Substrate selectivity and a novel role in inhibitor discrimination by residue 237 in the KPC-2 β-lactamase

Antimicrobial Agents and Chemotherapy

Volumn 54, Issue 7, 2010, Pages 2867-2877

  Papp Wallace, Krisztina M ^a,b   Taracila, Magdalena ^a,b   Hornick, John M ^b   Hujer, Andrea M ^a,b   Hujer, Kristine M ^a,b   Distler, Anne M ^a,c   Endimiani, Andrea ^a,b   Bonomo, Robert A ^a,b  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b LOUIS STOKES CLEVELAND VA MEDICAL CENTER   (United States)

^c Cuyahoga Community College   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMPICILLIN; BETA LACTAMASE; CARBAPENEM; CEFALOTIN; CEFOTAXIME; CLAVULANIC ACID; DORIPENEM; ERTAPENEM; IMIPENEM; KPC 2 BETA LACTAMASE; MEROPENEM; NITROCEFIN; PIPERACILLIN; SULBACTAM; SULFONE; TAZOBACTAM; UNCLASSIFIED DRUG; BACTERIAL PROTEIN; BETA LACTAM; BETA LACTAMASE INHIBITOR; BETA-LACTAMASE KPC-2; CARBAPENEMASE; CEPHALOSPORINASE; ENZYME INHIBITOR; PENICILLANIC ACID;

ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; ARTICLE; DNA SEQUENCE; ESCHERICHIA COLI; HYDROGEN BOND; MINIMUM INHIBITORY CONCENTRATION; MUTAGENESIS; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; WILD TYPE; ANALOGS AND DERIVATIVES; CHEMICAL STRUCTURE; CHEMISTRY; COMPUTER SIMULATION; ELECTROSPRAY MASS SPECTROMETRY; ENZYME SPECIFICITY; GENETICS; KINETICS; METABOLISM; MICROBIAL SENSITIVITY TEST; PROTEIN SECONDARY STRUCTURE; SITE DIRECTED MUTAGENESIS;

BACTERIAL PROTEINS; BETA-LACTAMASE INHIBITORS; BETA-LACTAMASES; BETA-LACTAMS; CEPHALOSPORINASE; CLAVULANIC ACID; COMPUTER SIMULATION; ENZYME INHIBITORS; HYDROGEN BONDING; KINETICS; MICROBIAL SENSITIVITY TESTS; MOLECULAR STRUCTURE; MUTAGENESIS, SITE-DIRECTED; PENICILLANIC ACID; PROTEIN STRUCTURE, SECONDARY; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; SUBSTRATE SPECIFICITY; SULBACTAM;

EID: 77953764780     PISSN: 00664804     EISSN: 10986596     Source Type: Journal    
DOI: 10.1128/AAC.00197-10     Document Type: Article

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