Synthesis and evaluation of N-(5-fluoro-2-phenoxyphenyl)-N-(2-[ 18F]fluoromethoxy-d2-5-methoxybenzyl)acetamide: A deuterium-substituted radioligand for peripheral benzodiazepine receptor

Bioorganic and Medicinal Chemistry

Volumn 13, Issue 5, 2005, Pages 1811-1818

  Zhang, Ming Rong ^a,b   Maeda, Jun ^a   Ito, Takehito ^a,b   Okauchi, Takashi ^a   Ogawa, Masanao ^a,b   Noguchi, Junko ^a,b   Suhara, Tetsuya ^a   Halldin, Christer ^c   Suzuki, Kazutoshi ^a  

^a NATIONAL INSTITUTE OF RADIOLOGICAL SCIENCES   (Japan)

^b 141 0032   (Japan)

^c KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Defluorination; Deuterium substitution; Peripheral benzodiazepine receptor; PET

Indexed keywords

ACETAMIDE DERIVATIVE; BENZODIAZEPINE RECEPTOR; CARBON; DEUTERIUM; DIIODOMETHANE D2; FLUMAZENIL C 11; FLUORIDE; FLUORINE 18; FLUOROMETHYL IODIDE D2 F 18; METHYL IODIDE; N (2,5 DIMETHOXYBENZYL) N (5 FLUORO 2 PHENOXYPHENYL)ACETAMIDE C 11; N (5 FLUORO 2 PHENOXYPHENYL) N (2 FLUOROMETHOXY D2 5 METHOXYBENZYL) ACETAMIDE; N (5 FLUORO 2 PHENOXYPHENYL) N (2 IODOMETHOXY D2 5 METHOXYBENZYL)ACETAMIDE; N (5 FLUORO 2 PHENOXYPHENYL) N 2 FLUOROMETHOXY D2 (5 METHOXYBENZYL) ACETAMIDE F 18; N SEC BUTYL 1 (2 CHLOROPHENYL) N METHYL 3 ISOQUINOLINECARBOXAMIDE; PHENOL; RADIOACTIVE MATERIAL; RADIOLIGAND; TETRABUTYLAMMONIUM FLUORIDE; UNCLASSIFIED DRUG;

ALKYLATION; ANIMAL TISSUE; ARTICLE; AUTORADIOGRAPHY; BINDING AFFINITY; BRAIN; CHEMICAL REACTION; COMPUTER ASSISTED EMISSION TOMOGRAPHY; CONTROLLED STUDY; DEFLUORINATION; DIAGNOSTIC IMAGING; DRUG BINDING; DRUG DETERMINATION; DRUG METABOLISM; DRUG SCREENING; DRUG SPECIFICITY; DRUG SYNTHESIS; HYDROGEN BOND; HYPOTHESIS; IC 50; MALE; METABOLIC RATE; MONKEY; MOUSE; NONHUMAN; PRECURSOR; PRIMATE; RADIOACTIVITY; RAT; RODENT; SKULL; SUBSTITUTION REACTION;

PRIMATES; RODENTIA;

EID: 13444280216     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2004.11.058     Document Type: Article

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