Comparison of four modulators of drug metabolism as protectants against the hepatotoxicity of the novel antitumor drug yondelis (ET-743) in the female rat and in hepatocytes in vitro

Cancer Chemotherapy and Pharmacology

Volumn 53, Issue 4, 2004, Pages 305-312

  Donald, Sarah ^a   Verschoyle, Richard D ^a   Greaves, Peter ^a   Orr, Samantha ^b   Jimeno, Jose ^c   Gescher, Andreas J ^a  

^a UNIVERSITY OF LEICESTER   (United Kingdom)

^b DE MONTFORT UNIVERSITY   (United Kingdom)

^c PHARMAMAR S A   (Spain)

Author keywords

Dexamethasone; ET 743; Hepatotoxicity Naphthoflavone; Phenobarbitone

Indexed keywords

ACETYLCYSTEINE; ALKALINE PHOSPHATASE; BETA NAPHTHOFLAVONE; BILIRUBIN; CYTOCHROME P450 3A; DEXAMETHASONE; PHENOBARBITAL; TETRAHYDROISOQUINOLINE DERIVATIVE; TRABECTEDIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; BONE MARROW TOXICITY; BREAST CARCINOMA; CONTROLLED STUDY; CYTOTOXICITY; DISEASE EXACERBATION; DRUG METABOLISM; FEMALE; HISTOPATHOLOGY; IN VITRO STUDY; LIVER CELL; LIVER PROTECTION; LIVER TOXICITY; NONHUMAN; OVARY CARCINOMA; PRIORITY JOURNAL; RAT; SARCOMA;

ACETYLCYSTEINE; ALKALINE PHOSPHATASE; ANIMALS; ANTINEOPLASTIC AGENTS, ALKYLATING; ASPARTATE AMINOTRANSFERASES; BETA-NAPHTHOFLAVONE; CELL SURVIVAL; DEXAMETHASONE; DIOXOLES; FEMALE; HEPATITIS, TOXIC; HEPATOCYTES; ISOQUINOLINES; LIVER; METABOLIC DETOXICATION, DRUG; PHENOBARBITAL; RATS; RATS, WISTAR; TETRAHYDROISOQUINOLINES;

EID: 1642388840     PISSN: 03445704     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00280-003-0744-3     Document Type: Article

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