P.D. Apparent pre- and postmenopausal bone loss evaluated with by DXA at different skeletal sites in women: the OFELY cohort. J. Bone Miner. Res. 12 (1997) 683-690
9. Riggs B.L., Melton III L.J., Robb R.A., Camp J.J., Atkinson E.J., Peterson J.M., et al. Population-based study of age and sex differences in bone volumetric density, size, geometry, and structure at different skeletal sites. J. Bone Miner. Res. 19 (2004) 1945-1954
10. Krolner B., and Pors Nielsen S. Bone mineral content of the lumbar spine in normal and osteoporotic women: crosssectional and longitudinal studies. Clin. Sci. 62 (1982) 329-336
11. Riggs B.L., Wahner H.W., Melton III L.J., Richelson L.S., Judd H.L., and Offord K.P. Rates of bone loss in appendicular skeletons of women. J. Clin. Invest. 77 (1986) 1487-1491
12. Riggs B.L., Melton III L.J., Robb R.A., Camp J.J., Atkinson E.J., McDaniel L., et al. A population-based assessment of rates of bone loss at multiple skeletal sites: evidence for substantial trabecular bone loss in young adult women and men. J. Bone Miner. Res. 23 (2008) 205-214
13. Citron J.T., Ettinger B., and Genant H.K. Spinal bone mineral loss in estrogen-replete, calcium-replete premenopausal women. Osteoporosis Int. 5 (1995) 228-233
14. Prior J.C., Vigna Y.M., Barr S.I., Kennedy S., Schulzer M., and Li D.K. Ovulatory premenopausal women lose cancellous spinal bone: a five year prospective study. Bone 18 (1996) 261-267
15. Uusi-Rasi K., Sievänen H., Pasanen M., and Kannus P. Age-related decline in trabecular and cortical density: a 5-year peripheral quantitative computed tomography follow-up study of pre- and postmenopausal women. Calcif. Tissue Int. 81 (2007) 249-253
16. Warming L., Hassage C., and Cristiansen C. Changes in bone mineral density with age in men and women: a longitudinal study. Osteoporosis Int. 13 (2002) 105-112
17. Sowers M., Crutchfield M., Bandekar R., Randolph J.F., Shapiro B., Schork M.A., et al. Bone mineral density and its change in pre- and perimenopausal white women: the Michigan Bone Health Study. J. Bone Miner. Res. 13 (1998) 1134-1140
18. Recker R.R., Davies K.M., Hinders S.M., Heaney R.P., Stegman M.R., and Kimmel D.B. Bone gain in young adult women. JAMA 268 (1992) 2403-2408
19. Mazess R.B., and Barden H.S. Bone density in premenopausal women: effects of age, dietary intake, physical activity smoking, and birth control. Am. J. Clin. Nutr. 53 (1991) 132-142
20. Kalender W.A., Felsenberg D., and Louis O. Reference values for trabecular and cortical vertebral bone density in single and dual-energy quantitative computed tomography. Eur. J. Radiol. 9 (1989) 75-80
21. Aaron J.E., Makins N.B., and Sagreiy K. The microanatomy of trabecular bone loss in normal ageing men and women. Clin. Orth. RR 215 (1987) 260-271
22. Pocock N.A., Eisman J.A., Hopper J.L., Yeates M.G., Sambrook P.N., and Ebert S. Genetic determinants of bone mass in adults. A twin study. J. Clin. Invest. 80 (1987) 706-710
23. Pocock N.A., Eisman J.A., Hopper J.L., Yeates M.G., Sambrook P.N., and Ebert S. Segregation analysis and variance components analysis of bone mineral density in healthy families. J. Bone Miner. Res. 12 (1995) 2017-2022
24. Kelly P.J., Nguyen T., Hopper J., Pocock N Sambrook P., and Eisman J. Changes in axial bone density with age: a twin study. J. Bone Miner. Res. 8 (1993) 11-17
25. Christian J.C., Yu PL Slemenda C.W., and Johnston C.C. Heritability of bone mass: a longitudinal study in aging male twins. Am. J. Hum. Genet. 44 (1989) 429-433
26. DiStefano M., Veneto G., Malservisi S., Cecchetti L., Minguzzi L., Strocchi A., et al. Lactose malabsorption and intolerance and peak bone mass. Gastroenterology 122 (2002) 1793-1799
27. Honkanen R., Pulkkinen P., Järvinen R., Kröger H., Lindstedt K., Tuppurainen M., et al. Does lactose intolerance predispose to low bone density? A population-based study of perimenopausal Finnish women. Bone 19 (1996) 23-28
28. Honkanen R., Kröger H., Alhava E., Turpeinen P., Tuppurainen M., and Saarikoski S. Lactose intolerance associated with fractures of weight-bearing bones in Finnish women aged 38-57 years. Bone 21 (1997) 473-477
29. Goulding A., Taylor R.W., Keil D., Gold E., Lewis-Barned N.J., and Williams S.M. Lactose malabsorption and rate of bone loss in older women. Age Ageing 28 (1999) 175-180
30. Kudlacek S., Freudenthaler O., Weissböeck H., Schneider B., and Willvonseder R. Lactose intolerance: a risk factor for reduced bone mineral density and vertebral fractures?. J. Gastroenterol. 37 (2002) 1014-1019
31. Slemenda C., Christian J., Hui S., Fitzgerald J., and Johnston C. No evidence for an effect of lactase deficiency on bone mass in premenopausal or postmenopausal women. J. Bone Miner. Res. 6 (1991) 1367-1371
32. Enattah N.S., Sahi T., Savilahti E., Terwilliger J.D., Peltonen L., and Järvelä I. Identification of a variant associated with adult type hypolactasia. Nat. Genet. 30 (2002) 233-237
33. Rasinperä H., Savilahti E., Enattah N.S., Kuokkanen M., Tötterman N., Lindahl H., et al. A genetic test which can be used to diagnose adult-type hypolactasia in children. Gut 53 (2004) 1571-1576
34. Obermayer-Pietsch B.M., Bonelli C.M., Walter D.E., Kuhn R.J., Fahrleitnerpammer A., Berghold A., et al. Genetic predisposition for adult lactose intolerance and relation to diet, bone density and bone fractures. J. Bone Miner. Res. 19 (2004) 42-47
35. Paturi M, Tapanainen H, Reinivuo H, Pietinen P, eds. The National FINDIET 2007 survey. Publications of National Public Health Institute 2008, Series B B23:79.
36. Enattah N., Välimäki V.V., Välimäki M.J., Löyttyniemi E., Sahi T., and Järvelä I. Molecularly defined lactose malabsorption, peak bone mass and bone turnover rate in young Finnish men. Calcif. Tissue Int. 75 (2004) 488-493
37. Enattah N., Pekkarinen T., Välimäki M.J., Löyttyniemi E., and Järvelä I. Genetically defined adult-type hypolactasia and self-reported lactose intolerance as risk factors of osteoporosis in Finnish postmenopausal women. Eur. J. Clin. Nutr. 59 (2005) 1105-1111
38. Enattah N.S., Sulkava R., Halonen P., Kontula K., and Järvelä I. Genetic variant of lactase-persistent C/T-13910 is associated with bone fractures in very old age. JAGS 53 (2005) 79-82
39. Raitakari O.T., Juonala M., Rönnemaa T., Keltikangas-Järvinen L., Räsänen L., Pietikäinen M., et al. Cohort profile: the Cardiovascular Risk in Young Finns Study. Int. J. Epidemiol. 37 (2008) 1220-1226
40. Lehtimäki T., Hemminki J., Rontu R., Mikkilä V., Räsänen L., Laaksonen M., et al. The effects of adult-type hypolactasia on body height growth and dietary calcium intake from childhood into young adulthood: a 21-year follow-up study - the Cardiovascular Risk in Young Finns Study. Pediatrics 118 (2006) 1553-1559
41. Välimäki MJ, Kärkkäinen M, Lamberg-Allardt C, Laitinen K, Alhava E, Heikkinen J, et al. Exercise, smoking, and calcium intake during adolescence and early adulthood as determinants of peak bone mass. BMJ 1994;309:230-5.
42. Vainio P., Ahonen E., Leinonen K., Sievänen H., and Koski E. Comparison of instruments for dual-energy X-ray bone mineral densitometry. Nucl. Med. Commun. 13 (1992) 252-255
43. Bonnick S.L., Johnston Jr. C.C., Kleerekoper M., Lindsay R., Miller P., Sherwood L., et al. Importance of precision in bone density measurements. J. Clin. Densitometry 4 (2001) 105-110
44. Livak K.J. Allelic discrimination using fluorogenic probes and the 5′ nuclease assay. Genet. Anal. 14 (1999) 143-149
45. Lamberg-Allardt C.J., Outila T.A., Kärkkäinen M.U., Rita H.J., and Valsta L.M. Vitamin D deficiency and bone health in healthy adults in Finland: could this be a concern in other parts of Europe?. J. Bone Miner. Res. 16 (2001) 2066-2073
46. Telama R., Yang X., Viikari J., Välimäki I., Wanne O., and Raitakari O. Physical activity from childhood to adulthood - a 21-year tracking study. Am. J. Prev. Med. 28 3 (2005) 267-273
47. Seeman E. Sexual dimorphism in skeletal size, density, and strength. J. Clin. Endocrinol. Metab. 86 (2001) 4576-4584
48. Lauretani F., Bandinelli S., Griswold M.E., Maggio M., Semba R., Guralnik J.M., et al. Longitudinal changes in BMD and bone geometry in a population-based study. J. Bone Miner. Res. 23 (2008) 400-408
49. Matkovic V., and Heaney R.P. Calcium balance during human growth: evidence for threshold behaviour. Am. J. Clin. Nutr. 55 (1992) 992-996
50. Matkovic V., Landoll J.D., Badenhop-Stevens N.E., Ha E.Y., Crncevic-Orlic Z., Li B., et al. Nutrition influences skeletal development from childhood to adulthood: a study of hip, spine, and forearm in adolescent females. J. Nutr. 134 (2004) 701S-705S
51. Theintz G., Buchs B., Rizzoli R., Slosman D., Clavien H., Sizonenko P.C., et al. Longitudinal monitoring of bone mass accumulation in healthy adolescents: evidence for a marked reduction after 16 years of age at the levels of lumbar spine and femoral neck in female subjects. J. Clin. Endocrinol. Metab. 75 (1992) 1060-1065
52. Gugatschka M., Dobnig H., Fahrleitner-Pammer A., Pietschmann P., Kudlacek S., Strele A., et al. Molecularly-defined lactose malabsorption, milk consumption and antropometric differences in adult males. QJ Med. 98 (2005) 857-863
53. Lember M., Torniainen S., Kull M., Kallikorm R., Saadla P., Rajasalu P., et al. Lactase non-persistence and milk consumption in Estonia. World J. Gastroenterol. 12 (2006) 7329-7331
54. Laaksonen M.M.L., Mikkilä V., Räsänen L., Rontu R., Lehtimäki T.J., Viikari J.S.A., et al., and the Cardiovascular Risk in Young Finns Study Group. Genetic lactase non-persistence, consumption of milk products and intakes of milk nutrients in finns from childhood to young adulthood. Br J Nutr 13 (2009) 1-10
55. Hangartner T.N. A study of the long-term precision of dual-energy X-ray absorptiometry bone densitometers and implications for the validity of the least-significant-change calculation. Osteoporosis Int. 18 (2007) 513-523
56. Sievänen H., Oja P., and Vuori I. Scanner-induced variability and quality assurance in longitudinal dual-energy X-ray absorptiometry measurements. Med. Phys. 21 (1994) 1795-1805
57. Bolotin H.H., Sievänen H., Grashuis J.L., Kuiper J.W., and Järvinen T.L.N. Inaccuracies inherent in patient-specific dual-energy X-ray absorptiometry bone mineral density measurements: comprehensive phantom-based evaluation. J. Bone Miner. Res. 16 (2001) 417-426
58. Philippov G., Seaborn C.J., and Phillips P.J. Reproducibility of DXA: potential impact on serial measurements and misclassification of osteoporosis. Osteoporosis Int. 12 (2001) 49-54
59. Bolotin H.H., Sievänen H., and Grashuis J.L. Patient-specific DXA bone mineral density inaccuracies: quantitative effects of nonuniform extraosseus fat distributions. J. Bone Miner. Res. 18 (2003) 1020-1027