Structure-function studies of the SLC17 transporter sialin identify crucial residues and substrate-induced conformational changes

Journal of Biological Chemistry

Volumn 285, Issue 25, 2010, Pages 19316-19323

  Courville, Pascal ^a   Quick, Matthias ^b   Reimer, Richard J ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b New York Presbyterian Columbia University Medical Center   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CONFORMATIONAL CHANGE; CYSTEINE RESIDUES; DIFFERENT EFFECTS; GLUCURONIC ACIDS; GLUTAMATE TRANSPORTERS; HUMAN DISEASE; N-ACETYLNEURAMINIC ACID; PHOSPHATE TRANSPORTERS; SIALIC ACIDS; STORAGE DISORDERS; STRUCTURE-FUNCTION STUDIES; SUBSTRATE RECOGNITION; SYMPORTS; THREE-DIMENSIONAL STRUCTURE; TRANSMEMBRANE HELICES; TRANSPORT MECHANISM; TRANSPORT RATE;

CARBOXYLIC ACIDS; GLUCOSE; GLYCEROL; SUBSTRATES; SUGAR (SUCROSE); THREE DIMENSIONAL;

ACIDS;

CARRIER PROTEIN; CYSTEINE; GLUCURONIC ACID; GLYCEROL 3 PHOSPHATE TRANSPORTER; MUTANT PROTEIN; N ACETYLNEURAMINIC ACID; PROTEIN GLPT; PROTEIN SLC17; SIALIN; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN FAMILY; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; PROTEIN TRANSPORT;

AMINO ACID SEQUENCE; ANIMALS; CYSTEINE; GLUCURONIC ACID; HUMANS; LYSOSOMAL STORAGE DISEASES; MOLECULAR SEQUENCE DATA; MUTATION; N-ACETYLNEURAMINIC ACID; ORGANIC ANION TRANSPORTERS; PROTEIN ISOFORMS; PROTEIN STRUCTURE, TERTIARY; RATS; SEQUENCE HOMOLOGY, AMINO ACID; STRUCTURE-ACTIVITY RELATIONSHIP; SYMPORTERS;

EID: 77953481979     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.130716     Document Type: Article

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