Design, Synthesis, and Biological Activity of 1,3-Disubstituted Ureas as Potent Inhibitors of the Soluble Epoxide Hydrolase of Increased Water Solubility

Journal of Medicinal Chemistry

Volumn 47, Issue 8, 2004, Pages 2110-2122

  Kim, In Hae ^a   Morisseau, Christophe ^a   Watanabe, Takaho ^a   Hammock, Bruce D ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 (3 CHLOROPHENYL) 3 (4 HYDROXYDECYL)UREA; 4 (3 ADAMANTAN 1 YLUREIDO)BUTYRYLOXY; EPOXIDE HYDROLASE; EPOXIDE HYDROLASE INHIBITOR; UNCLASSIFIED DRUG; UREA DERIVATIVE;

ARTICLE; BLOOD PRESSURE REGULATION; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG DESIGN; DRUG EFFICACY; DRUG FORMULATION; DRUG POTENCY; DRUG SYNTHESIS; HUMAN; HYDROPHILICITY; IN VITRO STUDY; IN VIVO STUDY; INFLAMMATION; LIPOPHILICITY; MOUSE; NONHUMAN;

ANIMALS; EPOXIDE HYDROLASES; HUMANS; MICE; SOLUBILITY; STRUCTURE-ACTIVITY RELATIONSHIP; TRANSITION TEMPERATURE; UREA; WATER;

EID: 1842555060     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm030514j     Document Type: Article

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