Identification and characterization of a lupus suppressor 129 locus on chromosome 3

Journal of Immunology

Volumn 184, Issue 11, 2010, Pages 6256-6265

  Carlucci, Francesco ^a   Fossati Jimack, Liliane ^a   Dumitriu, Ingrid E ^a   Heidari, Yasin ^a   Walport, Mark J ^a,c   Szajna, Marta ^a   Baruah, Paramita ^a   Garden, Oliver A ^b   Cook, H Terence ^a   Botto, Marina ^a  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

^b ROYAL VETERINARY COLLEGE   (United Kingdom)

^c WELLCOME TRUST SANGER INSTITUTE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIBODY; CD3 ANTIGEN; TRANSCRIPTION FACTOR FOXP3;

ALLELE; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIBODY PRODUCING CELL; ARTICLE; B LYMPHOCYTE; B LYMPHOCYTE ACTIVATION; CD4+ T LYMPHOCYTE; CHROMOSOME 3; CONGENIC STRAIN; CONTROLLED STUDY; GENE IDENTIFICATION; GENE LOCUS; GENETIC ANALYSIS; IMMUNIZATION; IN VITRO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEINURIA; REGULATORY T LYMPHOCYTE; SEROLOGY; SPLEEN; SYSTEMIC LUPUS ERYTHEMATOSUS; T LYMPHOCYTE ACTIVATION; URINALYSIS; ANIMAL; BIOSYNTHESIS; CELL SEPARATION; FLOW CYTOMETRY; FLUORESCENT ANTIBODY TECHNIQUE; GENETIC PREDISPOSITION; GENETICS; IMMUNOLOGY; PATHOLOGY; T LYMPHOCYTE; T LYMPHOCYTE SUBPOPULATION;

ANIMALS; AUTOANTIBODIES; B-LYMPHOCYTES; CELL SEPARATION; FLOW CYTOMETRY; FLUORESCENT ANTIBODY TECHNIQUE; GENETIC PREDISPOSITION TO DISEASE; LUPUS ERYTHEMATOSUS, SYSTEMIC; MICE; MICE, CONGENIC; T-LYMPHOCYTE SUBSETS; T-LYMPHOCYTES; T-LYMPHOCYTES, REGULATORY;

EID: 77953395284     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.0901463     Document Type: Article

References (30)

1. Fairhurst, A. M., A. E. Wandstrat, and E. K. Wakeland. 2006. Systemic lupus erythematosus: multiple immunological phenotypes in a complex genetic disease. Adv. Immunol. 92: 1-69.
2. Rhodes, B., and T. J. Vyse. 2008. The genetics of SLE: an update in the light of genome-wide association studies. Rheumatology (Oxford) 47: 1603-1611.
3. Morel, L., X. H. Tian, B. P. Croker, and E. K. Wakeland. 1999. Epistatic modifiers of autoimmunity in a murine model of lupus nephritis. Immunity 11: 131-139.
4. Morel, L., B. P. Croker, K. R. Blenman, C. Mohan, G. Huang, G. Gilkeson, and E. K. Wakeland. 2000. Genetic reconstitution of systemic lupus erythematosus immunopathology with polycongenic murine strains. Proc. Natl. Acad. Sci. USA 97: 6670-6675.
5. Subramanian, S., Y. S. Yim, K. Liu, K. Tus, X. J. Zhou, and E. K. Wakeland. 2005. Epistatic suppression of systemic lupus erythematosus: fine mapping of Sles1 to less than 1 mb. J. Immunol. 175: 1062-1072.
6. Bygrave, A. E., K. L. Rose, J. Cortes-Hernandez, J. Warren, R. J. Rigby, H. T. Cook, M. J. Walport, T. J. Vyse, and M. Botto. 2004. Spontaneous autoimmunity in 129 and C57BL/6 mice-implications for autoimmunity described in gene-targeted mice. PLoS Biol. 2: E243.
7. Heidari, Y., A. E. Bygrave, R. J. Rigby, K. L. Rose, M. J. Walport, H. T. Cook, T. J. Vyse, and M. Botto. 2006. Identification of chromosome intervals from 129 and C57BL/6 mouse strains linked to the development of systemic lupus erythematosus. Genes Immun. 7: 592-599.
8. Carlucci, F., J. Cortes-Hernandez, L. Fossati-Jimack, A. E. Bygrave, M. J. Walport, T. J. Vyse, H. T. Cook, and M. Botto. 2007. Genetic dissection of spontaneous autoimmunity driven by 129-derived chromosome 1 Loci when expressed on C57BL/6 mice. J. Immunol. 178: 2352-2360.
9. Liu, K., and C. Mohan. 2006. What do mouse models teach us about human SLE? Clin. Immunol. 119: 123-130.
10. Heidari, Y., L. Fossati-Jimack, F. Carlucci, M. J. Walport, H. T. Cook, and M. Botto. 2009. A lupus-susceptibility C57BL/6 locus on chromosome 3 (Sle18) contributes to autoantibody production in 129 mice. Genes Immun. 10: 47-55.
11. Monk, C. R., M. Spachidou, F. Rovis, E. Leung, M. Botto, R. I. Lechler, and O. A. Garden. 2005. MRL/Mp CD4+,CD25- T cells show reduced sensitivity to suppression by CD4+,CD25+ regulatory T cells in vitro: a novel defect of T cell regulation in systemic lupus erythematosus. Arthritis Rheum. 52: 1180-1184.
12. Haywood, M. E., L. Gabriel, S. J. Rose, N. J. Rogers, S. Izui, and B. J. Morley. 2007. BXSB/long-lived is a recombinant inbred strain containing powerful disease suppressor loci. J. Immunol. 179: 2428-2434.
13. Wang, Y., M. Nose, T. Kamoto, M. Nishimura, and H. Hiai. 1997. Host modifier genes affect mouse autoimmunity induced by the lpr gene. Am. J. Pathol. 151: 1791-1798.
14. Subramanian, S., K. Tus, Q. Z. Li, A. Wang, X. H. Tian, J. Zhou, C. Liang, G. Bartov, L. D. McDaniel, X. J. Zhou, et al. 2006. A Tlr7 translocation accelerates systemic autoimmunity in murine lupus. Proc. Natl. Acad. Sci. USA 103: 9970-9975.
15. Tarasenko, T., H. K. Kole, and S. Bolland. 2008. A lupus-suppressor BALB/c locus restricts IgG2 autoantibodies without altering intrinsic B cell-tolerance mechanisms. J. Immunol. 180: 3807-3814.
16. Mohan, C., Y. Yu, L. Morel, P. Yang, and E. K. Wakeland. 1999. Genetic dissection of Sle pathogenesis: Sle3 on murine chromosome 7 impacts T cell activation, differentiation, and cell death. J. Immunol. 162: 6492-6502.
17. Vratsanos, G. S., S. Jung, Y. M. Park, and J. Craft. 2001. CD4(+) T cells from lupus-prone mice are hyperresponsive to T cell receptor engagement with low and high affinity peptide antigens: a model to explain spontaneous T cell activation in lupus. J. Exp. Med. 193: 329-337.
18. Linterman, M. A., R. J. Rigby, R. K. Wong, D. Yu, R. Brink, J. L. Cannons, P. L. Schwartzberg, M. C. Cook, G. D. Walters, and C. G. Vinuesa. 2009. Follicular helper T cells are required for systemic autoimmunity. J. Exp. Med. 206: 561-576.
19. Hoffman, R. W. 2004. T cells in the pathogenesis of systemic lupus erythematosus. Clin. Immunol. 113: 4-13.
20. Grimaldi, C. M., D. J. Michael, and B. Diamond. 2001. Cutting edge: expansion and activation of a population of autoreactive marginal zone B cells in a model of estrogen-induced lupus. J. Immunol. 167: 1886-1890.
21. Li, Y., H. Li, and M. Weigert. 2002. Autoreactive B cells in the marginal zone that express dual receptors. J. Exp. Med. 195: 181-188.
22. Wither, J. E., C. Loh, G. Lajoie, S. Heinrichs, Y. C. Cai, G. Bonventi, and R. MacLeod. 2005. Colocalization of expansion of the splenic marginal zone population with abnormal B cell activation and autoantibody production in B6 mice with an introgressed New Zealand Black chromosome 13 interval. J. Immunol. 175: 4309-4319.
23. Duan, B., B. P. Croker, and L. Morel. 2007. Lupus resistance is associated with marginal zone abnormalities in an NZM murine model. Lab. Invest. 87: 14-28.
24. Attanavanich, K., and J. F. Kearney. 2004. Marginal zone, but not follicular B cells, are potent activators of naive CD4 T cells. J. Immunol. 172: 803-811.
25. Niu, H., E. S. Sobel, and L. Morel. 2008. Defective B-cell response to T-dependent immunization in lupus-prone mice. Eur. J. Immunol. 38: 3028-3040.
26. Park, C. L., R. S. Balderas, T. M. Fieser, J. H. Slack, G. J. Prud'Homme, F. J. Dixon, and A. N. Theofilopoulos. 1983. Isotypic profiles and other fine characteristics of immune responses to exogenous thymus-dependent and -independent antigens by mice with lupus syndromes. J. Immunol. 130: 2161-2167.
27. Chen, Y., C. Cuda, and L. Morel. 2005. Genetic determination of T cell help in loss of tolerance to nuclear antigens. J. Immunol. 174: 7692-7702.
28. Cuda, C. M., S. Wan, E. S. Sobel, B. P. Croker, and L. Morel. 2007. Murine lupus susceptibility locus Sle1a controls regulatory T cell number and function through multiple mechanisms. J. Immunol. 179: 7439-7447.
29. Abe, J., S. Ueha, J. Suzuki, Y. Tokano, K. Matsushima, and S. Ishikawa. 2008. Increased Foxp3(+) CD4(+) regulatory T cells with intact suppressive activity but altered cellular localization in murine lupus. Am. J. Pathol. 173: 1682-1692.
30. Yang, C. H., L. Tian, G. S. Ling, N. J. Trendell-Smith, L. Ma, C. K. Lo, D. I. Stott, F. Y. Liew, and F. P. Huang. 2008. Immunological mechanisms and clinical implications of regulatory T cell deficiency in a systemic autoimmune disorder: roles of IL-2 versus IL-15. Eur. J. Immunol. 38: 1664-1676.