메뉴 건너뛰기




Volumn 2, Issue , 2009, Pages 105-113

Role of trabectedin in the treatment of soft tissue sarcoma

Author keywords

Chemotherapy; DNA minor groove binder; Soft tissue sarcoma; Trabectedin

Indexed keywords

ANTHRACYCLINE; CAPECITABINE; DOXORUBICIN; IFOSFAMIDE; IRINOTECAN; PACLITAXEL; SEROTONIN 3 ANTAGONIST; TRABECTEDIN;

EID: 77953395371     PISSN: None     EISSN: 11786930     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (9)

References (79)
  • 2
    • 45149090773 scopus 로고    scopus 로고
    • Soft tissue sarcomas: ESMO clinical recommendations for diagnosis, treatment and follow-up
    • Casali PG, Jost L, Sleijfer S, Verweij J, Blay JY. Soft tissue sarcomas: ESMO clinical recommendations for diagnosis, treatment and follow-up. Ann Oncol. 2008;19(Suppl 2):ii89-ii93.
    • (2008) Ann Oncol , vol.19 , Issue.SUPPL. 2
    • Casali, P.G.1    Jost, L.2    Sleijfer, S.3    Verweij, J.4    Blay, J.Y.5
  • 3
    • 0031566814 scopus 로고    scopus 로고
    • Adjuvant chemotherapy for localised resectable soft-tissue sarcoma of adults: Meta-analysis of individual data
    • Sarcoma Meta-analysis Collaboration.
    • Adjuvant chemotherapy for localised resectable soft-tissue sarcoma of adults: meta-analysis of individual data. Sarcoma Meta-analysis Collaboration. Lancet. 1997;350:1647-1654.
    • (1997) Lancet , vol.350 , pp. 1647-1654
  • 4
    • 0027256397 scopus 로고
    • Randomized comparison of doxorubicin alone versus ifosfamide plus doxorubicin or mitomycin, doxorubicin, and cisplatin against advanced soft tissue sarcomas
    • Edmonson JH, Ryan LM, Blum RH, et al. Randomized comparison of doxorubicin alone versus ifosfamide plus doxorubicin or mitomycin, doxorubicin, and cisplatin against advanced soft tissue sarcomas. J Clin Oncol. 1993;11:1269-1275.
    • (1993) J Clin Oncol , vol.11 , pp. 1269-1275
    • Edmonson, J.H.1    Ryan, L.M.2    Blum, R.H.3
  • 5
    • 34547688913 scopus 로고    scopus 로고
    • Phase III trial of two investigational schedules of ifosfamide compared with standard-dose doxorubicin in advanced or metastatic soft tissue sarcoma: A European Organisation for Research and Treatment of Cancer Soft Tissue and Bone Sarcoma Group study
    • DOI 10.1200/JCO.2006.09.7717
    • Lorigan P, Verweij J, Papai Z, et al. Phase III trial of two investigational schedules of ifosfamide compared with standard-dose doxorubicin in advanced or metastatic soft tissue sarcoma: a European Organisation for Research and Treatment of Cancer Soft Tissue and Bone Sarcoma Group Study. J Clin Oncol. 2007;25:3144-3150. (Pubitemid 47218064)
    • (2007) Journal of Clinical Oncology , vol.25 , Issue.21 , pp. 3144-3150
    • Lorigan, P.1    Verweij, J.2    Papai, Z.3    Rodenhuis, S.4    Le Cesne, A.5    Leahy, M.G.6    Radford, J.A.7    Van Glabbeke, M.M.8    Kirkpatrick, A.9    Hogendoorn, P.C.W.10    Blay, J.-Y.11
  • 6
    • 0029005580 scopus 로고
    • Doxorubicin versus CYVADIC versus doxorubicin plus ifosfamide in first-line treatment of advanced soft tissue sarcomas: A randomized study of the European Organization for Research and Treatment of Cancer Soft Tissue and Bone Sarcoma Group
    • Santoro A, Tursz T, Mouridsen H, et al. Doxorubicin versus CYVADIC versus doxorubicin plus ifosfamide in first-line treatment of advanced soft tissue sarcomas: a randomized study of the European Organization for Research and Treatment of Cancer Soft Tissue and Bone Sarcoma Group. J Clin Oncol. 1995;13:1537-1545.
    • (1995) J Clin Oncol , vol.13 , pp. 1537-1545
    • Santoro, A.1    Tursz, T.2    Mouridsen, H.3
  • 7
    • 0034760282 scopus 로고    scopus 로고
    • Ifosfamide and epirubicin combination in untreated sarcomas: Two treatment schedules
    • DOI 10.1159/000055127
    • Serrone L, Zeuli M, Papaldo P, Nardoni C, Pacetti U, Cognetti F. Ifosfamide and epirubicin combination in untreated sarcomas: two treatment schedules. Onkologie. 2001;24:465-468. (Pubitemid 33033409)
    • (2001) Onkologie , vol.24 , Issue.5 , pp. 465-468
    • Serrone, L.1    Zeuli, M.2    Papaldo, P.3    Nardoni, C.4    Pacetti, U.5    Cognetti, F.6
  • 9
    • 0029001008 scopus 로고
    • High-dose ifosfamide: Circumvention of resistance to standard-dose ifosfamide in advanced soft tissue sarcomas
    • Le Cesne A, Antoine E, Spielmann M, et al. High-dose ifosfamide: circumvention of resistance to standard-dose ifosfamide in advanced soft tissue sarcomas. J Clin Oncol. 1995;13:1600-1608.
    • (1995) J Clin Oncol , vol.13 , pp. 1600-1608
    • Le Cesne, A.1    Antoine, E.2    Spielmann, M.3
  • 10
    • 0032870341 scopus 로고    scopus 로고
    • Saturable metabolism of continuous high-dose ifosfamide with mesna and GM-CSF: A pharmacokinetic study in advanced sarcoma patients
    • Swiss Group for Clinical Cancer Research (SAKK).
    • Cerny T, Leyvraz S, von Briel T, et al. Saturable metabolism of continuous high-dose ifosfamide with mesna and GM-CSF: a pharmacokinetic study in advanced sarcoma patients. Swiss Group for Clinical Cancer Research (SAKK). Ann Oncol. 1999;10:1087-1094.
    • (1999) Ann Oncol , vol.10 , pp. 1087-1094
    • Cerny, T.1    Leyvraz, S.2    Von Briel, T.3
  • 15
    • 0344110204 scopus 로고    scopus 로고
    • Dose-intensive chemotherapy with ifosfamide, epirubicin, and filgrastim for adult patients with metastatic or locally advanced soft tissue sarcoma: A phase II study
    • Reichardt P, Tilgner J, Hohenberger P, Dorken B. Dose-intensive chemotherapy with ifosfamide, epirubicin, and filgrastim for adult patients with metastatic or locally advanced soft tissue sarcoma: a phase II study. J Clin Oncol. 1998;16:1438-1443. (Pubitemid 28175763)
    • (1998) Journal of Clinical Oncology , vol.16 , Issue.4 , pp. 1438-1443
    • Reichardt, R.1    Tilgner, J.2    Hohenberger, P.3    Dorken, B.4
  • 16
    • 33645314364 scopus 로고    scopus 로고
    • Long-term results of a multicenter SAKK trial on high-dose ifosfamide and doxorubicin in advanced or metastatic gynecologic sarcomas
    • Leyvraz S, Zweifel M, Jundt G, et al. Long-term results of a multicenter SAKK trial on high-dose ifosfamide and doxorubicin in advanced or metastatic gynecologic sarcomas. Ann Oncol. 2006;17:646-651.
    • (2006) Ann Oncol , vol.17 , pp. 646-651
    • Leyvraz, S.1    Zweifel, M.2    Jundt, G.3
  • 17
    • 9744254464 scopus 로고    scopus 로고
    • Systemic therapy of soft tissue sarcoma: An improvement in outcome
    • DOI 10.1093/annonc/mdh926
    • Judson I. Systemic therapy of soft tissue sarcoma: an improvement in outcome. Ann Oncol. 2004;15(Suppl 4):iv193-iv196. (Pubitemid 39585334)
    • (2004) Annals of Oncology , vol.15 , Issue.SUPPL. 4
    • Judson, I.1
  • 18
    • 0033941746 scopus 로고    scopus 로고
    • Randomized phase III study comparing conventional-dose doxorubicin plus ifosfamide versus high-dose doxorubicin plus infosfamide plus recombinant human granulocyte-macrophage colony- Stimulating factor in advanced soft tissue sarcomas: A trial of the european organization for research and treatment of cancer/soft tissue and bone sarcoma group
    • Le Cesne A, Judson I, Crowther D, et al. Randomized phase III study comparing conventional-dose doxorubicin plus ifosfamide versus high-dose doxorubicin plus ifosfamide plus recombinant human granulocyte-macrophage colony-stimulating factor in advanced soft tissue sarcomas: A trial of the European Organization for Research and Treatment of Cancer/Soft Tissue and Bone Sarcoma Group. J Clin Oncol. 2000;18:2676-2684. (Pubitemid 30463549)
    • (2000) Journal of Clinical Oncology , vol.18 , Issue.14 , pp. 2676-2684
    • Le Cesne, A.1    Judson, I.2    Crowther, D.3    Rodenhuis, S.4    Keizer, H.J.5    Van Hoesel, Q.6    Blay, J.Y.7    Frisch, J.8    Van Glabbeke, M.9    Hermans, C.10    Van Oosterom, A.11    Tursz, T.12    Verweij, J.13
  • 19
    • 41149177493 scopus 로고    scopus 로고
    • Dose-intensive chemotherapy with growth factor or autologous bone marrow/stem cell transplant support in first-line treatment of advanced or metastatic adult soft tissue sarcoma: A systematic review
    • Verma S, Younus J, Stys-Norman D, Haynes AE, Blackstein M. Dose-intensive chemotherapy with growth factor or autologous bone marrow/stem cell transplant support in first-line treatment of advanced or metastatic adult soft tissue sarcoma: a systematic review. Cancer. 2008;112:1197-1205.
    • (2008) Cancer , vol.112 , pp. 1197-1205
    • Verma, S.1    Younus, J.2    Stys-Norman, D.3    Haynes, A.E.4    Blackstein, M.5
  • 20
    • 70349249554 scopus 로고    scopus 로고
    • Phase III trial of standard versus dose-intensified doxorubicin, ifosfamide and dacarbazine (MAID) in the first-line treatment of metastatic and locally advanced soft tissue sarcoma
    • Jan 16. [Epub ahead of print].
    • Fayette J, Penel N, Chevreau C, et al. Phase III trial of standard versus dose-intensified doxorubicin, ifosfamide and dacarbazine (MAID) in the first-line treatment of metastatic and locally advanced soft tissue sarcoma. Invest New Drugs. 2009. Jan 16. [Epub ahead of print].
    • (2009) Invest New Drugs
    • Fayette, J.1    Penel, N.2    Chevreau, C.3
  • 22
    • 21344443685 scopus 로고    scopus 로고
    • Genetic predictors for drug resistance in soft tissue sarcoma: A review of publications in 2004
    • DOI 10.1097/01.cco.0000166650.30793.f2
    • Fayette J, Blay JY. Genetic predictors for drug resistance in soft tissue sarcoma: a review of publications in 2004. Curr Opin Oncol. 2005;17:370-375. (Pubitemid 40904425)
    • (2005) Current Opinion in Oncology , vol.17 , Issue.4 , pp. 370-375
    • Fayette, J.1    Blay, J.-Y.2
  • 23
    • 0033571557 scopus 로고    scopus 로고
    • Paclitaxel in the treatment of patients with angiosarcoma of the scalp or face
    • Fata F, O'Reilly E, Ilson D, et al. Paclitaxel in the treatment of patients with angiosarcoma of the scalp or face. Cancer. 1999;86:2034-2037.
    • (1999) Cancer , vol.86 , pp. 2034-2037
    • Fata, F.1    O'Reilly, E.2    Ilson, D.3
  • 26
    • 34548446433 scopus 로고    scopus 로고
    • Sarcomas: Genetics, signalling, and cellular origins. Part I: the fellowship of TET
    • DOI 10.1002/path.2209
    • Riggi N, Cironi L, Suva ML, Stamenkovic I. Sarcomas: genetics, signalling, and cellular origins. Part 1: The fellowship of TET. J Pathol. 2007;213:4-20. (Pubitemid 47354561)
    • (2007) Journal of Pathology , vol.213 , Issue.1 , pp. 4-20
    • Riggi, N.1    Cironi, L.2    Suva, M.-L.3    Stamenkovic, I.4
  • 27
    • 35348997157 scopus 로고    scopus 로고
    • Sarcomas: Genetics, signalling, and cellular origins. Part 2: TET-independent fusion proteins and receptor tyrosine kinase mutations
    • DOI 10.1002/path.2208
    • Suva ML, Cironi L, Riggi N, Stamenkovic I. Sarcomas: genetics, signalling, and cellular origins. Part 2: TET-independent fusion proteins and receptor tyrosine kinase mutations. J Pathol. 2007;213:117-130. (Pubitemid 47612234)
    • (2007) Journal of Pathology , vol.213 , Issue.2 , pp. 117-130
    • Suva, M.-L.1    Cironi, L.2    Riggi, N.3    Stamenkovic, I.4
  • 29
    • 0034611483 scopus 로고    scopus 로고
    • A new, more efficient, and effective process for the synthesis of a key pentacyclic intermediate for production of ecteinascidin and phthalascidin antitumor agents
    • Martinez EJ, Corey EJ. A new, more efficient, and effective process for the synthesis of a key pentacyclic intermediate for production of ecteinascidin and phthalascidin antitumor agents. Org Lett. 2000;2:993-996.
    • (2000) Org Lett , vol.2 , pp. 993-996
    • Martinez, E.J.1    Corey, E.J.2
  • 30
    • 0034632436 scopus 로고    scopus 로고
    • Synthesis of ecteinascidin ET-743 and phthalascidin Pt-650 from cyanosafracin B
    • Cuevas C, Perez M, Martin MJ, et al. Synthesis of ecteinascidin ET-743 and phthalascidin Pt-650 from cyanosafracin B. Org Lett. 2000;2:2545-2548.
    • (2000) Org Lett , vol.2 , pp. 2545-2548
    • Cuevas, C.1    Perez, M.2    Martin, M.J.3
  • 32
    • 0033566150 scopus 로고    scopus 로고
    • Ecteinascidin 743: A minor groove alkylator that bends DNA toward the major groove
    • DOI 10.1021/jm990241l
    • Zewail-Foote M, Hurley LH. Ecteinascidin 743: a minor groove alkylator that bends DNA toward the major groove. J Med Chem. 1999;42:2493-2497. (Pubitemid 29344290)
    • (1999) Journal of Medicinal Chemistry , vol.42 , Issue.14 , pp. 2493-2497
    • Zewail-Foote, M.1    Hurley, L.H.2
  • 35
    • 0036830244 scopus 로고    scopus 로고
    • Differential cytostatic and apoptotic effects of ecteinascidin-743 in cancer cells: Transcription-dependent cell cycle arrest and transcription- independent JNK and mitochondrial mediated apoptosis
    • DOI 10.1074/jbc.M204644200
    • Gajate C, An F, Mollinedo F. Differential cytostatic and apoptotic effects of ecteinascidin-743 in cancer cells. Transcription-dependent cell cycle arrest and transcription-independent JNK and mitochondrial mediated apoptosis. J Biol Chem. 2002;277:41580-41589. (Pubitemid 35257462)
    • (2002) Journal of Biological Chemistry , vol.277 , Issue.44 , pp. 41580-41589
    • Gajate, C.1    An, F.2    Mollinedo, F.3
  • 36
    • 0031766324 scopus 로고    scopus 로고
    • In vitro antitumor activity of the novel marine agent, Ecteinascidin-743 (ET-743, NSC-648766) against human tumors explanted from patients
    • DOI 10.1023/A:1008224322396
    • Izbicka E, Lawrence R, Raymond E, et al. In vitro antitumor activity of the novel marine agent, ecteinascidin-743 (ET-743, NSC-648766) against human tumors explanted from patients. Ann Oncol. 1998;9:981-987. (Pubitemid 28496707)
    • (1998) Annals of Oncology , vol.9 , Issue.9 , pp. 981-987
    • Izbicka, E.1    Lawrence, R.2    Raymond, E.3    Eckhardt, G.4    Faircloth, G.5    Jimeno, J.6    Clark, G.7    Von Hoff, D.D.8
  • 39
    • 0032693607 scopus 로고    scopus 로고
    • High antitumour activity of ET743 against human tumour xenografts from melanoma, non-small-cell lung and ovarian cancer
    • DOI 10.1023/A:1008364727071
    • Hendriks HR, Fiebig HH, Giavazzi R, Langdon SP, Jimeno JM, Faircloth GT. High antitumour activity of ET743 against human tumour xenografts from melanoma, non-small-cell lung and ovarian cancer. Ann Oncol. 1999;10:1233-1240. (Pubitemid 29533575)
    • (1999) Annals of Oncology , vol.10 , Issue.10 , pp. 1233-1240
    • Hendriks, H.R.1    Fiebig, H.H.2    Giavazzi, R.3    Langdon, S.P.4    Jimeno, J.M.5    Faircloth, G.T.6
  • 40
    • 26244458402 scopus 로고    scopus 로고
    • In-vitro cytotoxicity of ET-743 (Trabectedin, Yondelis), a marine anti-cancer drug, in the Hep G2 cell line: Influence of cytochrome P450 and phase II inhibition, and cytochrome P450 induction
    • DOI 10.1097/01.cad.0000180121.16407.38
    • Brandon EF, Meijerman I, Klijn JS, et al. In vitro cytotoxicity of ET-743 (Trabectedin, Yondelis), a marine anti-cancer drug, in the Hep G2 cell line: influence of cytochrome P450 and phase II inhibition, and cytochrome P450 induction. Anticancer Drugs. 2005;16:935-943. (Pubitemid 41416084)
    • (2005) Anti-Cancer Drugs , vol.16 , Issue.9 , pp. 935-943
    • Brandon, E.F.A.1    Meijerman, I.2    Klijn, J.S.3    Den Arend, D.4    Sparidans, R.W.5    Lazaro, L.L.6    Beijnen, J.H.7    Schellens, J.H.M.8
  • 43
    • 77953434064 scopus 로고    scopus 로고
    • Phase I and pharmacokinetic study of the marinederived DNA minor groove binder ET-743 on a weekly × 3 every-4-week schedule in patients with advanced solid malignancies
    • Abstract # 373.
    • Forouzeh B, Hidalgo M, Denis L, et al. Phase I and pharmacokinetic study of the marinederived DNA minor groove binder ET-743 on a weekly × 3 every-4-week schedule in patients with advanced solid malignancies. Proc Am Soc Clin Oncol. 2001;20: Abstract # 373.
    • (2001) Proc Am Soc Clin Oncol , vol.20
    • Forouzeh, B.1    Hidalgo, M.2    Denis, L.3
  • 51
    • 41549089846 scopus 로고    scopus 로고
    • Randomized phase II study of trabectedin in patients with liposarcoma and leiomyosarcoma (L-sarcomas) after failure of prior anthracylines (A) and ifosfamide (I)
    • Yondelis Sarcoma Study Group. ASCO Annual Meeting Proceedings Part I Vol25, No 18S (June 20 Supplement), 10060.
    • Morgan JA, Le Cesne A, Chawla S, et al; Yondelis Sarcoma Study Group. Randomized phase II study of trabectedin in patients with liposarcoma and leiomyosarcoma (L-sarcomas) after failure of prior anthracylines (A) and ifosfamide (I). J Clin Oncol. 2007;25(June 20 Supplement):18S, ASCO Annual Meeting Proceedings Part I Vol25, No 18S (June 20 Supplement), 10060.
    • (2007) J Clin Oncol , vol.25 , Issue.JUNE 20 SUPPL.
    • Morgan, J.A.1    Le Cesne, A.2    Chawla, S.3
  • 53
    • 0009424924 scopus 로고    scopus 로고
    • Consistent evidence of activity of ecteinascidin (ET-743) in pretreated, advanced soft tissue sarcoma (ASTS): Results from a pooled analysis of three pivotal phase II clinical trials (p2ct) and safety profile of a 24 h infusion schedule
    • Le Cesne A, Misset JL, Demetri G, et al. Consistent evidence of activity of ecteinascidin (ET-743) in pretreated, advanced soft tissue sarcoma (ASTS): results from a pooled analysis of three pivotal phase II clinical trials (p2ct) and safety profile of a 24 h infusion schedule. European Journal of Cancer. 2001;37:S34-S.
    • (2001) European Journal of Cancer , vol.37
    • Le Cesne, A.1    Misset, J.L.2    Demetri, G.3
  • 54
    • 0242559104 scopus 로고    scopus 로고
    • Preclinical and clinical results with the natural marine product ET-743
    • DOI 10.1517/eoid.12.11.1843.21875
    • D'Incalci M, Jimeno J. Preclinical and clinical results with the natural marine product ET-743. Expert Opin Investig Drugs. 2003;12:1843-1853. (Pubitemid 37408131)
    • (2003) Expert Opinion on Investigational Drugs , vol.12 , Issue.11 , pp. 1843-1853
    • D'Incalci, M.1    Jimeno, J.2
  • 57
    • 77953418792 scopus 로고    scopus 로고
    • Trabectedin in Soft Tissue Sarcomas (STS) carrying a chromosomal translocation: An exploratory analysis
    • Abstract # 900 2007.
    • Grosso. Trabectedin in Soft Tissue Sarcomas (STS) carrying a chromosomal translocation: an exploratory analysis. Seattle, WA: 13th CTOS meeting, Nov 1-3, 2007. Abstract # 900 2007.
    • Seattle, WA: 13th CTOS Meeting, Nov 1-3, 2007
    • Grosso1
  • 58
    • 77953388617 scopus 로고    scopus 로고
    • Final results of a phase II trial of 3-hr infusion trabectedin in patients with recurrent sarcomas
    • Abstract # 524P 2006.
    • Dileo M. Final results of a phase II trial of 3-hr infusion trabectedin in patients with recurrent sarcomas. Istanbul, Turkey: 31st ESMO Congress Sept 29 - Oct 3, 2006. Abstract # 524P 2006.
    • Istanbul, Turkey: 31st ESMO Congress Sept 29 - Oct 3, 2006
    • Dileo, M.1
  • 59
    • 77953411902 scopus 로고    scopus 로고
    • Updated results of Phase II study of trabectedin (ET-743) in pretreated patients with advanced/ metastatic soft tissue sarcoma from a single institute
    • Abstract # 21506 2008.
    • Mohan V. Updated results of Phase II study of trabectedin (ET-743) in pretreated patients with advanced/ metastatic soft tissue sarcoma from a single institute. Chicago, IL: ASCO American Society of Clinical Oncology, 44th Annual Meeting, May 30 - Jun 3, 2008. Abstract # 21506 2008.
    • Chicago, IL: ASCO American Society of Clinical Oncology, 44th Annual Meeting, May 30 - Jun 3, 2008
    • Mohan, V.1
  • 60
    • 0036189675 scopus 로고    scopus 로고
    • Progression-free rate as the principal end-point for phase II trials in soft-tissue sarcomas
    • DOI 10.1016/S0959-8049(01)00398-7, PII S0959804901003987
    • Van Glabbeke M, Verweij J, Judson I, Nielsen OS. Progression-free rate as the principal end-point for phase II trials in soft-tissue sarcomas. Eur J Cancer. 2002;38:543-549. (Pubitemid 34185394)
    • (2002) European Journal of Cancer , vol.38 , Issue.4 , pp. 543-549
    • Van Glabbeke, M.1    Verweij, J.2    Judson, I.3    Nielsen, O.S.4
  • 64
    • 1642388840 scopus 로고    scopus 로고
    • Comparison of four modulators of drug metabolism as protectants against the hepatotoxicity of the novel antitumor drug yondelis (ET-743) in the female rat and in hepatocytes in vitro
    • DOI 10.1007/s00280-003-0744-3
    • Donald S, Verschoyle RD, Greaves P, Orr S, Jimeno J, Gescher AJ. Comparison of four modulators of drug metabolism as protectants against the hepatotoxicity of the novel antitumor drug yondelis (ET-743) in the female rat and in hepatocytes in vitro. Cancer Chemother Pharmacol. 2004;53:305-312. (Pubitemid 38392355)
    • (2004) Cancer Chemotherapy and Pharmacology , vol.53 , Issue.4 , pp. 305-312
    • Donald, S.1    Verschoyle, R.D.2    Greaves, P.3    Orr, S.4    Jimeno, J.5    Gescher, A.J.6
  • 65
    • 0036387382 scopus 로고    scopus 로고
    • Pharmacokinetics of ecteinascidin 743 administered as a 24-h continuous intravenous infusion to adult patients with soft tissue sarcomas: Associations with clinical characteristics, pathophysiological variables and toxicity
    • Puchalski TA, Ryan DP, Garcia-Carbonero R, et al. Pharmacokinetics of ecteinascidin 743 administered as a 24-h continuous intravenous infusion to adult patients with soft tissue sarcomas: associations with clinical characteristics, pathophysiological variables and toxicity. Cancer Chemother Pharmacol. 2002;50:309-319.
    • (2002) Cancer Chemother Pharmacol , vol.50 , pp. 309-319
    • Puchalski, T.A.1    Ryan, D.P.2    Garcia-Carbonero, R.3
  • 66
    • 42449133375 scopus 로고    scopus 로고
    • Fatal rhabdomyolysis as a complication of ET-743 (Yondelis) chemotherapy for sarcoma
    • Skorupa A, Beldner M, Kraft A, Montero AJ. Fatal rhabdomyolysis as a complication of ET-743 (Yondelis) chemotherapy for sarcoma. Cancer Biol Ther. 2007;6(7):1015-1017. (Pubitemid 351574950)
    • (2007) Cancer Biology and Therapy , vol.6 , Issue.7 , pp. 1015-1017
    • Skorupa, A.1    Beldner, M.2    Kraft, A.3    Montero, A.J.4
  • 67
    • 0037096739 scopus 로고    scopus 로고
    • Ecteinascidin-743 inhibits activated but not constitutive transcription
    • Friedman D, Hu Z, Kolb EA, Gorfajn B, Scotto KW. Ecteinascidin-743 inhibits activated but not constitutive transcription. Cancer Res. 2002;62:3377-3381. (Pubitemid 34651382)
    • (2002) Cancer Research , vol.62 , Issue.12 , pp. 3377-3381
    • Friedman, D.1    Hu, Z.2    Kolb, E.A.3    Gorfajn, B.4    Scotto, K.W.5
  • 70
    • 60849129809 scopus 로고    scopus 로고
    • Trabectedin (ET-743) promotes differentiation in myxoid liposarcoma tumors
    • Forni C, Minuzzo M, Virdis E, et al. Trabectedin (ET-743) promotes differentiation in myxoid liposarcoma tumors. Mol Cancer Ther. 2009;8:449-457.
    • (2009) Mol Cancer Ther , vol.8 , pp. 449-457
    • Forni, C.1    Minuzzo, M.2    Virdis, E.3
  • 71
    • 33748035692 scopus 로고    scopus 로고
    • Cross-talk between nucleotide excision and homologous recombination DNA repair pathways in the mechanism of action of antitumor trabectedin
    • DOI 10.1158/0008-5472.CAN-06-0179
    • Herrero AB, Martin-Castellanos C, Marco E, Gago F, Moreno S. Cross-talk between nucleotide excision and homologous recombination DNA repair pathways in the mechanism of action of antitumor trabectedin. Cancer Res. 2006;66:8155-8162. (Pubitemid 44299183)
    • (2006) Cancer Research , vol.66 , Issue.16 , pp. 8155-8162
    • Herrero, A.B.1    Martin-Castellanos, C.2    Marco, E.3    Gago, F.4    Moreno, S.5
  • 72
    • 41549100818 scopus 로고    scopus 로고
    • DNA repair functionality modulates the clinical outcome of patients with advanced sarcoma treated with trabectedin (ET-743)
    • 2006 ASCO Annual Meeting Proceedings Part I Vol24, No 18S (June 20 Supplement)
    • Schöffski P. DNA repair functionality modulates the clinical outcome of patients with advanced sarcoma treated with trabectedin (ET-743). Journal of Clinical Oncology, 2006 ASCO Annual Meeting Proceedings Part I Vol24, No 18S (June 20 Supplement), 2006:9522.
    • (2006) Journal of Clinical Oncology , pp. 9522
    • Schöffski, P.1
  • 75
    • 0034786774 scopus 로고    scopus 로고
    • Sequence-dependent enhancement of cytotoxicity produced by ecteinascidin 743 (ET-743) with doxorubicin or paclitaxel in soft tissue sarcoma cells
    • Takahashi N, Li WW, Banerjee D, Scotto KW, Bertino JR. Sequence-dependent enhancement of cytotoxicity produced by ecteinascidin 743 (ET-743) with doxorubicin or paclitaxel in soft tissue sarcoma cells. Clin Cancer Res. 2001;7:3251-3257 (Pubitemid 32963850)
    • (2001) Clinical Cancer Research , vol.7 , Issue.10 , pp. 3251-3257
    • Takahashi, N.1    Wei Wei, L.2    Banerjee, D.3    Scotto, K.W.4    Bertino, J.R.5
  • 76
    • 77953410730 scopus 로고    scopus 로고
    • Phase I clinical and pharmacokinetic study of trabectedin and doxorubicin in advanced soft tissue sarcoma and breast cancer
    • Dec 27. [Epub ahead of print].
    • Sessa C, Perotti A, Noberasco C, et al. Phase I clinical and pharmacokinetic study of trabectedin and doxorubicin in advanced soft tissue sarcoma and breast cancer. Eur J Cancer. 2008 Dec 27. [Epub ahead of print].
    • (2008) Eur J Cancer
    • Sessa, C.1    Perotti, A.2    Noberasco, C.3
  • 77
    • 53049092830 scopus 로고    scopus 로고
    • A phase I study of the safety and pharmacokinetics of trabectedin in combination with pegylated liposomal doxorubicin in patients with advanced malignancies
    • von Mehren M, Schilder RJ, Cheng JD, et al. A phase I study of the safety and pharmacokinetics of trabectedin in combination with pegylated liposomal doxorubicin in patients with advanced malignancies. Ann Oncol. 2008;19:1802-1809
    • (2008) Ann Oncol , vol.19 , pp. 1802-1809
    • Von Mehren, M.1    Schilder, R.J.2    Cheng, J.D.3
  • 78
    • 41549123853 scopus 로고    scopus 로고
    • Phase I and pharmacokinetics (PK) study of sequential paclitaxel and trabectedin every 2 weeks in patients with advanced solid tumors
    • ASCO Annual Meeting Proceedings Part I, 2006;24:(June 20 Supplement)
    • Papadopoulos. Phase I and pharmacokinetics (PK) study of sequential paclitaxel and trabectedin every 2 weeks in patients with advanced solid tumors. J Clin Oncol. 2006; ASCO Annual Meeting Proceedings Part I, 2006;24:(June 20 Supplement)18S, 2029.
    • (2006) J Clin Oncol , vol.18 S , pp. 2029
    • Papadopoulos1
  • 79
    • 41549144621 scopus 로고    scopus 로고
    • Phase I combination study of trabectedin (T) and capecitabine (C) in patients with advanced malignancies
    • ASCO Annual Meeting Proceedings Part I, 2006;24:(June 20 Supplement)
    • Gore L. Phase I combination study of trabectedin (T) and capecitabine (C) in patients with advanced malignancies. J Clin Oncol. 2006; ASCO Annual Meeting Proceedings Part I, 2006;24:(June 20 Supplement)18S, 2079.
    • (2006) J Clin Oncol , vol.18 S , pp. 2079
    • Gore, L.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.