Photodynamic therapy (PDT) and photodiagnosis (PD) using endogenous photosensitization induced by 5-aminolevulinic acid (ALA): Mechanisms and clinical results

Journal of Clinical Laser Medicine and Surgery

Volumn 14, Issue 5, 1996, Pages 289-304

  Kennedy, James C ^a   Marcus, Stuart L ^b   Pottier, Roy H ^c  

^a QUEEN S UNIVERSITY   (Canada)

^b DUSA Pharmaceuticals Inc   (United States)

^c ROYAL MILITARY COLLEGE OF CANADA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; COMPOSITION EFFECTS; DRUG PRODUCTS; ONCOLOGY; PHOTOCHEMICAL REACTIONS; PHOTOSENSITIVITY;

AMINOLEVULINIC ACID; ENDOGENOUS PHOTOSENSITIZATION; PHOTODIAGNOSIS;

PHOTODYNAMIC THERAPY;

AMINOLEVULINIC ACID; PHOTOSENSITIZING AGENT; PROTOPORPHYRIN;

ACTINIC KERATOSIS; ARTICLE; BARRETT ESOPHAGUS; BASAL CELL CARCINOMA; BIOACCUMULATION; BLADDER CANCER; BOWEN DISEASE; DIAGNOSTIC PROCEDURE; DIGESTIVE SYSTEM CANCER; DRUG CLEARANCE; ENDOMETRIUM ABLATION; FLUORESCENCE; HEAD AND NECK CANCER; HEME SYNTHESIS; HUMAN; INTRADERMAL DRUG ADMINISTRATION; INTRAPERITONEAL DRUG ADMINISTRATION; INTRAVENOUS DRUG ADMINISTRATION; NONHUMAN; ORAL DRUG ADMINISTRATION; PHOTODYNAMIC THERAPY; PHOTOSENSITIZATION; SKIN CARCINOMA; SUBCUTANEOUS DRUG ADMINISTRATION; TOPICAL DRUG ADMINISTRATION; TREATMENT INDICATION;

EID: 0030273742     PISSN: 10445471     EISSN: None     Source Type: Journal    
DOI: 10.1089/clm.1996.14.289     Document Type: Article

References (53)

1. Berlin, N.I., Neuberger, A., and Scott, J.J. (1956). The metabolism of d-aminolevulinic acid. Biochem. J. 64, 80-90 and 90-100.
2. Kappas, A., Sassa, S., Galbraith R.A., and Nordmann, Y. (1990). The porphyrias, in Hematology, 4th ed. W.J. Williams, E. Beutler, A.J. Erslev, and M.A. Lichtman (eds.). New York: McGraw-Hill, pp. 1305-1365.
3. De Matteis, F. (1988). Toxicological aspects of liver heme biosynthesis. Semin. Hematol. 25, 321-329.
4. Anderson, K.E. (1990). Erythrocyte disorders: Diseases related to abnormal heme or porphyrin metabolism, in Hematology, 4th ed. W.J. Williams, E. Beutler, A.J. Erslev, and M.A. Lichtman (eds.). New York: McGraw-Hill, pp. 722-741.
5. Matringe, M., Camadro, J-M., Labbe, P., and Scalla, R. (1989). Protoporphyrinogen oxidase as a molecular target for diphenyl ether herbicides. Biochem. J. 260, 231-235.
6. Brady, A.M., and Lock, E.A. (1992). Inhibition of ferrochelatase and accumulation of porphyrins in mouse hepatocyte cultures exposed to porphyrinogenic chemicals. Arch. Toxicol. 66, 175-181.
7. Donfrancesco, A., Deb, G., De Sio, L., Cozza, R., and Castellano, A. (1996). Role of deferoxamine in tumor therapy. Acta Haematol. 95, 66-69.
8. Lindner, P., Naredi, P., Peterson, A., and Hafstrom, L. (1995). Influence of hepatic artery occlusion and desferrioxamine on liver-tumour growth. Int. J. Cancer 63, 592-596.
9. Proulx, K.L., Woodard, S.I., and Dailey, H.A. (1993). In situ conversion of coproporphyrin to heme by murine mitochondria: terminal steps of the heme biosynthetic pathway. Protein Sci. 2, 1092-1098.
10. Sassa, S. (1990). Synthesis of heme, in Hematology, 4th ed. W.J. Williams, E. Beutler, A.J. Erslev, and M.A. Lichtman (eds.). New York: McGraw-Hill, pp. 322-329.
11. Abraham, N.G., Lavrosky, Y., Schwartzman, M.L., Stoltz, R.A., Levere, R.D., Gerritsen, M.E., Shibahara, S., and Kappas, A. (1995). Transfection of the human heme oxygenase gene into rabbit coronary microvessel endothelial cells: Protective effect against heme and hemoglobin toxicity. Proc. Natl. Acad. Sci. USA 92, 6798-6802.
12. Alfonso, S.G., Chinarro, S., Enriquez de Salamanca, R., and Battle, A.M. (1994). How the atmosphere and the presence of substrate affect the photo and non-photoinactivation of heme enzymes by uroporphyrin I. Int. J. Biochem. 26, 259-262.
13. Wike-Hooley, J.L., Haveman, J., and Reinhold, H.S. (1984). The relevance of tumor pH to the treatment of malignant diseases. Radiother. Oncol. 2, 343-366.
14. Waddell, W.J., and Bates, R.G. (1969). Intercellular pH. Physiol. Rev. 49, 285-329.
15. Barren, A.J., Kennedy, J.C., Jones, R.A., Nadeau, P., and Pettier, R.H. (1990). The effect of tissue and cellular pH on the selective biodistribution of porphyrin-type photochemotherapeutic agents: a volumetric titration study. J. Photochem. Photobiol., B: Biol. 6, 309-323.
16. Torti, S.V., and Torti, F.M. (1994). Iron and ferritin in inflammation and cancer. Adv. Inorganic Biochem. 10, 119-137.
17. Elliott, R.L., Elliott, M.C., Wang, F., and Head, J.F. (1993). Breast carcinoma and the role of iron metabolism. A cytochemical, tissue culture, and ultrastructural study. Ann. N.Y. Acad. Sci. 698, 159-166.
18. Peng, Q., Warloe, T., Moan, J., Heyerdahl, H., Steen, H.B., Nesland, J.M., and Giercksky, K.E. (1995). Distribution of 5-aminolevulinic acid-induced porphyrins in noduloulcerative basal cell carcinoma. Photochem. Photobiol. 62, 906-913.
19. Jori, G. (1989). In vivo transport and pharmacokinetic behavior of tumor photosensitizers, in Photosensitizing Compounds: Their Chemistry, Biology and Clinical use (Ciba Foundation Symposium 145). Chichester: Wiley, pp. 78-94.
20. Pottier, R.H., Chow, Y.F.A., LaPlante, J.P., Truscott, T.G., Kennedy, J.C., and Beiner, L.A. (1986). Non-invasive technique for obtaining fluorescence excitation and emission spectra in vivo. Photochem. Photobiol. 44, 679-687.
21. Kennedy, J.C., Nadeau, P., Petryka, Z.J., Pottier, R.H., and Weagle G. (1992). Clearance times of porphyrin derivatives from mice as measured by in vivo fluorescence spectroscopy. J. Photochem. Photobiol. B: Biol. 55, 729-734.
22. Stringer, M.R., Robinson, D.J., and Collins, P. (1996). Fluorescence analysis of ALA-induced protoporphyrin IX in psoriatic plaque, in Photochemotherapy Therapy and Other Modalities. B. Ehrenberg, G. Jori, and J. Moan, (eds.), Proc. SPIE 2625, pp. 405-412.
23. Kennedy, J.C., and Pottier, R.H. (1992). Endogenous protoporphyrin IX, a clinically useful photosensitizer for photodynamic therapy, J. Photochem. Photobiol. B 6, 275-292.
24. Wolf, P., Rieger, E., and Kerl, H. (1993). Topical photodynamic therapy with endogenous porphyrins after application of 5-aminolevulinic acid. J. Am. Acad. Dermatol. 28, 17-21.
25. Cairnduff, F., Stringer, M.R., Hudson, E.J., Ash, D.V., and Brown, S.B. (1994). Superficial photodynamic therapy with topical 5-aminolaevulinic acid for superficial primary and secondary skin cancer. Br. J. Cancer 69, 605-608.
26. Svanberg, K., Andersson, T., Killander, D., et al. (1994). Photodynamic therapy of non-melanoma malignant tumours of the skin using topical δ-amino levulinic acid sensitization and laser irradiation. Br. J. Dermatol. 130, 743-751.
27. Warloe, T., Peng, Q., Heyerdahl, H., Moan, J., Steen, H.B., and Giercksky, K.-E. (1995). Photodynamic therapy with 5-aminolevulinic acid induced porphyrins and DMSO/EDTA for basal cell carcinoma, in: 5th International Photodynamic Association Biennial Meeting. D.A. Cortese (ed.). Proc. SPIE 2371, pp. 226-235.
28. Calzavara-Pinton, P.G. (1995). Repetitive photodynamic therapy with topical δ-minolevulinic acid as an appropriate approach to the routine treatment of superficial on-melanoma skin cancers. J. Photochem. Photobiol., B: Biol. 29, 53-57.
29. Jeffes, E.W., Weinstein, G.W., McCullough, J.L., Nelson, J.S., Fong, N.L., and McCormick, A.J. (1993). Photodynamic therapy of actinic keratosis with topical delta aminolevulinic acid (ALA): A pilot dose ranging study. Abstract presented at Photomedicine Society annual meeting. Data on file at DUSA Pharmaceuticals, Inc.
30. Yang, J.Z., Van Vugt, D.A., Kennedy, J.C., and Reid, R.L. (1993). Evidence of lasting functional destruction of the rat endometrium after 5-aminolevuIinic acid-induced photodynamic ablation: Prevention of implantation. Am. J. Obstet. Gynecol. 168, 995-1001.
31. Wyss, P., Tromberg, B.J., Wyss, M.T. et al. (1994). Photodynamic destruction of endometrial tissue with topical 5-aminolevulinic acid in rats and rabbits. Am. J. Obstet. Gynecol. 171, 1176-1183.
32. Gannon, M.J., Johnson, N., Roberts, D.J.H. et al. (1995). Photosensitization of the endometrium with topical 5-aminolevulinic acid. Am. J. Obstet. Gynecol. 173, 1826-1828.
33. Svanberg, K., Wang, I., Rydell, R. et al. (1995). Fluorescence diagnostics of head and neck cancer utilizing oral administration of δ-aminolevulinic acid, in: 5th International Photodynamic Association Biennial Meeting. D.A. Cortese (ed.). Proc. SPIE 2371, pp. 129-141.
34. Wang, I., Svanberg, K., Andersson-Engels, S., Berg, R., and Svanberg, P. (1995). Photodynamic therapy of non-melanoma skin malignancies with topical δ-aminolevulinic acid: diagnostic measurements, in: 5th International Photodynamic Association Biennial Meeting. D.A. Cortese (ed.). Proc. SPIE 2371, pp. 243-252.
35. Kriegmair, M., Baumgartner, R., Kneuchel, R. et al. (1994). Fluorescence photodetection of neoplastic urothelial lesions following intravesical instillation of 5-aminolevulinic acid, Urology 44, 836-841.
36. Baumgartner, R., Kriegmair, M., Stepp, H. et al. (1993). Photodynamic diagnosis following intravesical instillation of aminolevulinic acid (ALA) - First clinical experiences in urology. Optical Methods for Tumor Treatment and Detection SPIE 1881, pp. 20-25.
37. Kriegmair, M., Baumgartner, R., Knuchel, R., Stepp, H., Hofstadter, F., and Hofstetter, A. (1996). Detection of early bladder cancer by 5-aminolevulinic acid induced porphyrin fluorescence, J. Urol. 165, 105-110.
38. Jichlinski, P., Forrer, M., Mizeret, J. et al. (1996). Clinical evaluation of a method for detecting superficial transitional cell carcinoma of the bladder by light-induced fluorescence of protoporphyrin IX following topical application of 5-aminolevulinic acid. Preliminary results. Lasers Surg. Med. (in press).
39. Loh, C.S., MacRobert, A.J., Bedwell, J., Regula, J., Krasner, N., and Brown, S.G. (1993). Oral versus intravenous administration of 5-aminolaevulinic acid for photodynamic therapy. Br. J. Cancer 68, 41-51.
40. Grant, W.E., Hopper, C., MacRobert, A.J., Speight, P.M., and Bown, S.G. (1993). Photodynamic therapy of oral cancer: photosensitisation with systemic aminolaevulinic acid. Lancet 342, 147-148.
41. Regula, J., MacRobert, A.J. Gorchein, A. et al. (1995). Photosensitization and photodynamic therapy of oesophageal, duodenal, and colorectal tumours using 5 aminolaevulinic acid induced protoporphyrin IX - a pilot study. Gut 36, 67-75.
42. Barr, H. (1995). Photodynamic therapy for Barrett's oesophagus. Int. Photodynam. 1, 6-8.
43. Szeimies, R-M., Sassy, T., and Landthaler, M. (1994). Penetration potency of topical applied δ-aminolevulinic acid for photodynamic therapy of basal cell carcinoma. Photochem. Photobiol. 59, 73-76.
44. Martin, A., Tope, W.D., Grevelink, J.M. et al. (1995). Lack of selectivity of protoporphyrin IX fluorescence for basal cell carcinoma after topical application of 5-aminolevulinic acid: implications for photodynamic treatment. Arch. Dermatol. Res. 287, 665-674.
45. Szeimies, R.-M., Abels, C., Fritsch, C., Steinbach, P. Bäumler, W., Karrer, S., Messmann, H., Goetz, A.E., Goerz, G., and Landthaler, M. (1996). Wavelength-dependent in vitro and in vivo photodynamic effects after sensitization with 5-aminolevulinic acid-induced protoporphyrin IX, in: Photochemotherapy: Photodynamic Therapy and Other Modalities. B. Ehrenberg, G. Jori, and J. Moan (eds.). Proc. SPIE 2625, pp. 44-47.
46. Moan, J., Iani, V., and Ma, L. (1996). Choice of proper wavelength for photochemotherapy, in: Photochemotherapy: Photodynamic Therapy and Other Modalities. B. Ehrenberg, G. Jori, and J. Moan (eds.). Proc. SPIE 2625, pp. 544-549.
47. Inhoffen, H.H., Brockmann, H., and Bliesener, K.-M. (1969). Further knowledge of chlorophyll and of hemin, XXX, Photoprotoporphyrins and their transformation into spirographis-and isospirographis-porphyrins. Leibigs Ann. Chem. 730, 173-185 (in German).
48. König, K., Schneckenburger, H., Ruck, A., and Steiner, R. (1993). In vivo photoproduct formation during PDT with ALA-induced endogenous porphyrin, J. Photochem. Photobiol. B: Biol. 18, 287-290.
49. Gudgin Dickson, E.F., and Pettier, R.H. (1995). On the role of protoporphyrin IX photoproducts in photodynamic therapy. J. Photochem. Photobiol. B: Biol. 29, 91-93.
50. Warloe, T., Heyerdahl, H., Giercksky, K.E., Peng, Q., Moan, J., and Steen, H.B. .(1995). Photodynamic therapy with 5-aminolevulinic acid esters for basal cell carcinoma, in: Photochemotherapy: Photodynamic Therapy and Other Modalities. B. Ehreberg, G. Jori, and J. Moan (eds.). Proc. SPIE 2625, p. 66 (abstract 2625-14).
51. Malik, Z., Ksotenich, G., Roitman, L., Ehrenberg, B., and Orenstein, A. (1995). Topical application of 5-aminolevulinic acid, DMSO and EDTA: protoporphyrin IX accumulation in skin and tumours of mice. J. Photochem. Photobiol. B: Biol. 28, 213-218.
52. Peng, Q., Moan, J., Ian, V., and Nesland, J.M. (1996). Effect of desferrioxamine on production of ALA-induced protoporphyrin IX in normal mouse skin, in: Photochemotherapy: Photodynamic Therapy and Other Modalities. B. Ehrenberg, G. Jori, and J. Moan (eds.). Proc. SPIE 2625, pp. 51-57.
53. Messmann, H., Mlkvy, P., Buonaccurso, G., Davies, C.L., MacRobert, A.J., and Bown, S.G. (1995). Enhancement of photodynamic therapy with 5-aminolevulinic acid-induced porphyrin photosensitization in normal rat colon by threshold and light fractionation studies. Br. J. Cancer 72, 589-594.