Symptoms with acid and nonacid reflux may be produced by different mechanisms

Diseases of the Esophagus

Volumn 22, Issue 5, 2009, Pages 467-470

  Agrawal, A ^a   Roberts, J ^a   Sharma, N ^a   Tutuian, R ^a   Vela, M ^a   Castell, D O ^a  

^a MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

Author keywords

Acid reflux; GERD; Mechanisms; Nonacid reflux; Symptoms

Indexed keywords

ADULT; AGED; ANALYTIC METHOD; ARTICLE; COUGHING; FEMALE; GASTRIC PH MONITORING; GASTROESOPHAGEAL REFLUX; HEARTBURN; HUMAN; MAJOR CLINICAL STUDY; MALE; MULTICHANNEL INTRALUMINAL IMPEDANCE; PH MEASUREMENT; PRIORITY JOURNAL; SYMPTOMATOLOGY;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; ANTACIDS; CATHETERIZATION; COUGH; ELECTRIC IMPEDANCE; EQUIPMENT DESIGN; ESOPHAGEAL PH MONITORING; ESOPHAGEAL SPHINCTER, LOWER; FEMALE; GASTRIC ACID; GASTROESOPHAGEAL REFLUX; HEARTBURN; HUMANS; MALE; MIDDLE AGED; TIME FACTORS; YOUNG ADULT;

EID: 67949115828     PISSN: 11208694     EISSN: 14422050     Source Type: Journal    
DOI: 10.1111/j.1442-2050.2009.00940.x     Document Type: Article

References (13)

1. Christensen J. Origins of sensation in the esophagus. Am J Physiol 1984; 246: G221-5.
2. Rodrigo J, Hernadez C J, Vidal M A et al. Vegetative innervation of the esophagus. II. Intraganglionic laminar endings. Acta Anat 1975; 92: 79-100.
3. Sengupta J N, Saha J K, Goyal R K. Stimulus-response function studies of esophageal mechanosensitive nociceptors in sympathetic afferents of opossum. J Neurophysiol 1990; 64 (3): 796-812.
4. De Castecker J S, Heading R C. Esophageal pH monitoring. Gastroenterol Clin North Am 1990; 19: 645-70.
5. Cervero F. Sensory innervation of the viscera: Peripheral basis of visceral pain. Physiol Rev 1994; 74: 95-138.
6. Mainie I, Tutuian R, Shay S et al. Acid and non-acid reflux in patients with persistent symptoms despite acid suppressive therapy. A multicenter study using combined ambulatory impedance-pH monitoring. Gut 2006; 55 (10): 1398-402.
7. Vaezi M F, Singh S, Richter J E. Role of acid and duodenogastric reflux in esophageal mucosal injury: A review of animal and human studies. Gastroenterology 1995; 108: 1897-907.
8. Chiba N, De Gara C J, Wilkinson J M et al. Speed of healing and symptom relief in grade II to IV gastroesophageal reflux disease: A meta-analysis. Gastroenterology 1997; 112: 1798-810.
9. Castell D O, Kahrilas P J, Richter J E etal. Esomeprazole (40 mg) compared with lansoprazole (30 mg) in the treatment of erosive esophagitis. Am J Gastroenterol 2002; 97: 575-83.
10. Sifrim D, Holloway R, Silny J et al. Acid, nonacid, and gas reflux in patients with gastroesophageal reflux disease during ambulatory 24-hour pH-impedance recordings. Gastroenterology 2001; 120: 1588-98.
11. Cervero F, Janig W. Visceral nociceptors: A new world order? Trends Neurosci 1992; 15: 374-8.
12. Bredenoord A J, Weusten B L, Curvers W L et al. Determinants of perception of heartburn and regurgitation. Gut 2006; 55: 313-18.
13. Zerbib F, Duriez A, Roman S, Capdepont M, Mion F. Determinants of gastro-oesophageal reflux perception in patients with persistent symptoms despite proton pump inhibitors. Gut 2008; 57: 156-60.