Dexamethasone, cerebrospinal fluid matrix metalloproteinase concentrations and clinical outcomes in tuberculous meningitis

PLoS ONE

Volumn 4, Issue 9, 2009, Pages

  Green, Justin A ^a   Tran, Chau T H ^b   Farrar, Jeremy J ^b   Nguyen, Mai T H ^b   Nguyen, Phu H ^b   Dinh, Sinh X ^b   Ho, Nghia D T ^b   Ly, Chuong V ^b   Tran, Hien T ^b   Friedland, Jon S ^a   Thwaites, Guy E ^a  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

^b OXFORD UNIVERSITY CLINICAL RESEARCH UNIT   (Viet Nam)

Author keywords

[No Author keywords available]

Indexed keywords

DEXAMETHASONE; GELATINASE A; GELATINASE B; INTERSTITIAL COLLAGENASE; MATRILYSIN; MATRIX METALLOPROTEINASE; NEUTROPHIL COLLAGENASE; PLACEBO; STROMELYSIN; STROMELYSIN 2; TISSUE INHIBITOR OF METALLOPROTEINASE; TISSUE INHIBITOR OF METALLOPROTEINASE 1; TISSUE INHIBITOR OF METALLOPROTEINASE 2; TISSUE INHIBITOR OF METALLOPROTEINASE 4; TUBERCULOSTATIC AGENT; GLUCOCORTICOID;

ADJUVANT THERAPY; ADULT; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG DOSE REDUCTION; DRUG MECHANISM; ENZYME KINETICS; FEMALE; HUMAN; MALE; MYCOBACTERIUM TUBERCULOSIS; NEUTROPHIL COUNT; PROGNOSIS; PROTEIN CEREBROSPINAL FLUID LEVEL; RANDOMIZED CONTROLLED TRIAL; TUBERCULOUS MENINGITIS; ADJUVANT CHEMOTHERAPY; CEREBROSPINAL FLUID; DRUG EFFECT; KINETICS; METABOLISM; METHODOLOGY; MIDDLE AGED; NEUTROPHIL; TREATMENT OUTCOME;

ADULT; CEREBROSPINAL FLUID; CHEMOTHERAPY, ADJUVANT; DEXAMETHASONE; FEMALE; GLUCOCORTICOIDS; HUMANS; KINETICS; MALE; MATRIX METALLOPROTEINASE 9; MATRIX METALLOPROTEINASES; MIDDLE AGED; NEUTROPHILS; PLACEBOS; TREATMENT OUTCOME; TUBERCULOSIS, MENINGEAL;

EID: 70349673239     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0007277     Document Type: Article

References (34)

1. Thwaites GE, Nguyen DB, Nguyen HD, Hoang TQ, Do TT, et al. (2004) Dexamethasone for the treatment of tuberculous meningitis in adolescents and adults. N Engl J Med 351: 1741-1751.
2. Simmons CP, Thwaites GE, Quyen NT, Chau TT, Mai PP, et al. (2005) The clinical benefit of adjunctive dexamethasone in tuberculous meningitis is not associated with measurable attenuation of peripheral or local immune responses. J Immunol 175: 579-590.
3. Thwaites GE, Macmullen-Price J, Tran TH, Pham PM, Nguyen TD, et al. (2007) Serial MRI to determine the effect of dexamethasone on the cerebral pathology of tuberculous meningitis: an observational study. Lancet Neurol 6: 230-236.
4. Schoeman JF, Elshof JW, Laubscher JA, Janse van Rensburg A, Donald PR (2001) The effect of adjuvant steroid treatment on serial cerebrospinal fluid changes in tuberculous meningitis. Ann Trop Paediatr 21: 299-305.
5. McGeer PL, McGeer EG (1999) Inflammation of the brain in Alzheimer's disease: implications for therapy. J Leukoc Biol 65: 409-415.
6. Rosenberg GA (2005) Matrix metalloproteinases biomarkers in multiple sclerosis. Lancet 365: 1291-1293.
7. Zhang K, McQuibban GA, Silva C, Butler GS, Johnston JB, et al. (2003) HIV-induced metalloproteinase processing of the chemokine stromal cell derived factor-1 causes neurodegeneration. Nat Neurosci 6: 1064-1071.
8. Okada S, Kita H, George TJ, Gleich GJ, Leiferman KM (1997) Migration of eosinophils through basement membrane components in vitro: role of matrix metalloproteinase-9. Am J Respir Cell Mol Biol 17: 519-528.
9. van Horssen J, Bo L, Vos CM, Virtanen I, de Vries HE (2005) Basement membrane proteins in multiple sclerosis-associated inflammatory cuffs: potential role in influx and transport of leukocytes. J Neuropathol Exp Neurol 64: 722-729.
10. Matsuura E, Umehara F, Hashiguchi T, Fujimoto N, Okada Y, et al. (2000) Marked increase of matrix metalloproteinase 9 in cerebrospinal fluid of patients with fungal or tuberculous meningoencephalitis. J Neurol Sci 173: 45-52.
11. Price NM, Farrar J, Tran TT, Nguyen TH, Tran TH, et al. (2001) Identification of a matrix-degrading phenotype in human tuberculosis in vitro and in vivo. J Immunol 166: 4223-4230.
12. Harris JE, Fernandez-Vilaseca M, Elkington PT, Horncastle DE, Graeber MB, et al. (2007) IFNgamma synergizes with IL-1beta to up-regulate MMP-9 secretion in a cellular model of central nervous system tuberculosis. FASEB J 21: 356-365.
13. Bottcher T, Spreer A, Azeh I, Nau R, Gerber J (2003) Matrix metalloproteinase-9 deficiency impairs host defense mechanisms against Streptococcus pneumoniae in a mouse model of bacterial meningitis. Neurosci Lett 338: 201-204.
14. Sellner J, Leib SL (2006) In bacterial meningitis cortical brain damage is associated with changes in parenchymal MMP-9/TIMP-1 ratio and increased collagen type IV degradation. Neurobiol Dis 21: 647-656.
15. Elkington PT, Nuttall RK, Boyle JJ, O'Kane CM, Horncastle DE, et al. (2005) Mycobacterium tuberculosis but not vaccine BCG specifically up-regulates matrix metalloproteinase-1. Am J Respir Crit Care Med 172: 1596-1604.
16. Cuadrado E, Ortega L, Hernandez-Guillamon M, Penalba A, Fernandez-Cadenas I, et al. (2008) Tissue plasminogen activator (t-PA) promotes neutrophil degranulation and MMP-9 release. J Leukoc Biol 84: 207-214.
17. Martineau AR, Newton SM, Wilkinson KA, Kampmann B, Hall BM, et al. (2007) Neutrophil-mediated innate immune resistance to mycobacteria. J Clin Invest 117: 1988-1994.
18. Rosenberg GA (2002) Matrix metalloproteinases in neuroinflammation. Glia 39: 279-291.
19. Chang JC, Wysocki A, Tchou-Wong KM, Moskowitz N, Zhang Y, et al. (1996) Effect of Mycobacterium tuberculosis and its components on macrophages and the release of matrix metalloproteinases. Thorax 51: 306-311.
20. Hoheisel G, Sack U, Hui DS, Huse K, Chan KS, et al. (2001) Occurrence of matrix metalloproteinases and tissue inhibitors of metalloproteinases in tuberculous pleuritis. Tuberculosis (Edinb) 81: 203-209.
21. Hrabec E, Strek M, Zieba M, Kwiatkowska S, Hrabec Z (2002) Circulation level of matrix metalloproteinase-9 is correlated with disease severity in tuberculosis patients. Int J Tuberc Lung Dis 6: 713-719.
22. Rivera-Marrero CA, Schuyler W, Roser S, Roman J (2000) Induction of MMP-9 mediated gelatinolytic activity in human monocytic cells by cell wall components of Mycobacterium tuberculosis. Microb Pathog 29: 231-244.
23. Harris JE, Nuttall RK, Elkington PT, Green JA, Horncastle DE, et al. (2007) Monocyte-astrocyte networks regulate matrix metalloproteinase gene expression and secretion in central nervous system tuberculosis in vitro and in vivo. J Immunol 178: 1199-1207.
24. Keller C, Lauber J, Blumenthal A, Buer J, Ehlers S (2004) Resistance and susceptibility to tuberculosis analysed at the transcriptome level: lessons from mouse macrophages. Tuberculosis (Edinb) 84: 144-158.
25. Taylor JL, Hattle JM, Dreitz SA, Troudt JM, Izzo LS, et al. (2006) A role for matrix metalloproteinase-9 in granuloma formation during pulmonary Mycobacterium tuberculosis infection. Infect Immun 74: 6135-6144.
26. Lee KY, Kim EH, Yang WS, Ryu H, Cho SN, et al. (2004) Persistent increase of matrix metalloproteinases in cerebrospinal fluid of tuberculous meningitis. J Neurol Sci 220: 73-78.
27. Sulik A, Wojtkowska M, Oldak E (2008) Elevated Levels of MMP-9 and TIMP-1 in the Cerebrospinal Fluid of Children with Echovirus Type 30 and Mumps Meningitis. Scand J Immunol 68: 323-327.
28. Opdenakker G, Van den Steen PE, Dubois B, Nelissen I, Van Coillie E, et al. (2001) Gelatinase B functions as regulator and effector in leukocyte biology. J Leukoc Biol 69: 851-859.
29. Leppert D, Leib SL, Grygar C, Miller KM, Schaad UB, et al. (2000) Matrix metalloproteinase (MMP)-8 and MMP-9 in cerebrospinal fluid during bacterial meningitis: association with blood-brain barrier damage and neurological sequelae. Clin Infect Dis 31: 80-84.
30. Thwaites GE, Simmons CP, Than Ha Quyen N, Thi Hong Chau T, Phuong Mai P, et al. (2003) Pathophysiology and prognosis in vietnamese adults with tuberculous meningitis. J Infect Dis 188: 1105-1115.
31. Liu L, Wang YX, Zhou J, Long F, Sun HW, et al. (2005) Rapid non-genomic inhibitory effects of glucocorticoids on human neutrophil degranulation. Inflamm Res 54: 37-41.
32. Snoek-van Beurden PA, Von den Hoff JW (2005) Zymographic techniques for the analysis of matrix metalloproteinases and their inhibitors. Biotechniques 38: 73-83.
33. Liu X, Han Q, Sun R, Li Z (2008) Dexamethasone regulation of matrix metalloproteinase expression in experimental pneumococcal meningitis. Brain Res 1207: 237-243.
34. Teasdale G, Jennett B (1974) Assessment of coma and impaired consciousness. A practical scale. Lancet 2: 81-84.