Micro- and nanoscale hydrogel systems for drug delivery and tissue engineering

Materials

Volumn 2, Issue 2, 2009, Pages 577-612

  Schwall, Christine T ^a   Banerjee, Ipsita A ^a  

^a FORDHAM UNIVERSITY   (United States)

Author keywords

Biosensor; Cancer therapy; Diabetes; Drug delivery; Hydrogel; Micro; Nano; Tissue engineering

Indexed keywords

CANCER THERAPY; CELL BASED THERAPIES; MICRO; NANO; NANOSCALE HYDROGELS; POLY (ETHYLENE OXIDE) (PEO); POLY(N-ISOPROPYL ACRYLAMIDE) (PNIPAM); TARGETED DRUG DELIVERY SYSTEMS;

ACRYLIC MONOMERS; BIOCOMPATIBILITY; BIODEGRADATION; BIOLOGICAL MATERIALS; BIOSENSORS; DRUG DELIVERY; MEDICAL PROBLEMS; NANOTECHNOLOGY; ONCOLOGY; POLYETHYLENE GLYCOLS; POLYETHYLENE OXIDES; TISSUE ENGINEERING;

HYDROGELS;

EID: 77953862459     PISSN: None     EISSN: 19961944     Source Type: Journal    
DOI: 10.3390/ma2020577     Document Type: Review

References (157)

1. Wang, S. Ordered mesoporous materials for drug delivery. Microp. Mesop. Mater. 2009, 117, 1-9.
2. Zhang, H.; Mardyani, S.; Chan, W.C.W.; Kumacheva, E. Design of biocompatible chitosan microgels for targeted pH-mediated intracellular release of cancer therapeutics. Biomacromolecules 2006, 7, 1568-1572.
3. Ethirajan, A.; Schoeller, K.; Musyanovych, A.; Ziener, U.; Landfester, K. Synthesis and optimization of gelatin nanoparticles using the miniemulsion process. Biomacromolecules 2008, 9, 2383-2389.
4. Bertholon, I.; Hommel, H.; Labarre, D.; Vauthier, C. Properties of polysaccharides grafted on nanoparticles investigated by EPR. Langmuir 2006, 22, 5485-5490.
5. Wenk, E.; Wandrey, A.J., Merkle, H.P.; Meinel, L. Silk fibroin spheres as a platform for controlled drug delivery. J. Contr. Rel. 2008, 132, 26-34.
6. Prato, M.; Kostarelos, K.; and Bianco, A. Functionalized carbon nanotubes in drug design and discovery. Acc. Chem. Res. 2008, 41, 60-68.
7. Yang, J.; Lee, J.; Kang, J.; Lee, K.; Suh, J.; Yoon, H.; Huh, Y.; Haam, S. Hollow silica nanocontainers as drug delivery vehicles. Langmuir 2008, 24, 3417-3421.
8. Ramachandran, S.; Flynn, P.; Tseng, Y.; Yu, Y.B. Electrostatically controlled hydrogelation of oligopeptides and protein entrapment. Chem. Mater. 2005, 17, 6583-6588.
9. Li, C.; Tang, Y.; Armes, S.P. Synthesis and characterization of biocompatible thermo-responsive gelators based on ABA triblock copolymers. Biomacromolecules 2005, 6, 994-999.
10. Descamps, M.; Hornez, J.C.; Leriche, A. Manufacture of hydroxyapatite beads for medical applications. J. Eur. Ceram. Soc. 2009, 29, 369-375.
11. Zhao, Q.; Li, B. pH-controlled drug loading and release from biodegradable microcapsules. Nanomed. Nanotechnol. Biol. Med. 2008, 4, 302-310.
12. Bachelder, E.M.; Beaudette, T.T.; Broaders, K.E.; Dashe, J.; Frechet, J.M.J. Acetal-derivatized dextran: An acid-responsive biodegradable material for therapeutic applications. J. Am. Chem. Soc. 2008, 130, 10494-10495.
13. Heffernan, M.J.; Murthy, N. Polyketal Nanoparticles: A new pH sensitive biodegradable Drug Delivery Vehicle. Bioconjug. Chem. 2005, 16, 1340-1342.
14. Yang, S.C.; Bhide, M.; Crispe, I.N.; Pierce, R.H.; Murthy, N. Polyketal copolymers: A new acidsensitive delivery vehicle for treating acute inflammatory disease. Bioconjug. Chem. 2008, 19, 1164-1169.
15. Liu, S.; Maheshwari, R.; Kiick, K.L. Polymer-based therapeutics. Macromolecules 2009, 42, 3-13.
16. Brookes, S.; Biessels, P.; Ng, N.F.L.; Woods, C.; Bell, D.N.; Adamson, G. Synthesis and characterization of a hemoglobin-ribavirin conjugate for targeted drug delivery. Bioconjug. Chem. 2006, 17, 530-537.
17. Temming, K.; Meyer, D.L.; Zabinski, R.; Dijkers, E.C.F.; Poelstra, K.; Molema, G.; Kok, R.J. Evaluation of RGD-targeted albumin carriers for specific delivery of auristatin E to tumor blood vessels. Bioconjug. Chem. 2006, 17, 1385-1394.
18. 3-targeted albumin conjugates by conjugation of a novel auristatin derivative. Mol. Pharm. 2007, 4, 686-694.
19. Xiong, X.; Mahmud, A.; Uludag, H.; Lavasanifar, A. Conjugation of arginine-glycine-aspartic acid peptides fo poly(ethylene oxide)-b-poly(ε-caprolactone) micelles for enhanced intracellular drug delivery to metastatic tumor cells. Biomacromolecules 2007, 8, 874-884.
20. Yang, P.; Sun, X.; Chiu, J.; Sun, H.; He, Q. Transferrin-mediated gold nanoparticle cellular uptake. Bioconjug. Chem. 2005, 16, 494-496.
21. Lu, Y.; Wu, J.; Wu, J.; Gonit, M.; Yang, X.; Lee, A.; Xiang, G.; Li, H.; Liu, S.; Marcucci, G.; Ratnam, M.; Lee, R.J. Role of formulation composition in folate receptor-targeted liposomal doxorubicin delivery to Acute Myelogenous Leukemia cells. Mol. Pharm. 2007, 4, 707-712.
22. 2 based production of magnetically responsive micro- and nanoparticles for drug targeting. Ind. Eng. Chem. Res. 2002, 41, 6049-6058.
23. Backer, M.V.; Aloise, R.; Przekop, K.; Stoletov, K.; Backer, J.M. Molecular vehicles for targeted drug delivery. Bioconjug. Chem. 2002, 13, 462-467.
24. Ambade, A.V.; Savariar, E.N.; Thayumanavan, S. Dendrimeric micelles for controlled drug release and targeted delivery. Mol. Pharm. 2005, 2, 264-272.
25. Wu, D.; Wang, T.; Lu, B.; Xu, X.; Cheng, S.; Jiang, X.; Zhang, X.; Zhuo, R. Fabrication of supramolecular hydrogels for drug delivery and stem cell encapsulation. Langmuir 2008, 24, 10306-10312.
26. van de Manakker, F.; van der Pot, M.; Vermonden, T.; van Nostrum, C.F.; Hennink, W.E. Selfassembling hydrogels based on β-Cyclodextrin/cholesterol inclusion complexes. Macromolecules 2008, 41, 1766-1773.
27. Wang, D.; Williams, C.G.; Li, Q.; Sharma, B.; Elisseeff, J.H. Synthesis and characterization of a novel degradable phosphate-containing hydrogel. Biomaterials 2003, 24, 3969-3980.
28. Jacchetti, E.; Emilitri, E.; Rodighiero, S.; Indrieri, M.; Gianfelice, A.; Lenardi, C.; Podesta, A.; Ranucci, E.; Ferruti, P.; Milani, P. Biomimetic poly(amidoamine) hydrogels as synthetic materials for cell culture. J. Nanobiotechnol. 2008, 6, doi: 10.1186/1477-3155-6-14.
29. Jansson, P.E.; Lindberg, B.; Sanford. P.A. Structural studies of gellan gum, an extracellular polysaccharide elaborated by Pseudomonas elodea. Carbohydr. Res. 1983, 124, 135-139.
30. Kurisawa, M.; Chung, J.E.; Yang, Y.Y.; Gao, S.J.; Uyama, H. Injectable biodegradable hydrogels composed of hyaluronic acid-tyramine conjugates for drug delivery and tissue engineering. Chem. Commun. 2005, 4312-4314.
31. Jia, X.; Burdick, J.A.; Kobler, J.; Clifton, R.J.; Rosowski, J.J.; Zeitels, S.M.; Langer, R. Synthesis and characterization of in situ cross-linkable hyaluronic acid-based hydrogels with potential application for vocal fold regeneration. Macromolecules 2004, 37, 3239-3248.
32. Jia, X.; Yeo, Y.; Clifton, R.J.; Jiao, T.; Kohane, D.S.; Kobler, J.B.; Zeitels, S.M.; Langer, R. Hyaluronic acid-based microgels and microgel networks for vocal fold regeneration. Biomacromolecules 2006, 7, 3336-3344.
33. Agrawal, S.K.; Sanabria-DeLong, N.; Jemian, P.R.; Tew, G.N.; Bhatia, S.R. Micro- to nanoscale structure of biocompatible PLA-PEO-PLA hydrogels. Langmuir 2007, 23, 5039-5044.
34. Sanabria-DeLong, N.; Crosby, A.J.; Tew, G.N. Photo-cross-linked PLA-PEO-PLA hydrogels from self-assembled physical netoworks: Mechanical properties and influences of assumed constitutive relationships. Biomacromolecules 2008, 9, 2784-2791.
35. Blandino, A.; Macias, M.; Cantero, D. Calcium alginate gel as encapsulation matrix for coimmobilized enzyme systems. Applied Biochemistry and Biotechnology 2003, 110, 53-60.
36. Dai, H.; Chen, Q.; Qin, H.; Guan, Y.; Shen, D.; Hua, Y.; Tang, Y.; Xu, J. A temperatureresponsive copolymer hydrogel in controlled drug delivery. Macromolecules 2006, 39, 6584-6589.
37. Wu, D.; Qiu, F.; Wang, T.; Jiang, X.; Zhang, X.; Zhuo, R. Toward the development of partially biodegradable and injectable thermoresponsive hydrogels for potential biomedical applications. Applied Materials and Interfaces. ACS Appl. Mater. Interfaces 2009, 1, 319-327.
38. Gong, Y.; Wang, C.; Lai, R.C.; Su, K.; Zhang, F.; Wang, D. An improved injectable polysaccharide hydrogel: modified gellan gum for long-term cartilage regeneration in vitro. J. Mater. Chem. 2009, 19, 1968-1977.
39. Matricardi, P.; Pontoriero, M.; Coviello, T.; Casadei, M.A.; Alhaique, F. In situ cross-linkable novel alginate-dextran methacrylate IPN hydrogels for biomedical applications: mechanical characterization and drug delivery properties. Biomacromolecules 2008, 9, 2014-2020.
40. Shim, W.S.; Yoo, J.S.; Bae, Y.H.; Lee, D.S. Novel injectable pH and temperature sensitive block copolymer hydrogel. Biomacromolecules 2005, 6, 2930-2934.
41. Langer, R.; Peppas, N.A. Advances in biomaterials, drug delivery, and bionanotechnology. AIChE J. 2003, 49, 2990-3006.
42. Sontjens, S.H.M.; Nettles, D.L.; Carnahan, M.A.; Setton, L.A.; Grinstaff, M.W. Biodendrimerbased hydrogel scaffolds for cartilage tissue repair. Biomacromolecules 2006, 7, 310-316.
43. Yan, H.; Saiani, A.; Gough, J.E.; Miller, A.F. Thermoreversible protein hydrogel as cell scaffold. Biomacromolecules 2006, 7, 2776-2782.
44. Shi, G.; Cai, Q.; Wang, C.; Lu, N.; Wang, S.; Bei, S. Fabrication and biocompatibility of cell scaffolds of poly (L-lactic acid) and poly (L-lactic-co-glycolic acid). Polym. Adv. Technol. 2002, 13, 227-232.
45. Xie, Y.; Yang, S.T.; Kniss, D.A. Three-dimensional cell-scaffold constructs promote efficient gene transfection: implications for cell-based gene therapy. Tissue Eng. 2001, 7, 585-598.
46. Halstenberg, S.; Panitch, A.; Rizzi, S.; Hall, H.; Hubbell, J.A. Biologically engineered proteingraft-poly(ethylene glycol) hydrogels: A cell adhesive and plasmin-degradable biosynthetic material for tissue repair. Biomacromolecules 2002, 3, 710-723.
47. Dadsetan, M.; Szatkowski, J.P.; Yaszemski, M.J.; Lu, L. Characterization of photo-cross-linked oligo[poly(ethylene glycol) fumarate] hydrogels for cartilage tissue engineering. Biomacromolecules 2007, 8, 1702-1709.
48. Franzesi, G.T.; Ni, B.; Ling, Y., Khademhosseini, A. A controlled-release strategy for the generation of cross-linked hydrogel microstructures. J. Am. Chem. Soc. 2006, 128, 15064-15065.
49. Yang, Z.; Xu, K.; Wang, L.; Gu, H.; Wei, H.; Zhang, M.; Xu, B. Self-assembly of small molecules affords multifuntional supramolecular hydrogels for topically treating simulated uranium wounds. Chem. Commun. 2005, 4414-4416.
50. Raemdonck, K.; Demeester, J.; De Smedt, S. Advanced nanogel engineering for drug delivery. Soft Matter 2009, 5, 707-715.
51. Hamidi, M.; Azadi, A.; Rafiei, P. Hydrogel nanoparticles in drug delivery. Adv. Drug Deliv. Rev. 2008, 60, 1638-1649.
52. Yang, Z.; Gu, H.; Zhang, Y.; Wang, L.; Xu, B. Small molecule hydrogels based on a class of antiinflammatory agents. Chem. Commun. 2004, 2, 208-209.
53. Malmsten, M. Soft drug delivery systems. Soft Matter 2006, 2, 760-769.
54. Kumar, M.N.V.R. Nano and microparticles as controlled drug delivery devices. J. Pharm. Pharmaceut. Sci. 2000, 3, 234-258.
55. Hoare, T.; Pelton, R. Impact of microgel morphology on functionalized microgel-drug interactions. Langmuir 2008, 24, 1005-1012.
56. Prevot, M.; Déjugnat, C.; Mohwald, H.; Sukhorukov, G.B. Behavior of temperature-sensitive pNIPAM confined in polyelectrolyte capsules. ChemPhysChem 2006, 7, 2497-2502.
57. Kang, M.S.; Gupta, V.K. Photochromic cross-links in thermoresponsive hydrogels of poly(Nisopropylacrylamide): Enthalpic and entropic consequences on swelling behavior. J. Phys. Chem. B 2002, 106, 4127-4132.
58. Yan, H.; Nishino, M.; Tsuboi, Y.; Kitamura, N.; Tsujii, K. Template-guided synthesis and individual characterization of poly (N-isopropylacrylamide)-based microgels. Langmuir 2005, 21, 7076-7079.
59. Budhlall, B.M.; Marquez, M.; Velev, O.D. Microwave, photo- and thermally responsive pNIPAm-gold nanoparticles microgels. Langmuir 2008, 24, 11959-11966.
60. Kim, J.; Lee, T.R. Thermo- and pH-responsive hydrogel-coated gold nanoparticles. Chem. Mater. 2004, 16, 3647-3651.
61. Singh, N.; Lyon, A. Au nanoparticle templated synthesis of pNIPAm nanogels. Chem. Mater. 2007, 19, 719-726.
62. Kazakov, S.; Kaholek, M.; Gazaryan, I.; Krasnikov, B.; Miller, K.; Levon, K. Ion concentration of external solution as a characteristic of micro-and nanogel ionic reservoirs. J. Phys. Chem. B 2006, 110, 15107-15116.
63. Huang, G.; Hu, Z. Phase behavior and stabilization of microgel arrays. Macromolecules 2007, 40, 3749-3756.
64. Debord, J.D.; Lyon, L.A. Thermoresponsive photonic crystals. J. Phys. Chem. B 2000, 104, 6327-6331.
65. Kazakov, S.; Kaholek, M.; Teraoka, I.; Levon, K. UV-induced gelation on nanometer scale using liposome reactor. Macromolecules 2002, 35, 1911-1920.
66. 1H NMR investigation of thermally triggered insulin release from poly(N-isopropylacrylamide) microgels. Biomacromolecules 2006, 7, 2918-2922.
67. Zhang, Y.; Guan, Y.; Zhou S. Synthesis and volume phase transitions of glucose-sensitive Microgels. Biomacromolecules 2006, 7, 3196-3201.
68. Kato, N.; Sakai, Y.; Shibata, S. Wide-range control of deswelling time for thermosensitive poly(N-isopropylacrylamide) gel treated by freeze-drying. Macromolecules 2003, 36, 961-963
69. Zhang, Y.; Guan, Y.; Zhou, S. Permeability control of glucose-sensitive nanoshells. Biomacromolecules 2007, 8, 3842-3847.
70. Hoare, T.; Pelton, R. Engineering glucose swelling responses in poly(N-isopropylacrlyamide)-based microgels. Macromolecules 2007, 40, 670-678.
71. Lawrence, D.B.; Cai, T.; Hu, Z.; Marquez, M.; Dinsmore, A.D. Temperature-responsive semipermeable capsules composed of colloidal microgel spheres. Langmuir 2007, 23, 395-398.
72. Sorrell, C.D.; Lyon, L.A. Bimodal swelling responses in microgel thin films. J. Phys. Chem. B 2007, 111, 4060-4066.
73. De Groot, J.H.; Spaans, C.J.; van Calck, R.V.; van Beijma, F.J.; Norrby, S.; Pennings, A.J. Hydrogels for an accommodating intraocular Lens: An explorative study. Biomacromolecules 2003, 4, 608-616.
74. Receveur, R.; Lindemans, F.W.; De Rooij, N.F. Microsystems technologies for implantable applications. J. Micromech. Microeng. 2007, 17, R50-R80.
75. Kim, J.; Nayak, S.; Lyon, A.L. Bioresponsive hydrogel microlenses. J. Am. Chem. Soc. 2005, 127, 9588-9592.
76. Allarakhia, L.; Lindstrom, R.L. Soft intraocular lenses. Int. J. Opthalmol. 1988, 12, 185-191.
77. Dong, L.; Agarwal, A.K.; Beebe, D.J.; Jiang, H. Adaptive liquid microlenses activated by stimuli-responsive hydrogels. Nature 2006, 442, 551-554.
78. Verestiuc, L.; Nastasescu, O.; Barbu, E.; Sarvaiya, I.; Green, K.L.; Tsibouklis, J. Functionalized chitosan/NIPAM (HEMA) hybrid polymer networks as inserts for ocular drug delivery: Synthesis, in vitro assessment, and in vivo evaluation. J. Biomed Mater. Res. A 2006, 77A, 726-735.
79. DeLouise, L.A.; Fauchet, P.M.; Miller, B.L.; Pentland, A.A. Hydrogel-supported opticalmicrocavity sensors. Adv. Mater. 2005, 17, 2199-2203.
80. Mack, N.H.; Wackerly, J.M.; Malyarchuk, V.; Rogers, J.A.; Moore, J.S.; Nuzzo, R.G. Optical transduction of chemical forces. Nano Lett. 2007, 7, 733-737.
81. Yoshimura, I.; Miyahara, Y.; Kasagi, N.; Yamane, H.; Ojida, A.; Hamachi I. Molecular recognition in a supramolecular hydrogel to afford a semi-wet sensor chip. J. Am. Chem. Soc., 2004, 126, 12204-12205.
82. Frisk, M.L.; Tepp, W.H.; Lin, G.; Johnson, E.A.; Beebe, D.J. Substrate-modified hydrogels for autonomous sensing bolulinum neurotoxin Type A. Chem. Mater. 2007, 19, 5842-5844.
83. Hong, Y.; Krsko, P.; Libera, M. Protein surface patterning using nanoscale PEG hydrogels. Langmuir 2004, 20, 11123-11126.
84. An, S.Y.; Bui, M.N.; Nam, Y.J.; Han, K.N.; Li, C.A.; Choo, J.; Lee, E.K.; Katoh, S.; Kumada, Y.; Seong, G.H. Preparation of monodisperse and size-controlled poly(ethylene glycol) hydrogel nanoparticles using liposome templates. J. Colloid Interface Sci. 2009, 331, 98-103.
85. Peppas, N.A.; Kavimandan, N.J. Nanoscale analysis of protein and peptide absorption: Insulin absorption using complexation and pH-sensitive hydrogels as delivery vehicles. Eur. J. Pharm. Sci. 2006, 29, 183-197.
86. Kim, S.; Kim, B.; Yadavalli, V.K.; Pishko, M.V. Encapsulation of enzymes within polymer spheres to create optical nanosensors for oxidative stress. Anal. Chem. 2005, 77, 6828-6833.
87. Tauro, J.R.; Gemeinhart, R.A. Extracellular protease activation of chemotherapeutics from hydrogel matrices: A new paradigm for local chemotherapy. Mol. Pharm. 2005, 2, 435-438.
88. Tauro, J.R.; Gemeinhart, R.A. Matrix metalloprotease triggered delivery of cancer chemotherapeutics from hydrogel matrixes. Bioconjug. Chem. 2005, 16, 1133-1139.
89. Koh, W.; Revzin, A.; Pishko, M.V. Poly(ethylene glycol) hydrogel microstructures encapsulating living cells. Langmuir 2002, 18, 2459-2462.
90. Lensen, M.C.; Mela, P.; Mourran, A.; Groll, J.; Heuts, J.; Rong, H.; Möller. Micro- and nanopatterned star poly(ethylene glycol) (PEG) materials prepared by UV-based imprint lithography. Langmuir 2007, 23, 7841-7846.
91. Kim, D.; Kim, P.; Song, I.; Cha, J.M.; Lee, S.H.; Kim, B.; Suh, K.Y. Guided three-dimensional growth of functional cardiomyocytes on polyethylene glycol nanostructures. Langmuir 2006, 22, 5419-5426.
92. Lee, J.; Bae, Y.H.; Sohn, Y.S.; Jeong, B. Thermogelling aqueous solutions of alternating multiblock copolymers of poly(L-lactic acid) and poly(ethylene glycol). Biomacromolecules 2006, 7, 1729-1734.
93. Allcock, H. R. In Biodegradable Polymers as Drug Delivery Systems; Chasin, M., Langer, R., Eds.; Marcel Dekker: New York, NY, USA, 1990.
94. Andrianov, A.K.; Payner, L.G.; Visscher, K.B.; Allcock, H.R.; Langer, R. Hydrolytic degradation of ionically cross-linked polyphosphazene microspheres J. Appl. Polym. Sci. 1994, 53, 1573-1578.
95. Cohen, S.; Bano, M.C.; Visscher, K.B.; Chow, M.; Allcock, H.; Langer, R. Ionically crosslinkable polyphosphazene: a novel polymer for microencapsulation. J. Am. Chem. Soc. 1990, 112, 7832-7833.
96. Greish, Y.E.; Bender, J.D.; Lakshmi, S.; Brown, P.W.; Allock, H.R. Laurencin, C.T. Low temperature formation of hydroxyapatite-poly (alkyl oxybenzoate) phosphazene composites for biomedical applications. Biomaterials 2005, 26, 1-9.
97. Vandorpe, J.; Schacht, E.; Dunn, S.; Hawley, A.; Stolnik, S.; Davis, S.S.; Garnett, M.C.; Davies, M.C.; Illum, L. Long circulating biodegradable poly(phosphazene) nanoparticles surface modified with poly(phosphazene)-poly(ethylene oxide) copolymer. Biomaterials. 1997, 18, 1147-1152.
98. Hoare, T.; Pelton, R. Charge-switching, amphoteric glucose-responsive microgels with physiological swelling activity. Biomacromolecules 2008, 9, 733-740.
99. Liu, Y.Y.; Shao, Y.H.; Lü, J. Preparation, properties and controlled release behaviors of pHinduced thermosensitive amphiphilic gels. Biomaterials. 2006, 27, 4016-4024.
100. Tartakovsky, A.; Drutis, D.M.; Carnali, J.O. The adsorption of cationic and amphoteric copolymers on glass surfaces: zeta potential measurements, adsorption isotherm determination, and FT Raman characterization J. Colloid Interface Sci. 2003, 363, 408-419.
101. Cavalieri, F.; Chiessi, E.; Villa, R.; Vigano, L.; Zaffaroni, N.; Telling, M.F.; Paradossi, G. Novel PVA-based hydrogel microparticles for doxorubicin delivery. Biomacromolecules 2008, 9, 1967-1973.
102. Kiser, P.F.; Wilson, G.; Needham, D. A synthetic mimic of the secretory granule for drug delivery. Nature 1998, 394, 459-462.
103. Kozlovskaya, V.; Sukhishvili, S.A. Amphoteric hydrogel capsules: Multiple encapsulation and release routes. Macromolecules 2006, 39, 6191-6199.
104. Shi, L.; Berkland, C. Acid-labile polyvinylamine micro- and nanogel capsules. Macromolecules 2007, 40, 4635-4643.
105. Dinarvand, R.; Alimorad, M.M.; Amanlou, M.; Akbari, H. In vitro release of clomipramine HCl and buprenorphine HCl from poly adipic anhydride (PAA) and poly trimethylene carbonate (PTMC) blends. J. Biomed. Mater. Res. A 2005, 75A, 185-191.
106. Shi, L.; Khondee, S.; Linz, T.H.; Berkland, C. Poly (N-vinylformamide) nanogels capable of pHsensitive protein release. Macromolecules 2008, 41, 6546-6554.
107. Maibaum, L.; Dinner, A.R.; Chandler, D. Micelle formation and the hydrophobic effect. J. Phys. Chem. B 2004, 108, 6778-6781.
108. Bromberg, L.; Temchenko, M.; Hatton, T.A. Dually responsive microgels from polyethermodified poly(acrylic acid): Swelling and drug loading. Langmuir 2002, 18, 4944-4952.
109. Choi, S.H.; Lee, S.H.; Park, T.G. Temperature-sensitive pluronic/poly(ethylenimine) nanocapsules for thermally triggered disruption of intracellular endosomal compartment. Biomacromolecules 2006, 7, 1864-1870.
110. Yang, Z.; Xu, B. Supramolecular hydrogels based on biofunctional nanofibers of self-assembled small molecules. J. Mater. Chem. 2007, 17, 2385-2393.
111. Huang, H.; Remsen, E.E.; Wooley, K.L. Amphiphilic core-shell nanospheres obtained by intramicellar shell cross-linking of polymer micelles with poly(ethylene oxide) linkers. Chem. Commun. 1998, 1415-1416.
112. Ray, S.; Das, A.K.; Banerjee, A. pH-responsive, bolaamphiphile-based smart metallo-hydrogels as potential dye-absorbing agents, water purifier, and vitamin B12 carrier. Chem. Mater. 2007, 19, 1633-1639.
113. Taylor, M.J.; Tanna, S.; Sahota, T.S.; Voermans, B. Rhelogical characterization of dextranconcanavalin A mixtures as a basis for a self-regulated drug delivery device. Eur. J. Pharm. Biopharm. 2006, 62, 94-100.
114. Tanna, S.; Taylor, M.J.; Sahota, T.S.; Sawicka, K. Glucose-responsive UV polymerised dextran- Concanavalin A Acrylic Derivatized Mixtures for Closed-Loop Insulin Delivery. Biomaterials 2006, 27, 1586-1597.
115. Yu, S.; Hu, J.; Pan, X.; Yao, P.; Jiang, M. Stable and pH-sensitive nanogels prepared by selfassembly of chitosan and ovalbumin. Langmuir 2006, 22, 2754-2759.
116. Muzzarelli, R.A.; Biagini, G.; Bellardini, M.; Simonelli, L.; Castaldini, C.; Fraatto G. Osteoconduction exerted by methylpyrolidinone chitosan in dental surgery. Biomaterials 1993, 4, 39-43.
117. Feng, Z.Q.; Chu, X.; Huang, N.P.; Wang, T.; Wang, Y.; Shi, X.; Ding, Y.; Gu, Z.Z. The effect of nanofibrous galactosylated chitosan scaffolds on the formation of rat primary hepatocyte aggregates and the maintenance of liver function. Biomaterials, 2009, 30, 2753-2763.
118. Illum, L. Chitosan and its use as a pharmaceutical excipient. Pharm. Res. 1998, 15, 1326-1331.
119. Henricus, M.M.; Fath, K.R.; Menzenski, M.Z.; Banerjee, I.A. Morphology controlled growth of chitosan-bound microtubes and a study of their biocompatibility and antibacterial activity. Macromol. Biosci. 2009, 9, 317-325.
120. Azmi, N.E.; Ahmad, M.; Abdullah, J.; Sidek, H.; Heng, L.Y.; Karuppiah, N. Biosensor based on glutamate dehydrogenase immobilized in chitosan for the determination of ammonium in water samples. Anal. Biochem. 2009, 388, 28-32.
121. Tsai, Y.C.; Chen, S.Y.; Lee, C.A. Amperometric cholesterol biosensors on carbon nanotubechitosan-platinum cholesterol oxidase nanobiocomposite. Sens. Actuat. B 2008, 135, 96-101.
122. Yi, H.; Wu, L.; Bently, W.E.; Ghodssi, R.; Rubloff, G.W.; Culver, J.N.; Payne, G.F. Biofabrication with Chitosan. Biomacromolecules 2005, 6, 2881-2894.
123. Zhang, H.; Mardyani, S.; Chan, W.C.W.; Kumacheva, E. Design of biocompatible chitosan microgels for targeted pH-mediated intracellular release of cancer therapeutics. Biomacromolecules 2006, 7, 1568-1572.
124. Brittain, H.G. Analytical Profiles of Drug Substances; Academic Press: California, USA, 1986; Vol. 5, pp. 284-306.
125. Nishikawa, T.; Akiyoshi, K.; Sunamoto, J. Macromolecules complexation between bovine serum albumin and the self-assembled hydrogel nanoparticles of hydrophobicized polysaccharides. J. Am. Chem. Soc. 1996, 118, 6110-6115.
126. Akiyoshi, K.; Nishikawa, T.; Mitsui, Y.; Miyata, T.; Michiko, K.; Sunamato, J. Self-assembly of polymer amphiphiles: thermodynamics of complexation between BSA and self-aggregate of cholesterol bearing pullulan. Colloids Surf. A 2006, 112, 94-100.
127. Nishikawa, T.; Akiyoshi, K.; Sunamoto, J. Supramolecular assembly between nanoparticles of hydrophobized polysaccharide and Soluble Protein complexation between the self-aggregate of cholesterol-bearing pullulan and ?α-chymotrypsin. Macromolecules, 1994, 27, 7654-7659.
128. Akiyoshi, K.; Nishikawa, A.; Shichibe, S.; Sunamoto, J. Stabilization of insulin upon supramolecular complexation with hydrophobized polysaccharide nanoparticle. Chem. Lett. 1995, 24, 707-708.
129. Akiyoshi, K.; Sasaki, Y.; Sunamoto, J. Molecular chaperone-like activity of hydrogel nanoparticles of hydrophobicized pullulan: thermal stabilization with refolding of carbonic anhydrase B. Bioconjug. Chem. 1999, 10, 321-324.
130. Ayame, H.; Morimoto, N.; Akiyoshi, K. Self-assembled cationic nanogels for intracellular protein delivery. Bioconjug. Chem. 2008, 19, 882-890.
131. Na, K.; Lee, E.S.; Bae, Y.H. Self-organized nanogels responding to tumor extracellular pH: pHdependent drug release and in vitro cytotoxicity against MCF-7 cells. Bioconj. Chem. 2007, 18, 1568-1574.
132. Sannino, A.; Madaghiele, M.; Conversano, F.; Mele, G.; Maffezzoli, A.; Netti, P.A.; Ambrosio, L.; Nicolais, L. Cellulose derivative-hyaluronic acid-based microporous hydrogels cross-linked through divinyl sulfone (DVS) to modulate equilibrium sorption capacity and network stability. Biomacromolecules 2004, 5, 92-96.
133. Ekaputra, A.K.; Prestwich, G.D.; Cool, S.M.; Hutmacher, D.W. Combining electrospun scaffolds with electrosprayed hydrogels leads to three-dimensional cellularization of hybrid constructs. Biomacromolecules 2008, 9, 2097-2103.
134. Nukavarapu, S.P.; Kumbar, S.G.; Nair, L.S.; Laurencin, C.T. Biomedical Nanostructures; Gonsalves, K.E., Halberstadt, C.R., Laurencin, C.T., Nair, L.S., Eds.; Wiley & Sons, Inc.: Hoboken, NJ, USA, 2008; Chapter 15, p. 397.
135. Shin, M.K.; Kim, S.I.; Kim, S.J. Controlled magnetic nanofiber hydrogels by clustering ferritin. Langmuir 2008, 24, 12107-12111.
136. Coradin, T.; Livage, J. Aqueous silicates in biological sol-gel applications: new perspectives for old precursors. Acc. Chem. Res. 2007, 40, 819-826.
137. Sidorenko, A.; Krupenkin, T.; Taylor, A.; Fratzl, P.; Aizenberg, J. Reversible switching of hydrogel-actuated nanostructures into complex micropatterns. Science 2007, 315, 487-490.
138. Tomalia, D.A.; Baker, H.; Dewald, J.R.; Hall, M.; Kallos, G.; Martin, S.; Roeck, J.; Ryder, J.; Smith, P. A new class of polymers: starbust-dendritic macromolecules. Polym. J. 1985, 17, 117-132.
139. Caminade, A.; Majoral, J. Nanomaterials based on phosphorous dendrimers. Acc. Chem. Res. 2004, 37, 341-348.
140. Sigal, G.B.; Mammen, M.; Dahmann, G.; Whitesides, G.M. Polyacrylamides bearing pendantsialoside groups strongly inhibit agglutination of erythrocytes by influenza virus: The strong inhibition reflects enhanced binding through cooperative polyvalent interactions. J. Am. Chem. Soc. 1996, 118, 3789-3800.
141. Roy, R.; Zanini, D.; Meunier, S.J.; Romaowska, A. Solid-Phase synthesis of dendritic sialoside inhibitors of influenza A Virus Haemagglutinin. Chem. Commun. 1993, 1869-1871.
142. Twyman, L.J.; Beezer, A.E.; Esfand, R., Hardy, M.J.; Mitchell, J.C. The synthesis of water soluble dendrimers, and their application as possible drug delivery systems. Tetrahedron Lett. 1999, 40, 1743-1746.
143. Liu, M.; Kono, K.; Frechet, J.M.J. Water-soluble dendritic unimolecular micelles: Their potential as drug delivery agents. J. Contr. Rel. 2000, 65, 121-131.
144. Zhuo, R.X.; Du, B.; Lu, Z.R. In vitro release of 5-fluorouracil with cyclic core dendritic polymer. J. Contr. Rel. 1999, 57, 249-257.
145. Degoricija, L.; Bansal, P.N.; Sontjens, S.H.M.; Joshi, N.S.; Takahashi, M.; Snyder, B.; Grinstaff, M.W. Hydrogels for osteochondral repair based on photocrosslinkable carbamate dendrimers. Biomacromolecules 2008, 9, 2863-2872.
146. Haraguchi, K.; Takehisa, T.; Ebato, M. Control of Cell cultivation and Cell sheet detachment on the surface of polymer/clay nanocomposite hydrogels. Biomacromolecules 2006, 7, 3267-3765.
147. Grieshaber, S.E.; Farran, A.J.E.; Lin-Gibson, S.; Kiick, K.L.; Jia, X. Synthesis and characterization of elastin-mimetic hybrid polymers with multiblock, alternating molecular architecture and elastomeric properties. Macromolecules 2009, 42, 2532-2541.
148. Atzet, S.; Curtin, S.; Trinh, P.; Bryant, S.; Ratner, B. Degradable poly(2-hydroxyethyl methacrylate)-co-polycaprolactone hydrogels for tissue engineering scaffolds. Biomacromolecules 2008, 9, 3370-3373.
149. Chao, G.T.; Huang, M.J.; Kan, B.; Gu, Y.C.; Gong, C.Y.; Yang, J.L.; Jia, W.J.; Liu, C.B.; Gou, M.L.; Tu, M.J.; Qian, Z.Y. Synthesis, characterization and hydrolytic degradation behavior of a novel biodegradable pH-sensitive hydrogel based on polycaprolactone, methacrylic acid and poly (ethylene glycol). J. Biomed. Mater. Res. A 2008, 85A, 36-46.
150. Lin, C.C.; Metters, A.T. Hydrogels in controlled release formulations: Network design and Mathematical Modeling. Adv. Drug Deliv. Rev. 2006, 58, 1379-1408.
151. Park, T.G.; Lu, W.Q.; Crotts, G. Importance of in-vitro experimental conditions on protein release kinetics, stability and polymer degradation in protein encapsulated poly (D,Llactic acidco-glycolic acid) microspheres. J. Contr. Rel. 1995, 33, 211-222.
152. Jiang, W.L.; Gupta, R.K.; Deshpande, M.C.; Schwendeman, S.P. Biodegradable poly(lactic-coglycolic acid) microparticles for injectable delivery of vaccine antigens. Adv. Drug Deliv. Rev. 2005, 57, 391-410.
153. Peppas, N.A.; Bures, P.; Leobandung, W.; Ichiwaka, H. Hydrogels in Pharmaceutical Formulations. Eur. J. Pharm. Biopharm. 2000, 50, 27-46.
154. TeBmar, J.; Brand, F.; Göpferich, A. Hydrogels for tissue engineering. In Fundamentals of Tissue Engineering and Regenerative Medicine; Springer: Berlin, Heidelberg, Germany, 2009; pp. 495-496.
155. Ma, P.X.; Choi, J.W. Biodegradable Polymer Scaffolds with Well-Defined Interconnected Spherical Pore Network. Tissue Eng. 2001, 7, 23-33.
156. Ferruti, P.; Bianchi, S.; Ranucci, E.; Chiellini, F.; Caruso, V. Novel Poly(amido-amine)-based hydrogels as scaffolds for tissue engineering. Macromol. Biosci. 2005, 5, 613-622.
157. Leach, J.B; Bivens, K.A.; Patrick, C.W., Jr.; Schmidt, C.E. Photocrosslinked hyaluronic acid hydrogels: natural, biodegradable tissue engineering scaffolds. Biotechnol. Bioeng. 2003, 82, 578-589.