In vitro evidence for competitive tspo binding of the imaging biomarker candidates vinpocetine and two iodinated daa1106 analogues in post mortem autoradiography experiments on whole hemisphere human brain slices

Current Radiopharmaceuticals

Volumn 2, Issue 1, 2009, Pages 42-48

  Gulyás, Balázs ^a   Makkai, Boglárka ^b   Nagy, Katalin ^b   Vas, Ádám ^c   Kása, Péter ^d   Andersson, Jan ^a   Suhara, Tetsuya ^e   Suzuki, Kazutoshi ^e   Higuchi, Makoto ^e   Beliczai, Zsuzsa ^f   Gulya, Károly ^f   Csiba, László ^b   Halldin, Christer ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b UNIVERSITY OF DEBRECEN   (Hungary)

^c GEDEON RICHTER LTD   (Hungary)

^d UNIVERSITY OF SZEGED   (Hungary)

^e NATIONAL INSTITUTE OF RADIOLOGICAL SCIENCES   (Japan)

^f UNIVERSITY OF SZEGED   (Hungary)

Author keywords

Daa1106; Human brain; Imaging biomarker; Peripheral benzodiazepine receptor (pbr); Radiopharmacon; Receptor binding; Tspo (18kda translocator protein); Vinpocetine; Whole hemisphere autoradiography

Indexed keywords

BENZODIAZEPINE RECEPTOR; CARRIER PROTEIN; DAA 1106; N (5 FLUORO 2 PHENOXYPHENYL) N (2 IODO 5 METHOXYBENZYL)ACETAMIDE I 125; N (5 IODO 2 PHENOXYPHENYL) N (2,5 DIMETHOXYBENZYL)ACETAMIDE I 125; TRACER; UNCLASSIFIED DRUG; VINPOCETINE;

ARTICLE; AUTOPSY; AUTORADIOGRAPHY; BINDING AFFINITY; BRAIN SLICE; BRAIN TISSUE; DRUG RECEPTOR BINDING; HEMISPHERE; HUMAN; HUMAN TISSUE; IN VITRO STUDY; PRIORITY JOURNAL;

EID: 77953800127     PISSN: 18744710     EISSN: None     Source Type: Journal    
DOI: 10.2174/1874471010902010042     Document Type: Article

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