Cutting edge: Autoimmune disease in day 3 thymectomized mice is actively controlled by endogenous disease-specific regulatory T cells

Journal of Immunology

Volumn 180, Issue 7, 2008, Pages 4366-4370

  Samy, Eileen T ^a,e   Wheeler, Karen M ^a   Roper, Randall J ^b   Teuscher, Cory ^c   Tung, Kenneth S K ^a,d  

^a UNIVERSITY OF VIRGINIA   (United States)

^b INDIANA UNIVERSITY   (United States)

^c UNIVERSITY OF VERMONT COLLEGE OF MEDICINE   (United States)

^d UNIVERSITY OF VIRGINIA HEALTH SYSTEM   (United States)

^e ROCHE BIOSCIENCE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTOIMMUNE DISEASE; CELL COUNT; CELL SECRETION; CONTROLLED STUDY; DACRYOADENITIS; FEMALE; GASTRITIS; IMMUNOLOGICAL TOLERANCE; LYMPH NODE; LYMPHADENITIS; MOUSE; NONHUMAN; OVARY DISEASE; PRIORITY JOURNAL; REGULATORY T LYMPHOCYTE; THYMECTOMY; ANIMAL; IMMUNOLOGY; MALE; NEWBORN; PATHOLOGY; TIME;

FORKHEAD TRANSCRIPTION FACTOR; FOXP3 PROTEIN, MOUSE; INTERLEUKIN 2 RECEPTOR ALPHA;

ANIMALS; ANIMALS, NEWBORN; AUTOIMMUNE DISEASES; FEMALE; FORKHEAD TRANSCRIPTION FACTORS; INTERLEUKIN-2 RECEPTOR ALPHA SUBUNIT; LYMPH NODES; MALE; MICE; T-LYMPHOCYTES, REGULATORY; THYMECTOMY; TIME FACTORS;

EID: 44449119050     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.180.7.4366     Document Type: Article

References (24)

1. Hogquist, K. A., T. A. Baldwin, and S. C. Jameson. 2005- Central tolerance: learning self-control in the thymus. Nat. Rev. Immunol. 5: 772-782.
2. + regulatory T cells in immunological tolerance to self and non-self. Nat. Immunol. 6: 345-352.
3. Nishizuka, Y., and T. Sakakura. 1969. Thymus and reproduction: sex-linked dysgenesis of the gonad after neonatal thymectomy in mice. Science 166: 753-755.
4. Kojima, A., and R. T. Prehn. 1981. Genetic susceptibility to post-thymectomy autoimmune diseases in mice. Immunogenetics 14: 15-27.
5. + regulatory T cells in the regional lymph node. J. Exp. Med. 202: 771-781.
6. Smith, H., Y. H. Lou, P. Lacy, and K. S. Tung. 1992. Tolerance mechanism in experimental ovarian and gastric autoimmune diseases. J. Immunol. 149: 2212-2218.
7. Tung, K. S. 1994. Mechanism of self-tolerance and events leading to autoimmune disease and autoantibody response. Clin. Immunol. Immunopathol. 73: 275-282.
8. Smith, H., I. M. Chen, R. Kubo, and K. S. Tung. 1989. Neonatal thymectomy results in a repertoire enriched in T cells deleted in adult thymus. Science 245: 749-752.
9. Asano, M., M. Toda, N. Sakaguchi, and S. Sakaguchi. 1996. Autoimmune disease as a consequence of developmental abnormality of a T cell subpopulation. J. Exp. Med. 184: 387-396.
10. + regulatory T cells can mediate suppressor function in the absence of transforming growth factor β1 production and responsiveness. J. Exp. Med. 196: 237-246.
11. Suri-Payer, E., A. Z. Amar, R. McHugh, K. Natarajan, D. H. Margulies, and E. M. Shevach. 1999. Post-thymectomy autoimmune gastritis: fine specificity and pathogenicity of anti-H/K ATPase-reactive T cells. Eur. J. Immunol. 29: 669-677.
12. Dujardin, H. C., O. Burlen-Defranoux, L. Boucontet, P. Vieira, A. Cumano, and A. Bandeira. 2004. Regulatory potential and control of Foxp3 expression in newborn CD4+ T cells. Proc. Natl. Acad. Sci. USA 101: 14473-14478.
13. Strober, W., I. J. Fuss, and R. S. Blumberg. 2002. The immunology of mucosal models of inflammation. Ann. Rev. Immunol. 20: 495-549.
14. Kim, J. M., J. P. Rasmussen, and A. Y. Rudensky. 2007. Regulatory T cells prevent catastrophic autoimmunity throughout the lifespan of mice. Nat. Immunol. 8:191-197.
15. Alard, P., C. Thompson, S. S. Agersborg, J. Thatte, Y. Setiady, E. Samy, and K. S. Tung. 2001. Endogenous oocyte antigens are required for rapid induction and progression ofautoimmune ovarian disease following day-3 thymectomy. J. Immunol. 166:4363-4369.
16. + suppressor T cells in vivo. Nat. Immunol. 3:33-41.
17. Fontenot, J. D., J. L. Dooley, A. G. Farr, and A. Y. Rudensky. 2005. Developmental regulation of Foxp3 expression during ontogeny. J. Exp. Med. 202: 901-906.
18. Tang, Q., J. Y. Adams, A. J. Tooley, M. Bi, B. T. Fife, P. Serra, P. Santamaria, R. M. Locksley, M. F. Krummel, and J. A. Bluestone. 2005. Visualizing regulatory T cell control of autoimmune responses in nonobese diabetic mice. Nat. Immunol. 7:83-92.
19. Anderson, M. S., E. S. Venanzi, L. Klein, Z. Chen, S. P. Berzins, S. J. Turley, H. von Boehmer, R. Bronson, A. Dierich, C. Benoist, and D. Mathis. 2002. Projection of an immunological self shadow within the thymus by the Aire protein. Science 298: 1395-1401.
20. Jiang, W., M. S. Anderson, R. Bronson, D. Mathis, and C. Benoist. 2005. Modifier loci condition autoimmunity provoked by aire deficiency. J. Exp. Med. 202: 805-815.
21. Anderson, M. S., E. S. Venanzi, Z. Chen, S. P. Berzins, C. Benoist, and D. Mathis. 2005. The cellular mechanism of aire control of T cell tolerance. Immunity 23:227-239.
22. Liston, A., D. H. Gray, S. Lesage, A. L. Fletcher, J. Wilson, K. E. Webster, H. S. Scott, R. L. Boyd, L. Peltonen, and C. C. Goodnow. 2004. Gene dosage-limiting role ofAire in thymic expression, clonal deletion, and organ-specific autoimmunity. J. Exp. Med. 200: 1015-1026.
23. + regulatory T cells. Blood 107:1056 - 1062.
24. Godfrey, V. L., J. E. Wilkinson, and L. B. Russell. 1991. X-linked lymphoreticular disease in the scurfy (sf) mutant mouse. Am. J. Pathol. 138: 1379-1387.