Subchronic studies in Sprague-Dawley rats to investigate mechanisms of MTBE-induced Leydig cell cancer

Toxicological Sciences

Volumn 72, Issue 1, 2003, Pages 31-42

  De Peyster, Ann ^a   Mac Lean, Kathryn J ^a   Stephens, Beth A ^a   Ahern, Lisa D ^a   Westover, Christian M ^a   Rozenshteyn, Diana ^a  

^a SAN DIEGO STATE UNIVERSITY   (United States)

Author keywords

Endocrine disruption; Leydig cell cancer; Mechanisms; Methyl t butyl ether (MTBE); Rats

Indexed keywords

AROMATASE; BUTANOL; CORN OIL; CYTOCHROME P450; ESTRADIOL; LUTEINIZING HORMONE; PROLACTIN; TERT BUTYL METHYL ETHER; TESTOSTERONE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOASSAY; BRAIN WEIGHT; CARCINOGENESIS; CARCINOGENICITY; CASTRATION; CELL ISOLATION; CONTROLLED STUDY; DOSE RESPONSE; ENZYME ACTIVITY; ESTRADIOL BLOOD LEVEL; FEEDING; HYPOTHALAMUS HYPOPHYSIS SYSTEM; INHALATION; LEYDIG CELL TUMOR; LIVER MICROSOME; LIVER WEIGHT; MALE; NONHUMAN; ORCHIECTOMY; ORGAN WEIGHT; PATHOPHYSIOLOGY; PEROXISOME; RAT; STEROIDOGENESIS; TESTIS; TESTOSTERONE BLOOD LEVEL; TESTOSTERONE SYNTHESIS;

ADMINISTRATION, INHALATION; ANIMALS; AROMATASE; CARCINOGENS; CORTICOSTERONE; CYTOCHROME P-450 ENZYME SYSTEM; ESTRADIOL; GONADOTROPINS; LEYDIG CELL TUMOR; LUTEINIZING HORMONE; MALE; METHYL ETHERS; ORCHIECTOMY; ORGAN SIZE; PEROXISOMES; PITUITARY HORMONES; RATS; RATS, SPRAGUE-DAWLEY; SOLVENTS; TESTOSTERONE; TOXICITY TESTS, CHRONIC; TUMOR CELLS, CULTURED; WEIGHT GAIN;

ANIMALIA; ZEA MAYS;

EID: 0037340884     PISSN: 10966080     EISSN: None     Source Type: Journal    
DOI: 10.1093/toxsci/kfg011     Document Type: Article

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