Two-generation reproductive toxicity study of methyl tertiary-butyl ether (MTBE) in rats

Journal of Applied Toxicology

Volumn 17, Issue SUPPL. 1, 1997, Pages

  Bevan, C ^a,f   Neeper Bradley, T L ^b   Tyl, R W ^b   Fisher, L C ^b   Panson, R D ^c   Kneiss, J J ^d   Andrews, L S ^e  

^a EXXONMOBIL UPSTREAM RESEARCH COMPANY   (United States)

^b Bushy Run Research Center   (United States)

^c Sunoco   (United States)

^d Oxygenated Fuels Association   (United States)

^e BP EXPLORATION   (United Kingdom)

^f RTI INTERNATIONAL   (United States)

Author keywords

Inhalation; Methyl tertiary butyl ether; MTBE; Rat; Reproductive toxicity

Indexed keywords

TERT BUTYL METHYL ETHER;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ATAXIA; BODY WEIGHT; CONTROLLED STUDY; FEMALE; HISTOPATHOLOGY; INHALATION; INHALATIONAL DRUG ADMINISTRATION; MALE; NONHUMAN; PERINATAL PERIOD; PRIORITY JOURNAL; PROGENY; RAT; REPRODUCTIVE TOXICITY;

ADMINISTRATION, INHALATION; AIR POLLUTANTS; ANIMALS; BODY WEIGHT; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; FETAL DEATH; FETUS; LITTER SIZE; LIVER; MALE; METHYL ETHERS; RATS; RATS, SPRAGUE-DAWLEY; REPRODUCTION;

ANIMALIA; ATAXIA;

EID: 0030981225     PISSN: 0260437X     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1099-1263(199705)17:1+3.0.CO;2-C     Document Type: Article

References (10)

1. Chem. Eng. News April 11, 13 (1994)
2. R. W. Biles, R. E. Schroder and C E. Holdsworth, Methyl tertiary butyl ether inhalataion in rats: a single generation study. Toxicol Ind. Health 3, 519-534 (1987).
3. US EPA, Testing Consent Order of Methyl Tertiary Butyl Ether and Response to the Interagency Testing Committee; Final Rule Fed. Reg. 53(62), 10391-10394 (1988).
4. W. M. Snellings and D. E. Dodd, Inhalation studies. In Handbook of In Vivo Toxicity Testing, ed by D. L. Arnold, H. C. Grice and D. R. Krewski, pp. 186-246. Academic Press, New York (1990)
5. C S. Weil, Selection of the valid number of sampling units and a consideration of their combination in toxicological studies involving reproduction, teratogenesis or carcinogenesis. Food Cosmet. Toxicol 8, 177-182 (1970).
6. H Levene, Robust tests for equality of variance. In Contributions to Probability and Statistics, ed. by I. Oikin et al. pp. 278-292. Stanford University Press, Stanford, CA (1960).
7. M. B. Brown and A. B. Forsythe, The small sample behaviour of some statistics which test the equality of several means. Technometrics 16, 129-132 (1974).
8. R. R. Sokal and F. J. Rohlf, Biometry. W. H. Freeman and Co., San Francisco, CA (1969).
9. A. W. Lington, D. E. Dodd, S. A. Ridlon, L. S. Andrews, J. F. Douglas and J. J. Kneiss, Evaluation of a 13-week inhalation toxicity study on methyl t-butyl ether (MTBE) in Fischer 344 rats J. Appl. Toxicol, this issue, S37-S44 (1997).
10. US EPA, Part III Environmental Protection Agency Toxic Substances Control Act (TSCA); Good Laboratory Practice Standards; Final Rule. Fed. Reg. 54(158), 34034-34050 (1989).