Molecular mechanisms of neuronal histamine and its receptors in obesity

Current Molecular Pharmacology

Volumn 2, Issue 3, 2009, Pages 249-252

  Masaki, Takayuki ^a   Yoshimatsu, Hironobu ^a  

^a OITA UNIVERSITY   (Japan)

Author keywords

Food intake; Histamine; Histamine H1 receptor; Histamine H3 receptor; Obesity

Indexed keywords

HISTAMINE; HISTAMINE H1 RECEPTOR; HISTAMINE H3 RECEPTOR; HISTAMINE RECEPTOR; HISTIDINE; LEPTIN;

ARTICLE; BODY WEIGHT; CALORIC INTAKE; CIRCADIAN RHYTHM; ENERGY EXPENDITURE; FOOD INTAKE; HUMAN; NERVE CELL; NONHUMAN; OBESITY; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; STOMACH SECRETION;

ANIMALS; BRAIN; ENERGY METABOLISM; HISTAMINE; HUMANS; MICE; NEURONS; NEUROTRANSMITTER AGENTS; OBESITY; RATS; RECEPTORS, HISTAMINE; SIGNAL TRANSDUCTION;

EID: 77953762851     PISSN: 18744672     EISSN: 18744702     Source Type: Journal    
DOI: 10.2174/1874467210902030249     Document Type: Article

References (54)

1. Brown, R. E.; Stevens, D. R.; Haas, H. L. The physiology of brainhistamine. Prog. Neurobiol. 2001, 63, 637-672.
2. Haas, H.; Panula, P. The role of histamine and the tuberomamillary nucleus in the nervous system. Nat. Rev. Neurosci. 2003, 4, 121-130.
3. Schwartz, J. C.; Arrang, J. M.; Garbarg, M.; Pollard, H.; Ruat, M. Histaminergic transmission in the mammalian brain. Physiol. Rev. 1991, 71, 1-51.
4. Terao, A.; Steininger, T. L.; Morairty, S. R.; Kilduff, T. S. Age- related changes in histamine receptor mRNA levels in the mouse brain. Neurosci. Lett. 2004, 355, 81-84.
5. Timmerman, H. Cloning of the H1 histamine receptor. Trends Pharmacol. Sci. 1992, 13, 6-7.
6. Masaki, T.; Chiba, S.; Tatsukawa, H.; Noguchi, H.; Kakuma, T.; Endo, M.; Seike, M.; Watanabe, T.; Yoshimatsu, H. The role of histamine H1 receptor and H2 receptor in LPS-induced liver injury. FASEB J. 2005, 19, 1245-12452.
7. Arrang, J. M.; Garbarg, M.; Schwartz, J. C. Auto-inhibition of brain histamine release mediated by a novel class (H3) of histamine receptor. Nature 1983, 302, 832-837.
8. Nguyen, T.; Shapiro, D. A.; George, S. R.; Setola, V.; Lee, D. K.; Cheng, R.; Rauser, L.; Lee, S. P.; Lynch, K. R.; Roth, B. L.; O'Dowd, B. F. Discovery of a novel member of the histamine receptor family. Mol. Pharmacol. 2001, 59, 427-433.
9. de Esch, I. J.; Thurmond, R. L.; Jongejan, A.; Leurs, R. The histamine H4 receptor as a new therapeutic target for inflammation. Trends Pharmacol. Sci. 2005, 26, 462-469.
10. Inoue, I.; Yanai, K.; Kitamura, D.; Taniuchi, I.; Kobayashi, T.; Niimura, K.; Watanabe, T.; Watanabe, T. Impaired locomotor activity and exploratory behavior in mice lacking histamine H1 receptors. Proc. Natl. Acad. Sci. USA 1996, 93, 13316-13320.
11. Parmentier, R.; Ohtsu, H.; Djebbara-Hannas, Z.; Valatx, J. L.; Watanabe, T.; Lin, J. S. Anatomical, physiological, and pharmacological characteristics of histidine decarboxylase knock-out mice: evidence for the role of brain histamine in behavioral and sleep- wake control. J. Neurosci. 2002, 22, 7695-7711.
12. Masaki, T.; Yoshimatsu, H. The hypothalamic H1 receptor: a novel therapeutic target for disrupting diurnal feeding rhythm and obesity. Trends Pharmacol. Sci. 2006, 27, 279-284.
13. Mollet, A.; Lutz, T. A.; Meier, S.; Riediger, T.; Rushing, P. A.; Scharrer, E.; Histamine H1 receptors mediate the anorectic action of the pancreatic hormone amylin. Histamine H1 receptors mediate the anorectic action of the pancreatic hormone amylin. Am. J. Physiol. Regul. Integr. Comp. Physiol. 2001, 281, R1442-1448.
14. Masaki, T.; Chiba, S.; Yasuda, T.; Noguchi, H.; Kakuma, T.; Wa-tanabe, T.; Sakata, T.; Yoshimatsu, H. Involvement of Hypothalamic Histamine H1-Receptor in the Regulation of Feeding Rhythm and Obesity. Diabetes 2004, 53, 2250-2260.
15. Takahashi, K.; Suwa, H.; Ishikawa, T.; Kotani, H. Targeted disruption of H3 receptors results in changes in brain histamine tone leading to an obese phenotype. J. Clin. Invest. 2002, 110, 1791-1799.
16. Fulop, A. K.; Foldes, A.; Buzas, E.; Hegyi, K.; Miklos, I. H.; Romics, L.; Kleiber, M.; Nagy, A.; Falus, A.; Kovacs, K. J. Hyperleptinemia, visceral adiposity, and decreased glucose tolerance in mice with a targeted disruption of the histidine decarboxylase gene. Endocrinology 2003, 144, 4306-4314.
17. Jorgensen, E. A.; Vogelsang, T. W.; Knigge, U.; Watanabe, T.; Warberg, J.; Kjaer, A. Increased susceptibility to diet-induced obesity in histamine-deficient mice. Neuroendocrinology 2006, 83, 289-294.
18. Masaki, T.; Yoshimatsu, H.; Chiba, S.; Watanabe, T.; Sakata, T. Targeted disruption of histamine H1-receptor attenuates regulatory effects of leptin on feeding, adiposity, and UCP family in mice. Diabetes 2001, 50, 385-391.
19. Tuomisto, L.; Yamatodani, A.; Jolkkonen, J.; Sainio, E. L. Airaksinen M. M. Inhibition of brain histamine synthesis increases food intake and attenuates vasopressin response to salt loading in rats. Methods Find Exp. Clin. Pharmacol. 1994, 16, 355-359.
20. Lecklin, A.; Etu-Seppala, P.; Stark, H.; Tuomisto, L. Effects of intracerebroventricularly infused histamine and selective H1, H2 and H3 agonists on food and water intake and urine flow in Wistar rats. Brain Res. 1998, 793, 279-288.
21. Sakata, T.; Ookuma, K.; Fukagawa, K.; Fujimoto, K.; Yoshimatsu, H.; Shiraishi, T.; Wada, H. Blockade of the histamine H1-receptor in the rat ventromedial hypothalamus and feeding elicitation. Brain Res. 1988, 441, 403-407.
22. Itoh, E.; Fujimiya, M.; Inui, A. Thioperamide, a histamine H3 receptor antagonist, powerfully suppresses peptide YY-induced food intake in rats. Biol. Psychiatry 1999, 45, 475-481.
23. Attoub, S.; Moizo, L.; Sobhani, I.; Laigneau, J.P.; Lewin, M.J.; Bado, A. The H3 receptor is involved in cholecystokinin inhibition of food intake in rats. Life Sci. 2001, 69, 469-478.
24. Kasaoka, S.; Tsuboyama-Kasaoka, N.; Kawahara, Y.; Inoue, S.; Tsuji, M.; Ezaki, O.; Kato, H.; Tsuchiya, T.; Okuda, H.; Nakajima, S. Histidine supplementation suppresses food intake and fat accu- mulation in rats. Nutrition 2004, 20, 991-996.
25. Yoshimatsu, H.; Chiba, S.; Tajima, D.; Akehi, Y.; Sakata, T. Histidine suppresses food intake through its conversion into neuronal histamine. Exp. Biol. Med. (Maywood) 2002, 227, 63-68.
26. Leurs, R.; Traiffort, E.; Arrang, J. M.; Tardivel Lacombe, J.; Ruat, M.; Schwartz, J. C. Guinea pig histamine H1 receptor. II. Stable expression in Chinese hamster ovary cells reveals the interaction with three major signal transduction pathways. J. Neurochem. 1994, 62, 519-527.
27. Richelson, E. Histamine H1 receptor-mediated guanosine 3′,5′- monophosphate formation by cultured mouse neuroblastoma cells. Science 1978, 201, 69-71.
28. Traiffort, E.; Vizuete, M. L.; Tardivel, L. J.; Souil, E.; Schwartz, J. C.; Ruat, M. The guinea pig histamine H2 receptor: gene cloning, tissue expression and chromosomal localization of its human counterpart. Biochem. Biophys. Res. Commun. 1995, 211, 570-577.
29. Baudry, M.; Martres, M. P.; Schwartz, J. C. H1 and H2 receptors in the histamine-induced accumulation of cyclic AMP in guinea pig brain slices. Nature 1975, 253, 362-364.
30. Hegstrand, L. R.; Kanof, P. D.; Greengard, P. Histamine-sensitive adenylate cyclase in mammalian brain. Nature 1976, 260, 163-165.
31. Sheng, M.; Thompson, M. A.; Greenberg, M. E. CREB: a Ca(2+)- regulated transcription factor phosphorylated by calmodulin- dependent kinases. Science 1991, 252, 1427-1430.
32. Lovenberg, T. W.; Roland, B. L.; Wilson, S. W.; Jiang, X.; Pyati, J.; Huvar, A.; Jackson, M. R.; Erlander, M. G. Cloning and functional expression of the human histamine H3 receptor. Mol. Pharmacol. 1999, 55, 1101-1107.
33. Morimoto, T.; Yamamoto, Y.; Yamatodani, A. Brain histamine and feeding behavior. Behav. Brain Res. 2001, 124, 145-150.
34. Masaki, T.; Chiba, S.; Yoshimichi, G.; Yasuda, T.; Noguchi, H.; Kakuma, T.; Sakata, T.; Yoshimatsu, H. Neuronal histamine regulates food intake, adiposity, and uncoupling protein expression in agouti yellow (A(y)/a) obesemice. Endocrinology 2003, 144, 2741-2748.
35. Malmlof, K.; Zaragoza, F.; Golozoubova, V.; Refsgaard, H. H.; Cremers, T.; Raun, K.; Wulff, B. S.; Johansen, P. B.; Westerink, B.; Rimvall, K. Influence of a selective histamine H3 receptor an- tagonist on hypothalamic neural activity, food intake and body weight. Int. J. Obes. (Lond.) 2005, 29, 1402-1412.
36. Malmlof, K.; Golozoubova, V.; Peschke, B.; Wulff, B. S.; Retsguhrd, H.; Johansen, P. B.; Cremers, T.; Rimvall, K. Increase of neuronal histamine in obese rats is associated with decreases in body weight and plasma triglycerides. Obesity (Silver Spring). 2006, 14, 2154-2162.
37. Tokita, S.; Takahashi, K.; Kotani, H. Recent advances in molecular pharmacology of the histamine systems: physiology and pharmacology of histamine H3 receptor: roles in feeding regulation and therapeutic potential for metabolic disorders. J. Pharmacol. Sci. 2006, 101, 12-18.
38. Sindelar, D. K.; Shepperd, M. L.; Pickard, R. T.; Alexander- Chacko, J.; Dill, M. J.; Cramer, J. W.; Smith, D. P.; Gadski, R. Central H3R activation by thioperamide does not affect energy balance. Pharmacol. Biochem. Behav. 2004, 78, 275-283.
39. Yoshimoto, R.; Miyamoto, Y.; Shimamura, K.; Ishihara, A.; Taka-hashi, K.; Kotani, H.; Chen, A. S.; Chen, H. Y.; Macneil, D. J.; Ka- natani, A.; Tokita, S. Therapeutic potential of histamine H3 recep- tor agonist for the treatment of obesity and diabetes mellitus. Proc. Natl. Acad. Sci. USA 2006, 103, 13866-13671.
40. Toyota, H.; Dugovic, C.; Koehl, M.; Laposky, A. D.; Weber, C.; Ngo, K.; Wu, Y.; Lee, D. H.; Yana, K.; Sakurai, E.; Watanabe, T.; Liu, C.; Chen, J.; Barbier, A. J.; Turek, F. W.; Fung-leung, W. P.; Lovenberg, T. W. Behavioral characterization of mice lacking histamine H3 receptors. Mol. Pharmacol. 2002, 62, 389-397.
41. Friedman, J. M. Modern science versus the stigma of obesity. Nat. Med. 2004, 10, 563-569.
42. Bouret, S. G.; Simerly, R. B. Minireview: leptin and development of hypothalamic feeding circuits. Endocrinology 2004, 145, 2621-16.
43. Takahashi, K. A.; Cone, R. D. Fasting induces a large, leptin-dependent increase in the intrinsic action potential frequency of orexigenic arcuate nucleus NPY/AgRP neurons. Endocrinology 2005, 146, 1043-1047.
44. Balthasar, N.; Coppari, R.; McMinn, J.; Liu, S.; Lee, C.; Tang, V.; Kenny, C.; Elmquisk, J. K. Leptin receptor signaling in POMC neurons is required for normal body weight homeostasis. Neuron 2004, 42, 983-991.
45. Yoshimatsu, H.; Itateyama, E.; Kondou, S.; Tajima, D.; Himeno, K.; Hidaka, S.; Kurokawa, M.; Sakata, T. Hypothalamic neuronal histamine as a target of leptin in feeding behavior. Diabetes 1999, 48, 2286-2291.
46. Morimoto, T.; Yamamoto, Y.; Yamatodani, A. Leptin facilitates histamine release from the hypothalamus in rats. Brain Res. 2000, 868, 367-369.
47. Morimoto, T.; Yamamoto, Y.; Mobarakeh, J. I.; Yanai, K.; Watanabe, T.; Watanabe, T.; Yamatodani, A. Involvement of the hista- minergic system in leptin-induced suppression of food intake. Physiol. Behav. 1999, 67, 679-683.
48. Toftegaard, C. L.; Knigge, U.; Kjaer, A.; Warberg, J. The role of hypothalamic histamine in leptin-induced suppression of short-term food intake in fasted rats. Regul. Pept. 2003, 111, 83-90.
49. Masaki, T.; Yoshimatsu, H. Neuronal histamine and histamine receptors in food intake and obesity. Mini. Rev. Med. Chem. 2007, 7, 821-825.
50. Yasuda, T.; Masaki, T.; Sakata, T.; Yoshimatsu, H. Hypothalamic neuronal histamine regulates sympathetic nerve activity and expression of uncoupling protein 1 mRNA in brown adipose tissue in rats. Neuroscience 2004, 125, 535-540.
51. Masaki, T.; Yoshimatsu, H. Therapeutic approach of histamine H3 receptors in obesity. Recent Pat. CNS Drug Discov. 2007, 2, 238-g240.
52. Masaki, T.; Yoshimatsu, H.; Sakata, T. Expression of rat uncoupling protein family mRNA levels by chronic treatment with thyroid hormone. Int. J. Obes. Relat. Metab. Disord. 2000, 24, S162-164.
53. Masaki, T.; Yoshimatsu, H.; Kakuma, T.; Chiba, S.; Hidaka, S.; Tajima, D.; Kurokawa, M.; Sakata, T. Induction of rat uncoupling protein-2 gene treated with tumour necrosis factor alpha in vivo. Eur. J. Clin. Invest. 1999, 29, 76-82.
54. Feldmann, H. M.; Golozoubova, V.; Cannon, B.; Nedergaard, J. UCP1 ablation induces obesity and abolishes diet-induced ther- mogenesis in mice exempt from thermal stress by living at thermoneutrality. Cell. Metab. 2009, 9, 203-209.