Human skin sandwich for assessing shunt route penetration during passive and iontophoretic drug and liposome delivery

Journal of Pharmacy and Pharmacology

Volumn 54, Issue 11, 2002, Pages 1481-1490

  Essa, Ebtessam A ^a   Bonner, Michael C ^a   Barry, Brian W ^a  

^a UNIVERSITY OF BRADFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ESTRADIOL; LIPOSOME; MANNITOL;

ADULT; AGED; ARTICLE; CLINICAL TRIAL; COMPARATIVE STUDY; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG ADMINISTRATION ROUTE; DRUG DELIVERY SYSTEM; DRUG PENETRATION; EPIDERMIS; FEMALE; HUMAN; HUMAN EXPERIMENT; HUMAN TISSUE; HYDROPHILICITY; IONTOPHORESIS; LIPOPHILICITY; MALE; NORMAL HUMAN; SKIN APPENDAGE; SKIN PENETRATION; STRATUM CORNEUM; BIOLOGICAL MODEL; IN VITRO STUDY; METABOLISM; PERMEABILITY; SKIN; SKIN ABSORPTION; TIME; TRANSPORT AT THE CELLULAR LEVEL;

AGED; BIOLOGICAL TRANSPORT; EPIDERMIS; ESTRADIOL; HUMANS; IONTOPHORESIS; LIPOSOMES; MALE; MANNITOL; MODELS, BIOLOGICAL; PERMEABILITY; SKIN; SKIN ABSORPTION; TIME FACTORS;

EID: 0036848940     PISSN: 00223573     EISSN: None     Source Type: Journal    
DOI: 10.1211/002235702135     Document Type: Article

References (39)

1. Abramson, H. A., Gorin, M. H. (1940) Skin reactions. IX. The electrophoretic demonstration of the patent pores of living human skin; its relation to the charge of the skin. J. Phys. Chem. 44: 1094-1102
2. Akhter, S. A., Bennett, S. L., Waller, I. L., Barry, B. W. (1984) An automated diffusion apparatus for studying skin penetration. Int. J. Pharmaceutics 21: 17-26
3. Banga, A. J. (1998) Electrically assisted transdermal and topical drug delivery. Taylor and Francis, London
4. Barry, B. W. (1983) Dermatological formulations: percutaneous absorption. Marcel Dekker, New York
5. Barry, B. W., Bennett, S. L. (1987) Effect of penetration enhancers on the permeation of mannitol, hydrocortisone and progesterone through human skin. J. Pharm. Pharmacol. 39: 535-546
6. Blume, A., Jansen, M., Ghyczy, M., Gareiss, J. (1993) Interaction of phospholipid liposomes with lipid model mixture of stratum corneum lipids. Int. J. Pharmaceutics 99: 219-228
7. Cevc, G., Blume, A. (1992) Lipid vesicles penetrate into intact skin owing to the transdermal osmotic gradients and hydration force. Biochim. Biophys. Acta 1104: 226-232
8. Cevc, G., Blume, A., Schätzlein, A., Gebauer, D., Paul, A. (1996) The skin: a pathway for systemic treatment with patches and lipid-based agent carriers. Adv. Drug Deliv. Rev. 18: 349-378
9. Cevc, G., Gebauer, D., Stieber, J., Schätzlein, A., Blume, G. (1998) Ultraflexible vesicles, Transfersomes, have an extremely low pore penetration resistance and transport therapeutic amounts of insulin across the intact mammalian skin. Biochim. Biophys. Acta 1368: 201-215
10. Cullander, C., Guy, R. H. (1991) Sites of iontophoretic current flow into the skin: identification and characterisation with the vibrating probe electrode. J. Invest. Derm. 97: 55-64
11. Du Plessis, J., Egbaria, K., Ramachandran, C., Weiner, N. D. (1992) Topical delivery of liposomally encapsulated gamma-interferon. Antiviral Res. 18: 259-265
12. El Maghraby, G. M. M. (2000) New drug delivery system through liposomes. PhD Thesis, University of Bradford, UK
13. El Maghraby, G. M. M., Williams, A. C., Barry, B. W. (1999) Skin delivery of oestradiol from deformable and traditional liposomes: mechanistic studies. J. Pharm. Pharmacol. 51: 1123-1134
14. El Maghraby, G. M. M., Williams, A. C., Barry, B. W. (2000) Oestradiol skin delivery from ultradeformable liposomes: refinement of surfactant concentration. Int. J. Pharmaceutics 196: 63-74
15. El Maghraby, G. M. M., Williams, A. C., Barry, B. W. (2001) Skin hydration and possible shunt route penetration in controlled estradiol delivery from ultradeformable and standard liposomes. J. Pharm. Pharmacol. 53: 1311-1322
16. Essa, E. A., Bonner, M. C., Barry, B. W. (2002) Iontophoretic estradiol skin delivery and tritium exchange in ultradeformable liposomes. Int. J. Pharmaceutics 240: 55-66
17. Hager, D. F., Mancuso, F. A., Nazarene, J. P., Sharkey, J. W., Sively, J. R. (1994) Evaluation of cultured skin equivalent as a model membrane for iontophoretic transport. J. Control. Release 30: 117-123
18. Hofland, H. E. J., Bouwstra, J. A., Boddé, H. E., Spies, F., Junginger, H. E. (1995) Interactions between liposomes and human stratum corneum in-vitro: freeze fracture electron microscopical visualization and small angle X-ray scattering studies. Br. J. Dermatol. 132: 853-856
19. Honeywell-Nguyen, P. L., De Graaff, A., Groenink, H. W. W., Junginger, H. E., Bouwstra, J. A. (2002) Interaction between elastic and rigid vesicles with human skin in-vivo and in-vitro. Proceedings of the 8th Perspectives in Percutaneous Penetration Conference, Antibes-Juan-les-Pins, Vol. 8A, p. 79
20. Ilel, B., Schaefer, H. (1991) Follicles play an important role in percutaneous absorption. J. Pharm. Sci. 80: 424-427
21. Jadoul, A., Doucet, J., Durand, D., Préat, V. (1996) Modifications induced on stratum corneum after in-vitro iontophoresis: ATR-FTIR and X-ray scattering studies. Int. J. Pharmaceutics 42: 165-173
22. Kim, A., Green, P. G., Rao, G., Guy, R. H. (1993) Convective solvent flow across the skin during iontophoresis. Pharm. Res. 10: 1315-1321
23. Kirjavainen, M., Mönkkönen, J., Saukkosaari, M., Valjakka-Koskela, R., Kiesvaara, J., Urtti, A. (1999) Phospholipids affect stratum corneum lipid bilayer fluidity and drug partitioning into bilayers. J. Control. Release 58: 207-214
24. Kirjavainen, M., Urtti, A., Mönkkönen, J., Hirvonen, J. (2000) Influence of lipids on the mannitol flux during transdermal iontophoresis in-vitro. J. Pharm. Sci. 10: 97-102
25. Kligman, A. M., Christophers, E. (1963) Preparation of isolated sheets of human stratum corneum. Arch. Dermatol. 88: 70-73
26. Lauer, A. C., Ramachandran, C., Leib, L. M., Niemiec, S., Weiner, N. D. (1996) Targeted delivery to pilosebaceous unit via liposomes. Adv. Drug Deliv. Rev. 18: 311-324.
27. Megrab, N. A., Williams, A. C., Barry, B. W. (1995) Oestradiol permeation across human skin, silastic and snake skin membranes: the effect of ethanol/water co-solvent systems. Int. J. Pharmaceutics 116: 101-112
28. Monteiro-Riviere, N. A. (1990) Altered epidermal morphology secondary to lidocaine iontophoresis: in-vivo and in-vitro studies in porcine skin. Fundam. Appl. Toxicol. 15: 174-185
29. New, R. R. C. (1990) Liposomes: a practical approach. Oxford University Press, Oxford
30. Olson, F., Hunt, C. A., Szoka, F. C., Vail, W. J., Papahadjopoulos, D. (1979) Preparation of liposomes of defined size distribution by extrusion through polycarbonate membranes. Biochim. Biophys. Acta 557: 9-23
31. Pikal, M. J. (2001) The role of electroosmotic flow in transdermal iontophoresis. Adv. Drug Deliv. Rev. 46: 281-305
32. Pikal, M. J., Shah, S. (1990a) Transport mechanisms in iontophoresis. II. Electroosmotic flow and transference number measurements for hairless mouse skin. Pharm. Res. 7: 213-221
33. Pikal, M. J., Shah, S. (1990b) Transport mechanisms in iontophoresis. III. An experimental study of the contributions of electroosmotic flow and permeability change in transport of low and high molecular weight solutes. Pharm. Res. 7: 222-229
34. Salole, E. G. (1986) Estradiol. In: Flory, K. (ed.) Analytical profile of drug substances. Vol. 15, Academic Press, Inc., New York, pp 283-318
35. Scheuplein, R. J. (1967) Mechanisms of percutaneous absorption. II. Transient diffusion and the relative importance of various routes of skin penetration. J. Invest. Dermatol. 48: 79-88
36. Singh, S., Maibach, H. I. (1996) Iontophoresis: an alternative to the use of carriers in cutaneous drug delivery. Adv. Drug Deliv. Rev. 18: 379-394
37. Wade, A., Weller, P. J. (1994) Handbook of pharmaceutical excipients. 2nd edn, The Pharmaceutical Press, London, pp 294-298
38. Williams, A. C., Barry, B. W. (1991) The enhancement index concept applied to terpene penetration enhancers for human skin and lipophilic (estradiol) and hydrophilic (5-fluorouracil) drugs. Int. J. Pharmaceutics 74: 157-168
39. Williams, A. C., Cornwell, P. A., Barry, B. W. (1992) On the non-Gaussian distribution of human skin permeabilities. Int. J. Pharmaceutics 86: 69-77