The hexosamine biosynthesis inhibitor azaserine prevents endothelial inflammation and dysfunction under hyperglycemic condition through antioxidant effects

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 296, Issue 3, 2009, Pages

  Rajapakse, Angana Gupta ^a   Ming, Xiu Fen ^a   Carvas, Joao M ^a   Yang, Zhihong ^a,b  

^a University of Fribourg   (Switzerland)

^b UNIVERSITY OF FRIBOURG   (Switzerland)

Author keywords

Adhesion molecules; Endothelium; Glucose; O linked acetylglusamine; Superoxide

Indexed keywords

ACETYLCHOLINE; AZASERINE; GLUCOSE; GLUTAMINE FRUCTOSE 6 PHOSPHATE AMINOTRANSFERASE; HEXOSAMINE; INTERCELLULAR ADHESION MOLECULE 1; MANGANESE SUPEROXIDE DISMUTASE; PEROXYNITRITE; RESVERATROL; SUPEROXIDE; TUMOR NECROSIS FACTOR ALPHA; VASCULAR CELL ADHESION MOLECULE 1; ANTIINFLAMMATORY AGENT; ANTIOXIDANT; ENZYME INHIBITOR; STILBENE DERIVATIVE; SUPEROXIDE DISMUTASE; VASODILATOR AGENT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; AORTA; ARTICLE; BIOSYNTHESIS; CELL CULTURE; CELL ISOLATION; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DRUG MECHANISM; ENDOTHELIAL DYSFUNCTION; ENDOTHELIUM CELL; ENDOTHELIUM LESION; ENZYME INHIBITION; HUMAN; HUMAN CELL; HYPERGLYCEMIA; INFLAMMATION; MALE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; UMBILICAL VEIN; UPREGULATION; VASODILATATION; ANIMAL; DOSE RESPONSE; DRUG ANTAGONISM; DRUG EFFECT; METABOLISM; PATHOPHYSIOLOGY; VASCULAR ENDOTHELIUM; WISTAR KYOTO RAT;

ACETYLCHOLINE; ANIMALS; ANTI-INFLAMMATORY AGENTS; ANTIOXIDANTS; AZASERINE; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTHELIUM, VASCULAR; ENZYME INHIBITORS; GLUCOSE; GLUTAMINE-FRUCTOSE-6-PHOSPHATE TRANSAMINASE (ISOMERIZING); HEXOSAMINES; HUMANS; HYPERGLYCEMIA; INFLAMMATION; INTERCELLULAR ADHESION MOLECULE-1; MALE; OXIDATIVE STRESS; RATS; RATS, INBRED WKY; STILBENES; SUPEROXIDE DISMUTASE; TUMOR NECROSIS FACTOR-ALPHA; VASCULAR CELL ADHESION MOLECULE-1; VASODILATION; VASODILATOR AGENTS;

EID: 64049093074     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.00756.2008     Document Type: Article

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