Downregulation of the reduced folate carrier transport activity by phenobarbital-type cytochrome P450 inducers and protein kinase C activators

Biochimica et Biophysica Acta - Biomembranes

Volumn 1768, Issue 6, 2007, Pages 1671-1679

  Halwachs, Sandra ^a   Kneuer, Carsten ^a   Honscha, Walther ^a  

^a UNIVERSITY OF LEIPZIG   (Germany)

Author keywords

CYP450 inducer; Methotrexate; Phenobarbital; Proteinkinase C; Regulation; Transport

Indexed keywords

CARBAMAZEPINE; CHLORPROMAZINE; CLOTRIMAZOLE; CONSTITUTIVE ANDROSTANE RECEPTOR; CYTOCHROME P450; FOLIC ACID; MESSENGER RNA; OKADAIC ACID; PHENOBARBITAL; PHORBOL 13 ACETATE 12 MYRISTATE; PHOSPHOPROTEIN PHOSPHATASE 1; PHOSPHOPROTEIN PHOSPHATASE 2A; PROTEIN KINASE C ACTIVATOR; REDUCED FOLATE CARRIER;

ANIMAL EXPERIMENT; ARTICLE; BLOOD LEVEL; CONTROLLED STUDY; DOWN REGULATION; IN VITRO STUDY; NONHUMAN; PRIORITY JOURNAL; PROTEIN STRUCTURE; PROTEIN TRANSPORT; RAT; SHORT COURSE THERAPY;

ANIMALS; CARBAMAZEPINE; CARRIER PROTEINS; CELL LINE, TUMOR; CHLORPROMAZINE; CLOTRIMAZOLE; CYTOCHROME P-450 ENZYME SYSTEM; DNA PRIMERS; DOWN-REGULATION; ENZYME ACTIVATORS; IMMUNOHISTOCHEMISTRY; OKADAIC ACID; PROTEIN KINASE C; RATS; RECEPTORS, CELL SURFACE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

RATTUS;

EID: 34249072232     PISSN: 00052736     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbamem.2007.03.023     Document Type: Article

References (40)

1. Matherly L.H., and Goldman I.D. Membrane transport of folates. Vitam. Horm. 66 (2003) 403-456
2. Kamen B. Folate and antifolate pharmacology. Semin. Oncol. 24 (1997) 30-39
3. Sirotnak F.M., and Tolner B. Carrier-mediated membrane transport of folates in mammalian cells. Annu. Rev. Nutr. 19 (1999) 91-122
4. Josting A., Diehl V., and Engert A. Methotrexat: Pharmakologie, Toxizität und Rescuemaβnahmen bei hochdosierter Behandlung. Der Onkologe 4 (1998) 974-985
5. Gromnica-Ihle E. Pharmacotherapy of rheumatoid arthritis. Z. Rheumatol. 61 (2002) 35-38
6. Moscow J.A., Gong M., He R., Sgagias M.K., Dixon K.H., Anzick S.L., Meltzer P.S., and Cowan K.H. Isolation of a gene encoding a human reduced folate carrier (RFC1) and analysis of its expression in transport-deficient, methotrexate-resistant human breast cancer cells. Cancer Res. 55 (1995) 3790-3974
7. Dixon K.H., Lampher B.C., Chiu J., Kelley K., and Cowan K.H. A novel cDNA restores reduced folate carrier activity and methotrexate sensitivity to transport deficient cells. J. Biol. Chem. 269 (1994) 17-20
8. Williams F.M., Murray R.C., Underhill T.M., and Flintoff W.F. Isolation of a hamster cDNA clone coding for a function involved in methotrexate uptake. J. Biol. Chem. 269 (1994) 5810-5816
9. Ferguson P.L., and Flintoff W.F. Topological and functional analysis of the human reduced folate carrier by hemagglutinin epitope insertion. J. Biol. Chem. 274 (1999) 16269-16278
10. Honscha W., Dötsch K.U., Thomsen N., and Petzinger E. Cloning and functional characterization of the bile acid-sensitive methotrexate carrier from rat liver cells. Hepatology 31 (2000) 1296-1304
11. Freisheim J.H., Price E.M., and Ratnam M. Folate coenzyme and antifolate transport proteins in normal and neoplastic cells. Folate coenzyme and antifolate transport proteins in normal and neoplastic cells. Adv. Enzyme Regul. 29 (1989) 13-26
12. Kneuer C., Honscha K.U., and Honscha W. Rat reduced-folate carrier-1 is localized basolaterally in MDCK kidney epithelial cells and contributes to the secretory transport of methotrexate and fluoresceinated methotrexate. Cell Tissue Res. 320 (2005) 517-524
13. Honscha W., and Petzinger E. Characterization of the bile acid sensitive methotrexate carrier of rat liver cells. Naunyn-Schmiedeberg's Arch. Pharmacol. 359 (1999) 411-419
14. Sierra E.E., and Goldman I.D. Recent advances in the understanding of the mechanism of membrane transport of folates and antifolates. Semin. Oncol. 26 (1999) 11-23
15. +-dependent reduced folate carrier 1 (RFC1) of humans and the sodium-dependent methotrexate carrier-1 (MTX-1) of the rat are orthologs. FEBS Lett. 566 (2004) 83-86
16. Sueyoshi T., and Negishi M. Phenobarbital response elements of cytochrome P450 genes and nuclear receptors. Annu. Rev. Pharmacol. Toxicol. 41 (2001) 123-143
17. Relling M.V., Pui C.H., Sandlund J.T., Rivera G.K., Hancock M.L., Boyett J.M., Schuetz E.G., and Evans W.E. Adverse effect of anticonvulsants on efficacy of chemotherapy for acute lymphoblastic leukaemia. Lancet 356 (2000) 285-290
18. Riva M., Landonio G., Defanti C.A., and Siena S. The effect of anticonvulsant drugs on blood levels of methotrexate. J. Neurooncol. 48 (2000) 249-250
19. Xu C., Li C.Y., and Kong A.N. Induction of phase I, II and III drug metabolism/transport by xenobiotics. Arch. Pharm. Res. 28 (2005) 249-268
20. Tzameli I., Pissios P., Schuetz E.G., and Moore D.D. The xenobiotic compound 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene is an agonist ligand for the nuclear receptor CAR. Mol. Cell Biol. 20 (2000) 2951-2958
21. Halwachs S., Kneuer C., and Honscha W. Endogenous expression of liver-specific drug transporters for organic anions in the rat hepatocytoma fusion cell line HPCT-1E3. Eur. J. Cell Biol. 84 (2005) 677-686
22. Meyer F.P. Indicative therapeutic and toxic drug concentrations in plasma: a tabulation. Int. J. Clin. Pharmcol., Ther. 32 (1994) 71-81
23. Kneuer C., Schrader S., and Honscha W. Alternative transcripts of rat slc19a1: cloning, genomic organisation, tissue specific promoters and alternative splicing. DNA Seq. 16 (2005) 1-6
24. Krauss G. Protein Kinase A. In: Krauss G. (Ed). Biochemistry of Signal Transduction and Regulation (2003), WILEY-VCH, Weinheim 280-283
25. Nguyen T.T., Dyer D.L., Dunnin D.D., Rubin S.A., Grant K.E., and Said H.M. Human intestinal folate transport: cloning, expression, and distribution of complementary RNA. Gastroenterology 112 (1997) 783-791
26. You G., Kuze K., Kohanski R.A., Amsler K., and Henderson S. Regulation of mOAT-mediated organic anion transport by okadaic acid and protein kinase C in LLC-PK(1) cells. J. Biol. Chem. 275 (2000) 10278-10284
27. Guo G.L., and Klaassen C.D. Protein kinase C suppresses rat organic anion transporting polypeptide 1- and 2-mediated uptake. J. Pharmacol. Exp. Ther. 299 (2001) 551-557
28. +/taurocholate cotransport. J. Biol. Chem. 273 (1998) 30039-30045
29. Chijiwa T., Mishima A., Hagiwara M., Sano Mhayashi K., Inoue T., Naito K., Toshioka T., and Hidaka H. Inhibition of forskolin-induced neurite outgrowth and protein phosphorylation by a newly synthesized selective inhibitor of cyclic AMP dependent protein kinase, N-[2-(p-bromocinnamylamino) ethyl]-5-isoquinoline sulfonamide (H-89), of PC12D pheochromocytoma cells. J. Biol. Chem. 65 (1990) 5267-5272
30. Vecht C.J., Wagner G.L., and Wilms E.B. Treating seizures in patients with brain tumors: drug interactions between antiepileptic and chemotherapeutic agents. Semin. Oncol. 30 (2003) 49-52
31. Sekine T., Cha S.H., Tsuda M., Apiwattanakul N., Nakajima N., Kanai Y., and Endou H. Identification of multispecific organic anion transporter 2 expressed predominantly in the liver. FEBS Lett. 429 (1998) 179-182
32. Kruh G.D., and Belinsky M.G. The MRP family of drug efflux pumps. Oncogene 22 (2003) 7537-7552
33. Kauffmann H.M., and Schrenk D. Sequence analysis and functional characterization of the 5′-flanking region of the rat multidrug resistance protein 2 (mrp2) gene. Biochem. Biophys. Res. Commun. 245 (1998) 325-331
34. Courtois A., Payen L., Le Ferrec E., Scheffer G.L., Guillouzo T.A., and Fardel O. Differential regulation of multidrug resistance-associated protein 2 (MRP2) and cytochromes P450 2B1/2 and 3A1/2 in phenobarbital-treated hepatocytes. Biochem. Pharmacol. 63 (2002) 333-341
35. Wright E., Vincent J., and Fernandez E.J. Thermodynamic characterization of the interaction between CAR-RXR and SRC-1 peptide by isothermal titration calorimetry. Biochemistry 46 (2007) 862-870
36. Nims R.W., Sinclair P.R., Sinclair J.F., Dragnev K.H., Jones C.R., Mellini D.W., Thomas P.E., and Lubet R.A. Dose-response relationships for the induction of P450 2B by 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene (TCPOBOP) in rat and cultured rat hepatocytes. Xenobiotica 23 (1993) 1411-1426
37. Toffoli G., Corona G., Tolusso B., Sartor F., Sorio R., Mini E., and Boiocchi M. Resistance to methotrexate in SKOV-3 cell lines after chronic exposure to carbamazepine is associated with a decreased expression of folate receptor. Int. J. Cancer 85 (2000) 683-690
38. Johnson D.R., Habeebu S.S., and Klaassen C.D. Increase in bile flow and biliary excretion of glutathione-derived sulfhydryls in rats by drug-metabolizing enzyme inducers is mediated by multidrug resistance protein 2. Toxicol. Sci. 66 (2002) 16-26
39. Said H.M., Ma T.Y., Ortiz A., Tapia A., and Valerio C.K. Intracellular regulation of intestinal folate uptake: studies with cultured IEC-6 epithelial cells. Am. J. Physiol. 272 (1997) C729-C736
40. Nabokina S.M., Ma T.Y., and Said H.M. Mechanism and regulation of folate uptake by human pancreatic epithelial MIA PaCa-2 cells. Am. J. Physiol., Cell Physiol. 287 (2004) C142-C148