Human platelets express heat shock protein receptors and regulate dendritic cell maturation

Blood

Volumn 99, Issue 10, 2002, Pages 3676-3682

  Hilf, Norbert ^a   Singh Jasuja, Harpreet ^a   Schwarzmaier, Petra ^a   Gouttefangeas, Cécile ^a   Rammensee, Hans Georg ^a   Schild, Hansjörg ^a  

^a UNIVERSITY OF TÜBINGEN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CD40 LIGAND; CD83 ANTIGEN; CD86 ANTIGEN; CYTOKINE; FLUORESCEIN ISOTHIOCYANATE; GLYCOPROTEIN GP 96; HEAT SHOCK PROTEIN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; THROMBIN;

ANTIGEN PRESENTING CELL; ARTICLE; CELL DEATH; CELL MATURATION; CONTROLLED STUDY; DENDRITIC CELL; ENDOPLASMIC RETICULUM; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IMMUNIZATION; INFLAMMATION; MAJOR HISTOCOMPATIBILITY COMPLEX RESTRICTION; PRIORITY JOURNAL; THROMBOCYTE; THROMBOCYTE AGGREGATION; THROMBOCYTE FUNCTION; VIRUS INFECTION; WOUND HEALING;

EID: 0037093080     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.V99.10.3676     Document Type: Article

References (41)

1. Sequential interaction of the chaperones BiP and GRP94 with immunoglobulin chains in the endoplasmic reticulum
2. The endoplasmic reticulum-resident stress protein gp96 binds peptides translocated by TAP
3. TAP-translocated peptides specifically bind proteins in the endoplasmic reticulum, including gp96, protein disulfide isomerase and calreticulin
4. Necrotic but not apoptotic cell death releases heat shock proteins, which deliver a partial maturation signal to dendritic cells and activate the NF-κB pathway
5. Virally induced lytic cell death elicits the release of immunogenic GRP94/gp96
6. Comparison of tumor-specific immunogenicities of stress-induced proteins gp96, hsp90, and hsp70
7. Immunotherapy of tumors with autologous tumor-derived heat shock protein preparations
8. Cutting edge: Receptor-mediated endocytosis of heat shock proteins by professional antigen-presenting cells
9. Cross-presentation of glycoprotein 96-associated antigens on major histocompatibility complex class I molecules requires receptor-mediated endocytosis
10. Minor H antigens introduced on H-2 different stimulating cells cross-react at the cytotoxic T cell level during in vivo priming
11. Cross-presentation: A general mechanism for CTL immunity and tolerance
12. Cytotoxic T-cell immunity to virus-infected non-haematopoietic cells requires presentation of exogenous antigen
13. The heat shock protein gp96 induces maturation of dendritic cells and down-regulation of its receptor
14. CD91: A receptor for heat shock protein gp96
15. The CD36 scavenger receptor as a receptor for Gp96
16. Endoplasmic reticulum chaperone gp96 is required for innate immunity but no cell viability
17. The heat shock protein Gp96 triggers classical signaling cascades vial Toll-like receptor 2 and 4
18. Cutaneous wound healing
19. Thrombocyte HLA molecules retain nonrenewable endogenous peptides of megakaryocyte lineage and do not stimulate direct allocytotoxicity in vitro
20. CD40 ligand on activated platelets triggers an inflammatory reaction of endothelial cells
21. Large-scale culture and selective maturation of human Langerhans cells from granulocyte colony-stimulating factor-mobilized CD34+ progenitors
22. Stimulation of histamine release from human basophils by human platelet factor 4
23. Cytokine RANTES released by thrombin-stimulated platelets is a potent attractant for human eosinophils
24. Chemokine and chemokine receptor mRNA expression in human platelets
25. Type beta transforming growth factor in human platelets: Release during platelet degranulation and action on vascular smooth muscle cells
26. Platelet immunoregulatory factors
27. Distinct subsets of dendritic cells resembling dermal DCs can be generated in vitro from monocytes, in the presence of different serum supplements
28. Consequences of cell death: Exposure to necrotic tumor cells, but not primary tissue cells or apoptotic cells, induces the maturation of immunostimulatory dendritic cells
29. The induction of tolerance by dendritic cells that have captured apoptotic cells
30. A discrete subpopulation of dendritic cells transports apoptotic intestinal epithelial cells to T cell areas of mesenteric lymph nodes
31. Antigen-specific inhibition of effector T cell function in humans after injection of immature dendritic cells
32. Activated platelets signal chemokine synthesis by human monocytes
33. Activated platelets induce monocyte chemotactic protein-1 secretion and surface expression of intercellular adhesion molecule-1 on endothelial cells
34. Induction of cytokine expression in leukocytes by binding of thrombin-stimulated platelets
35. Interaction with autologous platelets multiplies interleukin-1 and tumor necrosis factor production in mononuclear cells
36. GMP-140 mediates adhesion of stimulated platelets to neutrophils
37. Activated platelets induce superoxide anion release by monocytes and neutrophils through P-selectin (CD62)
38. Prevention of activated neutrophil adhesion to endothelium by soluble adhesion protein GMP140
39. Large-scale culture and selective maturation of human Langerhans cells from granulocyte colony-stimulating factor-mobilized CD34+ progenitors
40. Saturation, competition, and specificity in interaction of heat shock proteins (hsp) gp96, hsp90, and hsp70 with CD11b+ cells
41. CD91 is a common receptor for heat shock proteins gp96, hsp90, hsp70, and calreticulin