Induction of rat uncoupling protein-2 gene treated with tumour necrosis factor alpha in vivo

European Journal of Clinical Investigation

Volumn 29, Issue 1, 1999, Pages 76-82

  Masaki, T ^a,b   Yoshimatsu, H ^a,b   Kakuma, T ^a,b   Chiba, S ^a,b   Hidaka, S ^a,b   Tajima, D ^a,b   Kurokawa, M ^a,b   Sakata, T ^a,b  

^a OITA UNIVERSITY   (Japan)

^b OITA UNIVERSITY   (Japan)

Author keywords

Leptin; ob gene; Uncoupling protein

Indexed keywords

LEPTIN; MESSENGER RNA; TUMOR NECROSIS FACTOR ALPHA; UNCOUPLING PROTEIN;

ANIMAL EXPERIMENT; ANOREXIA; ARTICLE; BROWN ADIPOSE TISSUE; CONTROLLED STUDY; GENE INDUCTION; HORMONE BLOOD LEVEL; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SKELETAL MUSCLE; WHITE ADIPOSE TISSUE;

ADIPOSE TISSUE; ADIPOSE TISSUE, BROWN; ANIMALS; ANOREXIA; BODY TEMPERATURE; EATING; ENERGY METABOLISM; HOMEOSTASIS; ION CHANNELS; LEPTIN; MALE; MEMBRANE TRANSPORT PROTEINS; MITOCHONDRIAL PROTEINS; MUSCLE, SKELETAL; PROTEINS; RATS; RATS, INBRED STRAINS; RECOMBINANT PROTEINS; RNA, MESSENGER; TUMOR NECROSIS FACTOR-ALPHA; UNCOUPLING AGENTS;

EID: 0032968122     PISSN: 00142972     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2362.1999.00403.x     Document Type: Article

References (29)

1. 1 Nicholls DG, Locke RM. Thermogenic mechanism in brown fat. Physiol Rev 1984;64:1-64.
2. 2 Garlid KD, Orosz DE, Modriansky M, Vassanelli S, Jezek P. On the mechanism of fatty acid-induced proton transport by mitochondrial uncoupling protein. J Biol Chem 1996;271:2615-20.
3. 3 Spiegelman BM, Flier JS. Adipogenesis and obesity: rounding out the big picture. Cell 1996;87:377-87.
4. 4 Onai T, Kiltoy G, York DA, Bray GA. Regulation of beta 3-adrenergic receptor mRNA by sympathetic nerves and glucocorticoids in BAT of Zucker obese rats. Am J Physiol 1995;269: R519-26.
5. 5 Fleury C, Neverova M, Collins S., et al. Uncoupling protein-2: a novel gene linked to obesity and hyperinsulinemia. Nature Genet 1997;15:269-72.
6. 6 Gimeno RE, Dembski M, Weng X. et al. Cloning and characterization of an protein Homologue. Diabetes 1997;46:900-6.
7. 7 Hidaka S, Kakuma T, Yoshimatsu H, Yasunaga S, Kurokawa M, Sakata T. Molecular cloning of rat uncoupling protein 2 cDNA and its expression in genetically obese Zucker fatty (fa/fa) rats. Biochim Biophys Acta 1998;1389:178-81.
8. 8 Zhou Y-T, Shimabukuro M, Koyama K, et al. Induction by leptin of uncoupling protein-2 and enzymes of fatty acid oxidation. Proc Natl Acad Sci USA 1997;94:6386-90.
9. 9 Masaki T, Yoshimatsu H, Kakuma T, Hidaka S, Kurokawa M, Sakata T. Enhanced expression of uncoupling protein 2 gene in rat white adipose tissue and skeletal muscle following chronic treatment with thyroid hormone. FEBS Lett 1997;418:323-6.
10. 10 Boss O, Samec S, Dulloo A, Seydoux J, Muzzin P, Giacobino JP. Tissue-dependent upregulation of rat uncoupling protein-2 expression in response to fasting or cold. FEBS Lett 1997;412:111-4.
11. 11 Beutler B, Gerami A. Cachectin and tumor necrosis factor as two sides of the same biological coin. Nature 1986;320: 584-8.
12. 12 PA Kern, Simsolo RB. The expression of tumor necrosis factor in human adipose tissue. J Clin Invest 1995;95: 2111-9.
13. 13 Hotamisligil GS, Shargill NS, Spiegelman BM. Adipose expression of tumor necrosis factor-α: direct role in obesity-linked insulin resistance. Science 1993;259:87-91.
14. 14 Torti FM, Dieckmann B, Beutler B, Cerami A, Ringold GMA. Macrophage factor inhibits adipocyte gene expression: an in vitro model of cachexia. Science 1985;229:867-9.
15. 15 Petruschke TH, Hauner H. Tumor necrosis factor alpha presents the differentiation of human adipocyte precursor cells and causes delipidation of newly developed fat cells. J Clin Endocrinol Metab 1993;76:742-7.
16. 16 Cornelius P, Enerback S, Bjursell G, Olivercrona T, Pekala PH. Regulation of lipoprotein lipase mRNA content in 3T3-L1 cells by tumor necrosis factor. Biochem J 249:765-9.
17. 17 Pape ME, Kim KH. Effect of tumor necrosis factor on acetyl-coenzyme A carboxylase gene expression and preadipocyte differentiation. Mol Endocrinol 1988;2:395-403.
18. 18 Weiner FR, Smith PI J, Wertheimer S, Rubin CS. Regulation of gene expression by insulin and tumor necrosis factor alpha in 3T3-L1 cells, modulation of the transcription of genes encoding acyl-coA synthetase and stearoyl-coA desaturase-1. J Biol Cheim 266:23525-8.
19. 19 Stephens JM, Pekala PH. Transcriptional repression of the GLUT4 and C/EBP genes in 3T3-L1 adipocytes by tumor necrosis factor-alpha. J Biol Chem 1991;266:21835-45.
20. 20 Fantino M, Wieteska L. Evidence for a direct central anorectic effect of tumor-necrosis-factor-alpha in the rat. Physiol Behav 1993;53:477-83.
21. 21 Coombes RC, Rothwell NJ, Shah P, Stock MJ. Changes in thermogenesis and brown fat activity in response to tumor necrosis factor in the rat. Biosci Rep 1987;7:791-9.
22. 22 Grunfeld C, Zhao C, Fuller J et al. Endotoxin and cytokines induce expression of leptin, the ob gene product, in hamsters. J Clin Invest 1996;97:2152-7.
23. 23 Fukushima M, Tsutsui K, Kodama J, Sakata T. New inexpensive device for estimating dry food intake in small animals. Physiol Behavior 1979;22:1029-102.
24. 24 Sambrook J, Fritsch EF, Maniatis T. A laboratory manual, 2nd edn. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press.
25. 25 Yang Y, McLeese J, Weisbart M, Dionne J-L, Aubin RA. Simplified high throughput protocol for Northern hybridization. Nucleic Adds Res 1993;21:3337-8.
26. 26 Rothwell NJ. Central effects of TNF alpha on thermogenesis and fever in the rat. Biosci Rep 1988;8:345-52.
27. 27 Hadri KE, Courtalon A, Gauthereau X, Chambaut-Guerin AM, Pairault J, Feve B. Differential regulation by tumor necrosis factor-alpha of beta1-, beta2-, and beta3-, adreno-receptor gene expression in 3T3-F442A adipocytes. J Biol Chem 272:24514-21.
28. 28 Zhang Y, Proenca P, Maffei M, Barone M, Lepold L, Friedman JM. Positional cloning of the mouse obese gene and its human homologue. Nature 1994;372:425-32.
29. 29 Lee GH, Proenca R, Motez JM, et al. Abnormal splicing of the leptin receptor in diabetic mice. Nature 1996;379:632-5.