Is there a telomere-bound 'EST' telomerase holoenzyme?

Cell Cycle

Volumn 9, Issue 10, 2010, Pages 1913-1917

  DeZwaan, Diane C ^a   Freeman, Brian C ^a  

^a UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

Author keywords

Cdc13; DNA replication; Est1; Telomerase; Telomere

Indexed keywords

CDC13 PROTEIN; CELL DNA; DNA POLYMERASE; EST1 PROTEIN; EST3 PROTEIN; HOLOENZYME; HYBRID PROTEIN; NUCLEOTIDE; PROTEIN; SODIUM CHLORIDE; TELOMERASE; UNCLASSIFIED DRUG;

CELL CYCLE S PHASE; CHROMATIN IMMUNOPRECIPITATION; DNA REPLICATION; DOUBLE STRANDED DNA BREAK; ENZYME ACTIVITY; EUKARYOTE; GENE LOCUS; NONHUMAN; PHENOTYPE; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN INTERACTION; REVIEW; TELOMERE; YEAST;

EUKARYOTA; SACCHAROMYCETALES;

EID: 77953625099     PISSN: 15384101     EISSN: 15514005     Source Type: Journal    
DOI: 10.4161/cc.9.10.11536     Document Type: Review

References (47)

1. Muller HJ. The remaking of chromosomes. Collecting Net 1938; 13:182-98.
2. McClintock B. The stability of broken ends of chromosomes in Zae mays. Genetics 1941; 26:234-82.
3. Watson JD. Origin of concatemeric T7 DNA. Nat New Biol 1972; 239:197-201.
4. Olovnikov AM. A theory of marginotomy. J Theor Biol 1973; 41:181-90.
5. Blackburn EH. Telomeres. Trends Biochem Sci 1991; 16:378-81.
6. Gilson E, Geli V. How telomeres are replicated. Nat Rev Mol Cell Biol 2007; 8:825-38.
7. Shampay J, Szostak JW, Blackburn EH. DNA sequences of telomeres maintained in yeast. Nature 1984; 310:154-7. (Pubitemid 14086009)
8. Greider CW, Blackburn EH. The telomere terminal transferase of Tetrahymena is a ribonucleoprotein enzyme with two kinds of primer specificity. Cell 1987; 51:887-98.
9. Blackburn EH, Greider CW, Henderson E, Lee MS, Shampay J, Shippen-Lentz D. Recognition and elongation of telomeres by telomerase. Genome 1989; 31:553-60.
10. Lundblad V, Szostak JW. A mutant with a defect in telomere elongation leads to senescence in yeast. Cell 1989; 57:633-43.
11. Lendvay TS, Morris DK, Sah J, Balasubramanian B, Lundblad V. Senescence mutants of Saccharomyces cerevisiae with a defect in telo-mere replication identify three additional EST genes. Genetics 1996; 144:1399-412.
12. Hartwell LH, Mortimer RK, Culotti J, Culotti M. Genetic control of the cell division cycle in yeast: V. Genetic analysis of cdc mutants. Genetics 1973; 74:267-86.
13. Taggart AK, Zakian VA. Telomerase: what are the Est proteins doing? Curr Opin Cell Biol 2003; 15:275-80.
14. Linger BR, Price CM. Conservation of telomere protein complexes: shuffling through evolution. Crit Rev Biochem Mol Biol 2009; 44:434-46.
15. Singer MS, Gottschling DE. TLC1: template RNA component of Saccharomyces cerevisiae telomerase. Science 1994; 266:404-9.
16. Counter CM, Meyerson M, Eaton EN, Weinberg RA. The catalytic subunit of yeast telomerase. Proc Natl Acad Sci USA 1997; 94:9202-7.
17. Lingner J, Hughes TR, Shevchenko A, Mann M, Lundblad V, Cech TR. Reverse transcriptase motifs in the catalytic subunit of telomerase. Science 1997; 276:561-7.
18. Steiner BR, Hidaka K, Futcher B. Association of the Est1 protein with telomerase activity in yeast. Proc Natl Acad Sci USA 1996; 93:2817-21.
19. Zhou J, Hidaka K, Futcher B. The Est1 subunit of yeast telomerase binds the Tlc1 telomerase RNA. Mol Cell Biol 2000; 20:1947-55.
20. Hughes TR, Evans SK, Wellbaecher RG, Lundblad V. The Est3 protein is a subunit of yeast telomerase. Curr Biol 2000; 10:809-12.
21. Livengood AJ, Zaug AJ, Cech TR. Essential Regions of Saccharomyces cerevisiae Telomerase RNA: Separate Elements for Est1p and Est2p Interaction. Mol Cell Biol 2002; 22:2366-74.
22. Seto AG, Livengood AJ, Tzfati Y, Blackburn EH, Cech TR. A bulged stem tethers Est1p to telomerase RNA in budding yeast. Genes Dev 2002 16:2800-12.
23. Friedman KL, Heit JJ, Long DM, Cech TR. N-terminal domain of yeast telomerase reverse transcriptase: recruitment of Est3 to the telomerase complex. Mol Biol Cell 2003; 14:1-13.
24. Osterhage JL, Talley JM, Friedman KL. Proteasome-dependent degradation of Est1 regulates the cell cycle-restricted assembly of telomerase in Saccharomyces cerevisiae. Nat Struct Mol Biol 2006; 13:720-8.
25. Evans SK, Lundblad V. The Est1 subunit of Saccharomyces cerevisiae telomerase makes multiple contributions to telomere length maintenance. Genetics 2002; 162:1101-15.
26. Bianchi A, Negrini S, Shore D. Delivery of yeast telomerase to a DNA break depends on the recruitment functions of Cdc13 and Est1. Mol Cell 2004; 16:139-46.
27. Lin JJ, Zakian VA. An in vitro assay for Saccharomyces telomerase requires EST1. Cell 1995; 81:1127-35.
28. Lingner J, Cech TR, Hughes TR, Lundblad V. Three ever shorter telomere (EST) genes are dispensable for in vitro yeast telomerase activity. Proc Natl Acad Sci USA 1997; 94:11190-5.
29. Nugent CI, Hughes TR, Lue NF, Lundblad V. Cdc13p: a single-strand telomeric DNA-binding protein with a dual role in yeast telomere maintenance. Science 1996; 274:249-52.
30. Vitra-Pearlman V, Morris DK, Lundblad V. Est1 has the properties of a single-stranded telomere end-binding protein. Genes Dev 1996; 10:3094-104.
31. Qi H, Zakian VA. The Saccharomyces telomere-binding protein Cdc13 interacts with both the catalytic subunit of DNA polymerase alpha and the telomerase-associated est1 protein. Genes Dev 2000; 14:1777-88. (Pubitemid 30602996)
32. Evans SK, Lundblad V. Est1 and Cdc13 as comediators of telomerase access. Science 1999; 286:117-20.
33. Pennock E, Buckley K, Lundblad V. Cdc13 delivers separate complexes to the telomere for end protection and replication. Cell 2001; 104:387-96.
34. Taggart TR, Teng SC, Zakian VA. Est1p as a cell cycle-regulated activator of telomere-bound telomerase. Science 2002; 297:1023-6.
35. Marcand S, Brevet V, Mann C, Gilson E. Cell cycle restriction of telomere elongation. Curr Biol 2000; 10:487-90. (Pubitemid 30247340)
36. Stellwagen AE, Haimberger ZW, Veatch JR, Gottschling DE. Ku interacts with telomerase RNA to promote telomere addition at native and broken chromosome ends. Genes Dev 2003; 17:2384-95.
37. Fisher TS, Taggart AK, Zakian VA. Cell cycle-dependent regulation of yeast telomerase by Ku. Nat Struct Mol Biol 2004; 11:1198-205.
38. Chan A, Boule JB, Zakian VA. Two pathways recruit telomerase to Saccharomyces cerevisiae telomeres. PLoS Genet 2008; 4:1000236.
39. DeZwaan DC, Freeman BC. The conserved Est1 protein stimulates telomerase DNA extension activity. Proc Natl Acad Sci USA 2009; 106:17337-42.
40. Smith CD, Smith DL, DeRisi JL, Blackburn EH. Telomeric protein distributions and remodeling through the cell cycle in Saccharomyces cerevisiae. Mol Biol Cell 2003; 14:556-70.
41. Schramke V, Luciano P, Brevet V, Guillot S, Corda Y, Longhese MP, et al. RPA regulates telomerase action by providing Est1p access to chromosome ends. Nat Genet 2004; 36:46-54. (Pubitemid 38056207)
42. Toogun OA, Zeiger W, Freeman BC. The p23 molecular chaperone promotes functional telomerase complexes through DNA dissociation. Proc Natl Acad Sci USA 2007; 104:5765-70.
43. Porter SE, Greenwell PW, Ritchie KB, Petes TD. The DNA-binding protein Hdf1p (a putative Ku homologue) is required for maintaining normal telomere length in Saccharomyces cerevisiae. Nucleic Acids Res 1996; 24:582-5.
44. Hemann MT, Strong MA, Hao LY, Greider CW. The shortest telomere, not average telomere length, is critical for cell viability and chromosome stability. Cell 2001; 107:67-77.
45. Teixeira MT, Arneric M, Sperisen P, Lingner J. Telomere length homeostasis is achieved via a switch between telomerase-extendible and-nonextendible states. Cell 2004; 117:323-35.
46. Redon S, Reichenbach P, Lingner J. Protein RNA and protein protein interactions mediate association of human EST1A/SMG6 with telomerase. Nucleic Acids Res 2007; 35:7011-22.
47. DeZwaan DC, Toogun OA, Echtenkamp FJ, Freeman BC. The Hsp82 molecular chaperone promotes a switch between unextendable and extendable telomere states. Nat Struct Mol Biol 2009; 16:711-6.