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Volumn 63, Issue 3, 2006, Pages 295-309

In vitro phototoxicity of 5-aminolevulinic acid and its methyl ester and the influence of barrier properties on their release from a bioadhesive patch

Author keywords

5 Aminolevulinic acid; Bioadhesion; Drug delivery; Patches; Photodynamic therapy; Stratum corneum

Indexed keywords

ADHESIVE AGENT; AMINOLEVULINIC ACID; AMINOLEVULINIC ACID METHYL ESTER; PORPHIN; PROTOPORPHYRIN;

EID: 33646853695     PISSN: 09396411     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejpb.2006.03.002     Document Type: Article
Times cited : (23)

References (59)
  • 2
    • 0034790334 scopus 로고    scopus 로고
    • A follow-up study of recurrence and cosmesis in completely responding superficial and nodular basal cell carcinomas treated with methyl 5-aminolevulinate-based photodynamic therapy alone with prior curettage
    • Soler A.M., Warloe T., Berner A., and Giercksky K.E. A follow-up study of recurrence and cosmesis in completely responding superficial and nodular basal cell carcinomas treated with methyl 5-aminolevulinate-based photodynamic therapy alone with prior curettage. Br. J. Dermatol. 145 (2001) 467-471
    • (2001) Br. J. Dermatol. , vol.145 , pp. 467-471
    • Soler, A.M.1    Warloe, T.2    Berner, A.3    Giercksky, K.E.4
  • 6
    • 0035075886 scopus 로고    scopus 로고
    • Photodynamic therapy for large or multiple patches of Bowen's disease and basal cell carcinoma
    • Morton C.A., Whitehurst C., McColl J.H., Moore J.V., and MacKie R.M. Photodynamic therapy for large or multiple patches of Bowen's disease and basal cell carcinoma. Arch. Dermatol. 137 (2001) 319-324
    • (2001) Arch. Dermatol. , vol.137 , pp. 319-324
    • Morton, C.A.1    Whitehurst, C.2    McColl, J.H.3    Moore, J.V.4    MacKie, R.M.5
  • 7
    • 0034796827 scopus 로고    scopus 로고
    • Topical 5-aminolevulinic acid photodynamic therapy for extensive scalp actinic keratoses
    • Markham T., and Collins P. Topical 5-aminolevulinic acid photodynamic therapy for extensive scalp actinic keratoses. Br. J. Dermatol. 145 (2001) 502-504
    • (2001) Br. J. Dermatol. , vol.145 , pp. 502-504
    • Markham, T.1    Collins, P.2
  • 8
    • 0029403360 scopus 로고
    • Moisture-activated, electrically conducting bioadhesive hydrogels as interfaces for bioelectrodes: effect of film hydration on cutaneous adherence in wet environments
    • Woolfson A.D., McCafferty D.F., McCallion C.R., McAdams E.T., and Anderson J.McC. Moisture-activated, electrically conducting bioadhesive hydrogels as interfaces for bioelectrodes: effect of film hydration on cutaneous adherence in wet environments. J. Appl. Polym. Sci. 58 (1995) 1291-1296
    • (1995) J. Appl. Polym. Sci. , vol.58 , pp. 1291-1296
    • Woolfson, A.D.1    McCafferty, D.F.2    McCallion, C.R.3    McAdams, E.T.4    Anderson, J.McC.5
  • 9
    • 0024821527 scopus 로고
    • Miniature pig as an animal model to study photoaging
    • Fourtanier A., and Berrebi C. Miniature pig as an animal model to study photoaging. Photochem. Photobiol. 50 (1989) 771-784
    • (1989) Photochem. Photobiol. , vol.50 , pp. 771-784
    • Fourtanier, A.1    Berrebi, C.2
  • 10
    • 0030561008 scopus 로고    scopus 로고
    • Topical 5-aminolevulinic acid for photodynamic therapy of basal cell carcinoma. Evaluation of stratum corneum permeability in vitro
    • Bretschko E., Szeimies R.M., Landthaler M., and Lee G. Topical 5-aminolevulinic acid for photodynamic therapy of basal cell carcinoma. Evaluation of stratum corneum permeability in vitro. J. Control. Release 42 (1996) 203-208
    • (1996) J. Control. Release , vol.42 , pp. 203-208
    • Bretschko, E.1    Szeimies, R.M.2    Landthaler, M.3    Lee, G.4
  • 11
    • 0036138905 scopus 로고    scopus 로고
    • Self-adhesive thin films for topical delivery of 5-aminolevulinic acid
    • Lieb S., Szeimies R.M., and Lee G. Self-adhesive thin films for topical delivery of 5-aminolevulinic acid. Eur. J. Pharm. Biopharm. 53 (2002) 99-106
    • (2002) Eur. J. Pharm. Biopharm. , vol.53 , pp. 99-106
    • Lieb, S.1    Szeimies, R.M.2    Lee, G.3
  • 12
    • 0030988199 scopus 로고    scopus 로고
    • Characterization of the influence of some cyclodextrins on the stratum corneum from the hairless mouse
    • Bentley M.V.L.B., Vianna R.F., Wilson S., and Collett J.H. Characterization of the influence of some cyclodextrins on the stratum corneum from the hairless mouse. J. Pharm. Pharmacol. 49 (1997) 397-402
    • (1997) J. Pharm. Pharmacol. , vol.49 , pp. 397-402
    • Bentley, M.V.L.B.1    Vianna, R.F.2    Wilson, S.3    Collett, J.H.4
  • 13
    • 1642544609 scopus 로고    scopus 로고
    • Influence of plasticiser type and storage conditions on the properties of poly(methyl vinyl ether-co-maleic anhydride) bioadhesive films
    • McCarron P.A., Woolfson A.D., Donnelly R.F., Andrews G.P., Zawislak A., and Price J.H. Influence of plasticiser type and storage conditions on the properties of poly(methyl vinyl ether-co-maleic anhydride) bioadhesive films. J. Appl. Polym. Sci. 91 (2004) 1576-1589
    • (2004) J. Appl. Polym. Sci. , vol.91 , pp. 1576-1589
    • McCarron, P.A.1    Woolfson, A.D.2    Donnelly, R.F.3    Andrews, G.P.4    Zawislak, A.5    Price, J.H.6
  • 15
    • 33646839914 scopus 로고    scopus 로고
    • R.F. Donnelly, Bioadhesive Drug Delivery Systems for Photodynamic Therapy of Vulval Intraepithelial Neoplasia, PhD Thesis, Queens University Belfast, Belfast, UK, 2003.
  • 16
    • 0029959987 scopus 로고    scopus 로고
    • Fluorometric HPLC determination of 5-aminolevulinic acid (ALA) in the plasma and urine of lead workers: biological indicators of lead exposure
    • Oishi H., Nomiyama H., Nomiyama K., and Tomokuni K. Fluorometric HPLC determination of 5-aminolevulinic acid (ALA) in the plasma and urine of lead workers: biological indicators of lead exposure. J. Anal. Toxicol. 20 (1996) 106-110
    • (1996) J. Anal. Toxicol. , vol.20 , pp. 106-110
    • Oishi, H.1    Nomiyama, H.2    Nomiyama, K.3    Tomokuni, K.4
  • 18
    • 0026699181 scopus 로고    scopus 로고
    • J. Hanania, Z. Malik, The effect of EDTA and serum on endogenous porphyrins accumulation and photodynamic sensitization of human K562 leukemic cells, Cancer Lett. 65, 127-131.
  • 19
    • 0031205170 scopus 로고    scopus 로고
    • pH-dependent formation of 5-aminolevulinic acid-induced protoporphyrin IX in fibrosarcoma cells
    • Fuchs C., Riesenberg R., Siegert J., and Baumgartner R. pH-dependent formation of 5-aminolevulinic acid-induced protoporphyrin IX in fibrosarcoma cells. J. Photochem. Photobiol. B: Biol. 40 (1997) 49-54
    • (1997) J. Photochem. Photobiol. B: Biol. , vol.40 , pp. 49-54
    • Fuchs, C.1    Riesenberg, R.2    Siegert, J.3    Baumgartner, R.4
  • 20
    • 0022007427 scopus 로고
    • Photodynamic therapy of intraocular tumours. Examination of hematoporphyrin derivative distribution and long-term damage in rabbit ocular tissue
    • Gomer C.J., Jester J.V., Razum N.J., Szirth B.C., and Murphree L. Photodynamic therapy of intraocular tumours. Examination of hematoporphyrin derivative distribution and long-term damage in rabbit ocular tissue. Cancer Res. 45 (1985) 3718-3725
    • (1985) Cancer Res. , vol.45 , pp. 3718-3725
    • Gomer, C.J.1    Jester, J.V.2    Razum, N.J.3    Szirth, B.C.4    Murphree, L.5
  • 22
    • 0035676241 scopus 로고    scopus 로고
    • Photodynamic therapy with violet light and topical 5-aminolevulinic acid in the treatment of actinic keratosis, Bowen's disease and basal cell carcinoma
    • Dijkstra A.T., Majoie I.M.L., van Dongen J.W.F., van Weelden H., and van Vloten W.A. Photodynamic therapy with violet light and topical 5-aminolevulinic acid in the treatment of actinic keratosis, Bowen's disease and basal cell carcinoma. J. Eur. Acad. Dermatol. Venereol. 15 (2001) 550-554
    • (2001) J. Eur. Acad. Dermatol. Venereol. , vol.15 , pp. 550-554
    • Dijkstra, A.T.1    Majoie, I.M.L.2    van Dongen, J.W.F.3    van Weelden, H.4    van Vloten, W.A.5
  • 23
    • 0028155560 scopus 로고
    • Penetration potency of topical applied 5-aminolevulinic acid for photodynamic therapy of basal cell carcinoma
    • Sziemies R.M., Sassy T., and Landthaler M. Penetration potency of topical applied 5-aminolevulinic acid for photodynamic therapy of basal cell carcinoma. Photochem. Photobiol. 59 (1994) 73-76
    • (1994) Photochem. Photobiol. , vol.59 , pp. 73-76
    • Sziemies, R.M.1    Sassy, T.2    Landthaler, M.3
  • 24
    • 3042696425 scopus 로고    scopus 로고
    • Delta-aminolevulinic acid and blue light photodynamic therapy for treatment of multiple basal cell carcinomas in two patients with nevoid basal cell carcinoma syndrome
    • Itkin A., and Gilchrest B.A. Delta-aminolevulinic acid and blue light photodynamic therapy for treatment of multiple basal cell carcinomas in two patients with nevoid basal cell carcinoma syndrome. Dermatol. Surg. 30 (2004) 1054-1061
    • (2004) Dermatol. Surg. , vol.30 , pp. 1054-1061
    • Itkin, A.1    Gilchrest, B.A.2
  • 25
    • 33646832532 scopus 로고    scopus 로고
    • ® Product Information Sheet, Medicell International, London, UK, 1998.
  • 26
    • 33646843541 scopus 로고    scopus 로고
    • ® Product Information Sheet, Crawford Pharmaceuticals, Milton Keynes, UK, 1996.
  • 30
    • 0034649612 scopus 로고    scopus 로고
    • Ethylene glycol and amino acid derivatives of 5-aminolevulinic acid as new photosensitising precursors of protoporphyrin IX in cells
    • Berger Y., Greppi A., Siri O., Neier R., and Juillerat-Jeanneret L. Ethylene glycol and amino acid derivatives of 5-aminolevulinic acid as new photosensitising precursors of protoporphyrin IX in cells. J. Med. Chem. 43 (2000) 4738-4746
    • (2000) J. Med. Chem. , vol.43 , pp. 4738-4746
    • Berger, Y.1    Greppi, A.2    Siri, O.3    Neier, R.4    Juillerat-Jeanneret, L.5
  • 31
    • 0037375829 scopus 로고    scopus 로고
    • Evaluation of dipeptide-derivatives of 5-aminolevulinic acid as precursors for photosensitisers in photodynamic therapy
    • Berger Y., Ingrassia L., Neier R., and Juillerat-Jeanneret L. Evaluation of dipeptide-derivatives of 5-aminolevulinic acid as precursors for photosensitisers in photodynamic therapy. Bioorg. Med. Chem. 11 (2003) 1341-1351
    • (2003) Bioorg. Med. Chem. , vol.11 , pp. 1341-1351
    • Berger, Y.1    Ingrassia, L.2    Neier, R.3    Juillerat-Jeanneret, L.4
  • 35
    • 0036216452 scopus 로고    scopus 로고
    • Comparative permeation studies for 5-aminolevulinic acid and its n-butyl ester through stratum corneum and artificial skin constructs
    • Winkler A., and Muller-Goymann C.C. Comparative permeation studies for 5-aminolevulinic acid and its n-butyl ester through stratum corneum and artificial skin constructs. Eur. J. Pharm. Biopharm. 53 (2002) 281-287
    • (2002) Eur. J. Pharm. Biopharm. , vol.53 , pp. 281-287
    • Winkler, A.1    Muller-Goymann, C.C.2
  • 36
    • 0036113838 scopus 로고    scopus 로고
    • In vitro/in vivo correlations between transdermal delivery of 5-aminolevulinic acid and cutaneous protoporphyrin IX accumulation and effect of formulation
    • Tsai J.C., Chen H., Wong W., and Lo Y.L. In vitro/in vivo correlations between transdermal delivery of 5-aminolevulinic acid and cutaneous protoporphyrin IX accumulation and effect of formulation. Br. J. Dermatol. 146 (2002) 853-862
    • (2002) Br. J. Dermatol. , vol.146 , pp. 853-862
    • Tsai, J.C.1    Chen, H.2    Wong, W.3    Lo, Y.L.4
  • 37
    • 0347360162 scopus 로고    scopus 로고
    • Photodynamic therapy of skin cancer: controlled drug delivery of 5-ALA and its esters
    • Lopez R.F., Lange N., Guy R.H., and Bentley M.V.L.B. Photodynamic therapy of skin cancer: controlled drug delivery of 5-ALA and its esters. Adv. Drug Deliv. Rev. 56 (2004) 77-94
    • (2004) Adv. Drug Deliv. Rev. , vol.56 , pp. 77-94
    • Lopez, R.F.1    Lange, N.2    Guy, R.H.3    Bentley, M.V.L.B.4
  • 38
    • 33646839416 scopus 로고    scopus 로고
    • ® Product Information Sheet. Galderma, Herts, UK, 2003.
  • 40
    • 0141997132 scopus 로고    scopus 로고
    • Comparative in vitro percutaneous penetration of 5-aminolevulinic acid and two of its esters through excised hairless mouse skin
    • VandenAkker J.T.H.M., Holroyd J.A., Vernon D.I., Sterenborg H.J.C.M., and Brown S.B. Comparative in vitro percutaneous penetration of 5-aminolevulinic acid and two of its esters through excised hairless mouse skin. Lasers Surg. Med. 33 (2003) 173-181
    • (2003) Lasers Surg. Med. , vol.33 , pp. 173-181
    • VandenAkker, J.T.H.M.1    Holroyd, J.A.2    Vernon, D.I.3    Sterenborg, H.J.C.M.4    Brown, S.B.5
  • 41
    • 0034309770 scopus 로고    scopus 로고
    • Comparison of the pharmacokinetics and phototoxicity of protoporphyrin IX metabolized from 5-aminolevulinic acid and two derivatives in human skin in vivo
    • Gerscher S., Connelly J.P., Griffiths J., Brown S.B., MacRobert A.J., Wong G., and Rhodes L.E. Comparison of the pharmacokinetics and phototoxicity of protoporphyrin IX metabolized from 5-aminolevulinic acid and two derivatives in human skin in vivo. Photochem. Photobiol. 72 (2000) 569-574
    • (2000) Photochem. Photobiol. , vol.72 , pp. 569-574
    • Gerscher, S.1    Connelly, J.P.2    Griffiths, J.3    Brown, S.B.4    MacRobert, A.J.5    Wong, G.6    Rhodes, L.E.7
  • 42
    • 0035725829 scopus 로고    scopus 로고
    • A quantitative assessment of protoporphyrin IX metabolism and phototoxicity in human skin following dose-controlled delivery of the prodrugs 5-aminolaevulinic acid and 5-aminolaevelunic acid-n-pentylester
    • Gerscher S., Connelly J.P., Beijersbergen VanHenegouwen G.M.J., MacRobert A.J., Watt P., and Rhodes L.E. A quantitative assessment of protoporphyrin IX metabolism and phototoxicity in human skin following dose-controlled delivery of the prodrugs 5-aminolaevulinic acid and 5-aminolaevelunic acid-n-pentylester. Br. J. Dermatol. 144 (2001) 983-990
    • (2001) Br. J. Dermatol. , vol.144 , pp. 983-990
    • Gerscher, S.1    Connelly, J.P.2    Beijersbergen VanHenegouwen, G.M.J.3    MacRobert, A.J.4    Watt, P.5    Rhodes, L.E.6
  • 43
    • 0035883756 scopus 로고    scopus 로고
    • Selective distribution of porphyrins in skin-thick basal cell carcinoma after topical application of methyl 5-aminolevulinate
    • Peng Q., Soler A.M., Warloe T., Nesland J.M., and Giercksky K.E. Selective distribution of porphyrins in skin-thick basal cell carcinoma after topical application of methyl 5-aminolevulinate. J. Photochem. Photobiol. B: Biol. 62 (2001) 140-145
    • (2001) J. Photochem. Photobiol. B: Biol. , vol.62 , pp. 140-145
    • Peng, Q.1    Soler, A.M.2    Warloe, T.3    Nesland, J.M.4    Giercksky, K.E.5
  • 44
    • 0035313999 scopus 로고    scopus 로고
    • On the pharmacokinetics of topically applied 5-aminolevulinic acid and two of its esters
    • Moan J., Ma L.W., and Iani V. On the pharmacokinetics of topically applied 5-aminolevulinic acid and two of its esters. Int. J. Cancer 92 (2001) 139-143
    • (2001) Int. J. Cancer , vol.92 , pp. 139-143
    • Moan, J.1    Ma, L.W.2    Iani, V.3
  • 45
    • 0037211251 scopus 로고    scopus 로고
    • Pharmacology of protoporphyrin IX in nude mice after application of ALA and its esters
    • Moan J., Ma L.W., Juzeniene A., Iani V., Juzenas P., Apricena F., and Peng Q. Pharmacology of protoporphyrin IX in nude mice after application of ALA and its esters. Int. J. Cancer 103 (2003) 132-135
    • (2003) Int. J. Cancer , vol.103 , pp. 132-135
    • Moan, J.1    Ma, L.W.2    Juzeniene, A.3    Iani, V.4    Juzenas, P.5    Apricena, F.6    Peng, Q.7
  • 46
    • 0036726303 scopus 로고    scopus 로고
    • Topical application of 5-aminolevulinic acid and its methylester, hexylester and octylester derivatives: considerations for dosimetry in mouse skin model
    • Juzeniene A., Juzenas P., Iani V., and Moan J. Topical application of 5-aminolevulinic acid and its methylester, hexylester and octylester derivatives: considerations for dosimetry in mouse skin model. Photochem. Photobiol. 76 (2002) 329-334
    • (2002) Photochem. Photobiol. , vol.76 , pp. 329-334
    • Juzeniene, A.1    Juzenas, P.2    Iani, V.3    Moan, J.4
  • 47
    • 4043110527 scopus 로고    scopus 로고
    • Evaluation of the penetration of 5-aminolevulinic acid through basal cell carcinoma: a pilot study
    • Ahmadi S., McCarron P.A., Donnelly R.F., Woolfson A.D., and McKenna K. Evaluation of the penetration of 5-aminolevulinic acid through basal cell carcinoma: a pilot study. Exp. Dermatol. 13 (2004) 1-7
    • (2004) Exp. Dermatol. , vol.13 , pp. 1-7
    • Ahmadi, S.1    McCarron, P.A.2    Donnelly, R.F.3    Woolfson, A.D.4    McKenna, K.5
  • 48
    • 0031018214 scopus 로고    scopus 로고
    • Photobleaching of protoporphyrin IX in cells incubated with 5-aminolevulinic acid
    • Moan J., Streckyte G., Bagdonas S., Bech O., and Berg K. Photobleaching of protoporphyrin IX in cells incubated with 5-aminolevulinic acid. Int. J. Cancer 70 (1997) 90-97
    • (1997) Int. J. Cancer , vol.70 , pp. 90-97
    • Moan, J.1    Streckyte, G.2    Bagdonas, S.3    Bech, O.4    Berg, K.5
  • 49
    • 0023406818 scopus 로고
    • Relationship between cytoplasmic pH and proliferation during exponential growth and cellular quiescence
    • Musgrove E., Seaman M., and Hedley D. Relationship between cytoplasmic pH and proliferation during exponential growth and cellular quiescence. Exp. Cell Res. 172 (1987) 65-75
    • (1987) Exp. Cell Res. , vol.172 , pp. 65-75
    • Musgrove, E.1    Seaman, M.2    Hedley, D.3
  • 51
    • 0031586745 scopus 로고    scopus 로고
    • The pH dependancy of protoporphyrin IX formation in cells incubated with 5-aminolevulinic acid
    • Bech O., Berg K., and Moan J. The pH dependancy of protoporphyrin IX formation in cells incubated with 5-aminolevulinic acid. Cancer Lett. 113 (1997) 25-29
    • (1997) Cancer Lett. , vol.113 , pp. 25-29
    • Bech, O.1    Berg, K.2    Moan, J.3
  • 52
    • 0031972420 scopus 로고    scopus 로고
    • The influence of hypoxia and pH on aminolevulinic acid-induced photodynamic therapy in bladder cancer cells in vitro
    • Wyld L., Reed M.W.R., and Brown N.J. The influence of hypoxia and pH on aminolevulinic acid-induced photodynamic therapy in bladder cancer cells in vitro. Br. J. Cancer 77 (1998) 1621-1627
    • (1998) Br. J. Cancer , vol.77 , pp. 1621-1627
    • Wyld, L.1    Reed, M.W.R.2    Brown, N.J.3
  • 53
    • 6344231165 scopus 로고    scopus 로고
    • Phototoxicity of 5-aminolevulinic acid in the HeLa cell line as an indicative measure of photodynamic effect after topical administration to gynaecological lesions of intraepithelial form
    • McCarron P.A., Donnelly R.F., Gilmore B.F., Woolfson A.D., McClelland R., Zawislak A., and Price J.H. Phototoxicity of 5-aminolevulinic acid in the HeLa cell line as an indicative measure of photodynamic effect after topical administration to gynaecological lesions of intraepithelial form. Pharm. Res. 21 (2004) 1871-1879
    • (2004) Pharm. Res. , vol.21 , pp. 1871-1879
    • McCarron, P.A.1    Donnelly, R.F.2    Gilmore, B.F.3    Woolfson, A.D.4    McClelland, R.5    Zawislak, A.6    Price, J.H.7
  • 55
    • 6344239360 scopus 로고    scopus 로고
    • Photodynamic therapy of vulval intraepithelial neoplasia using bioadhesive patch-based delivery of aminolevulinic acid
    • McCarron P.A., Donnelly R.F., Woolfson A.D., and Zawislak A. Photodynamic therapy of vulval intraepithelial neoplasia using bioadhesive patch-based delivery of aminolevulinic acid. Drug Deliv. Sys. Sci. 3 (2003) 59-64
    • (2003) Drug Deliv. Sys. Sci. , vol.3 , pp. 59-64
    • McCarron, P.A.1    Donnelly, R.F.2    Woolfson, A.D.3    Zawislak, A.4
  • 57
    • 24644470274 scopus 로고    scopus 로고
    • Photodynamic treatment of lichen sclerosus and squamous hyperplasia using sustained topical delivery of aminolevulinic acid from a Novel Bioadhesive
    • McCarron P.A., Donnelly R.F., Woolfson A.D., Zawislak A., Price J.H., and Maxwell P. Photodynamic treatment of lichen sclerosus and squamous hyperplasia using sustained topical delivery of aminolevulinic acid from a Novel Bioadhesive. Br. J. Dermatol. 151 Suppl. 68 (2004) 105-106
    • (2004) Br. J. Dermatol. , vol.151 , Issue.SUPPL. 68 , pp. 105-106
    • McCarron, P.A.1    Donnelly, R.F.2    Woolfson, A.D.3    Zawislak, A.4    Price, J.H.5    Maxwell, P.6
  • 58
    • 33745859015 scopus 로고    scopus 로고
    • R.F. Donnelly, L.W. Ma, P., Juzenas, V., Iani, P.A., McCarron, A.D. Woolfson, J. Moan, Topical bioadhesive patch systems enhance selectivity of protoporphyrin IX accumulation in tumours. Photochem. Photobiol. (2006), in press.
  • 59
    • 33646836416 scopus 로고    scopus 로고
    • International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human use. ICH-Topic Q2B: Validation of Analytical Procedures: Methodology. Geneva, 1996.


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