O-linked β-N-acetylglucosamine during hyperglycemia exerts both anti-inflammatory and pro-oxidative properties in the endothelial system

Oxidative Medicine and Cellular Longevity

Volumn 2, Issue 3, 2009, Pages 172-175

  Gupta Rajapakse, Angana ^a   Ming, Xiu Fen ^a   Carvas, João M ^a   Yang, Zhihong ^a  

^a University of Fribourg   (Switzerland)

Author keywords

Adhesion molecules; Endothelial cells; Glucosamine; Inflammation; ROS

Indexed keywords

GLUCOSAMINE; INTERCELLULAR ADHESION MOLECULE 1; N ACETYLGLUCOSAMINE; O LINKED BETA N ACETYLGLUCOSAMINE; SUPEROXIDE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; VASCULAR CELL ADHESION MOLECULE 1;

ANTIGEN EXPRESSION; ANTIINFLAMMATORY ACTIVITY; ARTICLE; ENDOTHELIUM CELL; HUMAN; HUMAN CELL; HYPERGLYCEMIA; OXIDATIVE STRESS; TUMOR NECROSIS;

ACETYLGLUCOSAMINE; ANTI-INFLAMMATORY AGENTS; CELLS, CULTURED; ENDOTHELIAL CELLS; ENDOTHELIUM, VASCULAR; HEXOSAMINES; HUMANS; HYPERGLYCEMIA; INTERCELLULAR ADHESION MOLECULE-1; OXIDANTS; OXIDATIVE STRESS; TUMOR NECROSIS FACTOR-ALPHA; VASCULAR CELL ADHESION MOLECULE-1;

EID: 77953442462     PISSN: 19420900     EISSN: 19420994     Source Type: Journal    
DOI: 10.4161/oxim.2.3.8482     Document Type: Article

References (22)

1. Laczy B, Hill BG, Wang K, Paterson AJ, White CR, Xing D, et al. Protein O-GlcNAcylation: A new signaling paradigm for the cardiovascular system. Am J Physiol Heart Circ Physiol 2009; 296:13-28.
2. Yang X, Ongusaha PP, Miles PD, Havstad JC, Zhang F, So WV, et al. Phosphoinositide signalling links O-GlcNAc transferase to insulin resistance. Nature 2008; 451:964-969.
3. Copeland RJ, Bullen JW, Hart GW. Cross-talk between GlcNAcylation and phosphorylation: Roles in insulin resistance and glucose toxicity. Am J Physiol Endocrinol Metab 2008; 295:17-28.
4. Ngoh GA, Facundo HT, Hamid T, Dillmann W, Zachara NE, Jones SP. Unique hexosaminidase reduces metabolic survival signal and sensitizes cardiac myocytes to hypoxia/reoxygenation injury. Circ Res 2009; 104:41-49.
5. Champattanachai V, Marchase RB, Chatham JC. Glucosamine protects neonatal cardiomyocytes from ischemia-reperfusion injury via increased protein O-GlcNAc and increased mitochondrial Bcl-2. Am J Physiol Cell Physiol 2008; 294:1509-1520.
6. Jones SP, Zachara NE, Ngoh GA, Hill BG, Teshima Y, Bhatnagar A, et al. Cardioprotection by N-acetylglucosamine linkage to cellular proteins. Circulation 2008; 117:1172-1182.
7. Fulop N, Zhang Z, Marchase RB, Chatham JC. Glucosamine cardioprotection in perfused rat hearts associated with increased O-linked N-acetylglucosamine protein modification and altered p38 activation. Am J Physiol Heart Circ Physiol 2007; 292:2227-2236.
8. Marshall S, Nadeau O, Yamasaki K. Dynamic actions of glucose and glucosamine on hexosamine biosynthesis in isolated adipocytes: Differential effects on glucosamine 6-phosphate, UDP-N-acetylglucosamine and ATP levels. J Biol Chem 2004; 279:35313-35319.
9. Zou L, Yang S, Champattanachai V, Hu S, Chaudry IH, Marchase RB, Chatham JC. Glucosamine improves cardiac function following trauma-hemorrhage by increased protein O-GlcNAcylation and attenuation of NF{kappa}B signaling. Am J Physiol Heart Circ Physiol 2009; 296:515-523.
10. Ma L, Rudert WA, Harnaha J, Wright M, Machen J, Lakomy R, et al. Immunosuppressive effects of glucosamine. J Biol Chem 2002; 277:39343-39349.
11. Xing D, Feng W, Not LG, Miller AP, Zhang Y, Chen YF, et al. Increased protein O-GlcNAc modification inhibits inflammatory and neointimal responses to acute endoluminal arterial injury. Am J Physiol Heart Circ Physiol 2008; 295:335-342.
12. Rajapakse AG, Ming XF, Carvas JM, Yang Z. The hexosamine biosynthesis inhibitor azaserine prevents endothelial inflammation and dysfunction under hyperglycemic condition through antioxidant effects. Am J Physiol Heart Circ Physiol 2009; 296:815-822.
13. Hart GW, Housley MP, Slawson C. Cycling of O-linked b-N-acetylglucosamine on nucleocytoplasmic proteins. Nature 2007; 446:1017-1022.
14. Srinivasan V, Sandhya N, Sampathkumar R, Farooq S, Mohan V, Balasubramanyam M. Glutamine fructose-6-phosphate amidotransferase (GFAT) gene expression and activity in patients with type 2 diabetes: Inter-relationships with hyperglycaemia and oxidative stress. Clin Biochem 2007; 40:952-957.
15. Du XL, Edelstein D, Dimmeler S, Ju O, Sui C, Brownlee M. Hyperglycemia inhibits endothelial nitric oxide synthase activity by posttranslational modification at the Akt site. J Clin Invest 2001; 108:1341-1348.
16. Federici M, Menghini R, Mauriello A, Hribal ML, Ferrelli F, Lauro D, et al. Insulindependent activation of endothelial nitric oxide synthase is impaired by O-linked glycosylation modification of signaling proteins in human coronary endothelial cells. Circulation 2002; 106:466-472.
17. Musicki B, Kramer MF, Becker RE, Burnett AL. Inactivation of phosphorylated endothelial nitric oxide synthase (Ser-1177) by O-GlcNAc in diabetes-associated erectile dysfunction. Proc Natl Acad Sci USA 2005; 102:11870-11875.
18. Yang Z, Ming XF. Recent advances in understanding endothelial dysfunction in atherosclerosis. Clin Med Res 2006; 4:53-65.
19. Goldberg HJ, Whiteside CI, Hart GW, Fantus IG. Posttranslational, reversible O-glycosylation is stimulated by high glucose and mediates plasminogen activator inhibitor-1 gene expression and Sp1 transcriptional activity in glomerular mesangial cells. Endocrinology 2006; 147:222-231.
20. Luo B, Soesanto Y, McClain DA. Protein modification by O-linked GlcNAc reduces angiogenesis by inhibiting Akt activity in endothelial cells. Arterioscler Thromb Vasc Biol 2008; 28:651-657.
21. Singh LP, Cheng DW, Kowluru R, Levi E, Jiang Y. Hexosamine induction of oxidative stress, hypertrophy and laminin expression in renal mesangial cells: effect of the antioxidant alpha-lipoic acid. Cell Biochem Funct 2007; 25:537-550.
22. Kaneto H, Xu G, Song KH, Suzuma K, Bonner-Weir S, Sharma A, Weir GC. Activation of the hexosamine pathway leads to deterioration of pancreatic beta-cell function through the induction of oxidative stress. J Biol Chem 2001; 276:31099-31104.