Constrained analogues of tocainide as potent skeletal muscle sodium channel blockers towards the development of antimyotonic agents

European Journal of Medicinal Chemistry

Volumn 43, Issue 11, 2008, Pages 2535-2540

  Catalano, Alessia ^a   Carocci, Alessia ^a   Corbo, Filomena ^a   Franchini, Carlo ^a   Muraglia, Marilena ^a   Scilimati, Antonio ^a   De Bellis, Michela ^a   De Luca, Annamaria ^a   Camerino, Diana Conte ^a   Sinicropi, Maria Stefania ^b   Tortorella, Vincenzo ^a  

^a UNIVERSITY OF BARI   (Italy)

^b UNIVERSITY OF CALABRIA   (Italy)

Author keywords

Benzylation; Myotonia; Sodium channel blockers; Tocainide

Indexed keywords

1 BENZYL N (2,6 DIMETHYLPHENYL)PIPERIDINE 3 CARBOXAMIDE; 4 BENZYL N (2,6 DIMETHYLPHENYL)PIPERAZINE 2 CARBOXAMIDE; SODIUM CHANNEL AFFECTING AGENT; SODIUM CHANNEL BLOCKING AGENT; TOCAINIDE; UNCLASSIFIED DRUG; VOLTAGE GATED SODIUM CHANNEL;

ARTICLE; CHEMICAL STRUCTURE; DRUG ACTIVITY; DRUG POTENCY; DRUG SYNTHESIS; FROG; NONHUMAN; SKELETAL MUSCLE;

MOLECULAR STRUCTURE; MUSCLE, SKELETAL; MYOTONIA; SODIUM CHANNEL BLOCKERS; STRUCTURE-ACTIVITY RELATIONSHIP; TOCAINIDE;

EID: 54049101184     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2008.01.023     Document Type: Article

References (25)

1. Vaughan E.M., and Williams D.M. Pharmacol. Ther. 1 (1975) 115-138
2. Roden D.M., and Woosley R.L. New Engl. J. Med. 315 (1986) 41-45
3. Lindström P., and Lindblom U. Pain 28 (1987) 45-50
4. Lindblom U., and Lindström P. Pain 18 Suppl. 1 (1984) S411
5. Woolf C.J., and Wiesenfeld-Hallin Z. Pain 23 (1985) 361-374
6. Rüdel R., and Lehmann-Horn F. Physiol. Rev. 65 (1985) 310-356
7. Goldin A.L., Barchi R.L., Caldwell J.H., Hofmann F., Howe J.R., Hunter J.C., Kallen R.G., Mandel G., Meisler M.H., Netter Y.B., Noda M., Tamkun M.M., Waxman S.G., Wood J.N., and Catterall W.A. Neuron 28 (2000) 365-368
8. Cannon S.C. Neuromuscul. Disord. 7 (1997) 241-249
9. Conte Camerino D., Tricarico D., and Desaphy J.-F. Neurotherapeutics 4 (2007) 184-198
10. Herweg B., and Steinberg J.S. Card. Electrophysiol. Rev. 4 (2000) 255-261
11. Yarov-Yarovoy V., Brown J., Sharp E.M., Clare J.J., Scheuer T., and Catterall W.A. J. Biol. Chem. 276 (2001) 20-27
12. Yarov-Yarovoy V., McPhee J.C., Idsvoog D., Pate C., Scheuer T., and Catterall W.A. J. Biol. Chem. 277 (2002) 35393-35401
13. Franchini C., Corbo F., Lentini G., Bruno G., Scilimati A., Tortorella V., Conte Camerino D., and De Luca A. J. Med. Chem. 43 (2000) 3792-3798
14. Talon S., De Luca A., De Bellis M., Desaphy J.-F., Lentini G., Scilimati A., Corbo F., Franchini C., Tortorella P., Jockusch H., and Conte Camerino D. Br. J. Pharmacol. 134 (2001) 1523-1531
15. Muraglia M., Franchini C., Corbo F., Scilimati A., Sinicropi M.S., De Luca A., De Bellis M., Conte Camerino D., and Tortorella V. J. Heterocycl. Chem. 44 (2007) 1099-1103
16. De Luca A., Talon S., De Bellis M., Desaphy J.-F., Lentini G., Corbo F., Scilimati A., Franchini C., Tortorella V., and Conte Camerino D. Mol. Pharmacol. 64 (2003) 932-945
17. Lipkind G.M., and Fozzard H.A. Mol. Pharmacol. 68 (2005) 1611-1622
18. Ho B., Crider A.M., and Stables J.P. Eur. J. Med. Chem. 36 (2001) 265-286
19. McKenzie W.L., and Foye W.O. J. Med. Chem. 15 (1972) 291-295
20. Tenthorey P.A., Adams H.J., Kronberg G.H., and Takman B.H. J. Med. Chem. 24 (1981) 1059-1063
21. Still W.C., Kahn M., and Mitra A. J. Org. Chem. 43 (1978) 2923-2925
22. Crider A.M., Tita T.T., Wood J.D., and Hinko C.N. J. Pharm. Sci. 71 (1982) 1214-1219
23. W. Brieden, J.-P. Roduit, WO Patent 9529169, 1995.
24. Chem. Abstr. 124 (1995) 176151
25. De Luca A., Natuzzi F., Desaphy J.-F., Loni G., Lentini G., Franchini C., Tortorella V., and Conte Camerino D. Mol. Pharmacol. 57 (2000) 268-277