Antipsychotic drugs activate the C. elegans AKT pathway via the DAF-2 insulin/IGF-1 receptor

ACS Chemical Neuroscience

Volumn 1, Issue 6, 2010, Pages 463-473

  Weeks, Kathrine R ^a   Dwyer, Donard S ^a   Aamodt, Eric J ^a  

^a LOUISIANA STATE UNIVERSITY HEALTH SCIENCES CENTER   (United States)

Author keywords

Akt; Antipsychotic drugs; C. elegans; FOXO; Insulin signaling; Schizophrenia

Indexed keywords

ARIPIPRAZOLE; CALCINEURIN; CHLORPROMAZINE; CHLORPROTHIXENE; CLOZAPINE; FLUPHENAZINE; HALOPERIDOL; INSULIN; LOXAPINE; MITOGEN ACTIVATED PROTEIN KINASE; NEUROLEPTIC AGENT; OLANZAPINE; PERPHENAZINE; PROTEIN KINASE B; QUETIAPINE; RISPERIDONE; SEROTONIN; SOMATOMEDIN RECEPTOR; TRANSCRIPTION FACTOR FOXO; TRIFLUOPERAZINE; XANOMELINE;

ANIMAL EXPERIMENT; ARTICLE; BACTERIAL STRAIN; CAENORHABDITIS ELEGANS; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; DRUG INHIBITION; GENETIC ANALYSIS; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL;

AKT; ANTIPSYCHOTIC DRUGS; C. ELEGANS; FOXO; INSULIN SIGNALING; SCHIZOPHRENIA;

ANIMALS; ANTIPSYCHOTIC AGENTS; BENZODIAZEPINES; CAENORHABDITIS ELEGANS; CAENORHABDITIS ELEGANS PROTEINS; CELL NUCLEUS; CLOZAPINE; GUANOSINE TRIPHOSPHATE; LARVA; PROTO-ONCOGENE PROTEINS C-AKT; RECEPTOR, IGF TYPE 1; RECEPTOR, INSULIN; SIGNAL TRANSDUCTION; TRIFLUOPERAZINE;

CAENORHABDITIS ELEGANS;

EID: 77953661832     PISSN: None     EISSN: 19487193     Source Type: Journal    
DOI: 10.1021/cn100010p     Document Type: Article

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