Antioxidant effects of carotenoids

International Journal for Vitamin and Nutrition Research

Volumn 68, Issue 6, 1998, Pages 399-403

  Bast, Aalt ^a   Haenen, Guido R M M ^a   Van Den Berg, Robin ^a,b   Van Den Berg, Henk ^b  

^a MAASTRICHT UNIVERSITY   (Netherlands)

^b TNO   (Netherlands)

Author keywords

Carotene; Antioxidant; Carotenoids; Free radical; Lipid peroxidation; Lutein

Indexed keywords

ANTIOXIDANT; CAROTENOID; FREE RADICAL; OXYGEN;

CONFERENCE PAPER; DIET SUPPLEMENTATION; DRUG INTERACTION; ELECTRON TRANSPORT; HUMAN; METABOLISM;

ANTIOXIDANTS; CAROTENOIDS; DIETARY SUPPLEMENTS; DRUG INTERACTIONS; ELECTRON TRANSPORT; FREE RADICALS; HUMANS; OXYGEN;

EID: 0031773970     PISSN: 03009831     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (23)

1. Bast, A. (1994) Antioxidant pharmacotherapy. Drug News Persp. 7, 465-472.
2. Rice-Evans, C.A., Sampson, J., Bramley, P.M. and Holloway, D.E. (1997) Why do we expect carotenoids to be antioxidams in vivo. Free Rad. Res. 26, 381-398.
3. Van Acker, S.A.B.E., van den Berg, D.-J., Tromp, M.N.J.L., Griffioen, D.H., van Bennekom, W.P., van der Vijgh, W.J.F. and Bast, A. (1996) Structural aspects of antioxidant activity of flavonoids. Free Rad. Biol. Med. 20, 331-342.
4. Burton, G.W. and Ingold, K.U. (1984) β-carotene: an unusual type of lipid antioxidant. Science 224, 569-573.
5. Krinsky, N.I. (1989) Antioxidant functions of carotenoids. Free Rad. Biol. Med. 7, 617-635.
6. Miller, N.J., Rice-Evans, C.A., Davies, M.J., Gopinathan, V. and Miller, A. (1993) A novel method for measuring antioxidant capacity and its application to monitoring the antioxidant status in premature neonates. Clin. Sci. 84, 407-412.
7. Strube, M., Haenen, G.R.M.M., van den Berg, H. and Bast, A. (1997) Pitfalls in a method for assessment of total antioxidant capacity. Free Rad. Res. 26, 515-521.
8. Miller, N.J., Sampson, J., Candeias, L.P., Bramley, P.M. and Rice-Evans, C.A. (1996) Antioxidant activities of carotenes and xanthophylls. FEBS Lett. 384, 240-242.
9. Haenen, G.R.M.M. and Bast, A. (1983) Protection against lipid peroxidation by a microsomal glutathione-dependent labile factor. FEBS Lett. 159, 24-28.
10. Bast, A. (1995) The antioxidant-prooxidant balance in tissue injury and signal transmission. In: Cell and tissue protection in ophthalmology (Pleyer, U., Schmidt K.-H. and Thiel, H.-J., eds.) pp. 25-33, Thieme/Enke/Hippokrates Verlag, Stuttgart, Germany.
11. Palozza, P. and Krinsky, N.I. (1992) β-carotene and α-tocopherol are synergistic antioxidants. Arch. Biochem. Biophys. 297, 184-187.
12. Mortenson, A. and Skibsted, L.H. (1996) Kinetics of parallel electron transfer from β-carotene to phenoxyl radical and adduct formation between phenoxyl radical and β-carotene. Free Rad. Res. 25, 515-523.
13. Valgimigli, L., Lucarini, M., Pedulli, G.F. and Ingold, K.U. (1997) Does β-carotene really protect vitamin E from oxidation? J. Am. Chem. Soc. 119, 8095-8096.
14. Handelman, G.J. (1996) Carotenoids as scavengers of active oxygen species. In: Handbook of antioxidants (Cadenas, E. and Packer, L., eds.) pp. 259-314, Marcel Dekker, New York.
15. Mathews-Roth, M.M. (1993) Carotenoids in erythropoieic protoporphyria and other photosensitivity diseases. Ann. N.Y. Acad. Sci. 691, 127-138.
16. DiMascio, P., Kaiser, S. and Sies, H. (1989) Lycopene as the most efficient biological carotenoid singlet oxygen quencher. Arch. Biochem. Biophys. 274, 532-538.
17. Stratton, S., Schaefer, W. and Liebler, D. (1993) Isolation and identification of singlet oxygen oxidation products of beta-carotene. Chem. Res. Toxicol. 6, 542-547.
18. Handelman, G.J., van Kuijk, F. and Chatterjee, A. (1991) Characterization of products formed during autoxidation of beta-carotene. Free Rad. Biol. Med. 10, 427-437.
19. Yamauchi, R., Miyake, N., Inoue, H. and Kato, K. (1993) Products formed by peroxyl radical oxidation of β-carotene. J. Agric. Food Chem. 41, 708-713.
20. Gaziano, J.M., Hatta, A., Flynn, M., Johnson, E.J., Krinsky, N.I., Ridber, P.M., Hennekens C.H. and Frei, B. (1995) Supplementation with β-carotene in vivo and in vitro does not inhibit low density lipoprotein oxidation. Atherosclerosis 112, 187-195.
21. Hennekens, C.H., Buring, J., Manson, J.E., Stampfer, M., Rosner, B., Cook N.R., Belanger, C., La Motte, F., Gaziano, J.M., Ridber, P.M., Willett, W. and Peto, R. (1996) Lack of effect of long-term supplementation with β-carotene on the incidence of malignant neoplasms and cardiovascular disease. New Eng. J. Med. 334, 1145-1149.
22. ATBC The α-Tocopherol, β-Carotene Cancer Prevention Study Group (1994) The effect of vitamin E and beta carotene on the incidence of lung cancer and other cancers in male smokers. New Eng. J. Med. 330, 1029-1035.
23. Omenn, G.S., Goodman, G.E., Thongquist, M.D., Balmes, J., Cullen, M.R., Glass, A., Keogh, J.P., Meyskens, F., Valaris, B., Williams, J.H., Barnhart, S. and Hammar, S. (1996) Effects of a combination of β-carotene and vitamin A on lung cancer and cardiovascular disease. New Eng. J. Med. 334, 1150-1155.