Dioxin mediates downregulation of the reduced folate carrier transport activity via the arylhydrocarbon receptor signalling pathway

Toxicology and Applied Pharmacology

Volumn 246, Issue 1-2, 2010, Pages 100-106

  Halwachs, Sandra ^a   Lakoma, Cathleen ^a   Gebhardt, Rolf ^a   Schäfer, Ingo ^a   Seibel, Peter ^a   Honscha, Walther ^a  

^a UNIVERSITY OF LEIPZIG   (Germany)

Author keywords

Aryl hydrocarbon receptor; Dioxin; Folate homeostasis; Methotrexate; Regulation; Transport

Indexed keywords

2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; AROMATIC HYDROCARBON RECEPTOR; CYTOCHROME P450 1A1; DIOXIN; FOLIC ACID; REDUCED FOLATE CARRIER;

5' UNTRANSLATED REGION; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BINDING SITE; CARCINOGENESIS; CARDIOVASCULAR RISK; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOWN REGULATION; FOLIC ACID DEFICIENCY; GENE EXPRESSION; GENE TARGETING; GENETIC REGULATION; MALE; MOLECULAR MECHANICS; NONHUMAN; NUCLEOTIDE SEQUENCE; PROMOTER REGION; PROTEIN MOTIF; PROTEIN TRANSPORT; RAT; RECEPTOR BINDING; RECEPTOR UPREGULATION; SIGNAL TRANSDUCTION; TIME;

ANIMALS; BIOLOGICAL TRANSPORT, ACTIVE; CELL LINE, TUMOR; DIOXINS; DOWN-REGULATION; GENE EXPRESSION; GENES, REPORTER; LIVER; MALE; MEMBRANE TRANSPORT PROTEINS; MICE; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, ARYL HYDROCARBON; REPLICATION PROTEIN C; REPRESSOR PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TETRACHLORODIBENZODIOXIN;

RATTUS; VERTEBRATA;

EID: 77953713215     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2010.04.020     Document Type: Article

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