Nonacid reflux episodes reaching the pharynx are important factors associated with cough

Journal of Clinical Gastroenterology

Volumn 43, Issue 5, 2009, Pages 414-419

  Patterson, Neil ^a   Mainie, Inder ^a,b   Rafferty, Gerard ^a   McGarvey, Lorcan ^a   Heaney, Liam ^a   Tutuian, Radu ^c   Castell, Donald ^b   Johnston, Brian T ^a  

^a ROYAL VICTORIA HOSPITAL   (United Kingdom)

^b MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^c UNIVERSITY OF ZURICH   (Switzerland)

Author keywords

Gastroesophageal reflux disease and nonacid reflux; Multichannel intraluminal impedance and pH

Indexed keywords

ADULT; AGED; ARTICLE; ASTHMA; CALCULATION; CLINICAL ARTICLE; CONTROLLED STUDY; COUGHING; DISEASE ASSOCIATION; DYSPNEA; ESOPHAGUS; ESOPHAGUS PH; FEMALE; GASTROESOPHAGEAL REFLUX; HOARSENESS; HUMAN; IMPEDANCE; LOWER ESOPHAGUS SPHINCTER; MALE; MANOMETRY; MONITORING; PH; PHARYNX; PRIORITY JOURNAL; PROBABILITY; TECHNIQUE; WHEEZING;

ADULT; AGED; ASTHMA; CHRONIC DISEASE; COUGH; DYSPNEA; ELECTRIC IMPEDANCE; ESOPHAGEAL MOTILITY DISORDERS; ESOPHAGEAL PH MONITORING; ESOPHAGEAL SPHINCTER, UPPER; GASTROESOPHAGEAL REFLUX; HOARSENESS; HUMANS; MANOMETRY; MIDDLE AGED; PHARYNX; RESPIRATORY SOUNDS; RISK FACTORS;

EID: 67651100576     PISSN: 01920790     EISSN: None     Source Type: Journal    
DOI: 10.1097/MCG.0b013e31818859a3     Document Type: Article

References (16)

1. Kiljander TO, Harding SM, Field SK, et al. Effects of esomeprazole 40 mg twice daily on asthma: a randomized placebo-controlled trial. Am J Respir Crit Care Med. 2006; 173:1091-1097. (Pubitemid 43726889)
2. Sontag SJ, O'Connell S, Khandelwal S, et al. Effect of positions, eating, and bronchodilators on gastroesophageal reflux in asthmatics. Dig Dis Sci. 1990;35:849-856. (Pubitemid 20216454)
3. Irwin RS, Curley FJ, French CL. Chronic cough. The spectrum and frequency of causes, key components of the diagnostic evaluation, and outcome of specific therapy. Am Rev Respir Dis. 1990;141:640-647.
4. McGarvey LP, Heaney LG, Lawson JT, et al. Evaluation and outcome of patients with chronic non-productive cough using a comprehensive diagnostic protocol. Thorax. 1998;53:738-743.
5. Merati AL, Lim HJ, Ulualp SO. Meta-analysis of upper probe measurements in normal subjects and patients with laryngopharyngeal reflux. Ann Otol Rhinol Laryngol. 2005;114: 177-182.
6. Kawamura O, Aslam M, Rittmann T, et al. Physical and pH properties of gastroesophagopharyngeal refluxate: a 24-hour simultaneous ambulatory impedance and pH monitoring study. Am J Gastroenterol. 2004;99:1000-1010. (Pubitemid 38917800)
7. Oelschlager BK, Quiroga E, Isch JA, et al. Gastroesophageal and pharyngeal reflux detection using impedance and 24-hour pH monitoring in asymptomatic subjects: defining the normal environment. J Gastrointest Surg. 2006;10:54-62. (Pubitemid 41820588)
8. Shay S, Tutuian R, Sifrim D, et al. Twenty-four hour ambulatory simultaneous impedance and pH monitoring: a multicenter report of normal values from 60 healthy volunteers. Am J Gastroenterol. 2004;99:1037-1043. (Pubitemid 38917805)
9. Sifrim D, Dupont L, Blondeau K, et al. Weakly acidic reflux in patients with chronic unexplained cough during 24 hours pressure, pH, and impedance monitoring. Gut. 2005;54:449-454. (Pubitemid 40395491)
10. Blondeau K, Dupont LJ, Mertens V, et al. Improved diagnosis of gastro-oesophageal reflux in patients with unexplained chronic cough. Aliment Pharmacol Ther. 2007;25:723-732. (Pubitemid 46272521)
11. Srinivasan R, Vela MF, Katz PO, et al. Esophageal function testing using multichannel intraluminal impedance. Am J Physiol Gastrointest Liver Physiol. 2001;280:G457-G462. (Pubitemid 32487793)
12. Weusten BL, Roelofs JM, Akkermans LM, et al. The symptom-association probability: an improved method for symptom analysis of 24-hour esophageal pH data. Gastroenterology. 1994;107:1741-1745. (Pubitemid 24357628)
13. Johnson LF, De Meester TR. Twenty-four-hour pH monitoring of the distal esophagus: a quantitative measure of gastroesophageal reflux. Am J Gastroenterol. 1974;62:325-332.
14. Bredenoord AJ, Weusten LAM, Timmer R, et al. Characteristics of gastroesophageal reflux in symptomatic patients with and without excessive esophageal acid exposure. Am Gastroenterol. 2006;101:2470-2475. (Pubitemid 44665240)
15. Tutuian R, Vela MF, Hill EG, et al. Characteristics of symptomatic reflux episodes on Acid suppressive therapy. Am J Gastroenterol. 2008;103:1090-1096. (Pubitemid 351677992)
16. Cool M, Poelmans J, Feenstra L, et al. Characteristics and clinical relevance of proximal esophageal pH monitoring. Am J Gastroenterol. 2004;99:2317-2323. (Pubitemid 40039359)