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1 McClain KL, Leach CT, Jenson HB, Joshi VV, Ploock BH, Parmley RT, DiCarlo FJ, Chadwick EG, Murphy SB: Association of Epstoin-Barr virus with leiomyosarcomas in young people with AIDS. N Engl J Med 1995, 332:12-18.
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Soft tissue sarcoma and non-Hodgkin's lymphoma in workers exposed to phenoxy herbicides, chlorophenols, and dioxins: Two nested case-control studies
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3 Kogevinas M, Kauppinen T, Winkelmann R, Becher H, Bertazzi PA, Buenode-Mesquita HB, et al.: Soft tissue sarcoma and non-Hodgkin's lymphoma in workers exposed to phenoxy herbicides, chlorophenols, and dioxins: Two nested case-control studies. Epidemiology 1995, 6:396-402.
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6 Kramarova E, Kogevinas M, Thuyet Ahn C, Dingh Cau H, Cao Dao L, Stellman SD, Parkin DM: Exposure to agent orange and occurence of soft tissue sarcomas or non-Hodgkin lymphomas: an ongoing study in Vietnam, Environ Health Ferspect 1998, 106(suppl 2); 671-678. The impact of TCDD, one of the most toxic manmade chemicals, as a contaminant of Agent Orange on the incidence of soft tissue sarcomas and non-Hodgkin lymphoma in Vietnam is being investigated. This report indicates the stategy used to study this impact of that exposure in Vietnam. The use of an index reflecting geographical exposure will be compared to biological measurement of herbicides in both tissue and serum.
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Proliferate activity (MIB-1 index) is an independent prognostic parameter in patients with high-grade sott tissue sarcomas of subtypes other than malignant fibrous histiocytomas: A retrospective immunohistological study including 216 soft tissue sarcomas
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8 Jensen V, Brandt Sorensen F, Bentzen SM, Ladekarl M, Steen Nielsen O, Keller J, Jensen OM: Proliferate activity (MIB-1 index) is an independent prognostic parameter in patients with high-grade sott tissue sarcomas of subtypes other than malignant fibrous histiocytomas: a retrospective immunohistological study including 216 soft tissue sarcomas. Histopathology 1998, 32:536-546. Histopathologic grading is known to be important in the assessment of prognosis in STS. In this study the estimation of proliferative activity was shown to yield significant prognostic information within the group of high-grade sarcomas. The exclusion of MFH-type sarcomas within this high-grade group of tumors again seems to point to significant biological differences between the different sarcoma histiotypes.
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Ki-67 detected by MIB-1 predicts distant metastasis and tumor mortality in primary, high grade extremity soft tissue sarcoma
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14 Collin F, Chassevent A, Bonichon F, Bertrand G, Terier P, Coindre JM and the FNCLCC sarcoma group: Flow cytometric DNA content analysis of 185 soft tissue neoplasms indicates that S phase fraction is a prognostic factor for sarcomas. Cancer 1997, 79:2371-2379.
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16 Würl P, Taubert H, Meye A, Berger D, Lautenschläger Ch, Holzhausen H-J, et al.: Prognostic value of immunohistochemistry for p53 in primary soft tissue sarcomas: a multivariafe analysis of five antibodies. J Cancer Res Clin Oncol 1997, 123:502-508.
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19 Yoo J, Lee H-K, Kang C-S, Park W-S, Lee J-Y, Shim S-I: p53 gene mutations and p53 protein expression in human soft tissue sarcomas. Arch Pathol Lab Med 1997, 121:395-399.
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20 Schneider-Stock R, Radig K, Oda Y, Mellin W, Rys J, Niezabitowski A, Roessner A: p53 gene mutations in soft-tissue sarcomas correlations with p53 immunohistochemistry and DNA ploidy. J Cancer Res Clin Oncol 1997, 123:211-218.
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22 Würl P, Meye A, Schmidt H, Lautenschlager C, Kalthoff H, Rath FW, Taubert H: High prognostic significance of mdm2/p53 co-overexpression in soft tissue sarcomas of the extremities. Oncogene 1998, 16:1183-1185.
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23 Pollock R, Lang A, Ge T, Sun D, Tan M, Yu D: Wild-type p53 and a p53 temperature-sensitive mutant suppress human soft tissue sarcoma by enhancing cell cycle control. Clin Cancer Res 1998, 4:1985-1994. With the use of a human-derived p53-mutated leiomyosarcoma cell line, the impact of transfection with wild type p53 was evaluated both in-vitro and in-vivo. These studies suggest that restoration of wild type P53 protein expression results in decreased proliferative activity and increased cell cycle control. These data suggest that restoration of p53 might be a reasonable target for sarcoma treatment.
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No p161NK4A/CDKN2/MTS1 mutations independent of p53 status in soft tissue sarcomas
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24 Meye A, Würl P, Hinze R, Berger D, Bache M, Schmidt H, et al.: No p161NK4A/CDKN2/MTS1 mutations independent of p53 Status in soft tissue sarcomas. J Pathol 1998, 184:14-17. In 74 mesodermaf tumors no p16 mutation was observed with PCR-SSCP sequencing.
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34 Forus A, Berner J-M, Meza-Zepeda LA, Saeter G, Mischke D, Fodstad Ø, Myklebost O : Molecular characterization of a novel amplicon at 1q21-q22 freqently observed in human sarcomas. Brit J Cancer 1998, 78:495-503.
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35 Mertens F, Fletcher CDM, Dal Cin P, De Wever I, Mandahl N, Mitelkman F, Rosai J, Rydholm A, Sciot R, Tallini G, Van den Berghe H, Vanni R, Willen H: Cytogenetic analysis of 46 pleomorphic soft tissue sarcomas and correlation with morphologic and clinical features: a report of the CHAMP study group. Genes Chromosomes Cancer 1998, 22:16-25. In 46 pleomorphic soft tissue sarcomas no specific cytogenetic aberration could be identified.
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