Evaluation of electrospun PCL/gelatin nanofibrous scaffold for wound healing and layered dermal reconstitution

Acta Biomaterialia

Volumn 3, Issue 3 SPEC. ISS., 2007, Pages 321-330

  Chong, E J ^a   Phan, T T ^a   Lim, I J ^a   Zhang, Y Z ^a   Bay, B H ^a   Ramakrishna, S ^a   Lim, C T ^a  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

Electrospinning; Nanofiber; Nanofibrous scaffolds; Skin tissue engineering; Wound dressing

Indexed keywords

CELL ADHESION; CELL CULTURE; COST EFFECTIVENESS; ELECTROSPINNING; FIBROBLASTS; SCAFFOLDS (BIOLOGY); TISSUE;

'CURRENT; BIODEGRADABLE SCAFFOLD; DERMAL LAYERS; ELECTROSPUNS; NANOFIBROUS SCAFFOLDS; SKIN SUBSTITUTES; SKIN TISSUE ENGINEERING; TISSUES ENGINEERINGS; WOUND DRESSINGS; WOUND HEALING;

NANOFIBERS;

GELATIN; MOLECULAR SCAFFOLD; NANOFIBER; POLYCAPROLACTONE; POLYURETHAN;

ADHESION; ARTICLE; ARTIFICIAL SKIN; BIODEGRADABILITY; CELL ADHESION; CELL CULTURE; CELL GROWTH; CELL MIGRATION; CELL PROLIFERATION; COMPOSITE MATERIAL; CONTROLLED STUDY; COST EFFECTIVENESS ANALYSIS; DERMIS; EPITHELIZATION; FIBROBLAST; HUMAN; HUMAN CELL; PRIORITY JOURNAL; THICKNESS; TISSUE ENGINEERING; WOUND DRESSING; WOUND HEALING;

EID: 34147109865     PISSN: 17427061     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.actbio.2007.01.002     Document Type: Article

References (17)

1. Williams P.L., Bannister L.H., Berry M.M., Collins P., Dyson M., Dussek J.E., et al. Gray's anatomy - international student edition. 38th ed. (1995), Churchill Livingstone, Oxford
2. Langer R., and Vacanti J.P. Tissue engineering. Science 260 (1993) 920-926
3. Edwards C., and Marks R. Evaluation of biomechanical properties of human skin. Clin Dermatol 13 (1995) 375-380
4. Seals B.L., Otero T.C., and Panitch A. Polymeric biomaterials for tissue and organ regeneration. Mater Sci Eng: R: Reports 34 (2001) 147-230
5. Marler J.J., Upton J., Langer R., and Vacanti J.P. Transplantation of cells in matrices for tissue regeneration. Adv Drug Deliver Rev 33 (1998) 165-182
6. Luu Y.K., Kim K., Hsiao B.S., Chu B., and Hadijiargyrou M. Development of a nanostructured DNA delivery scaffold via electrospinning of PLGA and PLA-PEG block copolymer. J Controlled Release 89 (2003) 341-353
7. Li W.J., Laurencin C.T., Caterson E.J., Tuan R.S., and Ko F.K. Electrospun nanofibrous structure: a novel scaffold for tissue engineering. J Biomed Mater Res 60 4 (2002) 613-621
8. Matthews J.A., Wnek G.E., Simpson D.G., and Bowlin G.L. Electrospinning of collagen nanofibers. Biomacromolecules 3 (2002) 232-238
9. Lee C.H., Singla A., and Lee Y.Y. Biomedical applications of collagen. Int J Pharm 221 (2001) 1-22
10. Wnek G.E., Carr M.E., Simpson D.G., and Bowlin G.L. Electrospinning of nanofiber fibrinogen structures. Nano Lett 3 2 (2003) 213-216
11. Zhang Y.Z., Ouyang H.W., Lim C.T., Ramakrishna S., and Huang Z.M. Electrospinning of gelatin fibers and gelatin/PCL composite fibrous scaffolds. J Biomed Res Part B: Appl Biomater 72B (2005) 156-165
12. Phan T.T., Lim I.J., Tan E.K., Chua A., Bay B.H., and Lee S.T. Evaluation of cell culture on polyurethane-based membrane (Tegaderm™): implication for tissue engineering of skin. Cell Tissue Bank 6 2 (2005) 91-97
13. Xu C.Y., Inai R., Kotaki M., and Ramakrishna S. Aligned biodegradable nanofibrous structure: a potential scaffold for blood vessel engineering. Biomaterials 25 5 (2004) 877-886
14. Ma Z.W., Kotaki M., and Ramakrishna S. Surface modified nonwoven polysulphone (PSU) fiber mesh by electrospinning: a novel affinity membrane. J Membr Sci 272 1-2 (2006) 179-187
15. Yoshimoto H., Shin Y.M., Terai H., and Vacanti J.P. A biodegradable nanofiber scaffold by electrospinning and its potential for bone tissue engineering. Biomaterials 24 (2003) 2007-2082
16. Lee Y.H., Lee J.H., An I.-G., Kim C., Lee D.S., Lee Y.K., et al. Elecrospum dual-porosity structure and biodegradation morphology of Montmorillonite reinforced PLLA nanocomposite scaffolds. Biomaterials 26 (2005) 3165-3172
17. Chong EJ, Lim CT, Phan TT, Lim IJ, Ramakrishna S. Nanofibrous mat for tissue engineering, wound dressing and dermal reconstitution. International Application No. PCT/SG2005/000323; International Publication No. WO2006/036130 A1.