Checkpoint bypass and cell viability

Cell Cycle

Volumn 9, Issue 11, 2010, Pages 2102-2107

  Chung, Jon H ^a   Zhang, Yonggang ^a   Bunz, Fred ^a  

^a JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

Cdk2; Checkpoint; Ionizing radiation; Mitosis; p53

Indexed keywords

CYCLIN DEPENDENT KINASE 2; PROTEIN P53;

ALLELE; CELL CYCLE G2 PHASE; CELL CYCLE S PHASE; CELL DAMAGE; CELL DEATH; CELL FATE; CELL GROWTH; CELL LOSS; CELL PROLIFERATION; CELL SURVIVAL; CELL VIABILITY; CHROMOSOME SEGREGATION; DNA DAMAGE; DNA REPLICATION; ENZYME ACTIVITY; GENOTYPE; HUMAN; MITOSIS; NONHUMAN; REVIEW;

EID: 77953603153     PISSN: 15384101     EISSN: 15514005     Source Type: Journal    
DOI: 10.4161/cc.9.11.11849     Document Type: Review

References (30)

1. Chung JH, Bunz F. Cdk2 is required for p53-independent G(2)/M checkpoint control. PLoS Genet 2010; 6:1000863.
2. 2-M checkpoint response to DNA damage. Cancer Res 2007; 67:6685-90.
3. Lindqvist A, van Zon W, Karlsson Rosenthal C, Wolthuis RM. Cyclin B1-Cdk1 activation continues after centrosome separation to control mitotic progression. PLoS Biol 2007; 5:123.
4. Bartek J, Lukas J. Chk1 and Chk2 kinases in checkpoint control and cancer. Cancer Cell 2003; 3:421-9.
5. el-Deiry WS, Tokino T, Velculescu VE, Levy DB, Parsons R, Trent JM, et al. WAF1, a potential mediator of p53 tumor suppression. Cell 1993; 75:817-25.
6. 2 arrest after DNA damage. Science 1998; 282:1497-501.
7. Malumbres M, Harlow E, Hunt T, Hunter T, Lahti JM, Manning G, et al. Cyclin-dependent kinases: A family portrait. Nat Cell Biol 2009; 11:1275-6.
8. Santamaria D, Barriere C, Cerqueira A, Hunt S, Tardy C, Newton K, et al. Cdk1 is sufficient to drive the mammalian cell cycle. Nature 2007; 448:811-5.
9. Jackson SP, Bartek J. The DNA-damage response in human biology and disease. Nature 2009; 461:1071-8.
10. Hurley PJ, Bunz F. ATM and ATR: Components of an integrated circuit. Cell Cycle 2007; 6:414-7.
11. Mailand N, Diffley JF. CDKs promote DNA replication origin licensing in human cells by protecting Cdc6 from APC/C-dependent proteolysis. Cell 2005; 122:915-26. (Pubitemid 41345208)
12. Yoshida K, Sugimoto N, Iwahori S, Yugawa T, Narisawa-Saito M, Kiyono T, Fujita M. CDC6 interaction with ATR regulates activation of a replication checkpoint in higher eukaryotic cells. J Cell Sci 2010; 123:225-35.
13. Castedo M, Perfettini JL, Roumier T, Andreau K, Medema R, Kroemer G. Cell death by mitotic catastrophe: A molecular definition. Oncogene 2004; 23:2825-37. (Pubitemid 38638845)
14. 2/M checkpoint on genomic instability and cancer induction. Nat Rev Cancer 2007; 7:861-9.
15. Morrison C, Rieder CL. Chromosome damage and progression into and through mitosis in vertebrates. DNA Repair (Amst) 2004; 3:1133-9. (Pubitemid 38997957)
16. Xu B, Kim ST, Lim DS, Kastan MB. Two molecularly distinct G(2)/M checkpoints are induced by ionizing irradiation. Mol Cell Biol 2002; 22:1049-59.
17. +, a gene encoding a protein kinase homolog. Cell 1987; 49:559-67.
18. + functions as an inducer in the mitotic control of fission yeast. Cell 1986; 45:145-53.
19. Chan TA, Hermeking H, Lengauer C, Kinzler KW, Vogelstein B. 14-3-3Sigma is required to prevent mitotic catastrophe after DNA damage. Nature 1999; 401:616-20. (Pubitemid 129517080)
20. Malumbres M, Barbacid M. Cell cycle, CDKs and cancer: A changing paradigm. Nat Rev Cancer 2009; 9:153-66.
21. Puc J, Keniry M, Li HS, Pandita TK, Choudhury AD, Memeo L, et al. Lack of PTEN sequesters CHK1 and initiates genetic instability. Cancer Cell 2005; 7:193-204. (Pubitemid 40248344)
22. Tse AN, Carvajal R, Schwartz GK. Targeting checkpoint kinase 1 in cancer therapeutics. Clin Cancer Res 2007; 13:1955-60. (Pubitemid 46649860)
23. Powell SN, Bindra RS. Targeting the DNA damage response for cancer therapy. DNA Repair (Amst) 2009; 8:1153-65.
24. Merry C, Fu K, Wang J, Yeh IJ, Zhang Y. Targeting the checkpoint kinase Chk1 in cancer therapy. Cell Cycle 2010; 9:279-83.
25. Fukasawa K. Oncogenes and tumour suppressors take on centrosomes. Nat Rev Cancer 2007; 7:911-24. (Pubitemid 350165854)
26. Hinchcliffe EH, Sluder G. Two for two: Cdk2 and its role in centrosome doubling. Oncogene 2002; 21:6154-60.
27. Bunz F, Hwang PM, Torrance C, Waldman T, Zhang Y, Dillehay L, et al. Disruption of p53 in human cancer cells alters the responses to therapeutic agents. J Clin Invest 1999; 104:263-9.
28. Waldman T, Lengauer C, Kinzler KW, Vogelstein B. Uncoupling of S phase and mitosis induced by anticancer agents in cells lacking p21. Nature 1996; 381:713-6.
29. Kuntz K, O'Connell MJ. The G(2) DNA damage checkpoint: Could this ancient regulator be the achilles heel of cancer? Cancer Biol Ther 2009; 8:1433-9.
30. Zhang L, Yu J, Park BH, Kinzler KW, Vogelstein B. Role of BAX in the apoptotic response to anticancer agents. Science 2000; 290:989-92.