Mechanical factors and bone health: Effects of weightlessness and neurologic injury

Current Rheumatology Reports

Volumn 12, Issue 3, 2010, Pages 170-176

  Amin, Shreyasee ^a  

^a MAYO CLINIC   (United States)

Author keywords

Bone density; Mechanical stimuli; Space Flight; Spinal cord injury; Stroke; Weightlessness

Indexed keywords

ALENDRONIC ACID; BISPHOSPHONIC ACID DERIVATIVE;

BONE DENSITY; BONE METABOLISM; BONE REMODELING; BONE STRUCTURE; BONE TISSUE; BONE TURNOVER; CLINICAL TRIAL; ELECTROSTIMULATION THERAPY; EXERCISE; FRACTURE; HOMEOSTASIS; HUMAN; IMMOBILIZATION; MECHANICAL STIMULATION; MECHANOTRANSDUCTION; MICROGRAVITY; MUSCLE CONTRACTION; OSTEOLYSIS; OSTEOPOROSIS; PARALYSIS; PATHOGENESIS; REVIEW; RISK REDUCTION; SPACE FLIGHT; SPASTICITY; SPINAL CORD INJURY; STIMULUS RESPONSE; STROKE; WEIGHT BEARING; WEIGHTLESSNESS;

ADAPTATION, PHYSIOLOGICAL; BONE DENSITY; BONE RESORPTION; HUMANS; MECHANOTRANSDUCTION, CELLULAR; SPACE FLIGHT; SPINAL CORD INJURIES; STROKE; WEIGHTLESSNESS;

EID: 77953475814     PISSN: 15233774     EISSN: 15346307     Source Type: Journal    
DOI: 10.1007/s11926-010-0096-z     Document Type: Review

References (51)

1. Wolff J: The Law of Bone Remodeling [in German]. Berlin, Germany: Springer; 1986.
2. Kohrt WM, Barry DW, Schwartz RS: Muscle forces or gravity: what predominates mechanical loading on bone? Med Sci Sports Exerc 2009, 41:2050-2055.
3. McCarthy ID: Investigation of the role of venous pressure in bone changes during prolonged weightlessness. J Gravit Physiol 1996, 3:33-36.
4. Burger EH, Klein-Nulend J: Mechanotransduction in bone - role of the lacuno-canalicular network. FASEB J 1999, 13(Suppl): S101-S112.
5. Donahue SW, Jacobs CR, Donahue HJ: Flow-induced calcium oscillations in rat osteoblasts are age, loading frequency, and shear stress dependent. Am J Physiol Cell Physiol 2001, 281: C1635-C1641.
6. Gurkan UA, Akkus O: The mechanical environment of bone marrow: a review. Ann Biomed Eng 2008, 36:1978-1991. This is an excellent review of the hydrostatic pressure changes and fluid shear stresses within bone marrow that may govern bone homeostasis.
7. Robling AG, Castillo AB, Turner CH: Biomechanical and molecular regulation of bone remodeling. Annu Rev Biomed Eng 2006, 8:455-498.
8. Rambaut PC, Goode AW: Skeletal changes during space flight. Lancet 1985, 2:1050-1052.
9. LeBlanc AD, Spector ER, Evans HJ, Sibonga JD: Skeletal responses to space flight and the bed rest analog: a review. J Musculoskelet Neuronal Interact 2007, 7:33-47. This is an excellent overview of the effects of space flight on bone over the years of the manned space program.
10. Smith SM, Wastney ME, O'Brien KO, et al.: Bone markers, calcium metabolism, and calcium kinetics during extended-duration space flight on the Mir space station. J Bone Miner Res 2005, 20:208-218.
11. Holick MF: Perspective on the impact of weightlessness on calcium and bone metabolism. Bone 1998, 22(5 Suppl): 105S-111S.
12. Vico L, Collet P, Guignandon A, et al.: Effects of long-term microgravity exposure on cancellous and cortical weight-bearing bones of cosmonauts. Lancet 2000, 355:1607-1611.
13. Lang T, LeBlanc A, Evans H, et al.: Cortical and trabecular bone mineral loss from the spine and hip in long-duration spaceflight. J Bone Miner Res 2004, 19:1006-1012.
14. Lang TF, Leblanc AD, Evans HJ, Lu Y: Adaptation of the proximal femur to skeletal reloading after long-duration spaceflight. J Bone Miner Res 2006, 21:1224-1230.
15. Keyak JH, Koyama AK, LeBlanc A, et al.: Reduction in proximal femoral strength due to long-duration spaceflight. Bone 2009, 44:449-453. This was the first study that examined proximal femur strength estimated by finite element analyses following long-duration microgravity exposure and that identified that the observed bone strength loss is greater than bone density loss.
16. Sibonga JD, Evans HJ, Sung HG, et al.: Recovery of spaceflight-induced bone loss: bone mineral density after long-duration missions as fitted with an exponential function. Bone 2007, 41:973-978.
17. LeBlanc A, Lin C, Shackelford L, et al.: Muscle volume, MRI relaxation times (T2), and body composition after spaceflight. J Appl Physiol 2000, 89:2158-2164.
18. Bakker AD, Soejima K, Klein-Nulend J, Burger EH: The production of nitric oxide and prostaglandin E(2) by primary bone cells is shear stress dependent. J Biomech 2001, 34:671-677.
19. McAllister TN, Du T, Frangos JA: Fluid shear stress stimulates prostaglandin and nitric oxide release in bone marrow-derived preosteoclast-like cells. Biochem Biophys Res Commun 2000, 270:643-648.
20. Bikle DD, Halloran BP, Morey-Holton E: Space flight and the skeleton: lessons forthe earthbound. Endocrinologist 1997, 7:10-22.
21. Cowin SC: On mechanosensation in bone under microgravity. Bone 1998, 22(5 Suppl): 119S-125S.
22. Burger EH, Klein-Nulend J: Microgravity and bone cell mechanosensitivity. Bone 1998, 22(5 Suppl): 127S-130S.
23. Colleran PN, Wilkerson MK, Bloomfield SA, et al.: Alterations in skeletal perfusion with simulated microgravity: a possible mechanism for bone remodeling. J Appl Physiol 2000, 89:1046-1054.
24. LeBlanc AD, Schneider VS, Evans HJ, et al.: Bone mineral loss and recovery after 17 weeks of bed rest. J Bone Miner Res 1990, 5:843-850.
25. Laroche M: Intraosseous circulation from physiology to disease. Joint Bone Spine 2002, 69:262-269.
26. Shackelford LC, LeBlanc AD, Driscoll TB, et al.: Resistance exercise as a countermeasure to disuse-induced bone loss. J Appl Physiol 2004, 97:119-129.
27. Greenleaf JE: Physiology of Prolonged Bed Rest [technical memorandum]. Washington, DC: NASA; 1988.
28. Smith SM, Zwart SR, Block G, et al.: The nutritional status of astronauts is altered after long-term space flight aboard the International Space Station. J Nutr 2005, 135:437-443.
29. Almeida M, Han L, Martin-Millan M, et al.: Skeletal involution by age-associated oxidative stress and its acceleration by loss of sex steroids. J Biol Chem 2007, 282:27285-27297.
30. Ozgocmen S, Kaya H, Fadillioglu E, et al.: Role of antioxidant systems, lipid peroxidation, and nitric oxide in postmenopausal osteoporosis. Mol Cell Biochem 2007, 295:45-52.
31. Hamilton SA, Pecaut MJ, Gridley DS, et al.: A murine model for bone loss from therapeutic and space-relevant sources of radiation. J Appl Physiol 2006, 101:789-793.
32. Bushinsky DA, Ori Y: Effects of metabolic and respiratory acidosis on bone. Curr Opin Nephrol Hypertens 1993, 2:588-596.
33. Strollo F, Riondino G, Harris B, et al.: The effect of microgravity on testicular androgen secretion. Aviat Space Environ Med 1998, 69:133-136.
34. Carda S, Cisari C, Invernizzi M, Bevilacqua M: Osteoporosis after stroke: a review of the causes and potential treatments. Cerebrovasc Dis 2009, 28:191-200. This is an excellent review on the effects of stroke on bone.
35. Pang MY, Ashe MC, Eng JJ: Muscle weakness, spasticity and disuse contribute to demineralization and geometric changes in the radius following chronic stroke. Osteoporos Int 2007, 18:1243-1252.
36. Pang MY, Ashe MC, Eng JJ: Tibial bone geometry in chronic stroke patients: influence of sex, cardiovascular health, and muscle mass. J Bone Miner Res 2008, 23:1023-1030.
37. Celik B, Ones K, Ince N: Body composition after stroke. Int J Rehab Res 2008, 31:93-96.
38. Worthen LC, Kim CM, Kautz SA, et al.: Key characteristics of walking correlate with bone density in individuals with chronic stroke. J Rehabil Res Dev 2005, 42:761-768.
39. Jiang SD, Dai LY, Jiang LS: Osteoporosis after spinal cord injury. Osteoporos Int 2006, 17:180-192.
40. (Published erratum appears in Osteoporos Int 2006, 17:1278-1281.)
41. Dauty M, Perrouin Verbe B, Maugars Y, et al.: Supralesional and sublesional bone mineral density in spinal cord-injured patients. Bone 2000, 27:305-309.
42. Frey-Rindova P, de Bruin ED, Stüssi E, et al.: Bone mineral density in upper and lower extremities during 12 months after spinal cord injury measured by peripheral quantitative computed tomography. Spinal Cord 2000, 38:26-32.
43. Eser P, Frotzler A, Zehnder Y, et al.: Relationship between the duration of paralysis and bone structure: a pQCT study of spinal cord injured individuals. Bone 2004, 34:869-880.
44. Alekna V, Tamulaitiene M, Sinevicius T, Juocevicius A: Effect of weight-bearing activities on bone mineral density in spinal cord injured patients during the period of the first two years. Spinal Cord 2008, 46:727-732.
45. Jiang SD, Jiang LS, Dai LY: Mechanisms of osteoporosis in spinal cord injury. Clin Endocrinol (Oxf) 2006, 65:555-565.
46. Marenzana M, Chenu C: Sympathetic nervous system and bone adaptive response to its mechanical environment. J Musculoskelet Neuronal Interact 2008, 8:111-120.
47. Marsden J, Gibson LM, Lightbody CE, et al.: Can early onset bone loss be effectively managed in post-stroke patients? An integrative review of the evidence. Age Ageing 2008, 37:142-150.
48. Eng JJ, Pang MY, Ashe MC: Balance, falls, and bone health: role of exercise in reducing fracture risk after stroke. J Rehabil Res Dev 2008, 45:297-313.
49. Biering-Sorensen F, Hansen B, Lee BS: Non-pharmacological treatment and prevention of bone loss after spinal cord injury: a systematic review. Spinal Cord 2009, 47:508-518.
50. Giangregorio L, McCartney N: Bone loss and muscle atrophy in spinal cord injury: epidemiology, fracture prediction, and rehabilitation strategies. J Spinal Cord Med 2006, 29:489-500.
51. Gilchrist NL, Frampton CM, Acland RH, et al.: Alendronate prevents bone loss in patients with acute spinal cord injury: a randomized, double-blind, placebo-controlled study. J Clin Endocrinol Metab 2007, 92:1385-1390.