STAT3, p38 MAPK, and NF-κB drive unopposed monocyte-dependent fibroblast MMP-1 secretion in tuberculosis

American Journal of Respiratory Cell and Molecular Biology

Volumn 43, Issue 4, 2010, Pages 465-474

  O'Kane, Cecilia M ^a   Elkington, Paul T ^a   Jones, Michael D ^a   Caviedes, Luz ^b   Tovar, Marco ^b   Gilman, Robert H ^b,c   Stamp, Gordon ^a   Friedland, Jon S ^a  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

^b UNIVERSIDAD PERUANA CAYETANO HEREDIA   (Peru)

^c JOHNS HOPKINS BLOOMBERG SCHOOL OF PUBLIC HEALTH   (United States)

Author keywords

Human; Inflammation; Monocytes macrophages; Signal transduction; Stromal cells

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERSTITIAL COLLAGENASE; STAT3 PROTEIN; SYNAPTOPHYSIN; TISSUE INHIBITOR OF METALLOPROTEINASE 1; INTERLEUKIN 1BETA; MITOGEN ACTIVATED PROTEIN KINASE P38; STAT1 PROTEIN; STAT1 PROTEIN, HUMAN; STAT3 PROTEIN, HUMAN;

ARTICLE; FIBROBLAST; HUMAN; HUMAN CELL; IN VITRO STUDY; MACROPHAGE; MONOCYTE; MYCOBACTERIUM TUBERCULOSIS; PROTEIN EXPRESSION; PROTEIN SECRETION; SIGNAL TRANSDUCTION; STROMA CELL; TUBERCULOSIS; CELL LINE; CULTURE MEDIUM; CYTOLOGY; DRUG EFFECT; ENZYMOLOGY; GENETICS; KINETICS; METABOLISM; MICROBIOLOGY; PATHOLOGY; PHYSIOLOGY; PROMOTER REGION; PROTEIN BINDING; SECRETION;

MYCOBACTERIUM TUBERCULOSIS;

CELL LINE; CULTURE MEDIA, CONDITIONED; FIBROBLASTS; HUMANS; INTERLEUKIN-1BETA; KINETICS; MAP KINASE SIGNALING SYSTEM; MATRIX METALLOPROTEINASE 1; MONOCYTES; MYCOBACTERIUM TUBERCULOSIS; NF-KAPPA B; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PROMOTER REGIONS, GENETIC; PROTEIN BINDING; STAT1 TRANSCRIPTION FACTOR; STAT3 TRANSCRIPTION FACTOR; TISSUE INHIBITOR OF METALLOPROTEINASE-1; TUBERCULOSIS;

EID: 77958138970     PISSN: 10441549     EISSN: None     Source Type: Journal    
DOI: 10.1165/rcmb.2009-0211OC     Document Type: Article

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