-
1
-
-
0037376928
-
Pharmaceutical profiling in drug discovery
-
Kerns E.H., Di L. Pharmaceutical profiling in drug discovery. Drug Discov. Today 2003, 8:316-323.
-
(2003)
Drug Discov. Today
, vol.8
, pp. 316-323
-
-
Kerns, E.H.1
Di, L.2
-
3
-
-
0026078241
-
Tocainide therapy in muscle cramps and spasms due to neuromuscular disease
-
Puniani T.S., Bertorini T.E. Tocainide therapy in muscle cramps and spasms due to neuromuscular disease. Muscle Nerve 1991, 14:280-285.
-
(1991)
Muscle Nerve
, vol.14
, pp. 280-285
-
-
Puniani, T.S.1
Bertorini, T.E.2
-
4
-
-
0034609854
-
Synthesis of new 2,6-prolylxylidide analogues of tocainide as stereoselective blockers of voltage-gated Na(+) channels with increased potency and improved use-dependent activity
-
Franchini C., Corbo F., Lentini G., Bruno G., Scilimati A., Tortorella V., Conte Camerino D., De Luca A. Synthesis of new 2,6-prolylxylidide analogues of tocainide as stereoselective blockers of voltage-gated Na(+) channels with increased potency and improved use-dependent activity. J. Med. Chem. 2000, 43:3792-3798.
-
(2000)
J. Med. Chem.
, vol.43
, pp. 3792-3798
-
-
Franchini, C.1
Corbo, F.2
Lentini, G.3
Bruno, G.4
Scilimati, A.5
Tortorella, V.6
Conte Camerino, D.7
De Luca, A.8
-
5
-
-
0242439310
-
Optically active mexiletine analogues as stereoselective blockers of voltage-gated Na(+) channels
-
Franchini C., Carocci A., Catalano A., Cavalluzzi M.M., Corbo F., Lentini G., Scilimati A., Tortorella P., Conte Camerino D., De Luca A. Optically active mexiletine analogues as stereoselective blockers of voltage-gated Na(+) channels. J. Med. Chem. 2003, 46:5238-5248.
-
(2003)
J. Med. Chem.
, vol.46
, pp. 5238-5248
-
-
Franchini, C.1
Carocci, A.2
Catalano, A.3
Cavalluzzi, M.M.4
Corbo, F.5
Lentini, G.6
Scilimati, A.7
Tortorella, P.8
Conte Camerino, D.9
De Luca, A.10
-
6
-
-
36648999017
-
Synthesis of beta-proline like derivatives and their evaluation as sodium channel blockers
-
Muraglia M., Franchini C., Corbo F., Scilimati A., Sinicropi M.S., De Luca A., De Bellis M., Conte Camerino D., Tortorella V. Synthesis of beta-proline like derivatives and their evaluation as sodium channel blockers. J. Heterocyclic Chem. 2007, 44:1099-1103.
-
(2007)
J. Heterocyclic Chem.
, vol.44
, pp. 1099-1103
-
-
Muraglia, M.1
Franchini, C.2
Corbo, F.3
Scilimati, A.4
Sinicropi, M.S.5
De Luca, A.6
De Bellis, M.7
Conte Camerino, D.8
Tortorella, V.9
-
7
-
-
54049101184
-
Constrained analogues of tocainide as potent skeletal muscle sodium channel blockers towards the development of antimyotonic agents
-
Catalano A., Carocci A., Corbo F., Franchini C., Muraglia M., Scilimati A., De Bellis M., De Luca A., Conte Camerino D., Sinicropi M.S., Tortorella V. Constrained analogues of tocainide as potent skeletal muscle sodium channel blockers towards the development of antimyotonic agents. Eur. J. Med. Chem. 2008, 43:2535-2540.
-
(2008)
Eur. J. Med. Chem.
, vol.43
, pp. 2535-2540
-
-
Catalano, A.1
Carocci, A.2
Corbo, F.3
Franchini, C.4
Muraglia, M.5
Scilimati, A.6
De Bellis, M.7
De Luca, A.8
Conte Camerino, D.9
Sinicropi, M.S.10
Tortorella, V.11
-
8
-
-
61349189631
-
2D- and 3D-QSAR of tocainide and mexiletine analogues acting as Na(v)1.4 channel blockers
-
Carrieri A., Muraglia M., Corbo F., Pacifico C. 2D- and 3D-QSAR of tocainide and mexiletine analogues acting as Na(v)1.4 channel blockers. Eur. J. Med. Chem. 2009, 44:1477-1485.
-
(2009)
Eur. J. Med. Chem.
, vol.44
, pp. 1477-1485
-
-
Carrieri, A.1
Muraglia, M.2
Corbo, F.3
Pacifico, C.4
-
9
-
-
0017332486
-
Local anesthetics: hydrophilic and hydrophobic pathways for the drug-receptor reaction
-
Hille B. Local anesthetics: hydrophilic and hydrophobic pathways for the drug-receptor reaction. J. Gen. Physiol. 1977, 69:497-515.
-
(1977)
J. Gen. Physiol.
, vol.69
, pp. 497-515
-
-
Hille, B.1
-
10
-
-
0036162356
-
High-performance affinity chromatography: a powerful tool for studying serum protein binding
-
Hage D.S. High-performance affinity chromatography: a powerful tool for studying serum protein binding. J. Chromatogr. B 2002, 768:3-30.
-
(2002)
J. Chromatogr. B
, vol.768
, pp. 3-30
-
-
Hage, D.S.1
-
11
-
-
0035992779
-
Reversible and covalent binding of drugs to human serum albumin: methodological approaches and physiological relevance
-
Bertucci C., Domenici E. Reversible and covalent binding of drugs to human serum albumin: methodological approaches and physiological relevance. Curr. Med. Chem. 2002, 9:1463-1481.
-
(2002)
Curr. Med. Chem.
, vol.9
, pp. 1463-1481
-
-
Bertucci, C.1
Domenici, E.2
-
12
-
-
0025378934
-
Structure and ligand binding properties of human serum albumin
-
Kragh-Hansen U. Structure and ligand binding properties of human serum albumin. Dan. Med. Bull. 1990, 37:54-87.
-
(1990)
Dan. Med. Bull.
, vol.37
, pp. 54-87
-
-
Kragh-Hansen, U.1
-
13
-
-
0016801988
-
The characterization of two specific drug binding sites on human serum albumin
-
Sudlow G., Birkett D.J., Wade D.N. The characterization of two specific drug binding sites on human serum albumin. Mol. Pharmacol. 1975, 11:824-832.
-
(1975)
Mol. Pharmacol.
, vol.11
, pp. 824-832
-
-
Sudlow, G.1
Birkett, D.J.2
Wade, D.N.3
-
14
-
-
0002714675
-
Rapid chromatographic technique for preparative separations with moderate resolution
-
Still W.C., Kahn M., Mitra A. Rapid chromatographic technique for preparative separations with moderate resolution. J. Org. Chem. 1978, 43:2923-2925.
-
(1978)
J. Org. Chem.
, vol.43
, pp. 2923-2925
-
-
Still, W.C.1
Kahn, M.2
Mitra, A.3
-
15
-
-
85004281985
-
Trifluoroacetic acid-catalyzed 1,3-cycloaddition of the simplest iminium ylide leading to 3-or 3,4-substituted pyrrolidines and 2,5-dihydropyrroles
-
Terao Y., Kotaki H., Imai N., Achiwa K. Trifluoroacetic acid-catalyzed 1,3-cycloaddition of the simplest iminium ylide leading to 3-or 3,4-substituted pyrrolidines and 2,5-dihydropyrroles. Chem. Pharm. Bull. 1985, 33:2762-2766.
-
(1985)
Chem. Pharm. Bull.
, vol.33
, pp. 2762-2766
-
-
Terao, Y.1
Kotaki, H.2
Imai, N.3
Achiwa, K.4
-
16
-
-
67649985755
-
HSA binding of HIV protease inhibitors: a high-performance affinity chromatography study
-
Bertucci C., Pistolozzi M., Felix G., Danielson U.H. HSA binding of HIV protease inhibitors: a high-performance affinity chromatography study. J. Sep. Sci. 2009, 32:1625-1631.
-
(2009)
J. Sep. Sci.
, vol.32
, pp. 1625-1631
-
-
Bertucci, C.1
Pistolozzi, M.2
Felix, G.3
Danielson, U.H.4
-
17
-
-
0028080837
-
Evaluation of chiral stationary phases based on mixed immobilized proteins
-
Aubry A.F., Markoglou N., Descorps V., Félix G., Wainer I.W. Evaluation of chiral stationary phases based on mixed immobilized proteins. J. Chromatogr. A 1994, 685:1-6.
-
(1994)
J. Chromatogr. A
, vol.685
, pp. 1-6
-
-
Aubry, A.F.1
Markoglou, N.2
Descorps, V.3
Félix, G.4
Wainer, I.W.5
-
18
-
-
0032791826
-
Stereochemical resolution of racemates, in HPLC, using a chiral stationary phase based upon immobilized α-chymotrypsin. I. Structural chiral separations
-
Félix G., Descorps V. Stereochemical resolution of racemates, in HPLC, using a chiral stationary phase based upon immobilized α-chymotrypsin. I. Structural chiral separations. Chromatographia 1999, 49:595-605.
-
(1999)
Chromatographia
, vol.49
, pp. 595-605
-
-
Félix, G.1
Descorps, V.2
-
19
-
-
0027209713
-
Use of a human serum albumin-based stationary phase for high-performance liquid chromatography as a tool for the rapid determination of drug-plasma protein binding
-
Noctor T.A.G., Diaz-Perez M.J., Wainer I.W. Use of a human serum albumin-based stationary phase for high-performance liquid chromatography as a tool for the rapid determination of drug-plasma protein binding. J. Pharm. Sci. 1993, 82:675-676.
-
(1993)
J. Pharm. Sci.
, vol.82
, pp. 675-676
-
-
Noctor, T.A.G.1
Diaz-Perez, M.J.2
Wainer, I.W.3
-
20
-
-
0031670210
-
Ligand binding to a human serum albumin stationary phase: use of same-drug competition to discriminate pharmacologically relevant interactions
-
Ascoli G.A., Bertucci C., Salvadori P. Ligand binding to a human serum albumin stationary phase: use of same-drug competition to discriminate pharmacologically relevant interactions. Biomed. Chromatogr. 1998, 12:248-254.
-
(1998)
Biomed. Chromatogr.
, vol.12
, pp. 248-254
-
-
Ascoli, G.A.1
Bertucci, C.2
Salvadori, P.3
-
21
-
-
0029984724
-
Role of binding capacity versus binding strength in the separation of chiral compounds on protein-based high-performance liquid chromatography columns. Interactions of d- and l-tryptophan with human serum albumin
-
Yang J., Hage D.S. Role of binding capacity versus binding strength in the separation of chiral compounds on protein-based high-performance liquid chromatography columns. Interactions of d- and l-tryptophan with human serum albumin. J. Chromatogr. A 1996, 725:273-285.
-
(1996)
J. Chromatogr. A
, vol.725
, pp. 273-285
-
-
Yang, J.1
Hage, D.S.2
-
22
-
-
0003680152
-
-
Mc Graw-Hill, New York, A. Goodman, A.G. Gilman (Eds.)
-
The Pharmacological Basis of Therapeutics 1996, Mc Graw-Hill, New York. nineth ed. A. Goodman, A.G. Gilman (Eds.).
-
(1996)
The Pharmacological Basis of Therapeutics
-
-
-
23
-
-
0019467468
-
Serum protein binding of valproic acid in healthy subjects and in patients with liver disease
-
Urien S., Albengres E., Tillement J.P. Serum protein binding of valproic acid in healthy subjects and in patients with liver disease. Int. J. Clin. Pharmacol. Ter. Toxicol. 1981, 19:319-325.
-
(1981)
Int. J. Clin. Pharmacol. Ter. Toxicol.
, vol.19
, pp. 319-325
-
-
Urien, S.1
Albengres, E.2
Tillement, J.P.3
-
24
-
-
33748766072
-
Drug binding to human serum albumin: abridged review of results obtained with high-performance liquid chromatography and circular dichroism
-
Ascoli G.A., Domenici E., Bertucci C. Drug binding to human serum albumin: abridged review of results obtained with high-performance liquid chromatography and circular dichroism. Chirality 2006, 18:667-679.
-
(2006)
Chirality
, vol.18
, pp. 667-679
-
-
Ascoli, G.A.1
Domenici, E.2
Bertucci, C.3
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