Toll-like receptor 4-mediated c-Jun N-terminal kinase activation induces gp96 cell surface expression via AIMP1 phosphorylation

Biochemical and Biophysical Research Communications

Volumn 397, Issue 1, 2010, Pages 100-105

  Kim, Gyuyoup ^a   Han, Jung Min ^a   Kim, Sunghoon ^a,b  

^a Seoul National University   (South Korea)

^b Seoul National University   (South Korea)

Author keywords

AIMP1; gp96; JNK; LPS; MyD88; TLR4

Indexed keywords

ALANINE; GLYCOPROTEIN GP 96; LIPOPOLYSACCHARIDE; MYELOID DIFFERENTIATION FACTOR 88; PROTEIN P43; SERINE; STRESS ACTIVATED PROTEIN KINASE; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4; TOLL LIKE RECEPTOR 9; TUBULIN;

ARTICLE; CELL SURFACE; CONTROLLED STUDY; ENDOPLASMIC RETICULUM; ENZYME ACTIVATION; GENE MUTATION; HUMAN; HUMAN CELL; MOLECULAR MECHANICS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RECEPTOR UPREGULATION;

ANTIGENS, NEOPLASM; CELL MEMBRANE; CYTOKINES; ENDOPLASMIC RETICULUM; ENZYME ACTIVATION; HL-60 CELLS; HUMANS; IMMUNITY, INNATE; JNK MITOGEN-ACTIVATED PROTEIN KINASES; LIPOPOLYSACCHARIDES; MOLECULAR CHAPERONES; MUTATION; MYELOID DIFFERENTIATION FACTOR 88; NEOPLASM PROTEINS; PHOSPHORYLATION; RNA-BINDING PROTEINS; SERINE; TOLL-LIKE RECEPTOR 4;

EID: 77953611585     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2010.05.075     Document Type: Article

References (30)

1. Medzhitov R., and Janeway Jr. C.A. Decoding the patterns of self and nonself by the innate immune system. Science 296 (2002) 298-300
2. Roach J.C., Glusman G., Rowen L., Kaur A., Purcell M.K., Smith K.D., Hood L.E., and Aderem A. The evolution of vertebrate Toll-like receptors. Proc. Natl. Acad. Sci. USA 102 (2005) 9577-9582
3. Kawai T., and Akira S. TLR signaling. Cell Death Differ. 13 (2006) 816-825
4. McGettrick A.F., and O'Neill L.A.J. The expanding family of MyD88-like adaptors in Toll-like receptor signal transduction. Mol. Immunol. 41 (2004) 577-582
5. Kenny E.F., and O'Neill L.A.J. Signalling adaptors used by Toll-like receptors: an update. Cytokine 43 (2008) 342-349
6. Janssens S., and Beyaert R. A universal role for MyD88 in TLR/IL-1R-mediated signaling. Trends Biochem. Sci. 27 (2002) 474-482
7. Dunne A., and O'Neill L.A.J. The interleukin-1 receptor/Toll-like receptor superfamily: signal transduction during inflammation and host defense. Sci. STKE 171 (2003) re3
8. Li Z., Dai J., Zheng H., Liu B., and Caudill M. An integrated view of the roles and mechanisms of heat shock protein gp96-peptide complex in eliciting immune response. Front. Biosci. 7 (2002) d731-d751
9. Altmeyer A., Maki R.G., Feldweg A.M., Heike M., Protopopov V.P., Masur S.K., and Srivastava P.K. Tumor-specific cell surface expression of the-KDEL containing, endoplasmic reticular heat shock protein gp96. Int. J. Cancer 69 (1996) 340-349
10. Wiest D.L., Bhandoola A., Punt J., Kreibich G., McKean D., and Singer A. Incomplete endoplasmic reticulum (ER) retention in immature thymocytes as revealed by surface expression of "ER-resident" molecular chaperones. Proc. Natl. Acad. Sci. USA 94 (1997) 1884-1889
11. Hilf N., Singh-Jasuja H., Schwarzmaier P., Gouttefangeas C., Rammensee H.-G., and Schild H. Human platelets express heat shock protein receptors and regulate dendritic cell maturation. Blood 99 (2002) 3676-3682
12. Vabulas R.M., Braedel S., Hilf N., Singh-Jasuja H., Herter S., Ahmad-Nejad P., Kirschning C.J., da Costa C., Rammensee H.-G., Wagner H., and Schild H. The endoplasmic reticulum-resident heat shock protein gp96 activates dendritic cells via the Toll-like receptor 2/4 pathway. J. Biol. Chem. 277 (2002) 20847-20853
13. Singh-Jasuja H., Scherer H.U., Hilf N., Arnold-Schild D., Rammensee H.-G., Toes R.E.M., and Schild H. The heat shock protein gp96 induces maturation of dendritic cells and down-regulation of its receptor. Eur. J. Immunol. 30 (2000) 2211-2215
14. Binder R.J., Han D.K., and Srivastava P.K. CD91: a receptor for heat shock protein gp96. Nat. Immunol. 1 (2000) 151-155
15. Srivastava P. Roles of heat-shock proteins in innate and adaptive immunity. Nat. Rev. Immunol. 2 (2002) 185-194
16. Liu B., Dai J., Zheng H., Stoilova D., Sun S., and Li Z. Cell surface expression of an endoplasmic reticulum resident heat shock protein gp96 triggers MyD88-dependent systemic autoimmune diseases. Proc. Natl. Acad. Sci. USA 100 (2003) 15824-15829
17. Huang Q.Q., Sobkoviak R., Jockheck-Clark A.R., Shi B., Mandelin II A.M., Tak P.P., Haines III G.K., Nicchitta C.V., and Pope R.M. Heat shock protein 96 is elevated in rheumatoid arthritis and activates macrophages primarily via TLR2 signaling. J. Immunol. 182 (2009) 4965-4973
18. Han J.M., Kwon N.H., Lee J.Y., Jeong S.J., Jung H.J., Kim H.R., Li Z., and Kim S. Identification of gp96 as a novel target for treatment of autoimmune disease in mice. PLoS ONE 5 (2010) e9792
19. Quevillon S., Agou F., Robinson J.-C., and Mirande M. The p43 component of the mammalian multi-synthetase complex is likely to be the precursor of the endothelial monocyte-activating polypeptide II cytokine. J. Biol. Chem. 272 (1997) 32573-32579
20. Park S.G., Jung K.H., Lee J.S., Jo Y.J., Motegi H., Kim S., and Shiba K. Precursor of pro-apoptotic cytokine modulates aminoacylation activity of tRNA synthetase. J. Biol. Chem. 274 (1999) 16673-16676
21. Lee S.W., Kim G., and Kim S. Aminoacyl-tRNA synthetase-interacting multi-functional protein 1/p43 and emerging therapeutic protein working at systems level. Expert Opin. Drug Discov. 3 (2008) 945-957
22. Ko Y.-G., Park H., Kim T., Lee J.-W., Park S.G., Seol W., Kim J.E., Lee W.-H., Kim S.-H., Park J.-E., and Kim S. A cofactor of tRNA synthetase, p43, is secreted to up-regulate proinflammatory genes. J. Biol. Chem. 276 (2001) 23028-23033
23. Park H., Park S.G., Kim J., Ko Y.-G., and Kim S. Signaling pathways for TNF production induced by human aminoacyl-tRNA synthetase-associating factor, p43. Cytokine 20 (2002) 148-153
24. Park H., Park S.G., Lee J.-W., Kim T., Kim G., Ko Y.-G., and Kim S. Monocyte cell adhesion induced by a human aminoacyl-tRNA synthetase-associated factor, p43: identification of the related adhesion molecules and signal pathways. J. Leukoc. Biol. 71 (2002) 223-230
25. Park S.G., Kang Y.-S., Ahn Y.H., Lee S.H., Kim K.-R., Kim K.-W., Koh G.Y., Ko Y.-G., and Kim S. Dose-dependent biphasic activity of tRNA synthetase-associating factor, p43, in angiogenesis. J. Biol. Chem. 277 (2002) 45243-45248
26. Park S.G., Shin H., Shin Y.K., Lee Y., Choi E.-C., Park B.-J., and Kim S. The novel cytokine p43 stimulates dermal fibroblast proliferation and wound repair. Am. J. Pathol. 166 (2005) 387-398
27. Park S.G., Kang Y.S., Kim J.Y., Lee C.S., Ko Y.G., Lee W.J., Lee K.-U., Yeom Y.I., and Kim S. Hormonal activity of AIMP1/p43 for glucose homeostasis. Proc. Natl. Acad. Sci. USA 103 (2006) 14913-14918
28. Han J.M., Park S.G., Liu B., Park B.-J., Kim J.Y., Jin C.H., Song Y.W., Li Z., and Kim S. Aminoacyl-tRNA synthetase-interacting multifunctional protein 1/p43 controls endoplasmic reticulum retention of heat shock protein gp96: its pathological implications in lupus-like autoimmune diseases. Am. J. Pathol. 170 (2007) 2042-2054
29. Barton G.M., and Medzhitov R. Toll-like receptor signaling pathways. Science 300 (2003) 1524-1525
30. Papadimitraki E.D., Choulaki C., Koutala E., Bertsias G., Tsatsanis C., Gergianaki I., Raptopoulou A., Kritikos H.D., Mamalaki C., Sidiromos P., and Boumpas D.T. Expansion of Toll-like receptor 9-expressing B cells in active systemic lupus erythematosus: implications for the induction and maintenance of the autoimmune process. Arthritis. Rheum. 54 (2006) 3601-3611