Amphiregulin acts as an autocrine growth factor in two human polarizing colon cancer lines that exhibit domain selective EGF receptor mitogenesis

British Journal of Cancer

Volumn 80, Issue 7, 1999, Pages 1012-1019

  Damstrup, L ^a,b   Kuwada, S K ^c,d   Dempsey, P J ^a   Brown, C L ^a   Hawkey, C J ^a   Poulsen, H S ^b   Wiley, H S ^c   Coffey Jr , R J ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b FINSEN LABORATORY   (Denmark)

^c UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

^d VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

Colon cancer cell lines; EGFR; Ligand and proliferation; Polarized cells

Indexed keywords

AMPHIREGULIN; EPIDERMAL GROWTH FACTOR RECEPTOR; GROWTH FACTOR; NEUTRALIZING ANTIBODY; PLASTIC; TRANSFORMING GROWTH FACTOR ALPHA; TRITIUM;

APICAL MEMBRANE; ARTICLE; BASOLATERAL MEMBRANE; CANCER CELL CULTURE; CELL POLARITY; CELL PROLIFERATION; CELL STRAIN CACO 2; COLON CANCER; CONFOCAL MICROSCOPY; DNA SYNTHESIS; HUMAN; HUMAN CELL; MITOGENESIS; MONOLAYER CULTURE; NORTHERN BLOTTING; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SCATCHARD PLOT;

ANTIBODIES, MONOCLONAL; ANTINEOPLASTIC AGENTS; AUTOCRINE COMMUNICATION; CACO-2 CELLS; CELL DIVISION; CELL POLARITY; COLONIC NEOPLASMS; DNA; DNA REPLICATION; GLYCOPROTEINS; GROWTH SUBSTANCES; HUMANS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; RECEPTOR, EPIDERMAL GROWTH FACTOR; RNA, MESSENGER; TRANSFORMING GROWTH FACTOR ALPHA; TUMOR CELLS, CULTURED;

EID: 0032934041     PISSN: 00070920     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjc.6690456     Document Type: Article

References (39)

1. Amemiya K, Kurachi H, Adachi H, Morishige KI, Adachi K, Imai T and Miyake A (1994) Involvement of epidermal growth factor (EGF)/EGF receptor autocrine and paracrine mechanism in human trophoblast cells: functional differentiation in vitro. J Endocrinol 143: 291-301
2. Auricchio A, Di Domenico M, Castoria G, Bilancio A and Migliaccio A (1994) Epidermal growth factor induces protein tyrosine phosphorylation and association of p190 with ras-GTP-ase activating protein in Caco-2 cells. FEBS Lett 353: 16-20
3. Basson MD, Beidler DR, Turowski G, Zarif A, Modlin IM, Jena BP and Madri JA (1994) Effect of tyrosine kinase inhibition on basal and epidermal growth factor-stimulated human Caco-2 enterocyte sheet migration and proliferation. J Cell Physiol 160: 491-501
4. Basson MD, Modlin IM sind Madri JA (1992). Human enterocyte (Caco-2) migration is modulated in vitro by extracellular matrix composition and epidermal growth factor. J Clin Invest 90: 15-23
5. Bellot F, Moolenaar W, Kris R, Mirakhur B, Verlaan I, Ullrich A, Schlessinger J and Felder S (1990) High-affinity epidermal growth factor binding is specifically reduced by a monoclonal antibody, and appears necessary for early responses. J Cell Biol 110: 491-502
6. Bishop WP and Wen JT (1994) Regulation of Caco-2 cell proliferation by basolateral membrane epidermal growth factor receptors. Am J Physiol 267: G892-G900
7. Brown CL, Meise KS, Plowman GD, Coffey RJ and Dempsey PJ (1998) Cell surface ectodomain cleavage of human amphiregulin precursor is sensitive to a metalloprotease inhibitor. Release of a predominant N-glycosylated 43-kDa soluble form. J Biol Chem 273: 17258-17268
8. Chen P, Gupta K and Wells A (1994) Cell movement elicited by epidermal growth factor receptor requires kinase and autophosphorylation but is separable from mitogenesis. J Cell Biol 124: 547-555
9. Chinery R and Cox J (1995) Modulation of epidermal growth factor effects on epithelial ion transport by intestinal trefoil factor. Br J Pharmacol 115: 77-80
10. Coffey RJ, Hawkey C, Damstrup L, Graves-Deal R, Daniel VC, Dempsey PJ, Chinery R, Kirkland S, DuBois RN, Jetton TL and Morrow JD (1997) Vectorial release and TGFα mediated production of prostaglanding is polarized colon carcinoma cell lines. Proc Natl Acad Sci USA 94: 657-662
11. Cook PW, Pittelkow MR, Keeble WW, Graves-Deal R, Coffey RJ Jr and Shipley GD (1992) Amphiregulin messenger RNA is elevated in psoriatic epidermis and gastrointestinal carcinomas. Cancer Res 52: 3224-3227
12. Culouscou J-M, Remacle-Bonnet M, Carlton GW, Plowman GD and Shoyab M (1992) Colorectum cell-derived growth factor (CRDGF) is homologous to amphiregulin, a member of the epidermal growth factor family. Growth Factors 7: 195-205
13. Danielson PE, Forss-Petter S, Brow MA, Calavetta L, Douglass J, Milner RJ and Sutcliffe JG (1988) p1B15: a cDNA clone of the rat mRNA encoding cyclophilin. DNA 7: 261-267
14. Defize LH, Boonstra J, Meisenhelder J, Kruijer W, Tertoolen LG, Tilly BC, Hunter T, Van Bergen En Henegouwen PM, Moolenaar WH and De Laal SW (1989) Signal transduction by epidermal growth factor occurs through the subclass of high affinity receptors. J Cell Biol 109: 2495-2507
15. Dempsey PJ and Coffey RJ. Jr (1094) Basolateral targeting and efficient consumption of transforming growth factor-α when expressed in Madin-Darby canine kidney cells. J Biol Chem 269: 16878-16889
16. Dempsey PJ, Meise K, Yoshitake Y, Nishikawa K and Coffey RJ (1997) Apical enrichment of human EGF precursor in Madin-Darby canine kidney cells involves preferential basolateral ectodomain cleavage sensitive to a metalloprotease inhibitor. J Cell Biol 138: 1-12
17. Dobner PR, Kawasaki ES, Yu LY and Bancroft FC (1981) Thyroid or glucocorticoid hormone induces pre-growth hormone mRNA and its probable nuclear precursor in rat pituitary cells. Proc Natl Acad Sci USA 78: 2230-2234
18. Feldman HA (1972) Mathematical theory of complex ligand-binding systems at equilibrium: some methods for parameter fitting. Analyt Biochem 48: 317-338
19. Fowler KJ, Walker F, Alexander W, Hibbs ML, Nice EC, Bohmer RM, Mann GB, Thumwood C, Maglitto R, Danks JA, Chetty R, Burgess AW and Dunn AR (1995) A mutation in the epidermal growth factor receptor in waved-2 mice has a profound effect on receptor biochemistry that results in impaired lactation. Proc Natl Acad Sci USA 92: 1465-1469
20. Fuller SD and Simons K (1986) Transferrin receptor polarity and recycling accuracy in "tight" and "leaky" strains of Madin-Darby canine kidney cells. J Cell Biol 103: 1767-1779
21. Gex-Fabry M and Delisi C (1986) Regulation of interacting populations during endocytosis: models of growth factor-tumor promoter dynamics. Am J Physiol 250: R1123-R1132
22. Halter SA, Dempsey PJ, Matsui Y, Stokes MK, Graves-Deal R, Mogan BLM and Coffey RJ Jr (1992) Distinctive patterns of hyperplasia in transgenic mice with mouse mammary tumor virus transforming growth factor-α. Characterization of mammary gland and skin proliferation. Am J Pathol 140: 1131-1146
23. Robert M and Carlin C (1995) Cytoplasmic juxtamembrane domain of the human EGF receptor is required for basolateral localization in MDCK cells. J Cell Physiol 162: 434-446
24. Johnson GR, Saeki T, Gordon AW, Shoyab M, Salomon DS and Stromberg K (1992) Autocrine action of amphiregulin in a colon carcinoma cell line and immunocytochemical localization of amphiregulin in human colon. J Cell Biol 118: 741-751
25. Kirkland SC (1985) Dome formation by a Human Colonic Adenocarcinoma cell line (HCA-7). Cancer Res 45: 3790-3795
26. Lebivic G, Quaroni A and Rodriguez-Boulan E (1991) Microtubular organization and its involvement in the biogenetic pathways of plasma membrane proteins in Caco-2 intestinal epithelial cells. J Cell Biol 113: 275-288
27. Li S, Plowman GD, Buckley SD and Shipley GD (1992). Heparin inhibition of autonomous growlh implicates amphiregulin as an autocrine growth factor for normal human mammary epithelial cells. J Cell Physiol 153: 103-111
28. Luetteke NC, Phillips HK, Qiu TH, Copeland NG, Earp HS, Jenkins NA and Lee DC (1994) The mouse waved-2 phenotype results from a point mutation in the EGF receptor tyrosine kinase. Genes Dev 8: 399-413
29. Maratos-Flier E, Kao C-YY, Verdin EM and King GL (1987) Reseptor-mediated vectorial transcytosis of epidermal growth factor by Madin-Darby canine kidney cells. J Cell Biol 105: 1595-1601.
30. Martinez-Palomo A, Meza I, Beaty G and Cercijido M (1980) Experimental modulation of occluding junctions in a cultured transporting epithelium. J Cell Biol 87: 736-745.
31. Mayo KH, Nunez M, Burke C, Starbuck C, Lauffenburger D and Savage CR, Jr (1989) Epidermal growth factor receptor binding is not a simple one-step process. J Biol Chem 264: 17838-17844
32. Melton DA, Krieg PA, Rebagliati MR, Maniatis T, Zinn K and Green MR (1984) Efficient in vitro synthesis of biologically active RNA and RNA hybridization probes from plasmids containing a bacteriophage SP6 promoter. Nucleic Acids Res 12: 7035-7056
33. Milovic V, Deubner C, Zeuzem S, Piiper A, Caspary WF and Stein J (1995) EGF stimulates polyamine uptake in Caco-2 cells. Biochem Biophys Res Commun 206: 962-968
34. Pesonen M and Simons K (1983) Transepithelial transport of a viral membrane glycoprotein implanted into the apical plasma membrane of Madin-Darby canine kidney cells. II. Immunological quantitation. J Cell Biol 97: 638-643
35. Qi C-F, Liscia DS, Normanno N, Merlo G, Johnson GR, Gullick WJ, Ciardiello F, Saeki T, Brandt R, Kim N, Kenney N and Solomon DS (1994). Expression of transforming growth factor alpha, amphiregulin and cripto-1 in human breast carcinomas. Br J Cancer 69: 903-910
36. Scatchard G (1949) The attractions of proteins for small molecules and ions. Ann NY Acad Sci 51: 660-672
37. Traverse S, Seedorf K, Paterson H, Marshall CJ, Cohen P and Ullrich A (1994) EGF triggers neuronal differentiation of PC12 cells that overexpress the EGF receptor. Curr Biol 4: 694-701
38. Wofsy C, Goldstein R, Lund K and Wiley HS (1992). Implications of epidermal growth factor (EGF) induced EGF receptor aggregation. Biophys J 63: 98-110
39. Ziober BL, Willson JK, Hymphrey LE, Childress-Fields K and Brattain MG (1993) Autocrine transforming growth factor-alpha is associated with progression of transformed properties in human colon cancer cells. J Biol Chem 268: 691-698