Guidelines of the German respiratory society for diagnosis and treatment of adults suffering from acute or chronic cough;Leitlinie der deutschen gesellschaft für pneumologie und beatmungsmedizin zur diagnostik und therapie von erwachsenen patienten mit akutem und chronischem husten

Pneumologie

Volumn 64, Issue 6, 2010, Pages 336-373

  Kardos, P ^a   Berck, H ^b   Fuchs, K H ^c   Gillissen, A ^d   Klimek, L ^e   Morr, H ^f   Pfeiffer Kascha, D ^g   Schultze Werninghaus, G ^h   Sitter, H ⁱ   Voshaar, T ^j   Worth, H ^k  

^a Klinik Maingau Frankfurt am Main   (Germany)

^b Patientenliga Atemwegserkrankungen eV   (Germany)

^c AGAPLESION MARKUS KRANKENHAUS   (Germany)

^d Robert Koch Klinik   (Germany)

^e ZENTRUM FÜR RHINOLOGIE UND ALLERGOLOGIE   (Germany)

^f Pneumologische Klinik Waldhof Elgershausen   (Germany)

^g Outpatient Physiotherapy Clinic Praxis Röske   (Germany)

^h RUHR UNIVERSITY BOCHUM   (Germany)

ⁱ PHILIPPS UNIVERSITY MARBURG   (Germany)

^j Krankenhaus Bethanien   (Germany)

^k KLINIKUM FÜRTH   (Germany)

more..

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCYSTEINE; AMBROXOL; ANTIBIOTIC AGENT; BROMHEXINE; CARBOCISTEINE; CINEOLE; CODEINE; DEXTROMETHORPHAN; DIHYDROCODEINE; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; DORNASE ALFA; GUAIFENESIN; MORPHINE SULFATE; NOSCAPINE; PENTOXYVERINE;

ACUTE DISEASE; ALLERGY; ASTHMA; BRONCHIECTASIS; BRONCHOMALACIA; CHRONIC BRONCHITIS; CHRONIC DISEASE; CHRONIC OBSTRUCTIVE LUNG DISEASE; CLINICAL TRIAL; COUGHING; GASTROESOPHAGEAL REFLUX; GERMANY; HUMAN; LUNG EMBOLISM; LUNG INFECTION; LUNG TUMOR; MEDICAL SOCIETY; PHYSIOTHERAPY; PLEURISY; PNEUMONIA; PNEUMOTHORAX; POLYCHONDRITIS; PRACTICE GUIDELINE; PRIORITY JOURNAL; REVIEW; TUBERCULOSIS; ADULT; CONSENSUS DEVELOPMENT; COUGH; EVIDENCE BASED MEDICINE; RESPIRATORY TRACT DISEASES;

ACUTE DISEASE; ADULT; CHRONIC DISEASE; COUGH; EVIDENCE-BASED MEDICINE; GERMANY; HUMANS; RESPIRATORY TRACT DISEASES;

EID: 77953653364     PISSN: 09348387     EISSN: 14388790     Source Type: None    
DOI: 10.1055/s-0029-1244083     Document Type: Review

References (330)

1. Kardos P, Cegla U, Gillissen A et al. Leitlinie der Deutschen Gesellschaft für Pneumologie zur Diagnostik und Therapie von Patienten mit akutem und chronischem Husten. Pneumologie 2004 58 570-602 (Pubitemid 39144409)
2. Irwin R S., Baumann M H., Bolser D C. et al. Diagnosis and management of cough executive summary: ACCP evidence-based clinical practice guidelines. Chest 2006 129 1S-23S
3. Morice A H., McGarvey L, Pavord I. Recommendations for the management of cough in adults. Thorax 2006 61 (Suppl 1) i1-i24
4. Morice A H., Fontana G A., Belvisi M G. et al. ERS guidelines on the assessment of cough. Eur Respir J 2007 29 1256-1276
5. Morice A H., Fontana G A., Sovijarvi A R. et al. The diagnosis and management of chronic cough. Eur Respir J 2004 24 481-492
6. Kohno S, Ishida T, Uchida Y et al. The Japanese Respiratory Society guidelines for management of cough. Respirology 2006 11 (Suppl 4) S135-S186
7. The Lancet Cough guidelines choke on evidence. Lancet 2006 367 276
8. Chung K F., McGarvey L P., Widdicombe J. American College of Chest Physicians' cough guidelines. Lancet 2006 367 981-982
9. Irwin R, Guttermann D D. American College of Chest Physicians' cough guidelines. Lancet 2006 367 981
10. Schunemann H J., Jaeschke R, Cook D J. et al. An official ATS statement: grading the quality of evidence and strength of recommendations in ATS guidelines and recommendations. Am.J Respir Crit Care Med 2006 174 605-614
11. Brozek J L., Akl E A., Alonso-oello P et al. Grading quality of evidence and strength of recommendations in clinical practice guidelines. Part 1 of 3. An overview of the GRADE approach and grading quality of evidence about interventions. Allergy 2009 64 669-677
12. Society for Medical Decision Making. Committee on standardization of clinical algoritms Proposals for clinical algorithm standards. Med Decis Making 1992 12 149-154
13. Chung K F., Pavord I D. Prevalence, pathogenesis, and causes of chronic cough. Lancet 2008 371 1364-1374
14. Ford A C., Forman D, Moayyedi P et al. Cough in the community: a cross sectional survey and the relationship to gastrointestinal symptoms. Thorax 2006 61 975-979
15. Burt C W., Schappert S M. Ambulatory care visits to physician offices, hospital outpatient departments, and emergency departments: United States, 19992000. Vital Health Stat 2004 13 1-70
16. Irwin R S. Introduction to the diagnosis and management of cough: ACCP evidence-based clinical practice guidelines. Chest 2006 129 25S-27S
17. Everett C F., Kastelik J A., Thompson R H. et al. Chronic persistent cough in the community: a questionnaire survey. Cough 2007 3 5
18. Widdicombe J. Neurophysiology of the cough reflex. Eur Respir J 1995 8 1193-1202
19. Davenport P W., Vovk A, Duke R K. et al. The urge-to-cough and cough motor response modulation by the central effects of nicotine. Pulm Pharmacol Ther 2009 22 82-89
20. Braman S S., Corrao W M. Cough: differential diagnosis and treatment. Clin Chest Med 1987 8 177-188
21. Kohler D. Physiologie und Pathologie des Hustens. Pneumologie 2008 62 (Suppl 1) S14-S17
22. Kardos P. Chronisch persistierender Husten (CHP). Pneumologie 1995 49 2-13
23. Irwin, R. Cough. In: R. Irwin, F. Curley, R. Grossmann, eds. Symptoms of the Respiratory Tract. Armonk, N.Y. USA Futura Publishing Company Inc. 1997 1-54
24. Kohler D, Vastag E. Bronchial clearance. Pneumologie 1991 45 314-332
25. Salem H, Aviado D. Antitussive Drugs. Am J Med Sci 1964 247 585-600
26. Irwin R S., Rosen M J., Braman S S. Cough. A comprehensive review. Arch Intern Med 1977 137 1186-1191
27. Ing A J., Ngu M C., Breslin A B. Pathogenesis Of Chronic Persistent Cough Associated with gastroesophageal reflux. Am J Respir Crit Care Med 1994 149 160-167
28. Irwin R S., Curley F J., French C L. Chronic Cough. The Spectrum And Frequency of causes, key components of the diagnostic evaluation, and outcome of specific therapy. Am Rev Respir Dis 1990 141 640-647
29. Poe R H., Harder R V., Israel R H. Chronic Persistent Cough. Experience In Diagnosis and outcome using an anatomic diagnostic protocol. Chest 1989 95 723-728
30. Mello C J., Irwin R S., Curley F J. Predictive Values Of The Character, Timing, and complications of chronic cough in diagnosing its cause. Arch Intern Med 1996 156 997-1003
31. Kardos P, Gebhardt T. Chronisch persistierender Husten (CPH) in der Praxis: Diagnostik und Therapie bei 329 Patienten in 2 Jahren. Pneumologie 1996 50 437-441
32. Palombini B C., Villanova C A., Arajo E et al. A pathogenic triad in chronic cough: asthma, postnasal drip syndrome, and gastroesophageal reflux disease. Chest 1999 116 279-284
33. McGarvey L P., Heaney L G., Lawson J T. et al. Evaluation and outcome of patients with chronic non-productive cough using a comprehensive diagnostic protocol [see comments]. Thorax 1998 53 738-743
34. Holinger L D. Chronic Cough In Infants And Children. Laryngoscope 1986 96 316-322
35. Holinger L D., Sanders A D. Chronic Cough In Infants And Children: an update. Laryngoscope 1991 101 596-605
36. Dettmar P W., Strugala V, Fathi H et al. The online cough clinic developing guideline-based diagnosis and advice. Eur Respir J 2009 34 819-824
37. Pavord I D., Chung K F. Management of chronic cough. Lancet 2008 371 1375-1384
38. Corren J. The Impact Of Allergic Rhinitis On bronchial asthma. J Allergy Clin Immunol 1998 101 S352-S356
39. Hewlett E L., Edwards K M. Pertussis Not Just for Kids. N Engl J Med 2005 352 1215-1222
40. Poe R H., Israel R H., Utell M J. et al. Chronic Cough: Bronchoscopy Or Pulmonary Function testing? Am Rev Respir Dis 1982 126 160-162
41. Smyrnios N A., Irwin R S., Curley F J. Chronic Cough With A History Of excessive sputum production. The spectrum and frequency of causes, key components of the diagnostic evaluation, and outcome of specific therapy. Chest 1995 108 991-997
42. Irwin R S., Corrao W M., Pratter M R. Chronic Persistent Cough In The Adult: the spectrum and frequency of causes and successful outcome of specific therapy. Am Rev Respir Dis 1981 123 413-417
43. Irwin R S., Madison J M. Review Articles: Primary Care: The Diagnosis and Treatment of Cough. [Record Supplied By Publisher]. N Engl J Med 2000 343 1715-1721
44. Irwin R S., Madison J M. The Persistently Troublesome Cough. Am J Respir Crit Care Med 2002 165 1469-1474
45. Macfarlane J T., Colville A, Guion A et al Prospective study of aetiology and outcome of adult lower-respiratory-tract infections in the community. Lancet 1993 341 511-514
46. Arroll B, Kenealy T. Antibiotics for acute bronchitis. BMJ 2001 322 939-940
47. Heikkinen T, Järvinen A. The common cold. Lancet 2003 361 51-59
48. interdisziplinäre arbeitsgruppe allergische rhinitis der sektion hno allergische rhinokonjunktivitis. leitlinie der deutschen gesellschaft f̈r allergologie und klinische immunologie. Allergo J 2003 12 182-194
49. Buhl R, Berdel D, Criee C P. et al. Leitlinie zur Diagnostik und Therapie von Patienten mit Asthma. Pneumologie 2006 60 139-177
50. Gillissen A, Richter A, Oster H. Clinicalet al. efficacy of short-term treatment with extra-fine HFA beclomethasone dipropionate in patients with post-infectious persistent cough. J Physiol Pharmacol 2007 58 (Suppl 5) 223-232
51. Barber C M., Curran A D., Fishwick D et al. Impaired cough reflex in patients with recurrent pneumonia. Thorax 2003 58 645-646
52. Hoeffken G, Lorenz J, Kern W et al. Epidemiologie, Diagnostik, antimikrobielle Therapie und Management von erwachsenen Patienten mit ambulant erworbenen unteren Atemwegsinfektionen sowie ambulant erworbener Pneumonie Update 2009. Pneumologie 2009 63 e1-e68
53. Stein P D., Willis P W., DeMets D L. History and physical examination in acute pulmonary embolism in patients without preexisting cardiac or pulmonary disease. Am J Cardiol 1981 47 218-223
54. Brunnee T, Graf K, Kastens B et al. Bronchial hyperreactivity in patients with moderate pulmonary circulation overload. Chest 1993 103 1477-1481
55. Pison C, Malo J L., Rouleau J L. et al. Bronchial hyperresponsiveness to inhaled methacholine in subjects with chronic left heart failure at a time of exacerbation and after increasing diuretic therapy. Chest 1989 96 230-235
56. Irani F, Sanchis J. Inspiration- and cough-induced atrioventricular block. Can Med Assoc J 1971 105 735-736
57. Brandon N. Premature atrial contraction as an etiology for cough. Chest 2008 133 828
58. Baron S B., Huang S K. Cough syncope presenting as Mobitz type II atrioventricular block - an electrophysiologic correlation. Pacing Clin Electrophysiol 1987 10 65-69
59. Saito D, Matsuno S, Matsushita K et al. Cough syncope due to atrio-ventricular conduction block. Jpn Heart J 1982 23 1015-1020
60. Hart G, Oldershaw P J., Cull R E. et al. Syncope caused by cough-induced complete atrioventricular block. Pacing Clin Electrophysiol 1982 5 564-566
61. Mitton M. Paroxysmal atrioventricular block in a healthy patient receiving spinal anesthesia: a case report. AANA J 1993 61 605-609
62. Groneberg-Kloft B, Feleszko W, Dinh Q T. et al. Analysis and evaluation of environmental tobacco smoke exposure as a risk factor for chronic cough. Cough 2007 3 6
63. McGarvey L P., Forsythe P, Heaney L G. et al. Bronchoalveolar lavage findings in patients with chronic nonproductive cough. Eur Respir J 1999 13 59-65
64. Lee S Y., Cho J Y., Shim J J. et al. Airway inflammation as an assessment of chronic nonproductive cough. Chest 2001 120 1114-1120
65. Nelson S, Summer W R., Mason C M. The role of the inflammatory response in chronic bronchitis: therapeutic implications. Semin Respir Infect 2000 15 24-31
66. Kanner R E., Connett J E., Williams D E. et al. Effects of randomized assignment to a smoking cessation intervention and changes in smoking habits on respiratory symptoms in smokers with early chronic obstructive pulmonary disease: the Lung Health Study. Am J Med 1999 106 410-416
67. Krzyzanowski M, Robbins D R., Lebowitz M D. Smoking cessation and changes in respiratory symptoms in two populations followed for 13 years. Int J Epidemiol 1993 22 666-673
68. Tashkin D P., Clark V A., Coulson A H. et al. The UCLA population studies of chronic obstructive respiratory disease. VIII. Effects of smoking cessation on lung function: a prospective study of a free-living population. Am Rev Respir Dis 1984 130 707-715
69. Smith J A., Calverley P M. Cough in chronic obstructive pulmonary disease. Pulm Pharmacol Ther 2004 17 393-398
70. Burgel P R., Nesme-Meyer P, Chanez P et al. Cough and sputum production are associated with frequent exacerbations and hospitalizations in COPD subjects. Chest 2009 135 975-982
71. Vogelmeier C, Buhl R, Criee C P. et al. Leitlinie der Deutschen Atemwegsliga and der Deutschen Gesellschaft f̈r Pneumologie und Beatmungsmedizin zur Diagnostik und Therapie von Patienten mit chronisch obstruktiver Bronchitis und Lungenemphysem (COPD). Pneumologie 2007 61 e1-e40
72. Abouzgheib W, Pratter M R., Bartter T. Cough and asthma. Curr Opin Pulm Med 2007 13 44-48
73. Berg P, Wehrli R, Medici T C. [Asthmatic Cough. Monosymptomatic Bronchial Asthma In the form of a chronic cough] Asthmahusten. Das monosymptomatische Bronchialasthma in Form von chronischem Husten. Dtsch Med Wochenschr 1986 111 1730-1731
74. Connell E J., Rojas A R., Sachs M I. Cough-type asthma: a review. Ann Allergy 1991 66 278-282, 285
75. Corrao W M., Braman S S., Irwin R S. Chronic Cough As The Sole Presenting manifestation of bronchial asthma. N Engl J Med 1979 300 633-637
76. Frans A, Van Den Eeckhaut J. Cough As The Sole Manifestation Of airway hyperreactivity. J Laryngol Otol 1989 103 680-682
77. Johnson D, Osborn L M. Cough Variant Asthma: A Review Of the clinical literature. J Asthma 1991 28 85-90
78. Nowak D, Heinrich J, Jorres R et al. Prevalence of respiratory symptoms, bronchial hyperresponsiveness and atopy among adults: west and east Germany. Eur Respir J 1996 9 2541-2552
79. Sears M R., Jones D T., Holdaway M D. et al. Prevalence of bronchial reactivity to inhaled methacholine in New Zealand children. Thorax 1986 41 283-289
80. Dicpinigaitis P. Zafirlukast in cough-variant Asthma. J Asthma 2002 39 291-297
81. Fujimura M, Ogawa H, Nishizawa Y et al. Comparison of atopic cough with cough variant asthma: is atopic cough a precursor of asthma? Thorax 2003 58 14-18 (Pubitemid 36135352)
82. McGarvey L, Morice A H., Fujimura M et al. Atopic cough: little evidence to support a new clinical entity. Thorax 2003 58 736-737
83. Gibson P G., Dolovich J, Denburg J et al. Chronic Cough: Eosinophilic Bronchitis Without Asthma. Lancet 1989 1 1346-1348
84. Kardos P. Eosinophile Bronchitis ohne Asthma: eine weitere seltene Ursache f̈r chronisch persistirenden Husten? Pneumologie 2001 55 249-252
85. Brightling C E., Ward R, Goh K L. et al. Eosinophilic Bronchitis Is an Important Cause of Chronic Cough. Am J Respir Crit Care Med 1999 160 406-410
86. Sato S, Saito J, Sato Y et al. Clinical usefulness of fractional exhaled nitric oxide for diagnosing prolonged cough. Respir Med 2008 102 1452-1459
87. Lee J J., Lin R L., Chen C H. et al. Clinical manifestations of bronchogenic carcinoma. J Formos Med Assoc 1992 91 146-151
88. Hyde L, Hyde C I. Clinical manifestations of lung cancer. Chest 1974 65 299-306
89. Saito Y, Nagamoto N, Ota S et al. Results of surgical treatment for roentgenographically occult bronchogenic squamous cell carcinoma. J Thorac Cardiovasc Surg 1992 104 401-407
90. Skaug K, Eide G E., Gulsvik A. Prevalence and predictors of symptoms in the terminal stage of lung cancer: A community study. Chest 2007 131 389-394
91. Fathi H, Morice A H. Cough in palliative care. Progress in Palliative Care 2008 16 31-37
92. Hage R, de la Riviere A B., Seldenrijk C A. et al. Update in pulmonary carcinoid tumors: a review article. Ann Surg Oncol 2003 10 697-704
93. Bolser D C. Older-generation antihistamines and cough due to upper airway cough syndrome (UACS): efficacy and mechanism. Lung 2008 186 (Suppl 1) S74-S77
94. Corsico A G., Villani S, Zoia M C. et al. Chronic productive cough in young adults is very often due to chronic rhino-sinusitis. Monaldi Arch Chest Dis 2007 67 90-94
95. Federspil P. Antibiotische Therapie von Infektionen im Bereich von Kopf und Hals. Deutsche Gesellschaft für Hals-, Nasen-, Ohrenheilkunde, Kopf- und Halschirurgie. Laryngorhinootologie 2000 79 366-377
96. Dt. Ges. f. Hals-Nasen-Ohren-Heilkunde. KuH-C Leitlinie Reizhusten/R?usperzwang Erwachsene (Klinischer Algorithmus). HNO-Mitteilungen 1997 47 6S
97. Karkos P D., Wilson J A. Empiric treatment of laryngopharyngeal reflux with proton pump inhibitors: a systematic review. Laryngoscope 2006 116 144-148
98. Karkos P D., Potamianos S P., Apostolidis M T. et al. When Gastroenterology Met Otolaryngology: Laryngopharyngeal Reflux. The American Journal of Medicine 2006 119 e19-e20
99. Morice A H. Is reflux cough due to gastroesophageal reflux disease or laryngopharyngeal reflux? Lung 2008 186 S103-S106
100. Morice A, Everett C F., Mulrennan S A. et al. Exhaled breath condensate in chronic cough. Thorax 2005 60 259
101. Niimi A, Nguyen L T., Usmani O et al. Reduced pH and chloride levels in exhaled breath condensate of patients with chronic cough. Thorax 2004 59 608-612
102. Lee B, Woo P. Chronic cough as a sign of laryngeal sensory neuropathy: diagnosis and treatment. Ann Otol Rhinol Laryngol 2005 114 253-257
103. Morice A H., Fontana G A., Sovijarvi A RA et al. The diagnosis and management of chronic cough. Eur Respir J 2004 24 481-492
104. Christopher K L., Wood R P., Eckert R C. et al. Vocal-cord dysfunction presenting as asthma. N Engl J Med 1983 308 1566-1570
105. Balkissoon R. Vocal cord dysfunction, gastroesophageal reflux disease, and nonallergic rhinitis. Clin Allergy Immunol 2007 19 411-426
106. Newman K B., Mason U G., Schmaling K B. Clinical features of vocal cord dysfunction. Am J Respir Crit Care Med 1995 152 1382-1386
107. Thomas P S., Geddes D M., Barnes P J. Pseudo-steroid resistant asthma. Thorax 1999 54 352-356
108. Gibson P G., Vertigan A E. Speech pathology for chronic cough: A new approach. Pulm Pharmacol Ther 2009 22 159-162
109. Kenn K, Schmitz M. Vocal cord dysfunction, an important differential diagnosis of severe and implausible bronchial asthma. Pneumologie 1997 51 14-18
110. Vertigan A E., Gibson P G., Theodoros D G. et al. A review of voice and upper airway function in chronic cough and paradoxical vocal cord movement. Curr Opin Allergy Clin Immunol 2007 7 37-42
111. Kenn K. Vocal Cord Dysfunction (VCD) was wissen wir heute? Pneumologie 2007 61 431-439
112. Hollenz M, Stolte M, Labenz J. Prevalence of gastro-oesophageal reflux disease in general practice. Dtsch Med Wochenschr 2002 127 1007-1012
113. Schepp W, Allescher H D., Frieling T et al. Gastroösophageale Refluxkrankheit, Definitionen, DGVS-Leitlinien. Z Gastroenterol 2005 43 165-168
114. Koop H, Schepp W, Muller-Lissner S et al. Gastroösophageale Refluxkrankheit, DGVS-Leitlinien. Z Gastroenterol 2005 43 163-164
115. Dent J, Brun J, Fendrick A M. et al. An evidence-based appraisal of reflux disease management the Genval Workshop Report. Gut 1998 44 S1-S16
116. Fuchs K H., Eypasch E. Gastroesophageal reflux disease. In: Neugebauer E., ed. EAES Guidelines for Endoscopic Surgery. Heidelberg, New York Springer 2010 125-142
117. Kahrilas P J., Shaheen N J., Vaezi M F. American Gastroenterological Association Institute technical review on the management of gastroesophageal reflux disease. Gastroenterology 2008 135 1392-1413, 1413
118. Ing A J., Ngu M C., Breslin A B. Chronic Persistent Cough And Gastro-oesophageal Reflux. Thorax 1991 46 479-483
119. Irwin R S., French C L., Curley F J. et al. Chronic Cough Due To Gastroesophageal Reflux. Clinical, diagnostic, and pathogenetic aspects [see comments]. Chest 1993 104 1511-1517
120. Irwin R S., Zawacki J K., Curley F J. et al. Chronic Cough As The Sole Presenting manifestation of gastroesophageal reflux. Am Rev Respir Dis 1989 140 1294-1300
121. Demeter P, Pap A. The relationship between gastroesophageal reflux disease and obstructive sleep apnea. J Gastroenterol 2004 39 815-820 (Pubitemid 39409660)
122. Paterson W G., Murat B W. Combined ambulatory esophageal manometry and dual-probe pH-metry in evaluation of patients with chronic unexplained cough. Dig Dis Sci 1994 39 1117-1125
123. Patterson N, Mainie I, Rafferty G et al. Nonacid Reflux Episodes Reaching the Pharynx are Important Factors Associated With Cough. J Clin Gastroenterol 2009 43 414-419
124. Muller-Lissner S, Fibbe C, Frieling T et al. Gastroösophageale Refluxkrankheit, Diagnostik, DGVS-Leitlinien. Z Gastroenterol 2005 43 168-175
125. Howaizi M, Delafosse C. Omeprazole-induced intractable cough. Ann Pharmacother 2003 37 1607-1609
126. Leite L P., Johnston B T., Just R J. et al. Persistent acid secretion during omeprazole therapy: a study of gastric acid profiles in patients demonstrating failure of omeprazole therapy. Am J Gastroenterol 1996 91 1527-1531
127. Katzka D A., Paoletti V, Leite L et al. Prolonged ambulatory pH monitoring in patients with persistent gastroesophageal reflux disease symptoms: testing while on therapy identifies the need for more aggressive anti-reflux therapy. Am J Gastroenterol 1996 91 2110-2113
128. Johnston B T., Gideon R M., Castell D O. Excluding Gastroesophageal Reflux Disease As The cause of chronic cough [editorial]. J Clin Gastroenterol 1996 22 168-169
129. Ours T M., Kavuru M S., Schilz R J. et al. A prospective evaluation of esophageal testing and a double-blind, randomized study of omeprazole in a diagnostic and therapeutic algorithm for chronic cough. Am J Gastroenterol 1999 94 3131-3138
130. Mainie I, Tutuian R, Shay S et al. Acid and non-acid reflux in patients with persistent symptoms despite acid suppressive therapy: A multicentre study using combined ambulatory impedance-pH monitoring. Gut 2006 55 1398-1402
131. Agrawal A, Roberts J, Sharma N et al. Symptoms with acid and nonacid reflux may be produced by different mechanisms. Dis Esophagus 2009 22 467-470
132. Cool M, Poelmans J, Feenstra L et al. Characteristics and clinical relevance of proximal esophageal pH monitoring. Am J Gastroenterol 2004 99 2317-2323
133. Wo J M., Koopman J, Harrell S P. et al. Double-blind, placebo-controlled trial with single-dose pantoprazole for laryngopharyngeal reflux. Am J Gastroenterol 2006 101 1972-1978
134. Golub J S., Johns M M. III, Lim J H. et al. Comparison of an oropharyngeal pH probe and a standard dual pH probe for diagnosis of laryngopharyngeal reflux. Ann Otol Rhinol Laryngol 2009 118 1-5
135. Poe R H., Kallay M C. Chronic Cough and Gastroesophageal Reflux Disease: Experience With Specific Therapy for Diagnosis and Treatment. Chest 2003 123 679-684
136. Vaezi M F., Richter J E. Twenty-four-hour Ambulatory Esophageal PH Monitoring In the diagnosis of acid reflux-related chronic cough. South Med J 1997 90 305-311
137. Lazenby J P., Harding S M. Chronic cough, asthma, and gastroesophageal reflux. Curr Gastroenterol Rep 2000 2 217-223
138. Koufman J A., Aviv J E., Casiano R R. et al. Laryngopharyngeal reflux: position statement of the committee on speech, voice, and swallowing disorders of the American Academy of Otolaryngology-Head and Neck Surgery. Otolaryngol Head Neck Surg 2002 127 32-35
139. Galmiche J P., Zerbib F, Bruley des V. Review article: respiratory manifestations of gastro-oesophageal reflux disease. Aliment Pharmacol Ther 2008 27 449-464
140. Chang A B., Lasserson T J., Kiljander T O. et al. Systematic review and meta-analysis of randomised controlled trials of gastro-oesophageal reflux interventions for chronic cough associated with gastro-oesophageal reflux. BMJ 2006 332 11-17
141. Irwin R S., Zawacki J K., Wilson M M. et al. Chronic cough due to gastroesophageal reflux disease: failure to resolve despite total/near-total elimination of esophageal acid. Chest 2002 121 1132-1140
142. Fathi H, Moon T, Donaldson J et al. Cough in adult cystic fibrosis: diagnosis and response to fundoplication. Cough 2009 5 1
143. Novitsky Y W., Zawacki J K., Irwin R S. et al. Chronic cough due to gastroesophageal reflux disease: efficacy of antireflux surgery. Surg Endosc 2002 16 567-571
144. Allen C J., Anvari M. Does laparoscopic fundoplication provide long-term control of gastroesophageal reflux related cough? Surg Endosc 2004 18 633-637
145. Westcott C J., Hopkins M B., Bach K et al. Fundoplication for laryngopharyngeal reflux disease. J Am Coll Surg 2004 199 23-30
146. Brouwer R, Kiroff G K. Improvement of respiratory symptoms following laparoscopic Nissen fundoplication. ANZ J Surg 2003 73 189-193
147. Kaufman J A., Houghland J E., Quiroga E et al. Long-term outcomes of laparoscopic antireflux surgery for gastroesophageal reflux disease (GERD)-related airway disorder. Surg Endosc 2006 20 1824-1830
148. Catania R A., Kavic S M., Roth J S. et al. Laparoscopic Nissen fundoplication effectively relieves symptoms in patients with laryngopharyngeal reflux. J Gastrointest Surg 2007 11 1579-1587
149. Fuchs K H., Fischbach W, Labenz J et al. Gastroösophageale Refluxkrankheit, Chirurgische Therapie, DGVS-Leitlinien. Z Gastroenterol 2005 43 191-194
150. Lundell L, Attwood S, Ell C et al. Comparing laparoscopic antireflux surgery with esomeprazole in the management of patients with chronic gastro-oesophageal reflux disease: a 3-year interim analysis of the LOTUS trial. Gut 2008 57 1207-1213
151. Dicpinigaitis P V. Chronic cough due to asthma: ACCP evidence-based clinical practice guidelines. Chest 2006 129 75S-79S
152. Pandey C K., Raza M, Ranjan R et al. Intravenous lidocaine suppresses fentanyl-induced coughing: a double-blind, prospective, randomized placebo-controlled study. Anesth Analg 2004 99 1696-1698, table
153. Elli A, Aroldi A, Montagnino G et al. Mycophenolate mofetil and cough. Transplantation 1998 66 409
154. Hamel H, Bonniaud P, Sgro C et al. Chronic cough under treatment with paroxetine. Presse Med 2000 29 1045
155. Adibelli Z, Dilek M, Kocak B et al. An unusual presentation of sirolimus associated cough in a renal transplant recipient. Transplant Proc 2007 39 3463-3464
156. Chondrogiannis K D., Siontis G C., Koulouras V P. et al. Acute lung injury probably associated with infusion of propofol emulsion. Anaesthesia 2007 62 835-837
157. Choudry N B., Fuller R W., Pride N B. Sensitivity of the human cough reflex: effect of inflammatory mediators prostaglandin E2, bradykinin, and histamine. Am Rev Respir Dis 1989 140 137-141
158. Israili Z H., Hall W D. Cough And Angioneurotic Edema Associated With angiotensin-converting enzyme inhibitor therapy. A review of the literature and pathophysiology [see comments]. Ann Intern Med 1992 117 234-242
159. Lacourciere Y, Brunner H, Irwin R et al. Effects of modulators of the renin-angiotensin-aldosterone system on cough. Losartan Cough Study Group. J Hypertens 1994 12 1387-1393
160. Wright S W., Edwards K M., Decker M D. et al. Pertussis infection in adults with persistent cough. JAMA 1995 273 1044-1046
161. Boulouffe C, Vanpee D. Increasing cause of cough among adults. Emerg Med Australas 2008 20 280-283
162. Birkebaek N H., Kristiansen M, Seefeldt T et al. Bordetella pertussis and chronic cough in adults. Clin Infect Dis 1999 29 1239-1242
163. Jackson L A., Cherry J D., Wang S P. et al. Frequency of serological evidence of Bordetella infections and mixed infections with other respiratory pathogens in university students with cough illnesses. Clin Infect Dis 2000 31 3-6
164. Vincent J M., Cherry J D., Nauschuetz W F. et al. Prolonged afebrile nonproductive cough illnesses in American soldiers in Korea: a serological search for causation. Clin Infect Dis 2000 30 534-539
165. Centers for Disease Control and Prevention (CDC). Outbreaks of respiratory illness mistakenly attributed to pertussis New Hampshire, Massachusetts, and Tennessee, 20042006. MMWR Morb Mortal Wkly Rep 2007 56 837-842
166. Schaberg T, Forssbohm M, Hauer B et al. Richtlinien zur medikamentösen Behandlung der Tuberkulose im Erwachsenen- und Kindesalter. Pneumologie 2001 55 494-511
167. Ip M S., So S Y., Lam W K. et al. Endobronchial tuberculosis revisited. Chest 1986 89 727-730
168. Lee J H., Park S S., Lee D H. et al. Endobronchial tuberculosis. Clinical and bronchoscopic features in 121 cases [published erratum appears in Chest 1993 May; 103(5): 1640]. Chest 1992 102 990-994
169. Pierson D J., Lakshminarayan S, Petty T L. Endobronchial tuberculosis. Chest 1973 64 537-539
170. Stec S M., Grabczak E M., Bielicki P et al. Diagnosis and management of premature ventricular complexes-associated chronic cough. Chest 2009 135 1535-1541
171. Stec S, Dabrowska M, Zaborska B et al. Premature ventricular complex-induced chronic cough and cough syncope. Eur Respir J 2007 30 391-394
172. Niimi A, Kihara Y, Sumita Y et al. Cough reflex by ventricular premature contractions. Int Heart J 2005 46 923-926
173. Martin L, Gustaferro C. Chronic Cough Associated With Subacute Bacterial endocarditis. Mayo Clin Proc 1995 70 662-664
174. Shub C, Alexander B B. Persistent cough the presenting feature in unsuspected sarcoidosis: A case report. Mil Med 1971 136 757-758
175. Baughman R P., Iannuzzi M C., Lower E E. et al. Use of fluticasone in acute symptomatic pulmonary sarcoidosis. Sarcoidosis Vasc Diffuse Lung Dis 2002 19 198-204
176. Usalan C, Emri S. Exertional dyspnoea and nonproductive cough in a 22-year-old man. Postgrad Med J 2000 76 115-117
177. Kirsten D. Deutsche Gesellschaft f̈r Pneumologie: Empfehlungen für Diagnosis und Therapie der Sarkoidose. Pneumologie 1998 52 26-30
178. Lalloo U G., Lim S, DuBois R et al. Increased sensitivity of the cough reflex in progressive systemic sclerosis patients with interstitial lung disease. Eur Respir J 1998 11 702-705
179. Brown K K. Chronic cough due to chronic interstitial pulmonary diseases: ACCP evidence-based clinical practice guidelines. Chest 2006 129 180S-185S
180. Travis W D., King T EJ. American Thoracic Society/European Respiratory Society International Multidisciplinary Consensus Classification of the Idiopathic Interstitial Pneumonias. This joint statement of the American Thoracic Society (ATS), and the European Respiratory Society (ERS) was adopted by the ATS board of directors, June 2001 and by the ERS Executive Committee, June 2001. Am J Respir Crit Care Med 2002 165 277-304
181. Bargon J, Rust M, Kardos P et al. Salazosulfapyridine-induced eosinophilic pneumonia with pulmonary and cutaneous epithelioid cell granulomatosis in Sjögren syndrome. Pneumologie 1990 44 744-750
182. Imokawa S, Colby T V., Leslie K O. et al. Methotrexate pneumonitis: review of the literature and histopathological findings in nine patients. Eur Respir J 2000 15 373-381
183. Lengyel C, Boros I, Varkonyi T et al. Amiodarone-induced pulmonary fibrosis. Orv Hetil 1996 137 1759-1762
184. Martin W J., Rosenow E C. III. Amiodarone pulmonary toxicity. Recognition and pathogenesis (Part I). Chest 1988 93 1067-1075
185. Martin W J., Rosenow E C. III. Amiodarone pulmonary toxicity. Recognition and pathogenesis (Part 2). Chest 1988 93 1242-1248
186. Zingg K, Grossenbacher M, Conen D et al. Methotrexate pneumonitis. Schweiz Rundsch Med Prax 1999 88 573-578
187. Strimlan C V., Rosenow E C., Divertie M B. et al. Pulmonary manifestations of Sjögren's syndrome. Chest 1976 70 354-361
188. Cain H C., Noble P W., Matthay R A. Pulmonary manifestations of Sj?gren's syndrome. Clin Chest Med 1998 19 687-699, viii
189. Larson T S., Hall S, Hepper N G. et al. Respiratory tract symptoms as a clue to giant cell arteritis. Ann Intern Med 1984 101 594-597
190. Olopade C O., Sekosan M, Schraufnagel D E. Giant Cell Arteritis Manifesting As Chronic cough and fever of unknown origin. Mayo Clin Proc 1997 72 1048-1050
191. Breton J L., Ranfaing E, Depierre A et al. Bronchial involvement disclosing Wegener's granulomatosis. Rev Mal Respir 1986 3 153-155
192. Daum T E., Specks U, Colby T V. et al. Tracheobronchial involvement in Wegener's granulomatosis. Am J Respir Crit Care Med 1995 151 522-526
193. Spira A, Grossman R, Balter M. Large airway disease associated with inflammatory bowel disease. Chest 1998 113 1723-1726
194. Camus P, Piard F, Ashcroft T et al. The lung in inflammatory bowel disease. Medicine (Baltimore) 1993 72 151-183
195. Fontana G A., Lavorini F, Pistolesi M. Water aerosols and cough. Pulm Pharmacol Ther 2002 15 205-211
196. Ebihara S, Saito H, Kanda A et al. Impaired Efficacy of Cough in Patients With Parkinson Disease. Chest 2003 124 1009-1015
197. Pitts T, Bolser D, Rosenbek J et al. Impact of expiratory muscle strength training on voluntary cough and swallow function in Parkinson disease. Chest 2009 135 1301-1308
198. Schonhofer B, Voshaar T, Kohler D. Long-term lung sequelae following accidental chlorine gas exposure. Respiration 1996 63 155-159
199. Brooks S M., Weiss M A., Bernstein I L. Reactive airways dysfunction syndrome (RADS). Persistent asthma syndrome after high level irritant exposures. Chest 1985 88 376-384
200. Brooks S M., Hammad Y, Richards I et al. The spectrum of irritant-induced asthma: sudden and not-so-sudden onset and the role of allergy. Chest 1998 113 42-49
201. Rosen M J. Chronic cough due to bronchiectasis: ACCP evidence-based clinical practice guidelines. Chest 2006 129 122S-131S
202. Finegold I. Nontuberculous mycobacterial infection in the differential diagnosis of chronic cough. Allergy Asthma Proc 2008 29 343-344
203. Fujimoto T, Hillejan L, Stamatis G. Current strategy for surgical management of bronchiectasis. Ann Thorac Surg 2001 72 1711-1715
204. Kutlay H, Cangir A K., Enon S et al. Surgical treatment in bronchiectasis: analysis of 166 patients. Eur J Cardiothorac Surg 2002 21 634-637
205. Prieto D, Bernardo J, Matos M J. et al. Surgery for bronchiectasis. Eur J Cardiothorac Surg 2001 20 19-24
206. Imaizumi H, Kaneko M, Mori K et al. Reversible acquired tracheobronchomalacia of a combined crescent type and saber-sheath type. J Emerg Med 1995 13 43-49
207. Loring S H., O'Donnell C R., Feller-Kopman D J. et al. Central Airway Mechanics and Flow Limitation in Acquired Tracheobronchomalacia. Chest 2007 131 1118-1124
208. Bonnet R, Jorres R, Downey R et al. Intractable cough associated with the supine body position. Effective therapy with nasal CPAP. Chest 1995 108 581-585
209. Rapti A, Drossos C, Tzavelas D et al. Mounier-Kuhn syndrome (tracheobronchomegaly). Monaldi Arch Chest Dis 1995 50 195-198
210. Schwartz M, Rossoff L. Tracheobronchomegaly. Chest 1994 106 1589-1590
211. Kirchner J, Jacobi V, Kardos P et al. CT findings in extensive tracheobronchial amyloidosis. Eur Radiol 1998 8 352-354
212. Molina J F., Espinoza L R. Relapsing polychondritis. Baillieres Best Pract Res Clin Rheumatol 2000 14 97-109
213. Leske V, Lazor R, Coetmeur D et al. Tracheobronchopathia osteochondroplastica: A study of 41 patients. Medicine (Baltimore) 2001 80 378-390
214. Sutor G C., Glaab T, Eschenbruch C et al. Tracheobronchopathie osteochondroplastica: Eine ungew?hnliche Ursache einer Retentionspneumonie. Pneumologie 2001 55 563-567
215. Sen R P., Walsh T E. Fiberoptic bronchoscopy for refractory cough. Chest 1991 99 33-35
216. Willms H, Wiechmann V, Sack U et al. Tracheobronchopathia osteochondroplastica: A rare cause of chronic cough with haemoptysis. Cough 2008 4 4
217. Derkay C S., Wiatrak B. Recurrent respiratory papillomatosis: A review. Laryngoscope 2008 118 1236-1247
218. Guillou L, Sahli R, Chaubert P et al. Squamous cell carcinoma of the lung in a nonsmoking, nonirradiated patient with juvenile laryngotracheal papillomatosis. Evidence of human papillomavirus-11 DNA in both carcinoma and papillomas. Am J Surg Pathol 1991 15 891-898
219. Sweriduk S T., DeLuca S A. Juvenile laryngotracheal papillomatosis. Am Fam Physician 1986 33 155-156
220. Nagel S, Busch C, Blankenburg T et al. Behandlung der respiratorischen Papillomatose. Kasuistik zur systemischen Therapie mit Bevacizumab. Pneumologie 2009 63 387-389
221. Walther E K., Herberhold C. Treatment of laryngotracheal papillomatosis with combined use of laser surgery and intralesional administration of alpha-interferon (Roferon). Laryngorhinootologie 1993 72 485-491
222. Kujat A, Gillissen A, Zuber M A. Genetische Diagnose und Beratung bei Bronchiektasie. Erstdiagnose der zystischen Fibrose bei Erwachsenen. Dtsch Med Wochenschr 2002 127 501-502
223. Birring S S., Ing A J., Chan K et al. Obstructive sleep apnoea: A cause of chronic cough. Cough 2007 3 7
224. Widdicombe J. Upper airway reflexes. Curr Opin Pulm Med 1998 4 376-382
225. Lee P C., Cotterill J, Eccles R. Voluntary control of cough. Pulm Pharmacol Ther 2002 15 317-320
226. French C L., Irwin R S., Curley F J. et al. Impact of chronic cough on quality of life. Arch Intern Med 1998 158 1657-1661
227. Haque R A., Usmani O S., Barnes P J. Chronic idiopathic cough: a discrete clinical entity? Chest 2005 127 1710-1713
228. McGarvey L P. Does idiopathic cough exist? Lung 2008 186 (Suppl 1) S78-S81
229. Morice A H., Lowry R, Brown M J. et al. Angiotensin-converting enzyme and the cough reflex. Lancet 1987 2 1116-1118
230. Fuller R W. Cough provocation tests: Their clinical value. Pulm Pharmacol Ther 2002 15 273-276
231. McGarvey L P. Cough * 6: Which investigations are most useful in the diagnosis of chronic cough? Thorax 2004 59 342-346
232. Birring S S., Brightling C, Symon F et al. Idiopathic chronic cough: association with organA specific autoimmune disease and bronchoalveolar lymphocytosis. Thorax 2003 58 1066-1070
233. Altiner A, Wilm S, Daubener W et al. Sputum colour for diagnosis of a bacterial infection in patients with acute cough. Scand J Prim Health Care 2009 27 1-4
234. Irwin R S., Baumann M H., Bolser D C. et al. Diagnosis and management of cough executive summary: ACCP evidence-based clinical practice guidelines. Chest 2006 129 1S-23S
235. Macfarlane J, Holmes W, Gard P et al. Prospective study of the incidence, aetiology and outcome of adult lower respiratory tract illness in the community. Thorax 2001 56 109-114
236. Butler C C., Hood K, Verheij T et al. Variation in antibiotic prescribing and its impact on recovery in patients with acute cough in primary care: prospective study in 13 countries. BMJ 2009 338 b2242
237. Verheij T J., Hermans J, Mulder J D. Effects of doxycycline in patients with acute cough and purulent sputum: a double blind placebo controlled trial. Br J Gen Pract 1994 44 400-404
238. Jones A, Rowe B. Bronchopulmonary hygiene physical therapy for chronic obstructive pulmonary disease and bronchiectasis. The Cochrane Library 2. Oxford Update Software Ltd 2002
239. Mazzocco M C., Owens G R., Kirilloff L H. et al. Chest percussion and postural drainage in patients with bronchiectasis. Chest 1985 88 360-363
240. Gallon A. Evaluation of chest percussion in the treatment of patients with copious sputum production. Respir Med 1991 85 45-51
241. Sutton P P., Lopez V, Pavia D et al. Assessment of percussion, vibratory-shaking and breathing exercises in chest physiotherapy. Eur J Respir Dis 1985 66 147-152
242. Sutton P P., Parker R A., Webber B A. et al. Assessment of the forced expiration technique, postural drainage and directed coughing in chest physiotherapy. Eur J Respir Dis 1983 64 62-68
243. Lannefors L, Wollmer P. Mucus clearance with three chest physiotherapy regimes in cystic fibrosis: a comparison between postural drainage, PEP and physical exercise. Eur Respir J 1992 5 748-753
244. Mortensen J, Falk M, Groth S et al. The effects of postural drainage and positive expiratory pressure physiotherapy on tracheobronchial clearance in cystic fibrosis. Chest 1991 100 1350-1357
245. Miller S, Hall D O., Clayton C B. et al. Chest physiotherapy in cystic fibrosis: a comparative study of autogenic drainage and the active cycle of breathing techniques with postural drainage. Thorax 1995 50 165-169
246. Bott J, Blumenthal S, Buxton M et al. Guidelines for the physiotherapy management of the adult, medical, spontaneously breathing patient. Thorax 2009 64 i1-52
247. NICE Chronic Obstructive Pulmonary Disease National Clinical Guideline on Management. Thorax 2004 59 1-232
248. Gosselink R. Therapie, Training, Tests. In: Van den Berg F, ed. Angewandte Physiologie. Stuttgart New York Georg Thieme Verlag 2001 275-276
249. Hietpas B, Roth R. Huff coughing and airway patency. Respir Care 1979 24 710-713
250. Watkin G, Willig B W., Mutalithas K, Pavord I D., Birring S S. Improvement in Health Status following Outpatient Chest Physiotherapie for Patients with Refractory Chronic Cough. Thorax 2006 61 (Suppl 2) ii92
251. Jones A P., Rowe B H. Bronchopulmonary hygiene physical therapy for chronic obstructive pulmonary disease and bronchiectasis. Cochrane Database of Systematic Reviews 1998, Issue 4. Art. No.: CD000045
252. Pillastrini P, Bordini S, Bazzocchi G et al. Study of the effectiveness of bronchial clearance in subjects with upper spinal cord injuries: Examination of a rehabilitation programme involving mechanical insufflation and exsufflation. Spinal Cord 2006 44 614-616
253. Chatwin M, Ross E, Hart N et al. Cough augmentation with mechanical insufflation/exsufflation in patients with neuromuscular weakness. Eur Respir J 2003 21 502-508
254. Lauber B, Lauber J. Krankengymnastische Atemtherapie. In: Nolte D, ed. Manuale Pneumologicum. Deisenhofen bei M?nchen Dustri-Verlag Dr. Karl Feistle 1992 7
255. Cegla U H., Retzow A. Physiotherapy mit VRP1 bei chronisch obstruktiven Atemwegserkrankungen. Ergebnisse einer multizentrischen Vergleichsstudie. Pneumologie 1993 47 636-639
256. Thompson C S., Harrison S, Ashley J et al. Randomised crossover study of the Flutter device and the active cycle of breathing technique in non-cystic fibrosis bronchiectasis. Thorax 2002 57 446-448
257. Patterson J E., Bradley J M., Hewitt O et al. Airway clearance in bronchiectasis: a randomized crossover trial of active cycle of breathing techniques versus Acapella. Respiration 2005 72 239-242
258. Cegla U H., Jost H J., Harten A et al. Verlauf bei schwerer COPD mit und ohne Physiotherapie mit dem RC-Cornet. Pneumologie 2002 56 418-424
259. Cegla U H., Bautz M, Frode G et al. Physiotherapie bei Patienten mt COPD und tracheobronchialer Instabilität. Vergleich von zwei oszillierenden PEP Systemen (RC-Cornet, VRP1 Desitin). Ergebnisse einer randomisierten, prospektiven Studie mit 90 Patienten. Pneumologie 1997 51 129-136
260. Nakamura S, Mikami M, Kwakami M. Comparative evaluation of the Flutter and the Cornet in improving the cohesiveness of sputum from patients with bronchiectasis. European Respiratory 1998 12 212S-213S
261. Chaisson K M., Walsh S, Simmons Z et al. A clinical pilot study: High frequency chest wall oscillation airway clearance in patients with amyotrophic lateral sclerosis. Amyotroph Lateral Scler 2006 7 107-111
262. Weise S, Kardos P, Pfeiffer-Kascha D et al. Empfehlungen zur physiotherapeutischen Atemtherapie, 2. Auflage. Bad Lippspringe, M?nchen, Orlando Deutsche Atemwegsliga & Dustri Verlag Dr. Karl Feistle 2008 1-49
263. Morice A H., Widdicombe J, Dicpinigaitis P et al. Understanding cough. Eur Respir J 2002 19 6-7
264. Gillissen A. Is therapy for lung diseases with secretolytics useful?. Dtsch Med Wochenschr 2009 134 1237
265. Hausen T. Therapie von obstruktiven Atemwegserkrankungen. MMW-Fortschr Med 1991 46 700-703
266. Lurie A, Mestiri M, Huchon G et al. Methods for clinical assessment of expectorants: a critical review. Int J Clin Pharmacol Res 1992 12 47-52
267. Rubin B K. Mucolytics, expectorants, and mucokinetic medications. Respir Care 2007 52 859-865
268. Gillissen A, Tasci S, Ewig S et al. Sinn und Unsinn von Antitussiva. Internist (Berl) 2001 42 134-142
269. Shim C, King M, Williams M H. Jr. Lack of effect of hydration on sputum production in chronic bronchitis. Chest 1987 92 679-682
270. Marchette L C., Marchette B E., Abraham W M. et al. The effect of systemic hydration on normal and impaired mucociliary function. Pediatr Pulmonol 1985 1 107-111
271. Schroeder K, Fahey T. Systematic review of randomised controlled trials of over the counter cough medicines for acute cough in adults. BMJ 2002 324 329
272. Kemmerich B, Eberhardt R, Stammer H. Efficacy and tolerability of a fluid extract combination of thyme herb and ivy leaves and matched placebo in adults suffering from acute bronchitis with productive cough. A prospective, double-blind, placebo-controlled clinical trial. Arzneimittelforschung 2006 56 652-660
273. Kemmerich B. Evaluation of efficacy and tolerability of a fixed combination of dry extracts of thyme herb and primrose root in adults suffering from acute bronchitis with productive cough. A prospective, double-blind, placebo-controlled multicentre clinical trial. Arzneimittelforschung 2007 57 607-615
274. Koehler D. Inhalationstherapie bei chronischer Schleimretention. Pneumologie 1990 44 1166-1170
275. Haidl P, Schonhofer B, Siemon K et al. Inhaled isotonic alkaline versus saline solution and radioaerosol clearance in chronic cough. Eur Respir J 2000 16 1102-1108
276. Laube B L., Auci R M., Shields D E. et al. Effect of rhDNase on airflow obstruction and mucociliary clearance in cystic fibrosis. Am J Respir Crit Care Med 1996 153 752-760
277. Quan J M., Tiddens H A., Sy J P. et al. A two-year randomized, placebo-controlled trial of dornase alfa in young patients with cystic fibrosis with mild lung function abnormalities. J Pediatr 2001 139 813-820
278. Jones A P., Wallis C E. Recombinant human deoxyribonuclease for cystic fibrosis. Cochrane Database Syst Rev 2003 CD001127
279. Fuchs H J., Borowitz D S., Christiansen D H. et al. Effect of Aerosolized Recombinant Human DNase on Exacerbations of Respiratory Symptoms and on Pulmonary Function in Patients with Cystic Fibrosis. N Engl J Med 1994 331 637-642
280. Ghafouri M A., Patil K D., Kass I. Sputum changes associated with the use of ipratropium bromide. Chest 1984 86 387-393
281. Holmes P W., Barter C E., Pierce R J. Chronic persistent cough: use of ipratropium bromide in undiagnosed cases following upper respiratory tract infection. Respir Med 1992 86 425-429
282. Lowry R, Wood A, Johnson T et al. Antitussive properties of inhaled bronchodilators on induced cough. Chest 1988 93 1186-1189
283. Higenbottam T W. Anticholinergics and cough. Postgrad Med J 1987 63 (Suppl 1) 75-78
284. Shore S C., Weinberg E G. Ipratropium bromide inhalation for allergic rhinitis and chronic cough. S Afr Med J 1981 59 252
285. Pratter M R. Chronic upper airway cough syndrome secondary to rhinosinus diseases (previously referred to as postnasal drip syndrome): ACCP evidence-based clinical practice guidelines. Chest 2006 129 63S-71S
286. McLeod R L., Mingo G, O'Reilly S et al. Antitussive action of antihistamines is independent of sedative and ventilation activity in the guinea pig. Pharmacology 1998 57 57-64
287. Tay H L., Armoogum N, Tan L K. Nasal mucociliary clearance and salmeterol. Clin Otolaryngol 1997 22 68-70
288. Mortensen J, Lange P, Nyboe J et al. Lung mucociliary clearance. Eur J Nucl Med 1994 21 953-961
289. Hueston W. A comparison of albuterol and erythromycin for the treatment of acute bronchitis. J Fam Pract 1991 33 476-480
290. Smucny J J., Flynn C A., Becker L A. et al. Are beta2-agonists effective treatment for acute bronchitis or acute cough in patients without underlying pulmonary disease? A systematic review. J Fam Pract 2001 50 945-951
291. Pratter M R., Bartter T, Akers S et al. An Algorithmic Approach To Chronic Cough. Ann Intern Med 1993 119 977-983
292. Curley F J., Irwin R S., Pratter M R. et al. Cough and the common cold. Am Rev Respir Dis 1988 138 305-311
293. Corrao W M. Chronic Persistent Cough: Diagnosis And Treatment update. Pediatr Ann 1996 25 162-168
294. Smucny J, Fahey T, Becker L et al. Antibiotics for acute bronchitis. Cochrane Database Syst Rev 2004 CD000245
295. Angrill J, Agusti C, De Celis R et al. Bronchial Inflammation and Colonization in Patients with Clinically Stable Bronchiectasis. Am J Respir Crit Care Med 2001 164 1628-1632
296. Schaefer O P., Irwin R S. Unsuspected bacterial suppurative disease of the airways presenting as chronic cough. Am J Med 2003 114 602-606
297. Barker A F., Couch L, Fiel S B. et al. Tobramycin solution for inhalation reduces sputum Pseudomonas aeruginosa density in bronchiectasis. Am J Respir Crit Care Med 2000 162 481-485
298. Ramsey B W., Pepe M S., Quan J M. et al. Intermittent administration of inhaled tobramycin in patients with cystic fibrosis. Cystic Fibrosis Inhaled Tobramycin Study Group. N Engl J Med 1999 340 23-30
299. Steinfort D P., Steinfort C. Effect of long-term nebulized colistin on lung function and quality of life in patients with chronic bronchial sepsis. Intern Med J 2007 37 495-498
300. Tamm M, Eich C, Frei R et al. Inhalierbares Colistin bei zystischer Fibrose. Schweiz Med Wochenschr 2000 130 1366-1372
301. Ryan G, Mukhopadhyay S, Singh M. Nebulised anti-pseudomonal antibiotics for cystic fibrosis. Cochrane Database Syst Rev 2003 CD001021
302. Laitinen L A., Laitinen A, Haahtela T. A comparative study of the effects of an inhaled corticosteroid, budesonide, and a beta 2-agonist, terbutaline, on airway inflammation in newly diagnosed asthma: a randomized, double-blind, parallel-group controlled trial. Clin Exp.Allergy 1992 90 32-42
303. Higenbottam T. Cough induced by changes of ionic composition of airway surface liquid. Bull Eur Physiopathol Respir 1984 20 553-562
304. Chan P W., Debruyne J A. Inhaled nedocromil sodium for persistent cough in children. Med J Malaysia 2001 56 408-413
305. Young I H. Nedocromil sodium (Tilade) metered aerosol in the treatment of chronic cough. Med J Aust 1996 164 755
306. Moroni M, Porta C, Gualtieri G et al. Inhaled sodium cromoglycate to treat cough in advanced lung cancer patients. Br J Cancer 1996 74 309-311
307. Dicpinigaitis P V., Dobkin J B., Reichel J. Antitussive effect of the leukotriene receptor antagonist zafirlukast in subjects with cough-variant asthma. J Asthma 2002 39 291-297
308. Hansson L, Midgren B, Karlsson J A. Effects of inhaled lignocaine and adrenaline on capsaicin-induced cough in humans. Thorax 1994 49 1166-1168
309. Karlsson J A. Airway anaesthesia and the cough reflex. Bull Eur Physiopathol Respir 1987 23 (Suppl 10) 29s-36s
310. Udezue E. Lidocaine inhalation for cough suppression. Am J Emerg Med 2001 19 206-207
311. Lingerfelt B M., Swainey C W., Smith T J. et al. Nebulized lidocaine for intractable cough near the end of life. J Support Oncol 2007 5 301-302
312. Fuller R W., Jackson D M. Physiology and treatment of cough. Thorax 1990 45 425-430
313. Fuller R W., Karlsson J A., Choudry N B. et al. Effect of inhaled and systemic opiates on responses to inhaled capsaicin in humans. J Appl Physiol 1988 65 1125-1130
314. Eccles R. The powerful placebo in cough studies? Pulm Pharmacol Ther 2002 15 303-308
315. Taylor J A., Novack A H., Almquist J R. et al. Efficacy of cough suppressants in children. J Pediatr 1993 122 799-802
316. Eccles R, Morris S, Jawad M. Lack of effect of codeine in the treatment of cough associated with acute upper respiratory tract infection. J Clin Pharm Ther 1992 17 175-180
317. Morice A H., Menon M S., Mulrennan S A. et al. Opiate Therapy in Chronic Cough. Am J Respir Crit Care Med 2007 175 312-315
318. Kardos P. Stellenwert chemisch-synthetischer Antitussiva und Expektorantien. Pharm Unserer Zeit 2008 37 472-476
319. Chung K F. Currently available cough suppressants for chronic cough. Lung 2008 186 S82-S87
320. Dicpinigaitis P V., Rauf K. Treatment of chronic, refractory cough with baclofen. Respiration 1998 65 86-88
321. Dicpinigaitis P V., Dobkin J B. Antitussive effect of the GABA-agonist baclofen. Chest 1997 111 996-999
322. Irwin R S., Curley F J. The treatment of cough. A comprehensive review. Chest 1991 99 1477
323. George L, Rehman S U., Khan F A. Diaphragmatic rupture: A complication of violent cough. Chest 2000 117 1200-1201
324. De Maeseneer M, De Mey J, Debaere C et al. Rib fractures induced by coughing: An unusual cause of acute chest pain. Am J Emerg Med 2000 18 194-197
325. Prasad S, Baur L A. Fracture of the first rib as a consequence of pertussis infection. J Paediatr Child Health 2001 37 91-93
326. Tanaka T, Inoue H, Aizawa H et al. Case of cough syncope with seizure. Respiration 1994 61 48-50
327. Gelisse P, Genton P. Cough syncope misinterpreted as epileptic seizure. Epileptic Disord 2008 10 223-224
328. Mattle H P., Nirkko A C., Baumgartner R W. et al. Transient cerebral circulatory arrest coincides with fainting in cough syncope. Neurology 1995 45 498-501
329. Kopp I, Müller W, Lorenz W. Die zentrale Rolle von Outcome in Leitlinien und Disease-Management-Programmen. 8. Rundbrief. www.uni-duesseldorf. de/AWMF/ll/index.html zuletzt eingesehen am 15.4.2010
330. Weinbrenner S, Ollenschlager G. Leitlinien Grundlage neuer, zukunftsweisender Versorgungsformen. Bundesgesundheitsblatt. Gesundheitsforschung. Gesundheitsschutz 2008 51 558-564