Vectorial TGFβ signaling in polarized intestinal epithelial cells

Journal of Cellular Physiology

Volumn 224, Issue 2, 2010, Pages 398-404

  Yakovich, Adam J ^a   Huang, Qin ^b   Du, Jianguo ^a   Jiang, Bo ^a   Barnard, John A ^a,b  

^a NATIONWIDE CHILDREN S HOSPITAL   (United States)

^b THE OHIO STATE UNIVERSITY COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

SMAD2 PROTEIN; TRANSFORMING GROWTH FACTOR BETA; ISOPROTEIN; MEMBRANE PROTEIN; OCCLUDIN; PROTEIN SERINE THREONINE KINASE; TGF BETA TYPE I RECEPTOR; TGF-BETA TYPE I RECEPTOR; TRANSFORMING GROWTH FACTOR BETA RECEPTOR; TRANSFORMING GROWTH FACTOR BETA TYPE II RECEPTOR; TRANSFORMING GROWTH FACTOR BETA1; TRANSFORMING GROWTH FACTOR BETA2; TRANSFORMING GROWTH FACTOR-BETA TYPE II RECEPTOR;

ARTICLE; BASOLATERAL MEMBRANE; BIOTINYLATION; CANCER CELL CULTURE; CELL DIFFERENTIATION; CELL GROWTH; CELL MIGRATION; CELL POLARITY; CELL SPECIFICITY; CELL STRAIN; CELL STRAIN CACO 2; CELL TRANSFORMATION; COLON CANCER; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; EPITHELIUM CELL; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; INTESTINE EPITHELIUM; MESENCHYME CELL; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; PROTEIN SECRETION; SIGNAL TRANSDUCTION; ANIMAL; CELL MEMBRANE; CYTOLOGY; DOG; FLUORESCENT ANTIBODY TECHNIQUE; INTESTINE CELL; METABOLISM; PHOSPHORYLATION; PROTEIN TRANSPORT; WESTERN BLOTTING;

ANIMALS; BLOTTING, WESTERN; CACO-2 CELLS; CELL MEMBRANE; CELL POLARITY; DOGS; ENTEROCYTES; FLUORESCENT ANTIBODY TECHNIQUE; HUMANS; MEMBRANE PROTEINS; PHOSPHORYLATION; PROTEIN ISOFORMS; PROTEIN TRANSPORT; PROTEIN-SERINE-THREONINE KINASES; RECEPTORS, TRANSFORMING GROWTH FACTOR BETA; SIGNAL TRANSDUCTION; SMAD2 PROTEIN; TRANSFORMING GROWTH FACTOR BETA1; TRANSFORMING GROWTH FACTOR BETA2;

EID: 77953625316     PISSN: 00219541     EISSN: 10974652     Source Type: Journal    
DOI: 10.1002/jcp.22135     Document Type: Article

References (35)

1. Ando-Akatsuka Y, Saitou M, Hirase T, Kishi M, Sakakibara A, Itoh M, Yonemura S, Furuse M, Tsukita S. 1996. Interspecies diversity of the occludin sequence: cDNA cloning of human, mouse, dog, and rat-kangaroo homologues. J Cell Biol 133:43-47. (Pubitemid 126618596)
2. Baldassarre M, Laneve AM, Grosso R, Laforgia N. 2008. Celiac disease: Pathogenesis and novel therapeutic strategies. Endocr Metab Immune Disord Drug Targets 8:152-158.
3. Barrios-Rodiles M, Brown KR, Ozdamar B, Bose R, Liu Z, Donovan RS, Shinjo F, Liu Y, Dembowy J, Taylor IW, Luga V, Przulj N, Robinson M, Suzuki H, Hayashizaki Y, Jurisica I, Wrana JL. 2005. High-throughput mapping of a dynamic signaling network in mammalian cells. Science (New York, NY) 307:1621-1625.
4. Bulus NM, Sheng HM, Sizemore N, Oldham SM, Barnett JV, Coffey RJ, Beauchamp DR, Barnard JA. 2000. Ras-mediated suppression of TGFbetaRII expression in intestinal epithelial cells involves Raf-independent signaling. Neoplasia (New York, NY) 2:357-364.
5. Clayburgh DR, Shen L, Turner JR. 2004. A porous defense: The leaky epithelial barrier in intestinal disease. Lab Invest 843:282-291. (Pubitemid 41656483)
6. Damstrup L, Kuwada SK, Dempsey PJ, Brown CL, Hawkey CJ, Poulsen HS,Wiley HS, Coffey RJ, Jr. 1999. Amphiregulin acts as an autocrine growth factor in two human polarizing colon cancer lines that exhibit domain selective EGF receptor mitogenesis. Br J Cancer 80:1012-1019.
7. Darido C, Buchert M, Pannequin J, Bastide P, Zalzali H, Mantamadiotis T, Bourgaux JF, Garambois V, Jay P, Blache P, Joubert D, Hollande F. 2008. Defective claudin-7 regulation by Tcf-4 and Sox-9 disrupts the polarity and increases the tumorigenicity of colorectal cancer cells. Cancer Res 68:4258-4268.
8. Dempsey PJ, Coffey RJ. 1994. Basolateral targeting and efficient consumption of transforming growth factor-alpha when expressed in Madin-Darby canine kidney cells. J Biol Chem 269:16878-16889.
9. Dempsey PJ, Meise KS, Yoshitake Y, Nishikawa K, Coffey RJ. 1997. Apical enrichment of human EGF precursor inMadin-Darby canine kidney cells involves preferential basolateral ectodomain cleavage sensitive to a metalloprotease inhibitor. J Cell Biol 138:747-758. (Pubitemid 27365039)
10. Dignass AU, Sturm A. 2001. Peptide growth factors in the intestine. Eur J Gastroenterol Hepatol 13:763-770.
11. Gibson PR. 2004. Increased gut permeability in Crohn's disease: Is TNF the link? Gut 53:1724-1725.
12. Graham MF, Bryson GR, Diegelmann RF. 1990. Transforming growth factor beta 1 selectively augments collagen synthesis by human intestinal smooth muscle cells. Gastroenterology 99:447-453. (Pubitemid 20219102)
13. Hartsough MT, Mulder KM. 1997. Transforming growth factor-beta signaling in epithelial cells. Pharmacol Ther 75:21-41. (Pubitemid 27444685)
14. Hermiston ML, Gordon JI. 1995. Inflammatory bowel disease and adenomas in mice expressing a dominant negative N-cadherin. Science (New York, NY) 270:1203-1207.
15. Hesse D, Sauvant C, Holzinger H, Gekle M. 2004. Apical expression or expression in a non polarized cell of hOAT1 inverses regulation by epidermal growth factor (EGF) as compared to basolateral hOAT1. Cell Physiol Biochem 14:177-186. (Pubitemid 38586117)
16. Higashiyama S, Iwabuki H, Morimoto C, Hieda M, Inoue H, Matsushita N. 2008. Membrane-anchored growth factors, the epidermal growth factor family: Beyond receptor ligands. Cancer Sci 99:214-220. (Pubitemid 351228472)
17. Hirai R, Fijita T. 1996.Ahuman transforming growth factor-beta type II receptor that contains an insertion in the extracellular domain. Exp Cell Res 223:135-141. (Pubitemid 26063930)
18. Jhappan C, Stahle C, Harkins RN, Fausto N, Smith GH, Merlino GT. 1990. TGF alpha overexpression in transgenic mice induces liver neoplasia and abnormal development of the mammary gland and pancreas. Cell 61:1137-1146. (Pubitemid 20203495)
19. Kulkarni AB, Thyagarajan T, Letterio JJ. 2002. Function of cytokines within the TGF-beta superfamily as determined from transgenic and gene knockout studies in mice. Curr Mol Med 2:303-327. (Pubitemid 34649849)
20. Laukoetter MG, Nava P, Nusrat A. 2008. Role of the intestinal barrier in inflammatory bowel disease. World J Gastroenterol 14:401-407.
21. Massague J, Blain SW, Lo RS. 2000. TGFbeta signaling in growth control, cancer, and heritable disorders. Cell 103:295-309.
22. Massague J, Seoane J, Wotton D. 2005. Smad transcription factors. Genes Dev 19:2783-2810.
23. Murphy SJ, Dore JJ, Edens M, Coffey RJ, Barnard JA, Mitchell H, Wilkes M, Leof EB. 2004. Differential trafficking of transforming growth factor-beta receptors and ligand in polarized epithelial cells. Mol Biol Cell 15:2853-2862.
24. Murphy SJ, Shapira KE, Henis YI, Leof EB. 2007.Aunique element in the cytoplasmic tail of the type II transforming growth factor-beta receptor controls basolateral delivery. Mol Biol Cell 18:3788-3799.
25. Nakao A, Roijer E, Imamura T, Souchelnytskyi S, Stenman G, Heldin CH, ten Dijke P. 1997. Identification of Smad2, a human Mad-related protein in the transforming growth factor beta signaling pathway. J Biol Chem 272:2896-2900.
26. Nikawa J. 1994. A cDNA encoding the human transforming growth factor beta receptor suppresses the growth defect of a yeast mutant. Gene 149:367-372.
27. Ozdamar B, Bose R, Barrios-Rodiles M, Wang HR, Zhang Y, Wrana JL. 2005. Regulation of the polarity protein Par6 by TGFbeta receptors controls epithelial cell plasticity. Science (New York, NY) 307:1603-1609.
28. Panwala CM, Jones JC, Viney JL. 1998. A novel model of inflammatory bowel disease: Mice deficient for the multiple drug resistance gene, mdr1a, spontaneously develop colitis. J Immunol 161:5733-5744.
29. Simmons JG, Pucilowska JB, Keku TO, Lund PK. 2002. IGF-I and TGF-beta1 have distinct effects on phenotype and proliferation of intestinal fibroblasts. Am J Physiol 283:G809-G818.
30. Suzuki A, Shioda N, Maeda T, Tada M, Ueno N. 1994. Cloning of an isoform of mouse TGF-beta type II receptor gene. FEBS Lett 355:19-22.
31. Tian YC, Phillips AO. 2002. Interaction between the transforming growth factor-beta type II receptor/Smad pathway and beta-catenin during transforming growth factor-beta1-mediated adherens junction disassembly. Am J Pathol 160:1619-1628.
32. Walia B, Wang L, Merlin D, Sitaraman SV. 2003. TGF-beta down-regulates IL-6 signaling in intestinal epithelial cells: Critical role of SMAD-2. FASEB J 17:2130-2132.
33. Wrana JL, Attisano L, Carcamo J, Zentella A, Doody J, Laiho M,Wang XF, Massague J. 1992. TGF beta signals through a heteromeric protein kinase receptor complex.Cell 71:1003-1014.
34. Wrana JL, Attisano L,Wieser R, Ventura F, Massague J. 1994. Mechanism of activation of the TGF-beta receptor. Nature 370:341-347.
35. Xu Y, Pasche B. 2007. TGF-beta signaling alterations and susceptibility to colorectal cancer. Hum Mol Genet 16:R14-R20.