-
1
-
-
14644429730
-
Epoxide hydrolases: Their roles and interactions with lipid metabolism
-
Newman JW, Morisseau C, Hammock BD. Epoxide hydrolases: their roles and interactions with lipid metabolism. Prog Lipid Res 2005;44:1-51
-
(2005)
Prog Lipid Res
, vol.44
, pp. 1-51
-
-
Newman, J.W.1
Morisseau, C.2
Hammock, B.D.3
-
2
-
-
0001564040
-
Epoxide hydrolases
-
Guengerich, FP, editior, Pergamon, Oxford
-
Hammock BD, Storms DH, Grant DF. Epoxide hydrolases. In: Guengerich, FP, editior, Comprehensive toxicology. Pergamon, Oxford; 1997. p. 283-305
-
(1997)
Comprehensive Toxicology
, pp. 283-305
-
-
Hammock, B.D.1
Storms, D.H.2
Grant, D.F.3
-
4
-
-
0034711488
-
Soluble epoxide hydrolase regulates hydrolysis of vasoactive epoxyeicosatrienoic acids
-
Yu Z, Xu F, Huse LM, et al. Soluble epoxide hydrolase regulates hydrolysis of vasoactive epoxyeicosatrienoic acids. Circ Res 2000;87:992-998
-
(2000)
Circ Res
, vol.87
, pp. 992-998
-
-
Yu, Z.1
Xu, F.2
Huse, L.M.3
-
5
-
-
0242720683
-
Epoxyeicosatrienoic acids (EETs): Metabolism and biochemical function
-
Spector AA, Fang X, Snyder GD, et al. Epoxyeicosatrienoic acids (EETs): metabolism and biochemical function. Prog Lipid Res 2004;43:55-90
-
(2004)
Prog Lipid Res
, vol.43
, pp. 55-90
-
-
Spector, A.A.1
Fang, X.2
Snyder, G.D.3
-
6
-
-
0023689586
-
Cytosolic epoxide hydrolase in humans: Development and tissue distribution
-
DOI 10.1007/BF00332483
-
Pacifici GM, Temellini A, Giuliani L, et al. Cytosolic epoxide hydrolase in humans: development and tissue distribution. Arch Toxicol 1988;62:254-257 (Pubitemid 18266672)
-
(1988)
Archives of Toxicology
, vol.62
, Issue.4
, pp. 254-257
-
-
Pacific, G.M.1
Temellini, A.2
Giuliani, L.3
Rane, A.4
Thomas, H.5
Oesch, F.6
-
7
-
-
33645846611
-
Emerging role of epoxyeicotrienoic acids in coronary vascular function
-
Larsen BT, Gutterman DD, Hatoum OA. Emerging role of epoxyeicotrienoic acids in coronary vascular function. Eur J Clin Invest 2006;36:293-300
-
(2006)
Eur J Clin Invest
, vol.36
, pp. 293-300
-
-
Larsen, B.T.1
Gutterman, D.D.2
Hatoum, O.A.3
-
8
-
-
0033993749
-
Cytochrome P450 and arachidonic acid bioactivation: Molecular and functional properties of the arachidonate monooxygenase
-
Capdevila JH, Falck JR, Harris RC. Cytochrome P450 and arachidonic acid bioactivation: molecular and functional properties of the arachidonate monooxygenase. J Lipid Res 2000;41:163-181
-
(2000)
J Lipid Res
, vol.41
, pp. 163-181
-
-
Capdevila, J.H.1
Falck, J.R.2
Harris, R.C.3
-
9
-
-
0033619262
-
Cytochrome P450 2C is an EDHF synthase in coronary arteries
-
DOI 10.1038/46816
-
Fisslthaler B, Popp R, Kiss L, et al. Cytochrome P450 2C is an EDHF synthase in coronary arteries. Nature 1999;401:493-497 (Pubitemid 29470209)
-
(1999)
Nature
, vol.401
, Issue.6752
, pp. 493-497
-
-
Fissithaler, B.1
Popp, R.2
Kiss, L.3
Potente, M.4
Harder, D.R.5
Fleming, I.6
Busse, R.7
-
10
-
-
33644849675
-
Epoxyeicosatrienoic and dihydroxyeicosatrienoic acids dilate human coronary arterioles via BKca channels: Implications for soluble epoxide hydrolase inhibition
-
Larsen BT, Miura H, Hatoum OA, et al. Epoxyeicosatrienoic and dihydroxyeicosatrienoic acids dilate human coronary arterioles via BKca channels: implications for soluble epoxide hydrolase inhibition. Am J Physiol Heart Circ Physiol 2006;290:H491-499
-
(2006)
Am J Physiol Heart Circ Physiol
, vol.290
-
-
Larsen, B.T.1
Miura, H.2
Hatoum, O.A.3
-
11
-
-
0037432150
-
Endothelium-derived hyperpolarizing factor in human internal mammary artery is 11,12-epoxyeicosatrienoic acid and causes relaxation by activating smooth muscle BK (Ca) channels
-
Archer SL, Gragasin FS, Wu X, et al. Endothelium-derived hyperpolarizing factor in human internal mammary artery is 11,12-epoxyeicosatrienoic acid and causes relaxation by activating smooth muscle BK (Ca) channels. Circulation 2003;107:769-776
-
(2003)
Circulation
, vol.107
, pp. 769-776
-
-
Archer, S.L.1
Gragasin, F.S.2
Wu, X.3
-
12
-
-
0035138432
-
Cytochrome P450 metabolites of arachidonic acid in the control of renal function
-
Maier KG, Roman RJ. Cytochrome P450 metabolites of arachidonic acid in the control of renal function. Curr Opin Nephrol Hypertens 2001;10:81-87
-
(2001)
Curr Opin Nephrol Hypertens
, vol.10
, pp. 81-87
-
-
Maier, K.G.1
Roman, R.J.2
-
13
-
-
0025272059
-
Effects of 14,15-epoxyeicosatrienoic acid infusion on blood pressure in normal and hypertensive rats
-
Lin WK, Falck JR, Wong PY. Effects of 14,15-epoxyeicosatrienoic acid infusion on blood pressure in normal and hypertensive rats. Biochem Biophys Res Commun 1990;167:977-981
-
(1990)
Biochem Biophys Res Commun
, vol.167
, pp. 977-981
-
-
Lin, W.K.1
Falck, J.R.2
Wong, P.Y.3
-
14
-
-
9944254760
-
Vascular protective effects of cytochrome p450 epoxygenase-derived eicosanoids
-
Spiecker M, Liao JK. Vascular protective effects of cytochrome p450 epoxygenase-derived eicosanoids. Arch Biochem Biophys 2005;433:413-420
-
(2005)
Arch Biochem Biophys
, vol.433
, pp. 413-420
-
-
Spiecker, M.1
Liao, J.K.2
-
15
-
-
0033588034
-
Anti-inflammatory properties of cytochrome P450 epoxygenase-derived eicosanoids
-
Node K, Huo Y, Ruan X, et al. Anti-inflammatory properties of cytochrome P450 epoxygenase-derived eicosanoids. Science 1999;285:1276-1279
-
(1999)
Science
, vol.285
, pp. 1276-1279
-
-
Node, K.1
Huo, Y.2
Ruan, X.3
-
16
-
-
0033551176
-
Proinflammatory mediators chronically downregulate the formation of the endothelium-derived hyperpolarizing factor in arteries via a nitric oxide/cyclic GMP-dependent mechanism
-
Kessler P, Popp R, Busse R, et al. Proinflammatory mediators chronically downregulate the formation of the endothelium-derived hyperpolarizing factor in arteries via a nitric oxide/cyclic GMP-dependent mechanism. Circulation 1999;99:1878-1884
-
(1999)
Circulation
, vol.99
, pp. 1878-1884
-
-
Kessler, P.1
Popp, R.2
Busse, R.3
-
17
-
-
0036080081
-
P-450 metabolites of arachidonic acid in the control of cardiovascular function
-
Roman RJ. P-450 metabolites of arachidonic acid in the control of cardiovascular function. Physiol Rev 2002;82:131-185
-
(2002)
Physiol Rev
, vol.82
, pp. 131-185
-
-
Roman, R.J.1
-
18
-
-
33644859072
-
Effects of selective inhibition of cytochrome P-450 w-hydroxylases and ischemic preconditioning in myocardial protection
-
Nithipatikom K, Moore JM, Isbell MA, et al. Effects of selective inhibition of cytochrome P-450 w-hydroxylases and ischemic preconditioning in myocardial protection. Am J Physiol Heart Circ Physiol 2006;290:H500-505
-
(2006)
Am J Physiol Heart Circ Physiol
, vol.290
-
-
Nithipatikom, K.1
Moore, J.M.2
Isbell, M.A.3
-
19
-
-
33847419892
-
Mechanisms by which epoxyeicosatrienoic acids (EETs) elicit cardioprotection in rat hearts
-
Gross GJ, Hsu A, Flack JR, et al. Mechanisms by which epoxyeicosatrienoic acids (EETs) elicit cardioprotection in rat hearts. J Mol Cell Card 2007;42:687-691
-
(2007)
J Mol Cell Card
, vol.42
, pp. 687-691
-
-
Gross, G.J.1
Hsu, A.2
Flack, J.R.3
-
21
-
-
15744382006
-
Soluble epoxide hydrolase is a main effector of angiotensin II-induced hypertension
-
Jung O, Brandes RP, Kim IH, et al. Soluble epoxide hydrolase is a main effector of angiotensin II-induced hypertension. Hypertension 2005;45:759-765
-
(2005)
Hypertension
, vol.45
, pp. 759-765
-
-
Jung, O.1
Brandes, R.P.2
Kim, I.H.3
-
22
-
-
0036179501
-
Soluble epoxide hydrolase inhibition lowers arterial blood pressure in angiotensin II hypertension
-
Img JD, Zhao X, Capdevila JH, et al. Soluble epoxide hydrolase inhibition lowers arterial blood pressure in angiotensin II hypertension. Hypertension 2002;39:690-694
-
(2002)
Hypertension
, vol.39
, pp. 690-694
-
-
Img, J.D.1
Zhao, X.2
Capdevila, J.H.3
-
23
-
-
33644654633
-
An orally active epoxide hydrolase inhibitor lowers blood pressure and provides renal protection in salt-sensitive hypertension
-
Imig JD, Zhao X, Zaharis CZ, et al. An orally active epoxide hydrolase inhibitor lowers blood pressure and provides renal protection in salt-sensitive hypertension. Hypertension 2005;46:975-981
-
(2005)
Hypertension
, vol.46
, pp. 975-981
-
-
Imig, J.D.1
Zhao, X.2
Zaharis, C.Z.3
-
24
-
-
77953798116
-
-
Available from: http://www. aretetherapeutics.com
-
-
-
-
25
-
-
29344455172
-
Human soluble epoxide hydrolase: Structural basis of inhibition by 4-(3-cyclohexylureido)- carboxylic acids
-
Gomez GA, Morisseau C, Hammock BD, et al. Human soluble epoxide hydrolase: structural basis of inhibition by 4-(3-cyclohexylureido)- carboxylic acids. Protein Sci 2006;15:58-64
-
(2006)
Protein Sci
, vol.15
, pp. 58-64
-
-
Gomez, G.A.1
Morisseau, C.2
Hammock, B.D.3
-
26
-
-
1842555060
-
Design, synthesis, and biological activity of 1,2-disubstituted ureas as potent inhibitors of the soluble epoxide hydrolase of increased water solubility
-
Kim IH, Morrisseau C, Watanabe T, et al. Design, synthesis, and biological activity of 1,2-disubstituted ureas as potent inhibitors of the soluble epoxide hydrolase of increased water solubility. J Med Chem 2004;47:2110-2122
-
(2004)
J Med Chem
, vol.47
, pp. 2110-2122
-
-
Kim, I.H.1
Morrisseau, C.2
Watanabe, T.3
-
27
-
-
18644374475
-
Optimization of amide-based inhibitors of soluble epoxide hydrolase with improved water solubility
-
Kim IH, Heirtzler FR, Morisseau C, et al. Optimization of amide-based inhibitors of soluble epoxide hydrolase with improved water solubility. J Med Chem 2005;48:3621-3629
-
(2005)
J Med Chem
, vol.48
, pp. 3621-3629
-
-
Kim, I.H.1
Heirtzler, F.R.2
Morisseau, C.3
-
28
-
-
33748302000
-
Peptidyl-urea based inhibitors of soluble epoxide hydrolases
-
Morisseau C, Newman JW, Tsai HJ, et al. Peptidyl-urea based inhibitors of soluble epoxide hydrolases. Bioorg Med Chem Lett 2006;16:5439-5444
-
(2006)
Bioorg Med Chem Lett
, vol.16
, pp. 5439-5444
-
-
Morisseau, C.1
Newman, J.W.2
Tsai, H.J.3
-
29
-
-
33747157258
-
The 5-substituted piperazine as a novel secondary pharmacophore greatly improving the physical properties of urea-based inhibitors of soluble epoxide hydrolase
-
Li HY, Jin Y, Morisseau C, et al. The 5-substituted piperazine as a novel secondary pharmacophore greatly improving the physical properties of urea-based inhibitors of soluble epoxide hydrolase. Bioorg Med Chem 2006;14:6586-6592
-
(2006)
Bioorg Med Chem
, vol.14
, pp. 6586-6592
-
-
Li, H.Y.1
Jin, Y.2
Morisseau, C.3
-
30
-
-
0023190842
-
Inhibition of epoxide hydrolases and glutathione S-transferases by 2, 3, and 4-substituted derivatives 4¢-phenylchalcone and its oxide
-
Miyamoto T, Silva M, Hammock BD. Inhibition of epoxide hydrolases and glutathione S-transferases by 2,3, and 4-substituted derivatives 4¢-phenylchalcone and its oxide. Arch Biochem Biophys 1987;254:203-213
-
(1987)
Arch Biochem Biophys
, Issue.254
, pp. 203-213
-
-
Miyamoto, T.1
Silva, M.2
Hammock, B.D.3
-
31
-
-
0033529767
-
Potent urea and carbamate inhibitors of soluble epoxide hydrolases
-
Morisseau C, Goodrow MH, Dowdy D, et al. Potent urea and carbamate inhibitors of soluble epoxide hydrolases. Proc Natl Acad Sci 1999;96:8849-8854
-
(1999)
Proc Natl Acad Sci
, vol.96
, pp. 8849-8854
-
-
Morisseau, C.1
Goodrow, M.H.2
Dowdy, D.3
-
32
-
-
0027479886
-
Inhibition of epoxide hydrolase from human, monkey, bovine, rabbit and murine liver by trans-3-phenylglycidols
-
Dietze EC, Casas J, Kuwano E, et al. Inhibition of epoxide hydrolase from human, monkey, bovine, rabbit and murine liver by trans-3-phenylglycidols. Comp Biochem Physiol B 1993;104:309-314
-
(1993)
Comp Biochem Physiol B
, vol.104
, pp. 309-314
-
-
Dietze, E.C.1
Casas, J.2
Kuwano, E.3
-
33
-
-
69949091361
-
A strategy of employing aminoheterocycles as amide mimics to identify novel, potent and bioavailable soluble epoxide hydrolase inhibitors
-
Shen HC, Ding FX, Deng Q, et al. A strategy of employing aminoheterocycles as amide mimics to identify novel, potent and bioavailable soluble epoxide hydrolase inhibitors. Bioorg Med Chem Lett 2009;19:5716-5721
-
(2009)
Bioorg Med Chem Lett
, vol.19
, pp. 5716-5721
-
-
Shen, H.C.1
Ding, F.X.2
Deng, Q.3
-
34
-
-
77953781617
-
-
The Regents of the University of California. US005445956
-
The Regents of the University of California. Recombinant soluble epoxide hydrolase. US005445956; 1995
-
(1995)
Recombinant Soluble Epoxide Hydrolase
-
-
-
44
-
-
0033529767
-
Potent urea and carbamate inhibitors of soluble epoxide hydrolases
-
Morisseau C, Goodrow MH, Dowdy D, et al. Potent urea and carbamate inhibitors of soluble epoxide hydrolases. Proc Natl Acad Sci USA 1999;96:8849-8854
-
(1999)
Proc Natl Acad Sci USA
, vol.96
, pp. 8849-8854
-
-
Morisseau, C.1
Goodrow, M.H.2
Dowdy, D.3
-
45
-
-
77953759491
-
-
The Regents of the University of California. US20050164951
-
The Regents of the University of California. Inhibitors for the soluble epoxide hydrolase. US20050164951; 2005
-
(2005)
Inhibitors for the Soluble Epoxide Hydrolase
-
-
-
46
-
-
77953759491
-
-
The Regents of the University of California. US20050026844
-
The Regents of the University of California. Inhibitors for the soluble epoxide hydrolases US20050026844; 2005
-
(2005)
Inhibitors for the Soluble Epoxide Hydrolases
-
-
-
47
-
-
77953768977
-
-
The Regents of the University of California. US20090326039
-
The Regents of the University of California. Inhibitors of epoxide hydrolases. US20090326039; 2009
-
(2009)
Inhibitors of Epoxide Hydrolases
-
-
-
50
-
-
34548070313
-
Orally bioavailable potent soluble epoxide hydrolase inhibitors
-
Hwang SH, Tsai HJ, Liu JY, et al. Orally bioavailable potent soluble epoxide hydrolase inhibitors. J Med Chem 2007;50:3825-3840
-
(2007)
J Med Chem
, vol.50
, pp. 3825-3840
-
-
Hwang, S.H.1
Tsai, H.J.2
Liu, J.Y.3
-
61
-
-
77953770820
-
-
The Regents of the University of California. US006174695
-
The Regents of the University of California. Epoxide hydrolase inhibitor methods. US006174695; 2001
-
(2001)
Epoxide Hydrolase Inhibitor Methods
-
-
-
65
-
-
77953789951
-
-
The Regents of the University of California. WO2007022509
-
The Regents of the University of California. Use of sEH inhibitors as analgesics. WO2007022509; 2007
-
(2007)
Use of SEH Inhibitors As Analgesics
-
-
-
66
-
-
77953777295
-
-
The Regents of the University of California. US20080249055
-
The Regents of the University of California. Use of sEH inhibitors as analgesics. US20080249055; 2008
-
(2008)
Use of SEH Inhibitors As Analgesics
-
-
-
130
-
-
77953744433
-
-
Boehringer Ingelheim. US20030082665
-
Boehringer Ingelheim. Fluorescence polarization assay. US20030082665; 2003
-
(2003)
Fluorescence Polarization Assay
-
-
-
131
-
-
79851499536
-
-
Boehringer Ingelheim. WO2002082082
-
Boehringer Ingelheim. Fluorescence polarization assay. WO2002082082; 2002
-
(2002)
Fluorescence Polarization Assay
-
-
-
132
-
-
77953743604
-
-
Taisho Pharmaceutical Co. JP126454; 2007
-
Taisho Pharmaceutical Co. JP126454; 2007
-
-
-
-
133
-
-
77953733630
-
-
Taisho Pharmaceutical Co. WO2007043652
-
Taisho Pharmaceutical Co. 2-Thienylurea derivative. WO2007043652; 2007
-
(2007)
2-Thienylurea Derivative
-
-
-
137
-
-
85050459618
-
-
SmithKline Beecham Corporation. WO2008105968
-
SmithKline Beecham Corporation. Novel sEH inhibitors and their use. WO2008105968; 2008
-
(2008)
Novel SEH Inhibitors and Their Use
-
-
-
138
-
-
77953793102
-
-
SmithKline Beecham Corporation. WO2009097476
-
SmithKline Beecham Corporation. Novel sEH inhibitors and their use. WO2009097476; 2009
-
(2009)
Novel SEH Inhibitors and Their Use
-
-
-
139
-
-
77953793102
-
-
SmithKline Beecham Corporation. WO2009049165
-
SmithKline Beecham Corporation. Novel sEH inhibitors and their use. WO2009049165; 2009
-
(2009)
Novel SEH Inhibitors and Their Use
-
-
-
140
-
-
77953793102
-
-
SmithKline Beecham Corporation. WO2009097474
-
SmithKline Beecham Corporation. Novel sEH inhibitors and their use. WO2009097474; 2009
-
(2009)
Novel SEH Inhibitors and Their Use
-
-
-
141
-
-
77953793102
-
-
SmithKline Beecham Corporation. WO2009049157
-
SmithKline Beecham Corporation. Novel sEH inhibitors and their use. WO2009049157; 2009
-
(2009)
Novel SEH Inhibitors and Their Use
-
-
-
142
-
-
77953793102
-
-
SmithKline Beecham Corporation. WO2009049154
-
SmithKline Beecham Corporation. Novel sEH inhibitors and their use. WO2009049154; 2009
-
(2009)
Novel SEH Inhibitors and Their Use
-
-
-
143
-
-
77953793102
-
-
SmithKline Beecham Corporation. WO2009073772
-
SmithKline Beecham Corporation. Novel sEH inhibitors and their use. WO2009073772; 2009
-
(2009)
Novel SEH Inhibitors and Their Use
-
-
-
144
-
-
77953793102
-
-
SmithKline Beecham Corporation. WO2009049157
-
SmithKline Beecham Corporation. Novel sEH inhibitors and their use. WO2009049157; 2009
-
(2009)
Novel SEH Inhibitors and Their Use
-
-
-
146
-
-
77953735655
-
-
GlaxoSmithKline LLC. WO2010011917
-
GlaxoSmithKline LLC. sEH and 11 beta-HSD1 inhibitors. WO2010011917; 2010
-
(2010)
SEH and 11 beta-HSD1 Inhibitors
-
-
-
148
-
-
37249030951
-
-
Available from: http://www. aretetherapeutics.com
-
Available from
-
-
-
149
-
-
70349636047
-
Soluble epoxide hydrolase as a therapeutic target for cardiovascular diseases
-
Imig JD, Hammock BD. Soluble epoxide hydrolase as a therapeutic target for cardiovascular diseases. Nat Rev Drug Discov 2009;8:794-805
-
(2009)
Nat Rev Drug Discov
, vol.8
, pp. 794-805
-
-
Imig, J.D.1
Hammock, B.D.2
|