Structure of native protein C inhibitor provides insight into its multiple functions

Journal of Biological Chemistry

Volumn 282, Issue 18, 2007, Pages 13759-13768

  Li, Wei ^a   Adams, Ty E ^a   Kjellberg, Margareta ^b   Stenflo, Johan ^b   Huntington, James A ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b LUND UNIVERSITY HOSPITAL   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING SITES; CRYSTAL STRUCTURE; ENZYME INHIBITION; ESCHERICHIA COLI; HORMONES; NUCLEAR MAGNETIC RESONANCE;

CRYSTAL CONTACTS; HEPARIN; PROTEIN C INHIBITOR (PCI);

PROTEINS;

HEPARIN; MONOSACCHARIDE; PLASMINOGEN ACTIVATOR INHIBITOR 3; THYROXINE BINDING GLOBULIN; RECOMBINANT PROTEIN; SERINE PROTEINASE INHIBITOR; THYROXINE BINDING PROTEIN;

AMINO TERMINAL SEQUENCE; ARTICLE; CRYSTAL STRUCTURE; ESCHERICHIA COLI; FLUORESCENCE; NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PURIFICATION; PROTEIN STRUCTURE; BINDING SITE; CHEMISTRY; GENETICS; HUMAN; HYDROPHOBICITY; METABOLISM; PHYSIOLOGY; PROTEIN SECONDARY STRUCTURE; PROTEIN TERTIARY STRUCTURE; STRUCTURAL HOMOLOGY; STRUCTURE ACTIVITY RELATION; X RAY CRYSTALLOGRAPHY;

ESCHERICHIA COLI;

BINDING SITES; CRYSTALLOGRAPHY, X-RAY; HEPARIN; HUMANS; HYDROPHOBICITY; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PROTEIN BINDING; PROTEIN C INHIBITOR; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT PROTEINS; SERINE PROTEINASE INHIBITORS; STRUCTURAL HOMOLOGY, PROTEIN; STRUCTURE-ACTIVITY RELATIONSHIP; THYROXINE-BINDING PROTEINS;

EID: 34250332236     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M701074200     Document Type: Article

References (58)

1. Geiger, M., Zechmeister-Machhart, M., Uhrin, P., Hufnagl, P., Ecke, S., Priglinger, U., Xu, J., Zheng, X., and Binder, B. R. (1996) Immunopharmacology 32, 53-56
2. Gettins, P. G. W., Patston, P. A., and Olson, S. T. (1996) Serpins: Structure, Function and Biology, R. G. Landes Co., Austin, TX
3. Gettins, P. G. (2002) Chem. Rev. 102, 4751-4804
4. Marlar, R. A., and Griffin, J. H. (1980) J. Clin. Investig. 66, 1186-1189
5. Suzuki, K., Nishioka, J., and Hashimoto, S. (1983) J. Biol. Chem. 258, 163-168
6. Rezaie, A. R., Cooper, S. T., Church, F. C., and Esmon, C. T. (1995) J. Biol. Chem. 270, 25336-25339
7. Elisen, M. G., von dem, B., Bouma, B. N., and Meijers, J. C. (1998) Blood 91, 1542-1547
8. Geiger, M., Krebs, M., Jerabek, I., and Binder, B. R. (1997) Immunopharmacology 36, 279-284
9. Huntington, J. A., Read, R. J., and Carrell, R. W. (2000) Nature 407, 923-926
10. Olson, S. T., Swanson, R., Day, D., Verhamme, I., Kvassman, J., and Shore, J. D. (2001) Biochemistry 40, 11742-11756
11. Huntington, J. A. (2006) Trends Biochem. Sci. 31, 450-455
12. Schechter, I., and Berger, A. (1967) Biochem. Biophys. Res. Commun. 27, 157-162
13. Prendes-Garcia, M. J., Zechmeister-Machhart, M., Bielek, E., Vanyek-Zavadil, E., Breuss, J., Binder, B. R., and Geiger, M. (2001) J. Thromb. Haem. July, ox 989 (Abstract)
14. Dementiev, A., Dobo, J., and Gettins, P. G. (2006) J. Biol. Chem. 281, 3452-3457
15. Komiyama, T., Gron, H., Pemberton, P. A., and Salvesen, G. S. (1996) Protein Sci. 5, 874-882
16. Komiyama, T., Ray, C. A., Pickup, D. J., Howard, A. D., Thornberry, N. A., Peterson, E. P., and Salvesen, G. (1994) J. Biol. Chem. 269, 19331-19337
17. Irving, J. A., Pike, R. N., Dai, W., Bromme, D., Worrall, D. M., Silverman, G. A., Coetzer, T. H., Dennison, C., Bottomley, S. P., and Whisstock, J. C. (2002) Biochemistry 41, 4998-5004
18. Pratt, C. W., and Church, F. C. (1992) J. Biol. Chem. 267, 8789-8794
19. Garg, H. G., Linhardt, R. J., and Hales, C. A. (2005) in Chemistry and Biology of Heparin and Heparan Sulfate (Garg, H. G., Linhardt, R. J., and Hales, C. A., eds) pp. 367-398, Elsevier, Oxford
20. Kuhn, L. A., Griffin, J. H., Fisher, C. L., Greengard, J. S., Bouma, B. N., Espana, F., and Tainer, J. A. (1990) Proc. Natl. Acad. Sci. U. S. A. 87, 8506-8510
21. Shirk, R. A., Elisen, M. G., Meijers, J. C., and Church, F. C. (1994) J. Biol. Chem. 269, 28690-28695
22. Neese, L. L., Wolfe, C. A., and Church, F. C. (1998) Arch. Biochem. Biophys. 355, 101-108
23. Huntington, J. A. (2003) J. Thromb. Haemost. 1, 1535-1549
24. Carrell, R. W., Stein, P. E., Fermi, G., and Wardell, M. R. (1994) Structure 2, 257-270
25. Baglin, T. P., Carrell, R. W., Church, F. C., Esmon, C. T., and Huntington, J. A. (2002) Proc. Natl. Acad. Sci. U. S. A. 99, 11079-11084
26. Jin, L., Abrahams, J. P., Skinner, R., Petitou, M., Pike, R. N., and Carrell, R. W. (1997) Proc. Natl. Acad. Sci. U. S. A. 94, 14683-14688
27. O'Keeffe, D., Olson, S. T., Gasiunas, N., Gallagher, J., Baglin, T. P., and Huntington, J. A. (2004) J. Biol. Chem. 279, 50267-50273
28. Shen, L., Villoutreix, B. O., and Dahlback, B. (1999) Thromb. Haemost. 82, 72-79
29. Ecke, S., Geiger, M., Resch, I., Jerabek, I., Sting, L., Maier, M., and Binder, B. R. (1992) J. Biol. Chem. 267, 7048-7052
30. Hammond, G. L., Smith, C. L., Goping, I. S., Underhill, D. A., Harley, M. J., Reventos, J., Musto, N. A., Gunsalus, G. L., and Bardin, C. W. (1987) Proc. Natl. Acad. Sci. U. S. A. 84, 5153-5157
31. Pemberton, P. A., Stein, P. E., Pepys, M. B., Potter, J. M., and Carrell, R. W. (1988) Nature 336, 257-258
32. Suda, S. A., Gettins, P. G., and Patston, P. A. (2000) Arch. Biochem. Biophys. 384, 31-36
33. Jerabek, I., Zechmeister-Machhart, M., Binder, B. R., and Geiger, M. (2001) Eur. J. Biochem. 268, 5989-5996
34. Huntington, J. A., Kjellberg, M., and Stenflo, J. (2003) Structure 11, 205-215
35. Leslie, A. W. G. (1992) Joint CCP4 and ESF-EACMB Newsletter on Protein Crystallography. Daresbury Laboratory, Warrington, UK, Vol. 26
36. McCoy, A. J., Grosse-Kunstleve, R. W., Storoni, L. C., and Read, R. J. (2005) Acta Crystallogr. D Biol. Crystallogr. 61, 458-464
37. Brunger, A. T., Adams, P. D., Clore, G. M., Delano, W. L., Gros, P., GrosseKunstleve, R. W., Jiang, J. S., Kuszewski, J., Nilges, M., Pannu, N. S., Read, R. J., Rice, L. M., Simonson, T., and Warren, G. L. (1998) Acta Crystallogr. Sect. D 54, 905-921
38. Murshudov, G. N., Vagin, A. A., and Dodson, E. J. (1997) Acta Crystallogr. Sect. D 53, 240-255
39. McRee, D. E. (1992) J. Mol. Graphics 10, 44-46
40. Merritt, E. A., and Murphy, M. E. P. (1994) Acta Crystallogr. Sect. D 50, 869-873
41. Goger, B., Halden, Y., Rek, A., Mosl, R., Pye, D., Gallagher, J., and Kungl, A. J. (2002) Biochemistry 41, 1640-1646
42. Meagher, J. L., Olson, S. T., and Gettins, P. G. (2000) J. Biol. Chem. 275, 2698-2704
43. Rehault, S. M., Zechmeister-Machhart, M., Fortenberry, Y. M., Malleier, J., Binz, N. M., Cooper, S. T., Geiger, M., and Church, F. C. (2005) Biochim. Biophys. Acta 1748, 57-65
44. Zhou, A., Wei, Z., Read, R. J., and Carrell, R. W. (2006) Proc. Natl. Acad. Sci. U. S. A. 103, 13321-13326
45. Elliott, P. R., Abrahams, J. P., and Lomas, D. A. (1998) J. Mol. Biol. 275, 419-425
46. Dementiev, A., Simonovic, M., Volz, K., and Gettins, P. G. (2003) J. Biol. Chem. 278, 37881-37887
47. Horvath, A. J., Irving, J. A., Rossjohn, J., Law, R. H., Bottomley, S. P., Quinsey, N. S., Pike, R. N., Coughlin, P. B., and Whisstock, J. C. (2005) J. Biol. Chem. 280, 43168-43178
48. Elisen, M. G., Maseland, M. H., Church, F. C., Bouma, B. N., and Meijers, J. C. (1996) Thromb. Haemost. 75, 760-766
49. Johnson, D. J., Langdown, J., Li, W., Luis, S. A., Baglin, T. P., and Huntington, J. A. (2006) J. Biol. Chem. 281, 35478-35486
50. Johnson, D. J., Li, W., Adams, T. E., and Huntington, J. A. (2006) EMBO J. 25, 2029-2037
51. Li, W., Johnson, D. J., Esmon, C. T., and Huntington, J. A. (2004) Nat. Struct. Mol. Biol. 11, 857-862
52. Langdown, J., Carter, W. J., Baglin, T. P., and Huntington, J. A. (2006) FEBS Lett. 580, 4709-4712
53. Glasscock, L. N., Gerlitz, B., Cooper, S. T., Grinnell, B. W., and Church, F. C. (2003) Biochim. Biophys. Acta 1649, 106-117
54. Friedrich, U., Blom, A. M., Dahlback, B., and Villoutreix, B. O. (2001) J. Biol. Chem. 276, 24122-24128
55. Yang, L., Manithody, C., and Rezaie, A. R. (2002) Biochemistry 41, 6149-6157
56. Nishioka, J., Ning, M., Hayashi, T., and Suzuki, K. (1998) J. Biol. Chem. 273, 11281-11287
57. Fulton, K. F., Buckle, A. M., Cabrita, L. D., Irving, J. A., Butcher, R. E., Smith, I., Reeve, S., Lesk, A. M., Bottomley, S. P., Rossjohn, J., and Whisstock, J. C. (2005) J. Biol. Chem. 280, 8435-8442
58. Fujita, M., Izutani, W., Takahashi, K., Nishizawa, K., Shirono, H., and Koga, J. (2002) Thromb. Res. 105, 95-102