Gamma-oryzanol ameliorates insulin resistance and hyperlipidemia in rats with streptozotocin/nicotinamide-induced type 2 diabetes

International Journal for Vitamin and Nutrition Research

Volumn 80, Issue 1, 2010, Pages 45-53

  Cheng, Hsing Hsien ^a   Ma, Chien Ya ^a   Chou, Tsui Wei ^a,b   Chen, Ya Yen ^a   Lai, Ming Hoang ^c  

^a TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^b KAINAN UNIVERSITY   (Taiwan)

^c CARDINAL TIEN COLLEGE OF HEALTHCARE AND MANAGEMENT   (Taiwan)

Author keywords

Gamma oryzanol; Insulin resistance; Lipid metabolism; Palm oil; Type 2 diabetes mellitus

Indexed keywords

BILE ACID; FATTY ACID; GAMMA ORYZANOL; GLUCOSE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; INSULIN; LOW DENSITY LIPOPROTEIN CHOLESTEROL; NICOTINAMIDE; PALM OIL; SOYBEAN OIL; STEROL; TRIACYLGLYCEROL;

ANIMAL EXPERIMENT; ANIMAL MODEL; AREA UNDER THE CURVE; ARTICLE; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DIET; DRUG EFFECT; DRUG EFFICACY; GLUCOSE BLOOD LEVEL; HYPERLIPIDEMIA; INSULIN BLOOD LEVEL; INSULIN RESISTANCE; INSULIN SENSITIVITY; LIPID METABOLISM; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; RAT; RICE BRAN; STREPTOZOCIN DIABETES; TRIACYLGLYCEROL BLOOD LEVEL;

ANIMALS; ANTILIPEMIC AGENTS; BILE ACIDS AND SALTS; CHOLESTEROL; DIABETES MELLITUS, EXPERIMENTAL; DIABETES MELLITUS, TYPE 2; DIET; FECES; GLUCOSE TOLERANCE TEST; HYPERLIPIDEMIAS; HYPOGLYCEMIC AGENTS; INSULIN RESISTANCE; LIPOPROTEINS; LIVER; MALE; PHENYLPROPIONATES; PLANT OILS; RATS; RATS, WISTAR; STEROLS; TRIGLYCERIDES;

GLYCINE MAX; RATTUS; RATTUS NORVEGICUS;

EID: 77953512873     PISSN: 03009831     EISSN: None     Source Type: Journal    
DOI: 10.1024/0300-9831/a000005     Document Type: Article

References (39)

1. King, H., Aubert, R.E. and Herman, W.H. (1998) Global burden of diabetes, 1995-2025: prevalence, numerical estimates, and projections.Diabetes Care 21, 1414-1431.
2. Uusitupa, M., Siitonen, O., Aro, A. and Pyorala, K. (1985) Prevalence of coronary heart disease, left ventricular failure and hypertension in middle-aged newly diagnosed Type 2 (non-insulin dependent) diabetic subjects. Diabetologia 28, 22-27.
3. Haffner, S.M., Lehto, S., Rönnemaa,T., Pyörälä, K. and Laakso, M. (1998) Mortality from coronary heart disease in subjects with Type 2 diabetes and in non-diabetic subjects with and without prior myocardial infarction. N. Engl. J. Med. 339, 229-234.
4. Turner, R.C., Millins, H., Neil, H.A.W., Stratton, I.M., Manley, S.E., Matthews,D.R. and Holman, R.R. (1998) Risk factors for coronary artery disease in non-insulin dependent diabetes mellitus: United Kingdom prospective diabetes study (UKPDS: 23). BMJ 316, 823-828.
5. Betteridge, J., Colhoun, H. and Armitage, J. (2000) Status report of lipid lowering trials in diabetes. Curr. Opin. Lipidology 11, 621-626.
6. Ginsberg, H.N. (2000) Insulin resistance and cardiovascular disease. J. Clin. Invest. 106, 453-458.
7. Rivellese, A.A. and Lilli, S. (2003) Quality of dietary fatty acids, insulin sensitivity and type 2 diabetes. Biomed. Pharmacother. 57, 84-87.
8. Sugano, M., Koba, K. and Tsuji, E. (1999) Health benefits of rice bran oil. Anticancer Res. 19, 3651-3657.
9. Rukmini, C. and Raghuram, T.C. (1991) Nutritional and biochemical aspects of the hypolipidemic action of rice bran oil: a review. J. Am. Coll. Nutr. 10, 593-601.
10. Nicolosi, R.J., Rogers, E.J., Ausman, L.M. and Orthoefer, F.T. (1994) Rice bran oil and its health benefits. In: Rice Science and Technology (eds.?), pp. 421- 437, Marcel Dekker Inc., New York, NY..
11. Rong, N., Ausman, L.M. and Nicolosi, R.J. (1997) Oryzanol decreases cholesterol absorption and aortic fatty streaks in hamsters. Lipids 32, 303-309.
12. Arumughan, C., Skhariya, R. and Arora, R. (2004) Edible oil outlook for India. Inform. 15, 644.
13. Wilson, T.A., Nicolosi, R.J., Kotyla, T., Sundram, K. and Kritchevsky, D. (2005) Different palm oil preparations reduce plasma cholesterol concentrations and aortic cholesterol accumulation compared to coconut oil in hypercholesterolemic hamsters. Journal of Nutritional Biochemistry 16, 633-640.
14. Ladeia, A.M., Costa-Matos,E., Barata-Passos,R. and Guimaraes, A.C. (2008) A palm oil-rich diet may reduce serum lipids in healthy young individuals. Nutrition 24, 11-15.
15. Ganafa, A.A., Socci, R.R., Eatman (Eastman?), D., Silvestron, N., Abukhalaf, I.K. and Bayorh, M.A. (2002) Effect of palm oil on oxidative stress-induced hypertension in Sprague-Dawley rats. Am. J. Hypertens. 15, 725-731.
16. Popkin, B.M., Horton, S. and Kim, S. (2001) Trends in diet, nutritional status, and diet-related noncommunicable diseases in China and India: the economic costs of the nutrition transition. Nutr. Rev. 59, 379-390.
17. National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health. (2003) Prevent Diabetes Problems: keep your heart and blood vessels healthy. NIH Publication No. 03-4283.
18. National Heart, Lung, and Blood Institute, National Institutes of Health (NHLBI). (1997) Be heart smart. Eat foods lower in saturated fats and cholesterol. NIH Publication No. 97-4067.
19. Sayre, B. and Saunders, R. (1990) Rice bran and rice bran oil. Lipid Tech. 2, 72-76.
20. Sasaki, J., Takada, Y., Handa, K., Kusuda, M., Tanabe, Y., Matsunaga, A. and Arakawa, K. (1990) Effects of gamma-oryzanol on serum lipids and apolipoproteins in dyslipidemic schizophrenics receiving major tranquilizers. Clin. Ther. 12, 263-268.
21. Wilson, T.A., Nicolosi, R.J., Woolfrey, B. and Kritchevsky, D. (2007) Rice bran oil and oryzanol reduce plasma lipid and lipoprotein cholesterol concentrations and aortic cholesterol ester accumulation to a greater extent than ferulic acid in hypercholesterolemic hamsters. J. Nutr. Biochem. 18, 105-112.
22. Masiello, P., Broca, C., Gross, R., Roye, M., Manteghetti, M., Hillaive-Buys,D., Novelli, M. and Ribes, G. (1998) Development of a new model in adult rats administered streptozotocin and nicotinamide. Diabetes 47, 224-229.
23. Reeves, P.G., Nielsen, F.H. and Fahey, G.C. Jr. (1993) AIN-93 purified diets for laboratory rodents: final report of the American Institute of Nutrition ad hoc writing committee on the reformulation of the AIN-76 A rodent diet. J. Nutr. 123, 1939-1951.
24. National Science Council. (1994) Guide for the care and use of laboratory animals. Taipei, Taiwan, ROC.
25. Lepage, G. and Roy, C.C. (1986) Direct transesterification of all classes of lipids in a one-step reaction. J. Lipid Res. 27, 1114-1120.
26. Folch, J., Lees,M. and Sloane-Stanley, G.H. (1957) A simple method for the isolation and purification of total lipids from animal tissues. J. Biol. Chem. 226, 497-509.
27. Mashige, F., Tanaka, N., Maki, A., Kamei, S. and Yamanaka, M. (1981) Direct spectrophotometry of total bile acids in serum. Clin. Chem. 27, 1352-1356.
28. Cortez, M.Y., Torgan, C.E., Brozinick, J.T. Jr. and Ivy, J.L. (1991) Insulin resistance of obese Zucker rats exercise trained at two different intensities. Am. J. Physiol. 261, 613-619.
29. Durrington, P.N., Prais, H. and Bathanagar, D. (1999) Indications for cholesterol lowering medication: comparison of risk-assessment methods. Lancet 353, 278-281. (Pubitemid 29088120)
30. Tikkanen, M.J. and Adlercreutz, H. (2000) Dietary soy-derived isoflavone phytoestrogens. Could they have a role in coronary heart disease prevention? Biochem. Pharmacol. 60, 1-5.
31. Jackson, K.G., Wolstencroft, E.J., Bateman, P.A., Yaqoob, P. andWilliams, C.M. (2005) Greater enrichment of triacylglycerol-rich lipoproteins with apolipoproteins E and C-III after meals rich in saturated fatty acids than after meals rich in unsaturated fatty acids. Am. J. Clin. Nutr. 81, 25-34.
32. Sharma, R.D. and Rukmini, C. (1986) Rice bran oil and hypocholesterolemia in rats. Lipids 21, 715-717.
33. Yoshino, G., Kazumi, T. and Amano, M. (1989) Effects of oryzanol on hyperlipidemic subjects. Curr. Ther. Res. 45, 543-552.
34. Ishihara, M. (1984) Effect of oryzanol on serum lipid peroxide level and clinical symptoms of patients with climacteric disturbances. Asia Oceania J. Obstet. Gynaecol. 10, 317-323.
35. Seetharamaiah, G.S. and Chandrasekhara, N. (1990) Effect of oryzanol on cholesterol absorption and biliary and fecal bile acids in rats. Indian J. Med. Res. 92, 471-475.
36. Chen, C.W. and Cheng, H.H. (2006) A rice bran oil diet increases LDL-receptor and HMG-CoA reductase mRNA expressions and insulin sensitivity in rats with streptozotocin/nicotinamide-induced type 2 diabetes. J. Nutr. 136, 1472-1476.
37. Rukmini, C. and Raghuram, T.C. (1991) Nutritional and biochemical aspects of the hypolipidemic action of rice bran oil: a review. J. Am. Coll. Nutr. 10, 593-601.
38. Manco, M., Calvani, M. and Mingrone, G. (2004) Effects of dietary fatty acids on insulin sensitivity and secretion. Diabetes, Obesity and Metabolism 6, 400-413.
39. Ghafoorunissa, Ibrahim, A., Rajkumar,L. and Acharya, V. (2005) Dietary (n-3) long chain polyunsaturated fatty acids prevent sucrose-induced insulin resistance in rats. J. Nutr. 135, 2634-2638.