-
1
-
-
11144225205
-
Integrin-linked kinase: A cancer therapeutic target unique among its ILK
-
Hannigan G, Troussard AA, Dedhar S. Integrin-linked kinase: a cancer therapeutic target unique among its ILK. Nat Rev Cancer 2005; 5:5-7.
-
(2005)
Nat Rev Cancer
, vol.5
, pp. 5-7
-
-
Hannigan, G.1
Troussard, A.A.2
Dedhar, S.3
-
2
-
-
47749087950
-
Integrin-linked kinase - Essential roles in physiology and cancer biology
-
McDonald PC, Fielding AB, Dedhar S. Integrin-linked kinase - essential roles in physiology and cancer biology. J Cell Sci 2008; 121:3121-32.
-
(2008)
J Cell Sci
, vol.121
, pp. 3121-3132
-
-
McDonald, P.C.1
Fielding, A.B.2
Dedhar, S.3
-
3
-
-
0035950544
-
Mammary epithelial-specific expression of the integrin-linked kinase (ILK) results in the induction of mammary gland hyperplasias and tumors in transgenic mice
-
White DE, Cardiff RD, Dedhar S, Muller WJ. Mammary epithelial-specific expression of the integrin-linked kinase (ILK) results in the induction of mammary gland hyperplasias and tumors in transgenic mice. Oncogene 2001; 20:7064-72.
-
(2001)
Oncogene
, vol.20
, pp. 7064-7072
-
-
White, D.E.1
Cardiff, R.D.2
Dedhar, S.3
Muller, W.J.4
-
4
-
-
31544439674
-
Preferential dependence of breast cancer cells versus normal cells on integrin-linked kinase for protein kinase B/Akt activation and cell survival
-
Troussard AA, McDonald PC, Wederell ED, Mawji NM, Filipenko NR, Gelmon KA, et al. Preferential dependence of breast cancer cells versus normal cells on integrin-linked kinase for protein kinase B/Akt activation and cell survival. Cancer Res 2006; 66:393-403.
-
(2006)
Cancer Res
, vol.66
, pp. 393-403
-
-
Troussard, A.A.1
McDonald, P.C.2
Wederell, E.D.3
Mawji, N.M.4
Filipenko, N.R.5
Gelmon, K.A.6
-
5
-
-
9144270454
-
Regulation of tumor angiogenesis by integrin-linked kinase (ILK)
-
Tan C, Cruet-Hennequart S, Troussard A, Fazli L, Costello P, Sutton K, et al. Regulation of tumor angiogenesis by integrin-linked kinase (ILK). Cancer Cell 2004; 5:79-90.
-
(2004)
Cancer Cell
, vol.5
, pp. 79-90
-
-
Tan, C.1
Cruet-Hennequart, S.2
Troussard, A.3
Fazli, L.4
Costello, P.5
Sutton, K.6
-
6
-
-
13944256944
-
Inhibition of integrin-linked kinase by a selective small molecule inhibitor, QLT0254, inhibits the PI3K/PKB/mTOR, Stat3, and FKHR pathways and tumor growth, and enhances gemcitabine-induced apoptosis in human orthotopic primary pancreatic cancer xenografts
-
Yau CY, Wheeler JJ, Sutton KL, Hedley DW. Inhibition of integrin-linked kinase by a selective small molecule inhibitor, QLT0254, inhibits the PI3K/PKB/mTOR, Stat3, and FKHR pathways and tumor growth, and enhances gemcitabine-induced apoptosis in human orthotopic primary pancreatic cancer xenografts. Cancer Res 2005; 65:1497-504.
-
(2005)
Cancer Res
, vol.65
, pp. 1497-1504
-
-
Yau, C.Y.1
Wheeler, J.J.2
Sutton, K.L.3
Hedley, D.W.4
-
7
-
-
28044461715
-
Targeting integrin-linked kinase inhibits Akt signaling pathways and decreases tumor progression of human glioblastoma
-
Koul D, Shen R, Bergh S, Lu Y, de Groot JF, Liu TJ, et al. Targeting integrin-linked kinase inhibits Akt signaling pathways and decreases tumor progression of human glioblastoma. Mol Cancer Ther 2005; 4:1681-8.
-
(2005)
Mol Cancer Ther
, vol.4
, pp. 1681-1688
-
-
Koul, D.1
Shen, R.2
Bergh, S.3
Lu, Y.4
De Groot, J.F.5
Liu, T.J.6
-
8
-
-
74849132460
-
Oncogenic ILK, tumor suppression and all that JNK
-
Durbin AD, Hannigan GE, Malkin D. Oncogenic ILK, tumor suppression and all that JNK. Cell Cycle 2009; 8:4060-6.
-
(2009)
Cell Cycle
, vol.8
, pp. 4060-4066
-
-
Durbin, A.D.1
Hannigan, G.E.2
Malkin, D.3
-
9
-
-
34248158106
-
Integrin-linked kinase is required for epidermal and hair follicle morphogenesis
-
Lorenz K, Grashoff C, Torka R, Sakai T, Langbein L, Bloch W, et al. Integrin-linked kinase is required for epidermal and hair follicle morphogenesis. J Cell Biol 2007; 177:501-13.
-
(2007)
J Cell Biol
, vol.177
, pp. 501-513
-
-
Lorenz, K.1
Grashoff, C.2
Torka, R.3
Sakai, T.4
Langbein, L.5
Bloch, W.6
-
10
-
-
58149401291
-
Liver-specific ablation of integrin-linked kinase in mice results in abnormal histology, enhanced cell proliferation, and hepatomegaly
-
Gkretsi V, Apte U, Mars WM, Bowen WC, Luo JH, Yang Y, et al. Liver-specific ablation of integrin-linked kinase in mice results in abnormal histology, enhanced cell proliferation, and hepatomegaly. Hepatology 2008; 48:1932-41.
-
(2008)
Hepatology
, vol.48
, pp. 1932-1941
-
-
Gkretsi, V.1
Apte, U.2
Mars, W.M.3
Bowen, W.C.4
Luo, J.H.5
Yang, Y.6
-
11
-
-
70349232394
-
Enhanced liver regeneration following changes induced by hepatocyte-specific genetic ablation of integrin-linked kinase
-
Apte U, Gkretsi V, Bowen WC, Mars WM, Luo JH, Donthamsetty S, et al. Enhanced liver regeneration following changes induced by hepatocyte-specific genetic ablation of integrin-linked kinase. Hepatology 2009.
-
(2009)
Hepatology
-
-
Apte, U.1
Gkretsi, V.2
Bowen, W.C.3
Mars, W.M.4
Luo, J.H.5
Donthamsetty, S.6
-
12
-
-
49749146009
-
Expression of integrin-linked kinase is increased in differentiated cells
-
Haase M, Gmach CC, Eke I, Hehlgans S, Baretton GB, Cordes N. Expression of integrin-linked kinase is increased in differentiated cells. J Histochem Cytochem 2008; 56:819-29.
-
(2008)
J Histochem Cytochem
, vol.56
, pp. 819-829
-
-
Haase, M.1
Gmach, C.C.2
Eke, I.3
Hehlgans, S.4
Baretton, G.B.5
Cordes, N.6
-
13
-
-
0141534266
-
Integrin-linked kinase is a positive mediator of L6 myoblast differentiation
-
Miller MG, Naruszewicz I, Kumar AS, Ramlal T, Hannigan GE. Integrin-linked kinase is a positive mediator of L6 myoblast differentiation. Biochem Biophys Res Commun 2003; 310:796-803.
-
(2003)
Biochem Biophys Res Commun
, vol.310
, pp. 796-803
-
-
Miller, M.G.1
Naruszewicz, I.2
Kumar, A.S.3
Ramlal, T.4
Hannigan, G.E.5
-
14
-
-
4143113653
-
Suppression of malignant growth of human breast cancer cells by ectopic expression of integrin-linked kinase
-
Chen P, Shen WZ, Karnik P. Suppression of malignant growth of human breast cancer cells by ectopic expression of integrin-linked kinase. Int J Cancer 2004; 111:881-91.
-
(2004)
Int J Cancer
, vol.111
, pp. 881-891
-
-
Chen, P.1
Shen, W.Z.2
Karnik, P.3
-
15
-
-
4143127943
-
Overexpression of hyperactive integrin-linked kinase leads to increased cellular radiosensitivity
-
Cordes N. Overexpression of hyperactive integrin-linked kinase leads to increased cellular radiosensitivity. Cancer Res 2004; 64:5683-92.
-
(2004)
Cancer Res
, vol.64
, pp. 5683-5692
-
-
Cordes, N.1
-
16
-
-
33847382879
-
Integrin-linked kinase interacts with caspase-9 and -8 in an adhesion-dependent manner for promoting radiation-induced apoptosis in human leukemia cells
-
Hess F, Estrugo D, Fischer A, Belka C, Cordes N. Integrin-linked kinase interacts with caspase-9 and -8 in an adhesion-dependent manner for promoting radiation-induced apoptosis in human leukemia cells. Oncogene 2007; 26:1372-84.
-
(2007)
Oncogene
, vol.26
, pp. 1372-1384
-
-
Hess, F.1
Estrugo, D.2
Fischer, A.3
Belka, C.4
Cordes, N.5
-
17
-
-
67651006358
-
JNK1 determines the oncogenic or tumor-suppressive activity of the integrin-linked kinase in human rhabdomyosarcoma
-
Durbin AD, Somers GR, Forrester M, Pienkowska M, Hannigan GE, Malkin D. JNK1 determines the oncogenic or tumor-suppressive activity of the integrin-linked kinase in human rhabdomyosarcoma. J Clin Invest 2009; 119:1558-70.
-
(2009)
J Clin Invest
, vol.119
, pp. 1558-1570
-
-
Durbin, A.D.1
Somers, G.R.2
Forrester, M.3
Pienkowska, M.4
Hannigan, G.E.5
Malkin, D.6
-
18
-
-
67651006082
-
Integrin-linked kinase both Jekyll and Hyde in rhabdomyosarcoma
-
McDonald PC, Dedhar S, Keller C. Integrin-linked kinase: both Jekyll and Hyde in rhabdomyosarcoma. J Clin Invest 2009; 119:1452-5.
-
(2009)
J Clin Invest
, vol.119
, pp. 1452-1455
-
-
McDonald, P.C.1
Dedhar, S.2
Keller, C.3
-
19
-
-
74049103772
-
QLT0267, a small molecule inhibitor targeting integrin-linked kinase (ILK), and docetaxel can combine to produce synergistic interactions linked to enhanced cytotoxicity, reductions in P-AKT levels, altered F-actin architecture and improved treatment outcomes in an orthotopic breast cancer model
-
Kalra J, Warburton C, Fang K, Edwards L, Daynard T, Waterhouse D, et al. QLT0267, a small molecule inhibitor targeting integrin-linked kinase (ILK), and docetaxel can combine to produce synergistic interactions linked to enhanced cytotoxicity, reductions in P-AKT levels, altered F-actin architecture and improved treatment outcomes in an orthotopic breast cancer model. Breast Cancer Res 2009; 11:25.
-
(2009)
Breast Cancer Res
, vol.11
, pp. 25
-
-
Kalra, J.1
Warburton, C.2
Fang, K.3
Edwards, L.4
Daynard, T.5
Waterhouse, D.6
-
20
-
-
62149130798
-
Combined inhibition of integrin linked kinase and FMS-like tyrosine kinase 3 is cytotoxic to acute myeloid leukemia progenitor cells
-
Muranyi AL, Dedhar S, Hogge DE. Combined inhibition of integrin linked kinase and FMS-like tyrosine kinase 3 is cytotoxic to acute myeloid leukemia progenitor cells. Exp Hematol 2009; 37:450-60.
-
(2009)
Exp Hematol
, vol.37
, pp. 450-460
-
-
Muranyi, A.L.1
Dedhar, S.2
Hogge, D.E.3
-
21
-
-
0035920145
-
Regulation of protein kinase B/Akt-serine 473 phosphorylation by integrin-linked kinase critical roles for kinase activity and amino acids arginine 211 and serine 343
-
Persad S, Attwell S, Gray V, Mawji N, Deng JT, Leung D, et al. Regulation of protein kinase B/Akt-serine 473 phosphorylation by integrin-linked kinase: critical roles for kinase activity and amino acids arginine 211 and serine 343. J Biol Chem 2001; 276:27462-9.
-
(2001)
J Biol Chem
, vol.276
, pp. 27462-27469
-
-
Persad, S.1
Attwell, S.2
Gray, V.3
Mawji, N.4
Deng, J.T.5
Leung, D.6
-
22
-
-
84940372111
-
Urokinase-type Plasminogen Activator (uPA) is Inhibited with QLT0267 a Small Molecule Targeting Integrin-linked Kinase (ILK)
-
Dos Santos N, Habibi G, Wang M, Law JH, Andrews HA, Wei D, et al. Urokinase-type Plasminogen Activator (uPA) is Inhibited with QLT0267 a Small Molecule Targeting Integrin-linked Kinase (ILK). Translational Oncogenomics 2007; 2:67-79.
-
(2007)
Translational Oncogenomics
, vol.2
, pp. 67-79
-
-
Dos Santos, N.1
Habibi, G.2
Wang, M.3
Law, J.H.4
Andrews, H.A.5
Wei, D.6
-
23
-
-
0029885419
-
Selective interaction of JNK protein kinase isoforms with transcription factors
-
Gupta S, Barrett T, Whitmarsh AJ, Cavanagh J, Sluss HK, Derijard B, et al. Selective interaction of JNK protein kinase isoforms with transcription factors. EMBO J 1996; 15:2760-70. (Pubitemid 26176253)
-
(1996)
EMBO Journal
, vol.15
, Issue.11
, pp. 2760-2770
-
-
Gupta, S.1
Barrett, T.2
Whitmarsh, A.J.3
Cavanagh, J.4
Sluss, H.K.5
Derijard, B.6
Davis, R.J.7
-
24
-
-
0034644522
-
Signal transduction by the JNK group of MAP kinases
-
Davis RJ. Signal transduction by the JNK group of MAP kinases. Cell 2000; 103:239-52.
-
(2000)
Cell
, vol.103
, pp. 239-252
-
-
Davis, R.J.1
-
25
-
-
0242691046
-
AP-1: A double-edged sword in tumorigenesis
-
Eferl R, Wagner EF. AP-1: a double-edged sword in tumorigenesis. Nat Rev Cancer 2003; 3:859-68.
-
(2003)
Nat Rev Cancer
, vol.3
, pp. 859-868
-
-
Eferl, R.1
Wagner, E.F.2
-
26
-
-
0036098552
-
AP-1 as a regulator of cell life and death
-
Shaulian E, Karin M. AP-1 as a regulator of cell life and death. Nat Cell Biol 2002; 4:131-6.
-
(2002)
Nat Cell Biol
, vol.4
, pp. 131-136
-
-
Shaulian, E.1
Karin, M.2
-
27
-
-
17144371848
-
JNK2: A negative regulator of cellular proliferation
-
Sabapathy K, Wagner EF. JNK2: a negative regulator of cellular proliferation. Cell Cycle 2004; 3:1520-3. (Pubitemid 40521404)
-
(2004)
Cell Cycle
, vol.3
, Issue.12
, pp. 1520-1523
-
-
Sabapathy, K.1
Wagner, E.F.2
-
28
-
-
34547687918
-
Genetic deficiency of p38α reveals its critical role in myoblast cell cycle exit: The p38α-JNK connection
-
Perdiguero E, Ruiz-Bonilla V, Serrano AL, Munoz-Canoves P. Genetic deficiency of p38alpha reveals its critical role in myoblast cell cycle exit: the p38alpha-JNK connection. Cell Cycle 2007; 6:1298-303. (Pubitemid 47327960)
-
(2007)
Cell Cycle
, vol.6
, Issue.11
, pp. 1298-1303
-
-
Perdiguero, E.1
Ruiz-Bonilla, V.2
Serrano, A.L.3
Munoz-Canoves, P.4
-
29
-
-
0034676338
-
The integrin linked kinase (ILK) induces an invasive phenotype via AP-1 transcription factor-dependent upregulation of matrix metalloproteinase 9 (MMP-9)
-
Troussard AA, Costello P, Yoganathan TN, Kumagai S, Roskelley CD, Dedhar S. The integrin linked kinase (ILK) induces an invasive phenotype via AP-1 transcription factor-dependent upregulation of matrix metalloproteinase 9 (MMP-9). Oncogene 2000; 19:5444-52.
-
(2000)
Oncogene
, vol.19
, pp. 5444-5452
-
-
Troussard, A.A.1
Costello, P.2
Yoganathan, T.N.3
Kumagai, S.4
Roskelley, C.D.5
Dedhar, S.6
-
30
-
-
6344280968
-
Integrin-linked kinase regulates the nuclear entry of the c-Jun coactivator alpha-NAC and its coactivation potency
-
Quelo I, Gauthier C, Hannigan GE, Dedhar S, St-Arnaud R. Integrin-linked kinase regulates the nuclear entry of the c-Jun coactivator alpha-NAC and its coactivation potency. J Biol Chem 2004; 279:43893-9.
-
(2004)
J Biol Chem
, vol.279
, pp. 43893-43899
-
-
Quelo, I.1
Gauthier, C.2
Hannigan, G.E.3
Dedhar, S.4
St-Arnaud, R.5
-
31
-
-
0031962084
-
Integrin-linked protein kinase regulates fibronectin matrix assembly E-cadherin expression, and tumorigenicity
-
Wu C, Keightley SY, Leung-Hagesteijn C, Radeva G, Coppolino M, Goicoechea S, et al. Integrin-linked protein kinase regulates fibronectin matrix assembly, E-cadherin expression, and tumorigenicity. J Biol Chem 1998; 273:528-36.
-
(1998)
J Biol Chem
, vol.273
, pp. 528-536
-
-
Wu, C.1
Keightley, S.Y.2
Leung-Hagesteijn, C.3
Radeva, G.4
Coppolino, M.5
Goicoechea, S.6
-
32
-
-
0024536654
-
Chromosome 17 deletions and p53 gene mutations in colorectal carcinomas
-
Baker SJ, Fearon ER, Nigro JM, Hamilton SR, Preisinger AC, Jessup JM, et al. Chromosome 17 deletions and p53 gene mutations in colorectal carcinomas. Science 1989; 244:217-21.
-
(1989)
Science
, vol.244
, pp. 217-221
-
-
Baker, S.J.1
Fearon, E.R.2
Nigro, J.M.3
Hamilton, S.R.4
Preisinger, A.C.5
Jessup, J.M.6
-
33
-
-
39449093328
-
Identification of a PTEN-regulated STAT3 brain tumor suppressor pathway
-
de la Iglesia N, Konopka G, Puram SV, Chan JA, Bachoo RM, You MJ, et al. Identification of a PTEN-regulated STAT3 brain tumor suppressor pathway. Genes Dev 2008; 22:449-62.
-
(2008)
Genes Dev
, vol.22
, pp. 449-462
-
-
De La Iglesia, N.1
Konopka, G.2
Puram, S.V.3
Chan, J.A.4
Bachoo, R.M.5
You, M.J.6
-
34
-
-
70349454058
-
Functional identification of tumor-suppressor genes through an in vivo RNA interference screen in a mouse lymphoma model
-
Bric A, Miething C, Bialucha CU, Scuoppo C, Zender L, Krasnitz A, et al. Functional identification of tumor-suppressor genes through an in vivo RNA interference screen in a mouse lymphoma model. Cancer Cell 2009; 16:324-35.
-
(2009)
Cancer Cell
, vol.16
, pp. 324-335
-
-
Bric, A.1
Miething, C.2
Bialucha, C.U.3
Scuoppo, C.4
Zender, L.5
Krasnitz, A.6
-
35
-
-
34248352285
-
Integrin-linked kinase inhibitor KP-392 demonstrates clinical benefits in an orthotopic human non-small cell lung cancer model
-
Liu J, Costello PC, Pham NA, Pintillie M, Jabali M, Sanghera J, et al. Integrin-linked kinase inhibitor KP-392 demonstrates clinical benefits in an orthotopic human non-small cell lung cancer model. J Thorac Oncol 2006; 1:771-9.
-
(2006)
J Thorac Oncol
, vol.1
, pp. 771-779
-
-
Liu, J.1
Costello, P.C.2
Pham, N.A.3
Pintillie, M.4
Jabali, M.5
Sanghera, J.6
-
36
-
-
0034698755
-
The roles of integrin-linked kinase in the regulation of myogenic differentiation
-
Huang Y, Li J, Zhang Y, Wu C. The roles of integrin-linked kinase in the regulation of myogenic differentiation. J Cell Biol 2000; 150:861-72.
-
(2000)
J Cell Biol
, vol.150
, pp. 861-872
-
-
Huang, Y.1
Li, J.2
Zhang, Y.3
Wu, C.4
-
37
-
-
40949083412
-
Rictor and integrin-linked kinase interact and regulate Akt phosphorylation and cancer cell survival
-
McDonald PC, Oloumi A, Mills J, Dobreva I, Maidan M, Gray V, et al. Rictor and integrin-linked kinase interact and regulate Akt phosphorylation and cancer cell survival. Cancer Res 2008; 68:1618-24.
-
(2008)
Cancer Res
, vol.68
, pp. 1618-1624
-
-
McDonald, P.C.1
Oloumi, A.2
Mills, J.3
Dobreva, I.4
Maidan, M.5
Gray, V.6
-
38
-
-
0142027071
-
Derivation and characterization of a Wilms' tumour cell line, WiT 49
-
Alami J, Williams BR, Yeger H. Derivation and characterization of a Wilms' tumour cell line, WiT 49. Int J Cancer 2003; 107:365-74.
-
(2003)
Int J Cancer
, vol.107
, pp. 365-374
-
-
Alami, J.1
Williams, B.R.2
Yeger, H.3
-
39
-
-
13844254018
-
Pediatric pancreatoblastoma: Histopathologic and cytogenetic characterization of tumor and derived cell line
-
Barenboim-Stapleton L, Yang X, Tsokos M, Wigginton JM, Padilla-Nash H, Ried T, et al. Pediatric pancreatoblastoma: histopathologic and cytogenetic characterization of tumor and derived cell line. Cancer Genet Cytogenet 2005; 157:109-17.
-
(2005)
Cancer Genet Cytogenet
, vol.157
, pp. 109-117
-
-
Barenboim-Stapleton, L.1
Yang, X.2
Tsokos, M.3
Wigginton, J.M.4
Padilla-Nash, H.5
Ried, T.6
-
40
-
-
75149191872
-
Recurrent focal copy-number changes and loss of heterozygosity implicate two noncoding RNAs and one tumor suppressor gene at chromosome 3q13.31 in osteosarcoma
-
Pasic I, Shlien A, Durbin AD, Stavropoulos DJ, Baskin B, Ray PN, et al. Recurrent focal copy-number changes and loss of heterozygosity implicate two noncoding RNAs and one tumor suppressor gene at chromosome 3q13.31 in osteosarcoma. Cancer Res 2010; 70:160-71.
-
(2010)
Cancer Res
, vol.70
, pp. 160-171
-
-
Pasic, I.1
Shlien, A.2
Durbin, A.D.3
Stavropoulos, D.J.4
Baskin, B.5
Ray, P.N.6
-
41
-
-
44949231424
-
Analyzing real-time PCR data by the comparative C(T) method
-
Schmittgen TD, Livak KJ. Analyzing real-time PCR data by the comparative C(T) method. Nat Protoc 2008; 3:1101-8.
-
(2008)
Nat Protoc
, vol.3
, pp. 1101-1108
-
-
Schmittgen, T.D.1
Livak, K.J.2
-
42
-
-
33846064113
-
NCBI GEO: Mining tens of millions of expression profiles - Database and tools update
-
Barrett T, Troup DB, Wilhite SE, Ledoux P, Rudnev D, Evangelista C, et al. NCBI GEO: mining tens of millions of expression profiles - database and tools update. Nucleic Acids Res 2007; 35:760-5.
-
(2007)
Nucleic Acids Res
, vol.35
, pp. 760-765
-
-
Barrett, T.1
Troup, D.B.2
Wilhite, S.E.3
Ledoux, P.4
Rudnev, D.5
Evangelista, C.6
-
43
-
-
44849095864
-
The estrogen receptor pathway in rhabdomyosarcoma: A role for estrogen receptor-beta in proliferation and response to the antiestrogen 4′OH-tamoxifen
-
Greenberg JA, Somme S, Russnes HE, Durbin AD, Malkin D. The estrogen receptor pathway in rhabdomyosarcoma: a role for estrogen receptor-beta in proliferation and response to the antiestrogen 4′OH-tamoxifen. Cancer Res 2008; 68:3476-85.
-
(2008)
Cancer Res
, vol.68
, pp. 3476-3485
-
-
Greenberg, J.A.1
Somme, S.2
Russnes, H.E.3
Durbin, A.D.4
Malkin, D.5
|