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Volumn 62, Issue 6, 2010, Pages 685-695

Influence of penetration enhancers on topical delivery of 5-aminolevulinic acid from bioadhesive patches

Author keywords

5 aminolevulinic acid; Bioadhesive patch; Permeation enhancers; Topical drug delivery

Indexed keywords

AMINOLEVULINIC ACID; DIMETHYL SULFOXIDE; DRUG VEHICLE; LABRAFAC CC; LABRAFAC PG; LABRAFIL M1944CS; UNCLASSIFIED DRUG; EXCIPIENT; PHOTOSENSITIZING AGENT;

EID: 77953565911     PISSN: 00223573     EISSN: None     Source Type: Journal    
DOI: 10.1211/jpp.62.06.0004     Document Type: Article
Times cited : (16)

References (55)
  • 1
    • 0031885533 scopus 로고    scopus 로고
    • Photodynamic therapy in dermatology
    • Fritsch C et al. Photodynamic therapy in dermatology. Arch Dermatol 1998 134: 207 214.
    • (1998) Arch Dermatol , vol.134 , pp. 207-214
    • Fritsch, C.1
  • 3
    • 0033999403 scopus 로고    scopus 로고
    • 5-Aminolevulinic acid and its derivatives: Physical chemical properties and protoporphyrin IX formation in cultured cells
    • Uehlinger P et al. 5-Aminolevulinic acid and its derivatives: physical chemical properties and protoporphyrin IX formation in cultured cells. J Photochem Photobiol B 2000 54: 72 80.
    • (2000) J Photochem Photobiol B , vol.54 , pp. 72-80
    • Uehlinger, P.1
  • 4
    • 0033800795 scopus 로고    scopus 로고
    • The influence of the vehicle on the synthesis of porphyrins after topical application of 5-aminolaevulinic acid. Implications in cutaneous photodynamic sensitization
    • Casas A et al. The influence of the vehicle on the synthesis of porphyrins after topical application of 5-aminolaevulinic acid. Implications in cutaneous photodynamic sensitization. Br J Dermatol 2000 143: 564 572.
    • (2000) Br J Dermatol , vol.143 , pp. 564-572
    • Casas, A.1
  • 5
    • 0028998261 scopus 로고
    • Topical application of 5-aminolevulinic acid, DMSO and EDTA: Protoporphyrin IX accumulation in skin and tumours of mice
    • Malik Z et al. Topical application of 5-aminolevulinic acid, DMSO and EDTA: protoporphyrin IX accumulation in skin and tumours of mice. J Photochem Photobiol B 1995 28: 213 218.
    • (1995) J Photochem Photobiol B , vol.28 , pp. 213-218
    • Malik, Z.1
  • 6
    • 0027978325 scopus 로고
    • Tumour vascular shutdown following photodynamic therapy based on polyhaematoporphyrin or 5-aminolevulinic acid
    • Roberts DJH et al. Tumour vascular shutdown following photodynamic therapy based on polyhaematoporphyrin or 5-aminolevulinic acid. Int J Oncol 1994 5: 763 768.
    • (1994) Int J Oncol , vol.5 , pp. 763-768
    • Roberts, D.J.H.1
  • 7
    • 0023597397 scopus 로고
    • Mode of action of penetration enhancers in human skin
    • Barry BW. Mode of action of penetration enhancers in human skin. J Control Release 1987 6: 85 97.
    • (1987) J Control Release , vol.6 , pp. 85-97
    • Barry, B.W.1
  • 8
    • 0024804574 scopus 로고
    • Lipid-protein partitioning theory of skin enhancer activity: Finite dose technique
    • Goodman M, Barry BW. Lipid-protein partitioning theory of skin enhancer activity: finite dose technique. Int J Pharm 1989 57: 29.
    • (1989) Int J Pharm , vol.57 , pp. 29
    • Goodman, M.1    Barry, B.W.2
  • 9
    • 0034335291 scopus 로고    scopus 로고
    • Topical application of 5-aminolevulinic acid hexyl ester and 5-aminolevulinic acid to normal nude mouse skin: Differences in protoporphyrin IX fluorescence kinetics and the role of the stratum corneum
    • van den Akker JT et al. Topical application of 5-aminolevulinic acid hexyl ester and 5-aminolevulinic acid to normal nude mouse skin: differences in protoporphyrin IX fluorescence kinetics and the role of the stratum corneum. Photochem Photobiol 2000 72: 681 689.
    • (2000) Photochem Photobiol , vol.72 , pp. 681-689
    • Van Den Akker, J.T.1
  • 10
    • 21544479743 scopus 로고    scopus 로고
    • Topical glycerol monooleate/propylene glycol formulations enhance 5-aminolevulinic acid in vitro skin delivery and in vivo protoporphyrin IX accumulation in hairless mouse skin
    • Steluti R et al. Topical glycerol monooleate/propylene glycol formulations enhance 5-aminolevulinic acid in vitro skin delivery and in vivo protoporphyrin IX accumulation in hairless mouse skin. Eur J Pharm Biopharm 2005 60: 439 444.
    • (2005) Eur J Pharm Biopharm , vol.60 , pp. 439-444
    • Steluti, R.1
  • 11
    • 8644290733 scopus 로고    scopus 로고
    • Influence of 6-ketocholestanol on skin permeation of 5-aminolevulinic acid and evaluation of chemical stability
    • Auner BG et al. Influence of 6-ketocholestanol on skin permeation of 5-aminolevulinic acid and evaluation of chemical stability. J Pharm Sci 2004 93: 2780 2787.
    • (2004) J Pharm Sci , vol.93 , pp. 2780-2787
    • Auner, B.G.1
  • 12
    • 32544439698 scopus 로고    scopus 로고
    • Oleic acid as optimizer of the skin delivery of 5-aminolevulinic acid in photodynamic therapy
    • Pierre MB et al. Oleic acid as optimizer of the skin delivery of 5-aminolevulinic acid in photodynamic therapy. Pharm Res 2006 23: 360 366.
    • (2006) Pharm Res , vol.23 , pp. 360-366
    • Pierre, M.B.1
  • 13
    • 38349095489 scopus 로고    scopus 로고
    • Fluorescence characteristics and pharmacokinetic properties of a novel self-adhesive 5-ALA patch for photodynamic therapy of actinic keratoses
    • Fauteck JD et al. Fluorescence characteristics and pharmacokinetic properties of a novel self-adhesive 5-ALA patch for photodynamic therapy of actinic keratoses. Arch Dermatol Res 2008 300: 53 60.
    • (2008) Arch Dermatol Res , vol.300 , pp. 53-60
    • Fauteck, J.D.1
  • 14
    • 0036138905 scopus 로고    scopus 로고
    • Self-adhesive thin films for topical delivery of 5-aminolevulinic acid
    • Lieb S et al. Self-adhesive thin films for topical delivery of 5-aminolevulinic acid. Eur J Pharm Biopharm 2002 53: 99 106.
    • (2002) Eur J Pharm Biopharm , vol.53 , pp. 99-106
    • Lieb, S.1
  • 15
    • 29244481149 scopus 로고    scopus 로고
    • Design and evaluation of a water-soluble bioadhesive patch formulation for cutaneous delivery of 5-aminolevulinic acid to superficial neoplastic lesions
    • McCarron PA et al. Design and evaluation of a water-soluble bioadhesive patch formulation for cutaneous delivery of 5-aminolevulinic acid to superficial neoplastic lesions. Eur J Pharm Sci 2006 27: 268 279.
    • (2006) Eur J Pharm Sci , vol.27 , pp. 268-279
    • McCarron, P.A.1
  • 16
    • 15044350118 scopus 로고    scopus 로고
    • Evaluation of a water-soluble bioadhesive patch for photodynamic therapy of vulval lesions
    • McCarron PA et al. Evaluation of a water-soluble bioadhesive patch for photodynamic therapy of vulval lesions. Int J Pharm 2005 293: 11 23.
    • (2005) Int J Pharm , vol.293 , pp. 11-23
    • McCarron, P.A.1
  • 17
    • 33645871583 scopus 로고    scopus 로고
    • The effect of skin permeation enhancers on the formation of porphyrins in mouse skin during topical application of the methyl ester of 5-aminolevulinic acid
    • Bugaj A et al. The effect of skin permeation enhancers on the formation of porphyrins in mouse skin during topical application of the methyl ester of 5-aminolevulinic acid. J Photochem Photobiol B 2006 83: 94 97.
    • (2006) J Photochem Photobiol B , vol.83 , pp. 94-97
    • Bugaj, A.1
  • 20
    • 0030200107 scopus 로고    scopus 로고
    • Chemical instability of 5-aminolevulinic acid used in the fluorescence diagnosis of bladder tumours
    • Novo M et al. Chemical instability of 5-aminolevulinic acid used in the fluorescence diagnosis of bladder tumours. J Photochem Photobiol B 1996 34: 143 148.
    • (1996) J Photochem Photobiol B , vol.34 , pp. 143-148
    • Novo, M.1
  • 21
    • 1542719315 scopus 로고    scopus 로고
    • Transdermal delivery of zidovudine: Effect of terpenes and their mechanism of action
    • DOI 10.1016/j.jconrel.2003.11.022, PII S0168365903005807
    • Narishetty ST, Panchagnula R. Transdermal delivery of zidovudine: effect of terpenes and their mechanism of action. J Control Release 2004 95: 367 379. (Pubitemid 38340488)
    • (2004) Journal of Controlled Release , vol.95 , Issue.3 , pp. 367-379
    • Narishetty, S.T.K.1    Panchagnula, R.2
  • 22
    • 0018228183 scopus 로고
    • The skin of domestic mammals as a model for the human skin, with special reference to the domestic pig
    • Meyer W et al. The skin of domestic mammals as a model for the human skin, with special reference to the domestic pig. Curr Probl Dermatol 1978 7: 39 52.
    • (1978) Curr Probl Dermatol , vol.7 , pp. 39-52
    • Meyer, W.1
  • 23
    • 0020067173 scopus 로고
    • Methods for in vitro percutaneous absorption studies. II. Animal models for human skin
    • Bronaugh RL et al. Methods for in vitro percutaneous absorption studies. II. Animal models for human skin. Toxicol Appl Pharmacol 1982 62: 481 488.
    • (1982) Toxicol Appl Pharmacol , vol.62 , pp. 481-488
    • Bronaugh, R.L.1
  • 24
    • 29644438626 scopus 로고    scopus 로고
    • Pharmaceutical analysis of 5-aminolevulinic acid in solution and in tissues
    • Donnelly RF et al. Pharmaceutical analysis of 5-aminolevulinic acid in solution and in tissues. J Photochem Photobiol B 2006 82: 59 71.
    • (2006) J Photochem Photobiol B , vol.82 , pp. 59-71
    • Donnelly, R.F.1
  • 25
    • 0002246502 scopus 로고
    • Preparation of isolated sheets of human stratum corneum
    • Kligman AM, Christophers E. Preparation of isolated sheets of human stratum corneum. Arch Dermatol 1963 88: 702 705.
    • (1963) Arch Dermatol , vol.88 , pp. 702-705
    • Kligman, A.M.1    Christophers, E.2
  • 26
    • 0036726303 scopus 로고    scopus 로고
    • Topical application of 5-aminolevulinic acid and its methylester, hexylester and octylester derivatives: Considerations for dosimetry in mouse skin model
    • Juzeniene A et al. Topical application of 5-aminolevulinic acid and its methylester, hexylester and octylester derivatives: considerations for dosimetry in mouse skin model. Photochem Photobiol 2002 76: 329 334.
    • (2002) Photochem Photobiol , vol.76 , pp. 329-334
    • Juzeniene, A.1
  • 27
    • 0037436920 scopus 로고    scopus 로고
    • Influence of lipophilic counter-ions in combination with phloretin and 6-ketocholestanol on the skin permeation of 5-aminolevulinic acid
    • Auner BG et al. Influence of lipophilic counter-ions in combination with phloretin and 6-ketocholestanol on the skin permeation of 5-aminolevulinic acid. Int J Pharm 2003 255: 109 116.
    • (2003) Int J Pharm , vol.255 , pp. 109-116
    • Auner, B.G.1
  • 28
    • 4043119712 scopus 로고    scopus 로고
    • Enhancement of topical 5-aminolaevulinic acid delivery by erbium: YAG laser and microdermabrasion: A comparison with iontophoresis and electroporation
    • Fang JY et al. Enhancement of topical 5-aminolaevulinic acid delivery by erbium: YAG laser and microdermabrasion: a comparison with iontophoresis and electroporation. Br J Dermatol 2004 151: 132 140.
    • (2004) Br J Dermatol , vol.151 , pp. 132-140
    • Fang, J.Y.1
  • 29
    • 36448956821 scopus 로고    scopus 로고
    • Influence of solution viscosity and injection protocol on distribution patterns of jet injectors: Application to photodynamic tumour targeting
    • Donnelly RF et al. Influence of solution viscosity and injection protocol on distribution patterns of jet injectors: application to photodynamic tumour targeting. J Photochem Photobiol B 2007 89: 98 109.
    • (2007) J Photochem Photobiol B , vol.89 , pp. 98-109
    • Donnelly, R.F.1
  • 30
    • 47349128121 scopus 로고    scopus 로고
    • Microneedle-mediated intradermal delivery of 5-aminolevulinic acid: Potential for enhanced topical photodynamic therapy
    • Donnelly RF et al. Microneedle-mediated intradermal delivery of 5-aminolevulinic acid: potential for enhanced topical photodynamic therapy. J Control Release 2008 129: 154 162.
    • (2008) J Control Release , vol.129 , pp. 154-162
    • Donnelly, R.F.1
  • 31
    • 0034961456 scopus 로고    scopus 로고
    • Iontophoretic delivery of 5-aminolevulinic acid (ALA): Effect of pH
    • Lopez RF et al. Iontophoretic delivery of 5-aminolevulinic acid (ALA): effect of pH. Pharm Res 2001 18: 311 315.
    • (2001) Pharm Res , vol.18 , pp. 311-315
    • Lopez, R.F.1
  • 32
    • 0025942759 scopus 로고
    • Sequential activation of genes for heme pathway enzymes during erythroid differentiation of mouse Friend virus-transformed erythroleukemia cells
    • Fujita H et al. Sequential activation of genes for heme pathway enzymes during erythroid differentiation of mouse Friend virus-transformed erythroleukemia cells. Biochim Biophys Acta 1991 1090: 311 316.
    • (1991) Biochim Biophys Acta , vol.1090 , pp. 311-316
    • Fujita, H.1
  • 33
    • 0033995726 scopus 로고    scopus 로고
    • A vehicle for photodynamic therapy of skin cancer: Influence of dimethylsulphoxide on 5-aminolevulinic acid in vitro cutaneous permeation and in vivo protoporphyrin IX accumulation determined by confocal microscopy
    • De Rosa FS et al. A vehicle for photodynamic therapy of skin cancer: influence of dimethylsulphoxide on 5-aminolevulinic acid in vitro cutaneous permeation and in vivo protoporphyrin IX accumulation determined by confocal microscopy. J Control Release 2000 65: 359 366.
    • (2000) J Control Release , vol.65 , pp. 359-366
    • De Rosa, F.S.1
  • 34
    • 0033011563 scopus 로고    scopus 로고
    • Photodynamic therapy by topical aminolevulinic acid, dimethylsulphoxide and curettage in nodular basal cell carcinoma: A one-year follow-up study
    • Soler AM et al. Photodynamic therapy by topical aminolevulinic acid, dimethylsulphoxide and curettage in nodular basal cell carcinoma: a one-year follow-up study. Acta Derm Venereol 1999 79: 204 206.
    • (1999) Acta Derm Venereol , vol.79 , pp. 204-206
    • Soler, A.M.1
  • 35
    • 0031852312 scopus 로고    scopus 로고
    • Modified topical photodynamic therapy of superficial skin tumours, utilizing aminolevulinic acid, penetration enhancers, red light, and hyperthermia
    • Harth Y et al. Modified topical photodynamic therapy of superficial skin tumours, utilizing aminolevulinic acid, penetration enhancers, red light, and hyperthermia. Dermatol Surg 1998 24: 723 726.
    • (1998) Dermatol Surg , vol.24 , pp. 723-726
    • Harth, Y.1
  • 36
    • 0013240269 scopus 로고    scopus 로고
    • Systemic component of protoporphyrin IX production in nude mouse skin upon topical application of aminolevulinic acid depends on the application conditions
    • van den Akker JT et al. Systemic component of protoporphyrin IX production in nude mouse skin upon topical application of aminolevulinic acid depends on the application conditions. Photochem Photobiol 2002 75: 172 177.
    • (2002) Photochem Photobiol , vol.75 , pp. 172-177
    • Van Den Akker, J.T.1
  • 37
    • 0037428706 scopus 로고    scopus 로고
    • Topical application of ALA and ALA hexyl ester on a subcutaneous murine mammary adenocarcinoma: Tissue distribution
    • Perotti C et al. Topical application of ALA and ALA hexyl ester on a subcutaneous murine mammary adenocarcinoma: tissue distribution. Br J Cancer 2003 88: 432 437.
    • (2003) Br J Cancer , vol.88 , pp. 432-437
    • Perotti, C.1
  • 38
    • 0035977196 scopus 로고    scopus 로고
    • ALA and ALA hexyl ester-induced porphyrin synthesis in chemically induced skin tumours: The role of different vehicles on improving photosensitization
    • Casas A et al. ALA and ALA hexyl ester-induced porphyrin synthesis in chemically induced skin tumours: the role of different vehicles on improving photosensitization. Br J Cancer 2001 85: 1794 1800.
    • (2001) Br J Cancer , vol.85 , pp. 1794-1800
    • Casas, A.1
  • 39
    • 4043101830 scopus 로고    scopus 로고
    • Enhancement of photodynamic therapy by use of aminolevulinic acid/glycolic acid drug mixture
    • Ziolkowski P et al. Enhancement of photodynamic therapy by use of aminolevulinic acid/glycolic acid drug mixture. J Exp Ther Oncol 2004 4: 121 129.
    • (2004) J Exp Ther Oncol , vol.4 , pp. 121-129
    • Ziolkowski, P.1
  • 40
    • 0037448429 scopus 로고    scopus 로고
    • The enhancement effect of surfactants on the penetration of lorazepam through rat skin
    • Nokhodchi A et al. The enhancement effect of surfactants on the penetration of lorazepam through rat skin. Int J Pharm 2003 250: 359 369.
    • (2003) Int J Pharm , vol.250 , pp. 359-369
    • Nokhodchi, A.1
  • 41
    • 33947606082 scopus 로고    scopus 로고
    • The effect of terpene concentrations on the skin penetration of diclofenac sodium
    • Nokhodchi A et al. The effect of terpene concentrations on the skin penetration of diclofenac sodium. Int J Pharm 2007 335: 97 105.
    • (2007) Int J Pharm , vol.335 , pp. 97-105
    • Nokhodchi, A.1
  • 42
    • 49249107085 scopus 로고    scopus 로고
    • Physicochemical characterisation of a novel thermogelling formulation for percutaneous penetration of 5-aminolevulinic acid
    • Grüning N, Muller-Goymann CC. Physicochemical characterisation of a novel thermogelling formulation for percutaneous penetration of 5-aminolevulinic acid. J Pharm Sci 2008 97: 2311 2323.
    • (2008) J Pharm Sci , vol.97 , pp. 2311-2323
    • Grüning, N.1    Muller-Goymann, C.C.2
  • 43
    • 33646853695 scopus 로고    scopus 로고
    • In vitro phototoxicity of 5-aminolevulinic acid and its methyl ester and the influence of barrier properties on their release from a bioadhesive patch
    • Gilmore BF et al. In vitro phototoxicity of 5-aminolevulinic acid and its methyl ester and the influence of barrier properties on their release from a bioadhesive patch. Eur J Pharm Biopharm 2006 63: 295 309.
    • (2006) Eur J Pharm Biopharm , vol.63 , pp. 295-309
    • Gilmore, B.F.1
  • 44
    • 4844230007 scopus 로고    scopus 로고
    • Successful photodynamic therapy of vulval Paget's disease using a novel patch-based delivery system containing 5-aminolevulinic acid
    • Zawislak AA et al. Successful photodynamic therapy of vulval Paget's disease using a novel patch-based delivery system containing 5-aminolevulinic acid. BJOG 2004 111: 1143 1145.
    • (2004) BJOG , vol.111 , pp. 1143-1145
    • Zawislak, A.A.1
  • 45
    • 24644470274 scopus 로고    scopus 로고
    • Photodynamic treatment of lichen sclerosus and squamous hyperplasia using sustained topical delivery of aminolevulinic acid from a novel bioadhesive
    • McCarron PA et al. Photodynamic treatment of lichen sclerosus and squamous hyperplasia using sustained topical delivery of aminolevulinic acid from a novel bioadhesive. Br J Dermatol 2004 151: 105 106.
    • (2004) Br J Dermatol , vol.151 , pp. 105-106
    • McCarron, P.A.1
  • 46
    • 33644887720 scopus 로고    scopus 로고
    • The effect of dimethyl sulfoxide, 1-[2-(decylthio-)ethyl-] azacyclopentane-2-one and labrafac on porphyrin formation in mouse skin during topical application of methyl 5-aminolevulinate; A fluorescence and extraction study
    • Bugaj A et al. The effect of dimethyl sulfoxide, 1-[2-(decylthio-)ethyl-] azacyclopentane-2-one and labrafac on porphyrin formation in mouse skin during topical application of methyl 5-aminolevulinate; a fluorescence and extraction study. Photodiagn Photodyn Ther 2006 3: 27 33.
    • (2006) Photodiagn Photodyn Ther , vol.3 , pp. 27-33
    • Bugaj, A.1
  • 47
    • 0031018214 scopus 로고    scopus 로고
    • Photobleaching of protoporphyrin IX in cells incubated with 5-aminolevulinic acid
    • DOI 10.1002/(SICI)1097-0215(19970106)70:1<90::AID-IJC14>3.0.CO;2-H
    • Moan J et al. Photobleaching of protoporphyrin IX in cells incubated with 5-aminolevulinic acid. Int J Cancer 1997 70: 90 97. (Pubitemid 27059711)
    • (1997) International Journal of Cancer , vol.70 , Issue.1 , pp. 90-97
    • Moan, J.1    Streckyte, G.2    Bagdonas, S.3    Bech, O.4    Berg, K.5
  • 48
    • 0029763913 scopus 로고    scopus 로고
    • The influence of iron chelators on the accumulation of protoporphyrin IX in 5-aminolaevulinic acid-treated cells
    • Berg K et al. The influence of iron chelators on the accumulation of protoporphyrin IX in 5-aminolaevulinic acid-treated cells. Br J Cancer 1996 74: 688 697.
    • (1996) Br J Cancer , vol.74 , pp. 688-697
    • Berg, K.1
  • 49
    • 0030273742 scopus 로고    scopus 로고
    • Photodynamic therapy (PDT) and photodiagnosis (PD) using endogenous photosensitization induced by 5-aminolevulinic acid (ALA): Mechanisms and clinical results
    • Kennedy JC et al. Photodynamic therapy (PDT) and photodiagnosis (PD) using endogenous photosensitization induced by 5-aminolevulinic acid (ALA): mechanisms and clinical results. J Clin Laser Med Surg 1996 14: 289 304.
    • (1996) J Clin Laser Med Surg , vol.14 , pp. 289-304
    • Kennedy, J.C.1
  • 50
    • 18244379292 scopus 로고    scopus 로고
    • Dermal delivery of topically applied oligonucleotides via follicular transport in mouse skin
    • Dokka S et al. Dermal delivery of topically applied oligonucleotides via follicular transport in mouse skin. J Invest Dermatol 2005 124: 971 975.
    • (2005) J Invest Dermatol , vol.124 , pp. 971-975
    • Dokka, S.1
  • 51
    • 0034026126 scopus 로고    scopus 로고
    • The pilosebaceous unit: A pivotal route for topical drug delivery
    • Agarwal R et al. The pilosebaceous unit: a pivotal route for topical drug delivery. Methods Find Exp Clin Pharmacol 2000 22: 129 133.
    • (2000) Methods Find Exp Clin Pharmacol , vol.22 , pp. 129-133
    • Agarwal, R.1
  • 52
    • 0036848940 scopus 로고    scopus 로고
    • Human skin sandwich for assessing shunt route penetration during passive and iontophoretic drug and liposome delivery
    • Essa EA et al. Human skin sandwich for assessing shunt route penetration during passive and iontophoretic drug and liposome delivery. J Pharm Pharmacol 2002 54: 1481 1490.
    • (2002) J Pharm Pharmacol , vol.54 , pp. 1481-1490
    • Essa, E.A.1
  • 53
    • 33646563138 scopus 로고    scopus 로고
    • Overcoming the stratum corneum: The modulation of skin penetration. A review
    • Trommer H, Neubert RH. Overcoming the stratum corneum: the modulation of skin penetration. A review. Skin Pharmacol Physiol 2006 19: 106 121.
    • (2006) Skin Pharmacol Physiol , vol.19 , pp. 106-121
    • Trommer, H.1    Neubert, R.H.2
  • 55
    • 0028351443 scopus 로고
    • Comparative analysis of percutaneous absorption enhancement by d-limonene and oleic acid based on a skin diffusion model
    • Koyama Y et al. Comparative analysis of percutaneous absorption enhancement by d-limonene and oleic acid based on a skin diffusion model. Pharm Res 1994 11: 377 383.
    • (1994) Pharm Res , vol.11 , pp. 377-383
    • Koyama, Y.1


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